Both versions of the huNOG-EXL start with engraftment in the Taconic humanization lab by highly experienced technicians. The same engraftment protocol is used for both huNOG-EXL SA and huNOG-EXL EA mice, with hematopoietic stem cells (HSCs) for Early Access engraftments chosen from donors with proven successful engraftment.
huNOG-EXL EA mice ship out to customers within 2 weeks post-engraftment (WPE), whereas huNOG-EXL SA mice stay in the humanization lab through the 10 WPE QC check and ship to customers starting at 11 WPE.
Lifespan in Myeloid-Supportive HIS Mice
All myeloid-supportive HIS mice have limited lifespans due to a range of outcomes including anemia, thrombocytopenia, macrophage activation syndrome, and hemophagocytic lymphohistiocytosis. The huNOG-EXL has the longest demonstrated lifespan compared to competing models, but this varies by donor and can be impacted by environmental and experimental factors. Taconic has observed that huNOG-EXL mice can often survive for 30+ WPE, so researchers should plan for a typical study window of 22-26 WPE. Contact us for additional guidance on HIS model-specific housing and husbandry.