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Comparing Diet-Induced Obesity Performance of C57BL/6 Substrains

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Taconic White Paper:

Application of CRISPR/Cas-based Technology to the Rapid Generation of Genetically Engineered Mice

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  • Maternal Diet Modifications in NOD mice Can Alter Disease in Offspring

    On February 2, 2018, researchers at The Bartholin Institute, Biocenter in Copenhagen, Denmark, published a paper titled Gluten‐free diet during pregnancy alleviates signs of diabetes and celiac disease in NOD mouse offspring in the journal Diabetes Metabolism Research Reviews. NOD mice have been the model... Read more

  • The Replication Crisis in Preclinical Research

    With growing alarm at the failure to replicate published, influential studies, the life sciences community is turning their attention to the causes and consequences of the replication crisis. How can we improve in vivo research to secure the reliability of our results? Reproducibility in Life... Read more

  • Decision Expected Waiving Risk Assessments

    Proposed changes to the ICH S1 guidelines for rodent carcinogenicity testing of human pharmaceuticals would allow sponsors to waive the requirement for a two-year rat bioassay under certain conditions. A final ruling and guidance update are expected in June of 2018. Re-Examining Carcinogenicity Testing In... Read more

  • Preventing Genetic Drift in Germ-Free Mice

    Maintaining genetic integrity within breeding colonies is always a critical issue, but this is especially the case for germ-free and gnotobiotic mice1. Due to the small size and closed nature of most gnotobiotic colonies, these lines are especially vulnerable to genetic drift via the accumulation... Read more

  • What are Timed Pregnant Rodent Models?

    Timed pregnant mice and rats are important research tools, with applications in developmental research, genetic engineering, and generating tissue cultures. They are the most efficient way to obtain a cohort of embryos, fetuses, or pups with a precisely defined, matched age. But what exactly are... Read more

  • Humanized Mice in Safety and Toxicity Testing

    Humanized mice are invaluable tools for studying the function of the human immune system in an in vivo context, with applications for studying infectious disease, immuno-oncology, and immunology. Recently, Ryoji Ito and colleagues at the Central Institute for Experimental Animals in Japan demonstrated their efficacy... Read more

  • Diets High in Salt May Increase Sensitivity to Autoimmune Disease through Microbiome Alteration

    High salt diets have previously been shown to increase severity of certain types of induced autoimmune disease in mouse models via a signaling pathway, but the impact of these diets on the gut microbiome and intestinal inflammation have not been studied. Researchers at McMaster University... Read more

  • 2018 Society of Toxicology Annual Meeting — Hot Topics

    The annual Society of Toxicology (SOT) meeting is the largest toxicological meeting in the world. The 57th Annual Meeting and ToxExpo was held in San Antonio, Texas, and drew more than 6,100 scientists from Europe, Africa, Asia, Canada, and almost every state of the United... Read more