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  • Transportation Affects Gut Microbiome of Laboratory Mice

    Experimental controls are at the center of every quality experiment, and understanding the causes of microbiome variability is key to controlling for microbiome-related effects. Researchers that utilize murine models attempt to control for possible microbiome variability by ordering mice from the same vendor, using littermate... Read more

  • Sexual dimorphism in fear learning memory due to epigenetic modification by Cdk5

    Epigenetics of FLM, Stress, and Neuro-Degenerative Disease The epigenetic post-translational modifications of histone (hPTMs) is a notable cellular response mechanism to environmental stimuli2. Emerging reports point to the sexual dimorphism of epigenetic hPTMs within the neurobehavioral context of fear, learning, and memory (FLM), in neuro-degenerative... Read more

  • The IL-2 NOG: An Optimal Model for the Testing of CAR T cell Therapy in Solid Tumors

    Figure 1: HER2 CAR T cell efficacy in vivo is only observed in the hIL-2 transgenic NOG. Combined data of tumor growth curves of 5 different PDX models of cutaneous melanoma (MM11, 24, 29, 33, 46) in NOG or hIL-2 NOG. All 5 patient PDXs... Read more

  • How Animal Model Handling Affects Your Research

    Researchers who regularly work with mice and rats understand that incorrect handling practices creates unnecessary stress for the animal. If one is new to working with preclinical animal models, or is introducing a new strain to their work, a quick refresher on the benefits of... Read more

  • Studying T Cell Distribution in Syngeneic Tumor Models

    In a recent article in The Journal of Pharmacology and Experimental Therapeutics, Khot et al. examined the pharmacokinetics (PK) of exogenously administered T cells in a syngeneic tumor model. As immuno-oncology therapeutics expand into cell-based therapies, such as CAR-T cells, this type of research is... Read more

  • Market Growth of Immuno-oncology Drugs Improve Cancer Treatments

    Figure 1: Companies actively pursuing immunotherapies. Source: Trends in the Global Immuno-oncology Landscape (2018) The approval of Ipilimumab (Yervoy®, BMS) in 2011 finally offered hope to metastatic melanoma patients — and set off a revolution in cancer treatment. Since 2011, regulatory agencies have approved eleven... Read more

  • EACR 2019 Conference Series Review

    The EACR Conference on Immuno-Oncology attracted academic and pharmaceutical researchers from all over the world to the Casa Milà in Barcelona, Spain. Attendees shared their recent findings in fundamental and translational research and discussed clinical studies in immuno-oncology and immunotherapy. EACR 2019 Immuno-Oncology Conference Series... Read more

  • Overview of Genetic Modification Techniques

    The first genetically-modified mouse capable of transferring its modified genome to offspring was developed in the early 1980s. Since then, multiple genetic modification techniques have been developed to modify rodent genomes and are still commonly used today. Random and targeted transgenesis are commonly used today... Read more