UPCOMING WEBINAR:

The Most Important Mouse in the World: Your Guide to the C57BL/6 Mouse

Tuesday, August 8 at 11 a.m. ET

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Taconic White Paper:

Application of CRISPR/Cas-based Technology to the Rapid Generation of Genetically Engineered Mice

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  • HIV Drug Efficacy Affected by Microbiome Composition

    The metabolism of pharmacological compounds by our inhabitant microbes can have a significant effect on drug efficacy. While the best-known example may be the inactivation of the drug digoxin by gut flora1, Klatt et al. recently demonstrated that an imbalance in the healthy vaginal microbiome... Read more

  • Modeling Malaria with Humanization and Tissue Engineering

    The fight against malaria is hampered by the lack of good animal models. The most dangerous malaria parasite, Plasmodium falciparum, has a complex life cycle involving two hosts: mosquitoes and humans. In humans, the parasite has both a liver stage and a red blood cell... Read more

  • Researchers Demonstrate Vaccine Mediated Protection Against Zika Virus Using Pregnant Mice

    On July 13, 2017, researchers at Washington University School of Medicine published a paper titled, Vaccine Mediated Protection Against Zika Virus Induced Congenital Disease in the journal CELL1. In their study pregnant C57BL/6 mice vaccinated using an mRNA vaccine against the prM-E subunit of the... Read more

  • Can Anxiety Phenotypes Transfer via FMT?

    Connections between behavioral phenotypes and the microbiome continue to emerge from fecal microbiota transplantation (FMT) studies at McMaster University. Can Behavioral Phenotypes Be Transferred? Researchers at McMaster University first demonstrated the transfer of behavioral traits between mice via the gut microbiome by fecal microbiota transplantation... Read more

  • Humanized Mice in Cancer Bone Metastasis Studies

    Despite recent advances in cancer research and drug development, bone metastases remain incurable. Some of the most common cancers, such as breast, prostate, lung, and multiple myeloma frequently metastasize to bone1,2,3. As bone metastasis is difficult to treat and target, and because the bone itself... Read more

  • Modified DIO Protocols Improve Type 2 Diabetes Models

    Animal models of diet-induced obesity (DIO) are commonly used to model metabolic syndrome, but have some limitations. Can a modified DIO protocol produce better type 2 diabetes models? Developing Modified DIO Protocols DIO C57BL/6 mice are obese, glucose intolerant, insulin resistant, and display mild hyperglycemia.... Read more

  • Murine Lung Microbiome Webinar Recap

    On June 8, Dr. Kenneth Klingenberg Barfod — of the National Research Centre for the Working Environment, Denmark — presented a webinar on the importance of the murine lung microbiome, how the lung microbiome in mice can be manipulated experimentally, and its applications in disease... Read more

  • The Medicinal Microbiome: Presentations of Note

    A growing number of scientists are investigating the role of our microbiome in the development of and protection from disease. One area of particular interest is recovery from injury and infection. Recent publications examine the relationship between the microbiome and HIV infection (Wei Yang JS,... Read more