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An Introduction to Humanized Immune System (HIS) Mice -
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By definition, cell therapy is the transfer of autologous or allogeneic cellular material into a patient for medical purposes. Although the technique was first explored in the late 19th century, it has only recently gained traction as a standard of care in the medical field.... Read more
Amyotrophic lateral sclerosis (ALS) is a rare neurological disorder characterized by motor neuron degeneration in the primary motor cortex, brainstem, and spinal cord, which results in progressive muscular atrophy, weakness, and fatality1. Onset of this disease typically occurs in adulthood, and early symptoms are difficult... Read more
Cancer immunotherapies enhance the body's own immune system to control and eliminate tumors. Most clinical-stage immunotherapies target T cells of the adaptive immune system, especially cytotoxic CD8+ T cells. Myeloid cells have risen to prominence as worthwhile targets for immunomodulation. Within the immune landscape of... Read more
There are many factors that require consideration when designing any preclinical study, such as rodent model selection, housing conditions, treatment dosing schemes, and diet1. Exact specifications decided upon may, in some cases, be driven by availability or standard practices in the selected vivarium. In the... Read more
Since the launch of World Alzheimer's Month in 2012 by Alzheimer's Disease International, the prevalence of this disease has continued to climb. Today, approximately six million US patients are living with the disease. By 2050, an estimated 13 million people in the US will be... Read more
Regulatory T cells (Tregs) are a critical component of the immune system for regulating inflammatory responses. In the context of immune-mediated diseases, such as cancer or graft-versus-host disease (GvHD), Tregs can either drive or suppress disease pathogenesis. This two-sided role for Tregs and their impact... Read more
Obesity causes metabolic dysfunctions that lead to debilitating chronic diseases including type 2 diabetes, fatty liver disease, and cirrhosis. Diet-induced obese (DIO) rodents are popular models for studying obesity and pre-diabetes. In 1953, Fenton and Dowling manipulated nutrient composition across a range of refined rodent... Read more
Unique in its complexity, the central nervous system (CNS) has long represented a challenge for biomedical research, in part because the definition and characterization of constituent cell types remains incomplete. Indeed, one of the major goals behind the 2013 National Institutes of Health (NIH) launch... Read more
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