Development of Human NK Cells in hIL-2 NOG and hIL-15 NOG Mice

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  • Seasonal Cycling in the Gut Microbiome of the Hadza Hunter-gatherers of Tanzania

    Researchers from Stanford University published a paper in Science titled "Seasonal cycling in the gut microbiome of the Hadza hunter-gatherers of Tanzania" which examines the relationship between diet, seasons, and the microbiome. The authors performed a longitudinal study on 350 stool samples collected throughout a... Read more

  • Nature Biotechnology Publication: Translating microbiome futures

    Figure 1: Over the past five years, the scientific output in the microbiome field and the number of microbiome-related published patents has been steadily rising. Sources: PubMed (search terms "human microbiome" and "human microbiota"); Fankhauser et al.; University of Chicago Technology Commercialization; CBInsights; CrunchBase; GlobalData;... Read more

  • Sex Bias in Animal Model Research

    The National Institutes of Health (NIH) announced new policies in 2014 aimed at requiring NIH-funded researchers to address sex balance in preclinical cell and rodent models. Although exclusion of women in clinical research was identified as problematic decades ago, the preclinical research world has not... Read more

  • Rodent Sentinels — A Vital Link in Your Research

    Rodent health monitoring programs (also referred to as rodent health surveillance or sentinel monitoring programs) are designed to detect subclinical infections of rodents that potentially have detrimental effects to the health of the animals or the integrity of your research. Robust sentinel animal protocols are... Read more

  • Liver Awareness Month

    October marks National Liver Awareness month. Estimates for the global burden of chronic liver disease range from 50 million to over 100 million affected individuals. According to the Centers for Disease Control and Prevention (CDC), from 2000 — 2015 there was a 31% increase in... Read more

  • CRISPR Patent Update: Broad vs. Berkeley

    It was recently announced that the legal battle over the CRISPR/Cas9 patents is likely finished with the Broad Institute prevailing above UC Berkeley. This ongoing debate began in 2014 with multiple research groups and institutions claiming rights to the CRISPR/Cas9 technology. The researchers involved in... Read more

  • Investigating Tauopathies with Transgenic Mice

    In a recent manuscript by Musi and co-authors, a combinatorial approach was adopted to investigate the tauopathy-mediated mechanisms underlying human Alzheimer's Disease (AD) in post-mortem human brain tissue and transgenic mice1. Human neurodegenerative diseases comprise a heterogenous group of disorders, underpinned by complex interactions of... Read more

  • 2018 Nobel Prize in Physiology or Medicine Awarded to Two Immunologists

    Source: Karolinska Institutet On Monday, October 1, 2018 the Nobel Committee announced the recipients of this year's Nobel Prize in Physiology or Medicine. The two Nobel laureates were James P. Allison — a professor and immunologist from MD Anderson Cancer Center — and Tasuku Honjo... Read more