The Real Impact of Rodent Diet on Microbiome and Gut Health Research

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Application of CRISPR/Cas-based Technology to the Rapid Generation of Genetically Engineered Mice



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  • Selecting Donors for Fecal Microbiota Transplantation

    While fecal microbiota transplantation (FMT) is viewed as a relatively inexpensive and safe method for treating recurring Clostridium difficile infection and other maladies in humans, FMT is not without its challenges, particularly with regard to the screening and selection of fecal donors. In a recent... Read more

  • A First-Person Account of the Microbiome Revolution

    Segmented filamentous bacteria (SFB) in the terminal ileum of an 8-week-old Taconic B6 mouse In a new commentary article in Cell Host & Microbe, Ivaylo Ivanov provides a first-person account of the discovery that microbiota composition affects immune system development and response. Ten years after... Read more

  • Probiotics and Animal Health

    It's common knowledge that the microbiome is a hot area of biomedical research, with pharma and biotech placing big bets on microbiome therapeutics. But did you know that microbiome research and probiotics are also of interest to the animal health and agriculture markets? Farmers routinely... Read more

  • Experimental Impacts of Stress and Microbiome

    Exposure to stressful situations is difficult to avoid in the life of the laboratory mouse, but study design rarely accounts for the phenotypic effects of stress and the microbiome. Inevitable events and procedures, such as transportation, handling, and restraint, are known to induce stress in... Read more

  • Syngeneic Tumor Model Health Standards

    The growth in immuno-oncology research, in which the body's own immune system is recruited to fight a tumor, has prompted a shift in preclinical animal models used for oncology research. While traditional cell line xenografts in immunodeficient models are still widely used, they are generally... Read more

  • The Power of Laboratory Mice Infographic

    Looking for an accessible primer on the state of laboratory mice in biomedical research? Download Taconic Biosciences' new infographic The Power of Laboratory Mice, or request the infographic as a poster. This laboratory mice infographic can be a helpful reference to those just beginning their... Read more

  • Proposed Changes to ICH Carcinogenicity Testing Guidelines — Decision Delayed

    While evidence mounts in support of revised carcinogenicity testing guidelines, the number of Carcinogenicity Assessment Documents (CAD) submitted to the ICH S-1 expert working group fell below expected levels. After extending the submission period by two years9, the expert working group (EWG) will meet in... Read more

  • Modeling NK Cells in Immuno-Oncology

    What do Rituximab, Trastuzumab, and numerous other cancer immunotherapies have in common? Their anti-tumor efficacy involves the potent tumor-killing activity of natural killer (NK) cells. The induction of antibody-dependent cellular cytotoxicity (ADCC) in NK cells forms the basis for many important ongoing clinical efforts. These... Read more