Orthotopic-PDX Models: The Gold Standard in
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  • Defined Microbiome Profiles Can Improve Mouse Model Predictability

    It is well documented that the microbiome can impact both the development of disease and the efficacy of therapeutics. The microbiome also is consistently cited as a significant contributor to preclinical study variability and reproducibility, in part due to its effects on a mouse model's... Read more

  • The Role of Inflammation in Parkinson's Disease

    Parkinson's Disease (PD) affects over 10 million people worldwide and is the second most common neurodegenerative disorder1,2. Key research areas include genetics studies of patients with PD, target optimization for new treatments, the biology of cellular signaling pathways (α-synuclein, LRRK2, GBA, PRKN/PINK1, inflammation, and mitochondrial... Read more

  • Licensing Can Make or Break Access to Genetically Engineered Models

    Genetically engineered models (GEMs) serve as a backbone of drug discovery. Yet, accessing the most relevant GEM for a particular research objective is not always a simple task. Licensing issues can create hurdles for investigators who need a model ideally suited to their study objectives.... Read more

  • Three Methods for Generating Humanized Mice

    Humanized mice are valuable preclinical tools that enable researchers to perform more translationally-relevant studies. These models are mice that contain functioning human genes, cells, tissues, or microbiota. There are three ways to humanize a mouse: human immune system engraftment into an immunodeficient host, replacement of... Read more

  • Cell Therapy for Cancer: Preclinical Models to Study T cell-mediated Graft vs. Host Disease (GvHD)

    Even in the era of COVID-19, scientific research beyond the scope of novel infectious diseases marches on. Such was the case recently for the virtual 23rd annual American Society for Gene & Cell Therapy (ASGCT) meeting. ASGCT convenes the clinical and research communities and patient... Read more

  • Maintaining Quality Standards When Working with Research Models

    Factors affecting the quality and performance of research models include health, genetics, environment, and transportation. There are, of course, other factors, but these four can have the most significant impact on study outcomes and need to be considered when planning studies with animal models. Health... Read more

  • Webinar Q&A — Histopathological Characterization of the Diet Induced NASH B6

    The Diet Induced NASH B6 displays hepatic crown-like structures, which are a unique histopathological characteristic seen in human livers with NASH. These hepatic crown-like structures are macrophages surrounding hepatocytes with large lipid vacuoles (blue arrows). Macrophages also form inflammatory cell aggregates with other leukocytes (red... Read more

  • New edition of classic reference, The Laboratory Rat

    The Laboratory Rat is a classic reference book found on the shelves of many researchers worldwide. The third edition of this reference is now available and it's been completely refreshed since the second edition was published in 2005. Sponsored by the American College of Laboratory... Read more