Historical Control Database of Neoplastic and Non-neoplastic Lesions in 6 month Tg.rasH2 Studies

Thursday, May 25 at 11 a.m. ET

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Taconic White Paper:

Application of CRISPR/Cas-based Technology to the Rapid Generation of Genetically Engineered Mice



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  • Rise in Usage of Germ-Free Mice

    Germ-free mice are not new. Taconic Biosciences first started raising germ-free mice in 1960, after learning axenic husbandry techniques from the Laboratories of Bacteriology at the University of Notre Dame (LOBUND), where the first germ-free facility was established. Researchers have been using germ-free rodents since... Read more

  • Does the Microbiome Impact Neurological Diseases like Stroke and Seizure?

    Cerebral cavernous malformation (CCM) is a type of brain lesion in which normal tissue is displaced by collections of abnormal capillaries which are prone to leakage. CCM bleeding can cause strokes, seizures, and other neurologic deficits. The only current treatment for CCM is surgical removal.... Read more

  • Yeast Worsens Disease in a Mouse Model of Colitis

    Inflammatory bowel disease (IBD) is a disorder of the gastrointestinal tract which includes Crohn's disease and ulcerative colitis. In general, the majority of studies looking at the role of the human gut microbiome have focused on bacterial members. However, fungi are estimated to comprise 0.1%... Read more

  • Working Towards Microbiome Research Standards

    Microbiome research continues at an amazing pace, but labs around the world are racing ahead with few agreed-upon standards. This makes communication difficult and may undermine reproducibility. Growing Call for Microbiome Standards There are groups advocating for common standards, such as The Microbiome Coalition, and... Read more

  • Genetic Variation in C57BL/6 ES Cells and Knockout Mice

    Genetically engineered animal models (GEMs) are powerful tools for biomedical research and drug discovery, but genetic variation in animal models derived from distinct ES cell lines and subsequent breeding can impact both the interpretation and reproducibility of studies which employ them1. While recent advances in... Read more

  • Accelerating Parkinson's Disease Research Through Strategic Partnerships

    The Michael J. Fox Foundation (MJFF), established in 2000, is dedicated to finding a cure for Parkinson's disease (PD) by supporting research agendas toward development of improved therapies for Parkinson's disease patients. Unlike many private research funding institutions that rely on external scientific advisors and... Read more

  • The Real Impact of Rodent Diet on Microbiome and Gut Health Research Webinar Q&A

    Dr. Michael Pellizzon of Research Diets, Inc., recently presented a webinar on the underappreciated impact of rodent diets on microbiome and gut health research, where simple husbandry decisions can profoundly affect both animal model phenotypes and experimental outcomes. Due to time constraints, many of the... Read more

  • Review of 3rd Annual Translational Microbiome Conference

    This year was the 3rd year of the Translational Microbiome Conference held in Boston, Massachusetts. Boston is a major hub of microbiome research in academia, biotech, and pharma industries. This conference draws attendees from around the world who all want to better understand how the... Read more