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Beyond HSCs: Humanized Immune System Models Based on PBMCs and Isolated Immune Cell Subsets

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  • Which mouse model is best for engrafting human PBMCs?

    Humanized immune system mice generated by engrafting immunodeficient hosts with human peripheral blood mononuclear cells (PBMCs) have been critical tools for evaluating T-cell dependent immunotherapies. However, novel immunodeficient hosts are demonstrating their ability to extend the utility of PBMC-humanization beyond conventional T-cell focused work. The... Read more

  • Comparison Guide: huNOG-EXL, NSG-SGM3 and MISTRG

    Several super immunodeficient models expressing cytokines designed to drive myeloid cell lineage commitment have been generated. The most advanced cytokine transgenic mouse models are the huNOG-EXL, NSG-SGM3 and the MISTRG. This group of models has promise to improve human immune system engraftment in mice, but... Read more

  • An Overview of Mouse Models for COVID-19

    COVID-19 is rapidly spreading around the globe and constitutes a global health crisis. This disease is caused by the SARS-CoV-2 virus, a coronavirus related to the SARS-CoV virus which caused the global SARS outbreak in 20031,2. Preclinical research on SARS may provide insight into useful... Read more

  • The Translational Relevance of IBD Mouse Models

    Many animal models have been developed to study inflammatory bowel disease (IBD), and they remain in general use for screening of potential new therapies. But a recent review article questions the relevance of many of these models, citing evidence that they may not accurately predict... Read more

  • NASH Research Updates in 2020

    International Liver Congress™ 2019 Statistics. Source: EASL Nonalcoholic steatohepatitis (NASH) continues to be a hot topic in metabolic disease research. The NASH research field gathers twice a year at major conferences: The Liver Meeting is organized by the American Association for the Study of Liver... Read more

  • Webinar Q&A — Microbiological Monitoring of Germ-Free and Gnotobiotic Colonies

    Dr. Paula Roesch recently presented a webinar on microbiological monitoring of germ-free and gnotobiotic colonies. Taconic Biosciences has decades of experience in this area and Dr. Roesch presented a thorough look at all aspects of the process, starting from tools and approaches to process validation... Read more

  • New Rab29 Overexpression Mouse Model for Parkinson's Disease

    Parkinson's disease (PD) is the second most common neurodegenerative disease (after Alzheimer's disease) and the most common movement disorder. The worldwide incidence of PD has more than doubled since 1990 to an estimated 6.1 million PD patients globally in 20161. In the United States in... Read more

  • 2020 Microbiome Conferences

    Please see the Translational Microbiome Research Forum's Events for updated information regarding meeting cancellations and changes Looking for a microbiome conference or workshop? 2020 looks to be a banner year for microbiome conferences. Here are some upcoming sessions we'll be following with interest. 2020 Microbiome... Read more