Nested Isolation: A Low-Cost Housing Strategy to Boost Microbiome Research Capabilities

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Taconic White Paper:

Application of CRISPR/Cas-based Technology to the Rapid Generation of Genetically Engineered Mice



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    Humanized microbiota Swiss Webster mice infected with C. difficile efficiently clear the pathogen when maintained on a diet with microbiota-accessible carbohydrates (MAC+), but remain persistently infected when on a MAC-deficient diet (MD1, MD2). Switching from a MAC-deficient diet promotes rapid pathogen clearance. Figure from Hryckowian... Read more

  • Maternal Diet Modifications in NOD mice Can Alter Disease in Offspring

    On February 2, 2018, researchers at The Bartholin Institute, Biocenter in Copenhagen, Denmark, published a paper titled Gluten‐free diet during pregnancy alleviates signs of diabetes and celiac disease in NOD mouse offspring in the journal Diabetes Metabolism Research Reviews. NOD mice have been the model... Read more

  • The Replication Crisis in Preclinical Research

    With growing alarm at the failure to replicate published, influential studies, the life sciences community is turning their attention to the causes and consequences of the replication crisis. How can we improve in vivo research to secure the reliability of our results? Reproducibility in Life... Read more