Ensure Reproducible Microbiome Profiles in In Vivo Research

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Application of CRISPR/Cas-based Technology to the Rapid Generation of Genetically Engineered Mice

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  • The Next Ten Years of Microbiome Research

    Source: Proctor1 The Human Microbiome Project's former Program Coordinator, Lita Proctor, set out priorities for the next ten years of human microbiome research in a wide-ranging article for Nature1. She also provides reflections on the completed Human Microbiome Project that helped jump-start microbiome research in... Read more

  • The more things change, the more they stay the same: the Amylin liver NASH (AMLN) Diet

    A wide variety of high fat diet-induced non-alcoholic steatohepatitis (NASH) models have been used to recapitulate certain etiological aspects of the disease, with refinements in dietary formulations made over the past decade. Amylin liver NASH model The Amylin liver NASH (AMLN) model was described by... Read more

  • Importance of Vitamins in Human and Murine Diets

    Vitamins are organic molecules that are essential for proper metabolism and bodily function. While they go by different names, most vitamins are actually groups of chemically-related organic molecules known as vitamers1. Some vitamins must be obtained from dietary sources as they are produced in insufficient... Read more

  • Webinar Q&A — The Diet Induced NASH B6: A Translational NASH Model for Drug Discovery

    Dr. Janell Richardson recently presented a webinar on the Diet Induced NASH B6, a translational model of NASH for drug discovery. She provided an excellent introduction to the global health problem of nonalcoholic steatohepatitis (NASH), gave an overview of different types of preclinical NASH models... Read more

  • The Benefits of Environmental Enrichment for Laboratory Mice

    The natural behavior of mice includes burrowing, foraging, exploring, gnawing, and nest building. These behaviors are essential to the well-being of the animal, and if prevented from performing these activities mice may engage in non-productive repetitive behaviors1,2. Prevention from responding to their natural inclinations could... Read more

  • IBD Severity and Fungi in Microbiome

    Source: Limon et al.1 The microbiome includes not just bacteria, but also fungi, viruses and parasites. While most of the attention has been on bacterial components of the microbiome, new research links a commensal yeast found on human skin to disease severity in inflammatory bowel... Read more

  • Modeling Stem Cell Transplantation Treatments for HIV

    HIV is a rare, incurable virus that attacks the human immune system. According to the World Health Organization, approximately 36.9 million people are living with HIV or AIDS, and close to 1 million deaths per year are caused by the disease. Currently, there is no... Read more

  • Adipose Tissue and Hormone Regulation

    The incidence of metabolic disease and the number of obese patients in the US is growing at an alarming rate. While the Western diet and lack of exercise may be to blame for some, there are complex biological processes that underlie the progression of obesity... Read more