Nested Isolation: A Low-Cost Housing Strategy to Boost Microbiome Research Capabilities

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Application of CRISPR/Cas to the Generation of Genetically Engineered Mice

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  • Application of CRISPR/Cas to the Generation of Genetically Engineered Mice White Paper

    UPDATE: This White Paper has been updated in 2018 to reflect the latest technological advances and usage recommendations of CRISPR/Cas in the generation of research models. CRISPR/Cas gene editing has emerged as a versatile technology for inducing precise genetic alterations in a number of different... Read more

  • The Long-Term Impacts of Traumatic Brain Injury

    National Vital Statistics System Mortality Data — United States, 2001-2010 (Deaths) Traumatic brain injury (TBI) is a growing problem. An estimated 10 million people are affected annually worldwide by TBI, and the burden of mortality and morbidity that imposes on society makes TBI a pressing... Read more

  • Research on Common Ocular Abnormalities in C57BL/6N Mice

    In May 2018 researchers at the University of California-Davis and Université de Strasbourg published a paper titled, A Population Study of Common Ocular Abnormalities in C57BL/6N rd8 Mice in the journal, Investigative Ophthalmology and Visual Science. C57BL/6N mice, which carry the rd8 mutation, are the... Read more

  • Limitations of Feces as Proxy for Gut Microbiota

    A myriad of factors can influence the gut microbiota composition of laboratory rats and mice: diet, stress, circadian rhythm, vendor source, how they are housed, and more. Since different gut microbiota compositions can elicit different phenotypes under otherwise similar experimental conditions, understanding what shapes the... Read more

  • Webinar Q&A — Humanized Mice in Preclinical Immuno-Oncology

    Dr. Paul Volden recently presented a webinar on humanized mice in preclinical immuno-oncology research. Many of the questions you submitted to his Q&A session went unanswered due to time constraints, so here's the full Q&A. General Immuno-Oncology Questions Dr. Paul Volden (PV): I would not... Read more

  • New Options for IO Efficacy Testing

    Structure of EMD Serono's bifunctional immune-oncology therapeutic M7824, from Lan et al.1 While new cancer immunotherapies offer fresh hope, not all patients respond to the currently available treatments. The race is on to identify efficacious combination therapies and next generation therapeutics, but preclinical efficacy testing... Read more

  • World MS Day

    To mark World MS Day and raise awareness of this disease, we're taking a look at the state of preclinical MS research and efforts to produce more translatable MS animal models. What is Multiple Sclerosis? Multiple sclerosis (MS) is a progressive disease of the nervous... Read more

  • Feed Your Gut Microbiota for Improved Health

    Humanized microbiota Swiss Webster mice infected with C. difficile efficiently clear the pathogen when maintained on a diet with microbiota-accessible carbohydrates (MAC+), but remain persistently infected when on a MAC-deficient diet (MD1, MD2). Switching from a MAC-deficient diet promotes rapid pathogen clearance. Figure from Hryckowian... Read more