Parkinson's Disease Mouse and Rat Models for Drug Discovery & Neurodegenerative Disease Research

Parkinson’s disease models are precisely genetically modified mice or rats that recapitulate key features of Parkinson’s disease in humans. These models may carry specific gene mutations or show brain changes similar to what has been identified in the human disease, like loss of dopamine neurons or buildup of alpha-synuclein protein. These models help researchers better understand how Parkinson's disease develops and progresses over time. 

Mouse models are essential tools in Parkinson’s disease research because they can be genetically modified to replicate key aspects of the disease, such as dopamine neuron loss, motor symptoms, and the accumulation of alpha-synuclein protein. These models allow scientists to study the underlying causes of Parkinson’s, track disease progression, and explore the effects of potential treatments. Mice are also genetically similar to humans, cost-effective, and well-suited for controlled laboratory studies, making them ideal for advancing Parkinson’s research.

These models help researchers understand disease mechanisms, test new therapies, and evaluate the efficacy and safety of potential treatments.

Standardize the age, sex, environment, and diet of your experimental cohort. Speak with a Taconic scientist to plan your next project. 

Yes, many strains are available as cryopreserved embryos or sperm, allowing for on-demand recovery and reducing colony maintenance costs. Cryopreservation ensures strain availability, genetic stability, and cost-effective colony management.