Next Generation Humanized Mice in Immuno-Oncology - Part II

Thursday, April 26 at 11 a.m. ET/ 5 p.m. CET

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Taconic White Paper:

Application of CRISPR/Cas-based Technology to the Rapid Generation of Genetically Engineered Mice



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  • The Advantages and Limitations of Easi-CRISPR

    CRISPR/Cas9 genome editing technology enables the modification of the mouse and rat genomes with unprecedented simplicity and speed but is subject to limitations that restrict its application to the introduction of simple mutations such as constitutive knockout or point mutation alleles. Easi-CRISPR overcomes those limitations... Read more

  • Commensal Microbes May Initiate and Drive Immune Responses in Lupus

    Spontaneous lupus erythematosus (SLE) is a chronic autoimmune disease with an unclear cause. Nearly all lupus patients have high levels of anti-nuclear antibodies with a relatively high proportion being pathogenic anti-Ro protein antibodies. At the end of March, researchers at Yale University published a paper... Read more

  • Video: Mouse Models Used to Study Immuno-oncology

    Taconic Biosciences' Dr. Philip Dubé discusses mouse models used to study immuno-oncology in this video excerpt from the webinar, "Advanced Toolkit For Syngeneic Tumor Modeling in Mice". There are essentially two types of models used in pre-clinical immuno-oncology research: Syngeneic models — a mouse tumor... Read more

  • Seminar: Humanized Mice in Preclinical Bone Metastasis Studies

    All are welcome to Biocom's continuing education seminar on the use of humanized mice in immuno-oncology and bone metastasis studies on April 12, 2018 at Larkspur Landing. Immuno-Oncology Seminar BioCom will hold an in-person continuing education seminar to explore new study design options in immuno-oncology... Read more

  • Taconic's Guide to AACR 2018

    This April 22,000 scientists from nearly 100 countries will gather in Chicago for the American Association for Cancer Research 2018 Annual Meeting. Over the course of five days, 6,000 scientists will share results from recent studies, spurring discussion and debate. Attendees can visit 400 exhibitors... Read more

  • Non-Antibiotic Drugs Impact the Human Gut Microbiota

    A new study in Nature, published in March 2018, revealed novel potential adverse effects of a broad variety of marketed drugs. The researchers found that many drugs designed to target human cells and not microbes could inhibit the growth of different intestinal bacterial strains. This... Read more

  • Gender-Dependent Impacts of Herbicides on the Microbiome

    It is heavily debated whether the use of the weedkiller glyphosate in agriculture and gardening can induce dysbiosis of the gut microbiota, negatively affecting human and animal health. Dysbiosis is an imbalance in the microbiome composition associated with conditions such as colitis, metabolic syndrome, allergies,... Read more

  • Should You Breed or Buy Your Own Rodent Models?

    Many research investigators are faced with a decision: should they buy laboratory rodents from a commercial vendor, or produce them with an in-house breeding colony? There are many factors to evaluate before the decision to "breed or buy" can be made. Following are a few... Read more