Next-Generation NOG Models

Further genetic modifications have been carried out on the CIEA NOG mouse to develop next-generation models to improve experimental outcomes in a wide range of applications. 

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Fc gamma Receptor Knockout: FcResolv NOG Models

The FcResolv NOG models are the first and only super immunodeficient mice with knockout of murine Fc gamma receptors to improve accuracy of results when assessing antibody-based therapeutics

MHC Class I Knockout

  • The B2m-NOG is an immunodeficient CIEA NOG mouse® with an additional knockout of the B2m gene which disrupts MHC class I antigen presentation.
  • B2m-NOG mice can successfully engraft human PBMCs and tumors.
  • Compared to NOG, B2m-NOG mice have markedly delayed GvHD onset after human PBMC engraftment, providing an expanded study window (8+ weeks). 
  • Available engrafted with human PBMCs as huPBMC-B2m-NOG.

TK-NOG for Liver Humanization

The TK-NOG mouse offers inducible hepatocyte ablation and may be used for liver humanization studies.

The NOG Portfolio

The NOG mouse is a widely used and versatile super immunodeficient mouse which offers many advantages over standard nude and scid strains, particularly for engraftment of challenging cell lines, patient-derived xenografts, and immune system humanization.

The NOG mouse is the base of a flexible platform which includes a variety of next-generation models which have specific utility as well as several different types of humanized immune system (HIS) models.

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