Estrogen-Related Effects in Breast Cancer Xenograft Models

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Application of CRISPR/Cas-based Technology to the Rapid Generation of Genetically Engineered Mice



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  • Mice with Horse Microbiota Validate Health Promoting Diet for Foals

    Photo courtesy of F. Lindenberg Animal feed retailer Brogaarden recently launched a new prebiotic diet for foals that can reduce the risk of developing conditions such as Equine Metabolic Syndrome and colitis later in life. The diet works by promoting beneficial gut bacteria, such as... Read more

  • The Importance of Long QT Syndrome Research

    April 17, 2002 was a day of record breaking heat in New York State. The day is very clear in my mind for several reasons; it was my last birthday in my 20s, I had just bought my first house (and was taking the week... Read more

  • Immunogenic peptide from PSF1 identified as potential new cancer vaccine target

    Although much of the press for immuno-oncology (IO) has focused on checkpoint inhibitors, researchers are exploring many other types of IO therapeutics. Other types of IO therapies under development include bi-specific antibodies, CAR-T cells, and cancer vaccines. Researchers at Shionogi and Osaka University recently published... Read more

  • The Effect of Gut Bacteria on Bone Health Cannot be Generalized

    Previously, a number of different studies using germ-free (GF) mice have indicated that the gut microbiota regulates bone density. However, the results have been conflicting. Reports demonstrate both beneficial and detrimental effects of the microbiota on bone health. A new study published in mSphere in... Read more

  • Tauopathy Alzheimer's Disease Models Yield Contrasting Results

    In a recent Alzheimer's Research and Therapy article, scientists described failing to elicit beneficial effects from a tau-directed antibody therapy while evaluating its efficacy in the Tg4510 mouse, an Alzheimer's disease (AD) model with a tamoxifen-controlled transgene expressing P301L mutant tau. The results contrast prior... Read more

  • Selecting Translatable NASH Animal Models

    The global obesity epidemic has pushed associated liver diseases to the forefront of research, yet no existing animal model of NASH or NAFLD fully recapitulates its clinical presentation. This presents a challenge for effective study design: how do you select the most appropriate and translatable... Read more

  • 2018 Microbiome Conferences

    Looking for a microbiome meeting or conference to attend in 2018? The Translational Microbiome Research Forum (TMRF) lists thirty-two 2018 conferences, so far, and updates their event page upon announcement of new meetings. A quick survey of the events shows eighteen taking place in the... Read more

  • Webinar Review: Immuno-oncology and the Microbiome

    In a recent webinar, Dr. Benjamin Cuiffo of Biomodels addressed the role of microbiome in preclinical immuno-oncology research. There is growing evidence that microbial imbalance (dysbiosis) is associated with many illnesses, including inflammation, autoimmune disease, and even cancer — but many researchers fail to account... Read more