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Murine Lung in Microbiome Research

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Taconic White Paper:

Application of CRISPR/Cas-based Technology to the Rapid Generation of Genetically Engineered Mice

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  • Ali Zahalka Wins AACR 2017 Travel Award

    For his work investigating mechanisms connecting SNS-mediated microenvironmental effects to prostate cancer progression, Ali Zahalka was awarded Taconic Biosciences' American Association for Cancer Research (AACR) 2017 Annual Meeting Travel Award. "Our lab is interested in identifying factors that promote early-stage cancer progression," Ali told Taconic,... Read more

  • Rise in Usage of Germ-Free Mice

    Germ-free mice are not new. Taconic Biosciences first started raising germ-free mice in 1960, after learning axenic husbandry techniques from the Laboratories of Bacteriology at the University of Notre Dame (LOBUND), where the first germ-free facility was established. Researchers have been using germ-free rodents since... Read more

  • Does the Microbiome Impact Neurological Diseases like Stroke and Seizure?

    Cerebral cavernous malformation (CCM) is a type of brain lesion in which normal tissue is displaced by collections of abnormal capillaries which are prone to leakage. CCM bleeding can cause strokes, seizures, and other neurologic deficits. The only current treatment for CCM is surgical removal.... Read more

  • Yeast Worsens Disease in a Mouse Model of Colitis

    Inflammatory bowel disease (IBD) is a disorder of the gastrointestinal tract which includes Crohn's disease and ulcerative colitis. In general, the majority of studies looking at the role of the human gut microbiome have focused on bacterial members. However, fungi are estimated to comprise 0.1%... Read more

  • Working Towards Microbiome Research Standards

    Microbiome research continues at an amazing pace, but labs around the world are racing ahead with few agreed-upon standards. This makes communication difficult and may undermine reproducibility. Growing Call for Microbiome Standards There are groups advocating for common standards, such as The Microbiome Coalition, and... Read more

  • Genetic Variation in C57BL/6 ES Cells and Knockout Mice

    Genetically engineered animal models (GEMs) are powerful tools for biomedical research and drug discovery, but genetic variation in animal models derived from distinct ES cell lines and subsequent breeding can impact both the interpretation and reproducibility of studies which employ them1. While recent advances in... Read more

  • Accelerating Parkinson's Disease Research Through Strategic Partnerships

    The Michael J. Fox Foundation (MJFF), established in 2000, is dedicated to finding a cure for Parkinson's disease (PD) by supporting research agendas toward development of improved therapies for Parkinson's disease patients. Unlike many private research funding institutions that rely on external scientific advisors and... Read more

  • The Real Impact of Rodent Diet on Microbiome and Gut Health Research Webinar Q&A

    Dr. Michael Pellizzon of Research Diets, Inc., recently presented a webinar on the underappreciated impact of rodent diets on microbiome and gut health research, where simple husbandry decisions can profoundly affect both animal model phenotypes and experimental outcomes. Due to time constraints, many of the... Read more