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Application of CRISPR/Cas-based Technology to the Rapid Generation of Genetically Engineered Mice

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  • Methods of Animal Model Identification

    Animal identification is a vital element in any research project requiring the use of animal models. The identification of an animal may be the only link to essential data, such as sex, genotype, study parameters, and results. Animal identification systems also assist with breeding record... Read more

  • Measles Outbreak Reaches Record Levels

    As of May 2019, the World Health Organization is reporting that the number of measles cases worldwide has quadrupled compared to the same time last year. In the US alone, there have been 1,022 cases thus far in 2019, making this the highest number of... Read more

  • Studying Genetic and Physiological Effects of Space Travel

    An article published recently in Science highlights the unique journey of two identical twins — Mark and Scott Kelly — who have enabled the study of extended space flight and the effects it has on the human body. Together, they spent a combined 574 days... Read more

  • Mouse Kidney Parvovirus (MKPV) - A New Mouse Pathogen

    The kidneys of immunodeficient mice infected with MKPV appear pale and shrunken on gross necropsy. Histology reveals significant fibrosis. Source: Roediger et al. Cell 20181. A consortium of researchers from Australia and the US has announced the discovery of a novel mouse parvovirus, named mouse... Read more

  • Animal Models and Infectious Disease

    Animal models play a critical role in studying a variety of infectious diseases, from lyme to influenza and salmonella, and selecting an appropriate model system for each is key. Both immunocompetent and immunodeficient mice have a role to play in infectious disease studies. Inbred Mouse... Read more

  • What is Cytochrome P450?

    Cytochromes P450 (CYP) is a superfamily of proteins involved in metabolism and inactivation of foreign substances and toxins. Each protein in this family is highly specialized with unique, dedicated pathways inside the cell. CYPs are transmembrane proteins commonly found in the plasma membrane of the... Read more

  • Transportation Affects Gut Microbiome of Laboratory Mice

    Experimental controls are at the center of every quality experiment, and understanding the causes of microbiome variability is key to controlling for microbiome-related effects. Researchers that utilize murine models attempt to control for possible microbiome variability by ordering mice from the same vendor, using littermate... Read more

  • Sexual dimorphism in fear learning memory due to epigenetic modification by Cdk5

    Epigenetics of FLM, Stress, and Neuro-Degenerative Disease The epigenetic post-translational modifications of histone (hPTMs) is a notable cellular response mechanism to environmental stimuli2. Emerging reports point to the sexual dimorphism of epigenetic hPTMs within the neurobehavioral context of fear, learning, and memory (FLM), in neuro-degenerative... Read more