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Controlling the Macroenvironment: A Novel Approach to Germ-free Derivations

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Application of CRISPR/Cas-based Technology to the Rapid Generation of Genetically Engineered Mice

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  • Webinar Q&A — Liver Biopsies in a Mouse Model of NASH

    Stephanie Oldham and Christian Rivera of AstraZeneca recently presented a webinar on the use of a survivable liver biopsy in NASH mouse models, which is a technique that can provide valuable information on disease stage in individual mice prior to study initiation. In particular, it... Read more

  • CRISPR/Cas9 Intellectual Property Landscape for Rodent Model Generation

    CRISPR/Cas9 is an extremely useful tool for both academic and commercial researchers. It is also widely used in the generation of custom mice and rats from licensed animal model vendors. However, there are multiple patents covering this technology and understanding the differences between them is... Read more

  • Genetic Background of Mice Influences Microbiome

    Source: Graphical Abstract. Khan et al., 20191 The microbiome continues to be an important topic in both human health research and in popular culture. The microbiome is cited as a factor in multiple diseases, neurological conditions, and immune responses to foreign pathogens. Specific compositions of... Read more

  • Benefits of Humanized Mice for CAR-T Immunotherapy Studies

    CAR T cell (CAR-T) therapy is a relatively recent immunotherapy with the first drugs approved for human use by the FDA in 2017. This type of immunotherapeutic utilizes T cells extracted from patient blood which are subsequently modified to target cancer cells. The modification enables... Read more

  • Utilizing CRISPR/Cas9 as a genome editing therapeutic in mouse models of human disease

    The application of CRISPR/Cas9 as a mammalian gene editing technology has tremendously matured over the last decade. This has paved the way for the development of CRISPR/Cas9 as therapeutic tool to treat human genetic disease, while making it easier to create the genetically modified animal... Read more

  • SIOP and Russell & Burch's 3Rs

    R.L. Burch and W.M.S. Russell2 W.M.S. Russell (1925-2006) and R.L. Burch (1926-1996) originated the concepts of replacement, reduction, and refinement, which they published in their 1959 book, The Principles of Humane Experimental Technique (Principles)1. The Principles was presented not as the final word of this... Read more

  • Alzheimer's Disease: Steps towards more translational research models

    Alzheimer's Disease International reports there are 50 million people worldwide living with Alzheimer's Disease (AD), but there remain few approved treatments and no cure. The amount spent to care for patients with AD is over $1 trillion USD, or 1% of global GDP, and experts... Read more

  • After 40 Years a New TB Drug is Approved

    Source: TB Alliance Nonprofit Wins FDA Approval for Tuberculosis Drug At the end of the summer, the TB Alliance announced the approval of a new drug to treat some of the most drug-resistant forms of tuberculosis (TB). This is the first time the US Food... Read more