How to Harness the Microbiome - Considerations and Implications of the Microbiome in Preclinical Research with Reproducible Results

Thursday, September 28 at 11 a.m. ET

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Taconic White Paper:

Application of CRISPR/Cas-based Technology to the Rapid Generation of Genetically Engineered Mice



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  • Remember to ARRIVE

    In 2010 the ARRIVE (Animals in Research: Reporting In Vivo Experiments) guidelines1 were proposed to address several reproducibility issues with in vivo animal model studies: Only 59% of 271 biomedical studies using rats, mice, or non-human primates that were assessed stated the hypothesis or objective... Read more

  • Improving Quality with the 3Rs

    Designing your animal model studies with the 3Rs in mind — Replace, Reduce, Refine — is not only more humane, but can measurably improve the quality and efficiency of your research projects. When we think of improving quality in the life sciences, we might immediately... Read more

  • Webinar Q&A — Your Guide to the C57BL/6 Mouse

    Did you miss Dr. Philip Dubé's recent webinar, The Most Important Mouse in the World - Your Guide to the C57BL/6 Mouse? His presentation explored genetic diversity amongst C57BL/6 substrains, the implications for GEM models, and the utility of the C57BL/6 mouse in studies of... Read more

  • Chronic Pain Management Research and the Opioid Crisis

    Developing novel drugs for chronic pain management — both more effective and less addictive than opioids — will reduce the number of patients at risk of opioid dependence. Chronic Pain and the Opioid Crisis More than 25% of Americans suffer from chronic pain. This is... Read more

  • LEM1 C. difficile Strain Prevents Pathogenic Infection

    Researchers at Georgia State University made a surprising discovery1 while establishing a mouse model of C. difficile infection: a novel, endogenous strain of the bacteria which blooms after antibiotic therapy and protects its host from disease. This could potentially confound experimental results, as the LEM1... Read more

  • Humanized Mice at the Summer Toxicology Forum

    The 43rd annual Summer Toxicology forum meeting was held on July 10-12, 2017 in Annapolis Maryland. The afternoon of July 10th was dedicated to a section titled "Use of Humanized Mice for Drug Development". The session was moderated by James Monroe, PhD, senior principle scientist... Read more

  • Baby Formula Feeding and the Infant Microbiome

    Breastfeeding versus formula feeding of infants can be a controversial subject. Those who believe the "breast is best" may be interested in a new study which reports that components in infant formula modify the establishment of a baby's gut microbiota. How Formula Affects the Infant... Read more

  • Are Dirty Mice Superior Immunology Models?

    In a recent review article, David Masopust and his coauthors from the University of Minnesota Medical School discuss the relevancy of mouse models for use in immunological studies and translatability of immune system studies using SPF mice. Of Mice, Dirty Mice, and Men: Using Mice... Read more