huSelect™ Services for humanized immune system mice
huSelect™ services are ideal for researchers carrying out pre-clinical studies who want to improve project outcomes to accelerate therapeutics to market.
huSelect Customized Humanization Options
Humanized immune system (HIS) mice are critical tools for in vivo evaluation of biological therapeutic target efficacy. HIS mice require a human donor source of CD34+ hematopoietic stem cells (HSCs), but genetic variance across donors can lead to inconsistent outcomes.
Taconic has developed a suite of offerings to address the issue of donor-to-donor variability by utilizing our extensive and well-characterized CD34+HSC inventory and expertise in immune cell characterization. Suitable for use in any of our CD34+ humanized immune system models (huNOG-EXL, FcResolv huNOG-EXL, huNOG, FcResolv NOG) or in a model of your choice.
huSelect Service* | Description |
| Select CD34+ HSC donors based on one or more HLA criteria | Our extensive CD34+ HSC donor catalog supports a wide range of HLA types for to suit your study parameters. |
| Request a specific CD34+ HSC donor | Repeat studies using CD34+ donors from prior orders |
| Reserve CD34+ cells for future use | Ensure an ongoing supply of CD34+ cells from selected donors |
| Pre-characterized CD34+ HSC donors | A number of donors have been validated in huNOG-EXL mice and pre-characterized for human immune cell populations for four timepoints out to 30 weeks post-engraftment. Data available upon request. |
| On-demand analysis of immune cell characterization | Flow cytometry services for immune cell analysis of models prior to shipping or for customer-provided samples. A variety of panels are available. |
*All service options are subject to availability. Other restrictions may apply.
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