Modeling Prostate Cancer Therapies with
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  • Nude Mice, Xenografts, and Treating Baldness

    A recent article published in the Columbia Magazine highlights the work of researcher Angela Christiano and her radical solutions to addressing baldness. Dr. Christiano has been working on studies involving hair loss since 1996, with one of her most notable achievements being the discovery of... Read more

  • DHA's Role in NASH Pathogenesis

    Nonalcoholic steatohepatitis (NASH) is associated with a chronic proinflammatory state of the liver1-3,10. The clinical pathogenesis of NASH progresses from a steatotic/intralobular inflammatory/hepatocellular ballooning state to progressing levels of fibrosis and in later stages, an increased incidence of cirrhosis and/or hepatocellular carcinoma8-13. The etiology underlying... Read more

  • Why SNP test your mice?

    Single nucleotide polymorphisms (SNPs) are variations in the genome that occur when a single nucleotide is altered. While single base-pair changes may seem minor, they are key indicators of strain differences among mice and rats1. SNP testing is vital in many colony management applications, from... Read more

  • Skin Cancer Detection and Prevention

    With most of the United States experiencing warmer weather, increased sun exposure can lead to an increased risk of developing skin cancer. There are more new cases of skin cancer in the US each year than breast, prostate, lung, and colon cancers combined. The most... Read more

  • Apolipoproteins in Animal Models of Cardiovascular Disease

    Cardiovascular disease (CVD) is a term that encompasses multiple heart and blood-vessel-related maladies. The CDC reports that it is the leading cause of death amongst both men and women in the US each year, with roughly 800,000 deaths estimated by the American Heart Association in... Read more

  • Video: Genetic Background in Syngeneic Models

    Through this excerpt from Taconic Biosciences' Webinar, "Advanced Toolkit For Syngeneic Tumor Modeling in Mice," Dr. Philip Dubé considers the role of genetic background when identifying the proper syngeneic model as well as the importance of validating substrain and specific cell line. Syngeneic models depend... Read more

  • What is NASH?

    Recent reports indicate that nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) are emerging public health threats. NAFLD is a common chronic liver disease, with estimates of incidence around 25% worldwide. NASH represents the more severe end of the NAFLD spectrum, with inflammation and... Read more

  • World Microbiome Day 2019

    World Microbiome Day is on June 27th this year. World Microbiome Day began in 2018 to demonstrate its emergence as a subject with global impact. That impact is being felt across a variety of disciplines including science, medicine, and nutrition. "World Microbiome Day aims to... Read more