Patient-Derived Xenografts on Humanized Mice

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Application of CRISPR/Cas-based Technology to the Rapid Generation of Genetically Engineered Mice

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  • What You Need to Know About Colorectal Cancer

    March is National Colorectal Cancer Awareness Month. To increase awareness, the Colorectal Cancer Alliance (CC Alliance) has launched a public awareness campaign called "Don't Assume". This organization aims to challenge assumptions about colorectal cancer through online, print, and social media marketing. Unfortunately, this type of... Read more

  • Summary of colitis mouse models in IBD research

    Inflammatory bowel diseases (IBD) arise from a convergence of underlying genetic susceptibility, immune system dysfunction, environmental factors, and shifts in gut microbiota. Due to the multifactorial feature of these diseases, different animal models have been utilized to investigate the underlying mechanisms and develop potential therapeutic... Read more

  • How Tumor Cells Escape T Cells

    Immunogenic tumor cells often display protein antigens at their surface, which can be recognized by T cells and serve as a signal for T cells to attack the tumor. However, one long-standing paradox is that tumor-specific T cells often co-exist with the tumor cells. If... Read more

  • Studying Hand, Foot, and Mouth Disease with Humanized Mice

    Enterovirus-A71 (EV-A71), a member of the genus Enterovirus in the Picornaviridae family1, is one of the most common causes of hand, foot, and mouth disease (HFMD) in younger children2,3 and occasionally causes large-scale epidemics worldwide, especially within the Asia-Pacific region. In addition, EV-A71 is consistently... Read more

  • Depression and the Microbiome

    New research is regularly being published on the connection between the gut microbiome and the central nervous system (CNS) — together known as the gut-brain axis. Alterations in the composition of intestinal microbiota have also been associated with antibiotic use and the progression of infectious... Read more

  • Rpe65 Variants Affect Vision in Animal Models

    Vision researchers are very familiar with several mutations which can affect sight in mice. Chang et al. cataloged 16 separate mutations causing retinal degeneration. Two of the better known mutations are Pde6brd1 (commonly called rd1) and Crb1rd8 (commonly called rd8). The rd1 mutation is present... Read more

  • Animal Models and the Question of Adult Neurogenesis

    Adult neurogenesis is the process of generating new neurons after embryonic and postnatal development have concluded. The creation of neural connections later in life has important implications for learning and memory, cognitive decline, and neurobiological diseases such as Alzheimer's. As a result, this topic has... Read more

  • Acclimating Research Animals Through Effective Nurturing

    Welcoming a new cohort of animals into your facility can be very exciting for the research team; this is, unfortunately, very stressful for the animals. Stress induced by transportation, cage changes, initial weigh-ins, and changes in food and watering systems is very common when animals... Read more