CIEA NOG mouse®

CIEA NOG ® Constitutive Knockout / Spontaneous Mutant Mouse Model
  • Live
  • Mouse
  • Male & Female Available
  • Albino
  • Available for direct purchase by CRO
Model No.NomenclatureGenotype
NOG-FNOD.Cg-Prkdcscid Il2rgtm1Sug/JicTacsp/sp;ko/ko
NOG-MNOD.Cg-Prkdcscid Il2rgtm1Sug/JicTacsp/sp;ko/y
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Overview

Nomenclature: NOD.Cg-Prkdcscid Il2rgtm1Sug/JicTac

 

The first and most versatile severely immunodeficient mouse model 

  • Immunodeficient model lacking mature T, B, and NK cells
  • Displays reduced complement activity
  • Has dysfunctional macrophages and dendritic cells
  • Displays no leakiness of T and B cells with increasing age
  • Very low incidence of lymphoma (unlike NOD scid model)
  • Does not develop diabetes
  • Excellent model for a variety of xenograft and human cell engraftment studies
  • Applications in research involving Cancer, Infectious Disease, Immunology, Regenerative Medicine, Humanization, Autoimmune Disease, Immunotherapy Vaccine, GvHD/Transplantation, Hematopoiesis, Oncology, Inflammation/Allergy, and Safety Assessment
  • The Il2rg gene is sex-linked

Availability

Available now*
*Please note that advanced order placement is encouraged for male mice. Ordering 4 or more weeks prior to the desired shipping date is recommended when requesting males older than 3-weeks of age.

Origin

The CIEA NOG mouse® was developed by Mamoru Ito of the Central Institute for Experimental Animals (CIEA) in Japan. The Prkdc scid mutation was identified by Mel Bosma of the Fox Chase Cancer Center in a C.B-17 congenic mouse population. This mutation was backcrossed onto the NOD/ShiJic strain at CIEA for at least eight generations. The Il2rg targeted mutation was developed by Dr. Kazuo Sugamura of Tohoku University by targeting the gene in ES cells derived from a 129 strain. Portions of exons 7 and 8 were replaced with a neo cassette. Targeted ES cells were injected into C57BL/6 blastocysts. Resultant chimeras were backcrossed onto the C57BL/6JJic background for at least eight generations. The CIEA NOG mouse® was developed by backcrossing the C57BL/6JJic-Il2rg line to the NOD/ShiJic-Prkdc scid line for a total of eight generations. Taconic received stock in 2006, and the line was derived through embryo transfer. The CIEA NOG mouse® colony was refreshed in 2011 and 2015 via rederivation of new stock using donors/donor material sourced from the CIEA NOG mouse® foundation colony at CIEA. The mice are maintained by breeding females homozygous for both the Prkdc scid and Il2rg mutant alleles with males that are homozygous for the Prkdc scid allele and hemizygous for the Il2rg mutant allele.

Genetics

Species:Mouse
Strain Type:Congenic
Allele Type:Constitutive Knockout;Spontaneous Mutant
Coat Color:Albino
Genetic Background:NOD

Guides & Publications

Initial Publication: Ito M, Hiramatsu H, Kobayashi K, Suzue K, Kawahata M, Hioki K, Ueyama Y, Koyanagi Y, Sugamura K, Tsuji K, Heike T, Nakahata T. (2002) NOD/SCID/γ mouse: an excellent recipient mouse model for engraftment of human cells. Blood 100(9):3175-3182.

Applications & Therapeutic Areas

  • Immunology
  • Infectious Disease
  • Inflammation
  • Oncology & Immuno-Oncology
  • Safety Assessment
  • Vaccine Research
  • Cell and Tissue Humanized

Transit, Housing & Welfare

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Packing Practices

Taconic standard practice is to recombine animals of different home cages and/or ages from a single model and sex during packing, except in specific cases where Taconic's animal welfare policy prohibits recombination due to aggression or other concerns.  When an order is fulfilled with animals from more than one week of birth, this standard practice results in animals from a range of birth weeks packed together in a single TTC. When an order is fulfilled with animals from genotyped models, this standard practice results in animals from different home cages packed together in a single TTC.

Customers who wish to keep animals from different weeks of birth separated should place orders with the special instruction "Divide and label by age."  Note that this special request can result in increased costs for additional Taconic Transit Cages, dividers and/or freight charges.

Data

Average litter size: 7

CIEA NOG mouse®

Nonprofit users (excluding users at nonprofit foundations which are affiliated with a for-profit entity): For internal research purposes, the CIEA NOG mouse® Conditions of Use for nonprofit users apply. If you wish to perform sponsored research or fee-for-service contract research using the CIEA NOG mouse®, please inquire for access conditions.

For-profit users and users at foundations which are affiliated with for-profit entities: The CIEA NOG mouse® Conditions of Use for for-profit users apply.

The CIEA NOG mouse® is produced and distributed under license rights to the following patents and trademarks:

  • Japanese Patent No. 3,753,321
  • US Patent No. 7,145,055; 5,464,764; 5,487,992; 5,627,059; 5,631,153; 5,789,215; 6,204,061; 6,653,113; 6,689,610
    EP Patent No. 1,338,198
  • Japanese Trademark Reg. No. 4,823,423
  • US Trademark Reg. No. 3,118,040
  • EU Trademark Reg. No. 3,736,758

Pricing - USD

Opportunist Free (OF) Health Standard

NOG Female

NOG-F Genotype sp/sp;ko/ko

Age in WeeksQuantity 1 - 49Quantity 50 - 99Quantity 100 - 999
3 to 10$253.00$236.00$228.00

NOG Male

NOG-M Genotype sp/sp;ko/y

Age in WeeksQuantity 1 - 49Quantity 50 - 99Quantity 100 - 999
3 to 10$194.00$189.00$181.00

Pricing - EUR

Opportunist Free (OF) Health Standard

NOG Female

NOG-F Genotype sp/sp;ko/ko

Age in WeeksQuantity 1 - 49Quantity 50 - 99Quantity 100 - 999
3 to 10€248,00€239,00€228,00

NOG Male

NOG-M Genotype sp/sp;ko/y

Age in WeeksQuantity 1 - 49Quantity 50 - 99Quantity 100 - 999
3 to 10€181,00€173,00€166,00

Pricing - USD Nonprofit

Opportunist Free (OF) Health Standard

NOG Female

NOG-F Genotype sp/sp;ko/ko

Age in WeeksQuantity 1 - 49Quantity 50 - 99Quantity 100 - 999
3 to 10$112.00$105.00$101.00

NOG Male

NOG-M Genotype sp/sp;ko/y

Age in WeeksQuantity 1 - 49Quantity 50 - 99Quantity 100 - 999
3 to 10$107.00$104.00$100.00

Pricing - EUR Nonprofit

Opportunist Free (OF) Health Standard

NOG Female

NOG-F Genotype sp/sp;ko/ko

Age in WeeksQuantity 1 - 49Quantity 50 - 99Quantity 100 - 999
3 to 10€112,00€108,00€103,00

Specialized Inventory

NOG-FLQuantity 1 - 199
Female With Litter€1.260,00

Specialized Inventory

NOG-UPQuantity 1 - 199
Untimed Pregnant Female€809,00

*Untimed pregnant requests are filled with late gestation pregnant females. Pups may be delivered in transit.

NOG Male

NOG-M Genotype sp/sp;ko/y

Age in WeeksQuantity 1 - 49Quantity 50 - 99Quantity 100 - 999
3 to 10€102,00€97,00€94,00

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