Patient-Derived Xenografts on Humanized Mice

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Application of CRISPR/Cas-based Technology to the Rapid Generation of Genetically Engineered Mice

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  • Webinar review: Patient-Derived Xenografts on Humanized Mice

    Dr. Jens Hoffmann of EPO presented a webinar highlighting new data on preclinical immuno-oncology research using humanized models. The growth in immuno-oncology (IO) research has created a need for more relevant models. The IO field includes many types of drugs, including: genetically engineered immune cells... Read more

  • Raising Heart Health Awareness: American Heart Month

    February marks American Heart Month — a campaign aimed at educating citizens about the importance of cardiovascular health. The National Heart, Lung, and Blood Institute (NHLBI) is encouraging visitors to their website to adopt heart-healthy behaviors through increasing exercise, as well as positive diet and... Read more

  • 3 Common Flu Shot Myths

    For roughly fifty percent of US citizens, getting an annual flu shot is a normal yearly event. However, for the other half of the population, there are numerous reasons why they hesitate before getting one or resist it completely. Below, we list common myths about... Read more

  • Current Liquid Biopsy Landscape

    There are over 1.7 million new cancer diagnoses each year in the US alone1. While recent advances in immuno-oncology and personalized medicine have the potential to decrease cancer deaths, there is still a lack of commonly-used early diagnostic tests to detect the presence of cancer... Read more

  • Rederivation of Mouse Models at Higher Health Statuses

    Rederiving murine research models is the process of transferring embryos from one animal into another which is either germ-free or hosts only specifically identified microbiota. This "resets" the health status of the line, allowing the offspring of mice or rats that were previously infected with... Read more

  • Animal Models in Space Research

    On Wednesday, December 5th, the Falcon 9 SpaceX rocket launched to the International Space Station (ISS) carrying 5,600 lbs of supplies; a small portion of which were mice of varying ages2. Animal models have been used in space research since the 1940s, and these ongoing... Read more

  • A Simple Guide to CRISPR

    In the short time since the introduction of CRISPR technology in 1987, it has proved to be a valuable tool. In 2018, there were over 17,000 publications on CRISPR gene editing technology compared to seven years earlier when there were less than 100 publications. The... Read more

  • Effective Communication Improves Quality

    Let's listen in on a hypothetical conversation between a scientist and their procurement department where communication is being used ineffectively: PROCUREMENT OFFICER seated at desk. Enter a SCIENTIST. SCIENTIST: Order me twenty-four B6 mice. Males and Females. Seven weeks of age. PROCUREMENT: (Thinking to themselves)... Read more