An exclusive portfolio of translational (humanized & knockout) mouse models for an improved prediction of the Absorption, Distribution, Metabolism, Excretion, and Toxicity (ADMET) characteristics of novel compounds in humans.
ADMET Portfolio
Translational mouse models for ADMET studies
Applications
- Drug-drug interactions
- Human metabolite testing
- Assessment of bioavailability and clearance
- PKPD modeling
- Carcinogenicity testing
- Infectious diseases
- Drug metabolism
- Toxicity testing
Benefits
- Improved drug candidate selection
- Improved identification of drug liabilities and human-specific metabolites prior to clinical trials
- Higher clinical success rates
- Reduced costs
| Genetically Engineered Mice | |||||
|---|---|---|---|---|---|
| Xenoreceptor Panel | Cytochrome P450 Panel | Transporter Panel | |||
| Knockouts | Humanized | Knockouts | Humanized | Knockouts | Humanized |
| Ahr | AHR | Cyp1a1/1a2 * | Bcrp | ||
| Car | CAR | Cyp2c | CYP2C9 | Mdr1a | |
| Cyp2d | CYP2D6 | Mdr1a/b | |||
| Pxr | PXR | Cyp3a (7-gene) | CYP3A4/3A7 | Mdr1a/b-Bcrp | |
| Pxr-Car | PXR-CAR | Cyp3a (8-gene) | Liver CYP3A4 | Mrp1 | MRP2 |
| Pxr-Car-Ahr | Gut CYP3A4 | Oatp1a/1b | OATP1B1 | ||
| Liver & Gut CYP3A4 | OATP1B3 | ||||
| OATP1B1-1B3 | |||||
* Inquire
Composite Models (Humanized) | Host Strain for Liver Humanization | Carcinogenicity Models | Related Models |
|---|---|---|---|
| PXR-CAR-CYP3A4/3A7 | TK-NOG | rasH2™ mouse | HRN™ |
| TSG-p53 (cryopreserved) | HRN nude |
Taconic offers non-GLP compound profiling services using selected ADMET models
ADMET services from Taconic may include:
- Consultancy using ADMET mice
- Partial services (compound administration & tissue extraction)
- Full services (with sub-contractors, if required)
Your Benefits
- Consistency of animal handling prior & during experiments
- Cost saving by avoiding animal shipment
- Overcome bottlenecks in internal pipeline
