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Significance of Bone Metastases and Targeting Tumor, Bone and Immune System

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Application of CRISPR/Cas-based Technology to the Rapid Generation of Genetically Engineered Mice

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  • Marvel Super Heroes Take on IBD

    Takeda Pharmaceuticals has joined forces with Marvel Custom Solutions to develop a graphic novel in which the super heroes have Crohn's disease or ulcerative colitis, and other characters care for family members or patients with Inflammatory Bowel Disease (IBD). As part of a Takeda program... Read more

  • 2017 Microbiome in Mouse Models Workshop Review — Best Practices

    Part III: Best Practices for Study Design This is the third of a three-part recap of Navigating the Challenges of Studying the Microbiome in Mouse Models: Design, Execution and Utility, a sponsored workshop at the 2017 Translational Microbiome Conference. Part I: Participants and Presentations Part... Read more

  • Alzheimer's Requires Aggressive Funding — and Better Models

    More than 5.5 million Americans are living with Alzheimer's disease (AD), the sixth leading cause of death among adults in the US. Aggressive research funding and improved animal models of Alzheimer's disease are urgent priorities. Increasing Alzheimer's Research Funding On July 19, 2017, the House... Read more

  • 2017 Microbiome in Mouse Models Workshop Review — Key Topics

    Part II: Microbiome Workshop Topics This is the second of a three-part recap of Navigating the Challenges of Studying the Microbiome in Mouse Models: Design, Execution and Utility, a sponsored workshop at the 2017 Translational Microbiome Conference. Part I: Participants and Presentations Part II: Microbiome... Read more

  • Parkinson's Disease Model with Endogenous LRRK2 Regulation

    No single Parkinson's Disease (PD) model fully reproduces the complexity of the disease in humans. Developing an assortment of PD models has been essential for furthering our understanding of, and the development of potential treatments for, the disease. Adding to the arsenal of PD rodent... Read more

  • 2017 Microbiome in Mouse Models Workshop Review

    Part I: Participants and Presentations This is the first of a three-part recap of Navigating the Challenges of Studying the Microbiome in Mouse Models: Design, Execution and Utility, a sponsored workshop at the 2017 Translational Microbiome Conference. Part I: Participants and Presentations Part II: Microbiome... Read more

  • HIV Drug Efficacy Affected by Microbiome Composition

    The metabolism of pharmacological compounds by our inhabitant microbes can have a significant effect on drug efficacy. While the best-known example may be the inactivation of the drug digoxin by gut flora1, Klatt et al. recently demonstrated that an imbalance in the healthy vaginal microbiome... Read more

  • Modeling Malaria with Humanization and Tissue Engineering

    The fight against malaria is hampered by the lack of good animal models. The most dangerous malaria parasite, Plasmodium falciparum, has a complex life cycle involving two hosts: mosquitoes and humans. In humans, the parasite has both a liver stage and a red blood cell... Read more