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Patient-Derived Xenografts on Humanized Mice

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Taconic White Paper:

Application of CRISPR/Cas-based Technology to the Rapid Generation of Genetically Engineered Mice

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  • A Simple Guide to CRISPR

    In the short time since the introduction of CRISPR technology in 1987, it has proved to be a valuable tool. In 2018, there were over 17,000 publications on CRISPR gene editing technology compared to seven years earlier when there were less than 100 publications. The... Read more

  • Effective Communication Improves Quality

    Let's listen in on a hypothetical conversation between a scientist and their procurement department where communication is being used ineffectively: PROCUREMENT OFFICER seated at desk. Enter a SCIENTIST. SCIENTIST: Order me twenty-five B6 mice. Males and Females. Seven weeks of age. PROCUREMENT: (Thinking to themselves)... Read more

  • Pros and Cons of Statins

    HMG-CoA reductase inhibitors, or Statins, are a class of lipid-lowering medications prescribed to reduce the risk of developing heart disease. First introduced to the market in 1987, statins are one of the most commonly prescribed medications today with around 40 million users in the US... Read more

  • How Are Animal Models Validated?

    Animal models have led to significant leaps in understanding and advancement in human medicine. They are essential for drug discovery and connecting hypothesis-driven benchwork to the patient. However, scientists have struggled with how to define the value of a given animal model1. Animal Model Validation... Read more

  • 'Twas the End of the Year

    With apologies to Clement C. Moore 'Twas the end of the year, and in laboratories throughout Scientists were working, to get that last paper out; The final experiments were designed with true care, In the hopes of results and citations so rare. The protocols were... Read more

  • A Deep Dive into AI-based Animal Body Part Detection

    Photo courtesy of Dr. Alexander Mathis Animal behavior can provide valuable scientific insight, from assessing model validity of a disease state to understanding the function of complex neural circuits6,12. Accurately tracking an animal's body parts (such as limbs, digits, ears, snout, tail) is especially relevant... Read more

  • Modelling Autophagy in Cellular Processes

    Autophagy in Cellular Processes Autophagy is derived from Greek and means self(auto)-eating(phagy). This process occurs in all eukaryotic cell types that contain a lysosomal compartment. In fact, basal autophagy contributes to long-lived protein degradation, organelle turnover in the cytoplasm, and the recycling of macromolecules to... Read more

  • Bacteria Making Headlines in 2018

    In the last few months, multiple bacterial species have been making headlines. This review will outline three types of bacteria and how specific strains may prevent or encourage the development of bacterial infections. I) Escherichia coli (E. coli) The strain that is undoubtedly the most... Read more