UPCOMING WEBINAR:

Survival Guide to Maintaining Genetic Integrity in Breeding Colonies

Tuesday, November 28 at 11 a.m. ET / 5 p.m. CET

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Taconic White Paper:

Application of CRISPR/Cas-based Technology to the Rapid Generation of Genetically Engineered Mice

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  • A Redox Link between APOE4 and Alzheimer's Disease Risk?

    A Redox Link between APOE4 and Alzheimer's Disease Risk? Individuals homozygous for APOE4, one of three common genetic variants encoding Apolipoprotein E (apoE), carry approximately twelve-times higher risk for an Alzheimer's disease (AD) diagnosis. A recent study suggests a potentially critical link between apoE4 and... Read more

  • Hot Topics at AALAS National Meeting 2017

    During the week of October 15, 2017, I attended the 68th National AALAS meeting in Austin, Texas. It has been almost twenty years since I attended my first AALAS National meeting, and it was an excellent opportunity to meet new people and reconnect with colleagues... Read more

  • Foundational Gnotobiotics Concepts

    Gnotobiology isn't new, but the dramatic expansion of microbiome research has outpaced the development of a common nomenclature within the gnotobiotic research community. Many different, and sometimes confusing, terms are used when referring to different gnotobiotic concepts. To help, here's an overview of the most... Read more

  • Reference DNA from Key Mouse Strains Now Available

    Reproducibility Requires Genetic Quality The genetic integrity of laboratory mice and rats is an important contributor to research reproducibility, which is why commercial animal vendors invest in maintaining the genetic quality of standard inbred and outbred strains. As the technology to produce genetically engineered models... Read more

  • Webinar Q&A — Advanced Toolkit for Syngeneic Tumor Modeling in Mice

    Did you miss Dr. Philip Dubé's recent webinar, Advanced Toolkit for Syngeneic Tumor Modeling in Mice? His presentation introduced advanced concepts and critical considerations for studying immuno-oncology mechanisms and therapeutics in mice. Webinar Synopsis: Syngeneic models are becoming more advanced due to the availability of... Read more

  • Microbiome Summit Exploring Industry-Academic Partnerships

    International microbiome experts from academia and industry recently came together for the inaugural Microbiome Summit in Copenhagen, Denmark on October 5, 2017. Hosted by the Medicon Valley Alliance (MVA), this summit was intended to "bring together key ... stakeholders from academia, industry and the hospital... Read more

  • Cryopreservation Decision Tree

    Use of genetically engineered rodent models in research requires maintaining the lines through some level of continuous breeding. This can be costly, labor intensive, and result in inefficient use of limited vivarium space — while leaving valuable genetic lines vulnerable to catastrophic loss and genetic... Read more

  • Novel Humanized Mouse Model Mirrors Patient Responses to Immunotherapy

    For the first time, a team of scientists reproduced clinical responses to adoptive T-cell transfer in a rodent model of metastatic melanoma. This could support more accurate preclinical evaluation of novel immunotherapy agents. As described in Nature Communications, University of Gothenburg researchers leveraged the super-immunodeficient... Read more