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Murine Lung in Microbiome Research

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Application of CRISPR/Cas-based Technology to the Rapid Generation of Genetically Engineered Mice

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  • Considerations for Rodent Irradiation

    Rodent irradiation is an important tool in immunology and oncology rodent studies and has been critical in learning about tumor biology, transplant biology and immune system function. Understanding the biophysical and biological factors involved in irradiation studies is critical for optimizing model performance and improving... Read more

  • Industrial PhD Program Supports Microbiota Research

    Three years ago, Taconic Biosciences and the University of Copenhagen came together to sponsor an Industrial PhD student through a program supported by Innovation Fund Denmark (IFD). IFD invests in new knowledge and technology creating growth and employment in Denmark. The Industrial PhD Program The... Read more

  • Animal Models of Type 2 Diabetes: The GK Rat

    Studying the long-term complications of diabetic pathology is more relevant than ever, driving increased interest in animal models of type 2 diabetes. According to the World Health Organization (WHO) the number of people with diabetes (includes both type 1 and type 2) has risen from... Read more

  • Webinar Recap: Historical Control Database of Spontaneous Lesions in Tg.rasH2 Mice

    On May 25, 2017, Dr. Madhav Paranjpe presented a webinar on the state of evidence surrounding the use of Tg.RasH2 carcinogenicity studies as a substitute for the two-year mouse bioassay. His presentation — "Historical Control Database of Spontaneous Lesions (Neoplastic & Non-Neoplastic) in Transgenic Tg.rasH2... Read more

  • The Microbiome and Visceral Pain

    The gut microbiome may contribute to or modulate the pain of visceral hypersensitivity, but how the microbiome affects neurotransmission, pain perception, and GI function is not well understood. Pokusaeva and colleagues hypothesized that production of the neurotransmitter γ-aminobutyric acid (GABA) by gut bacteria such as... Read more

  • Efficacy Studies in Humanized Mice from AACR 2017

    Mice engrafted with a human immune system — HIS or humanized mice — have secured important roles as efficacy models in the immuno-oncology therapeutic development pipeline. Several impressive examples of efficacy studies in humanized mice were on display at the 2017 American Association for Cancer... Read more

  • AAI Travel Grant Supports GvHD Researcher

    Taconic AAI 2017 travel grant awardee, Trivendra Tripathi (left) and Taconic Field Applications Scientist, Philip Dubé Taconic Biosciences awarded this year's AAI Travel Grant to Dr. Trivendra Tripathi, who presented his work on immunotherapy for graft-versus-host disease (GvHD) at the 2017 Annual Meeting of the... Read more

  • Animal Models of Addiction and the Opioid Crisis

    As the opioid crisis continues, every week brings new and alarming developments, legislative attempts to address the epidemic, and new formulations of street drugs which are contaminated, or resistant to naloxone. This has sparked a variety of debates concerning how we can best address the... Read more