The SD LRRK2 Knockout Rat, available as part of The Michael J. Fox Foundation Parkinson's Disease Catalog, is a CRISPR/Cas9-generated model developed in collaboration with The Michael J. Fox Foundation featuring a deletion of the Lrrk2 gene (leucine-rich repeat kinase 2). Lrrk2 mutations are the most common monogenic cause of Parkinson’s disease, accounting for ~5-6% of familial and 1-3% of sporadic cases. Now available from Taconic Biosciences as of May 2026, this model supports research into Lrrk2 biology, disease mechanisms, and therapeutic development.
SD LRRK2 Knockout Rat
Application Areas:
| Model No. | Nomenclature | Genotype |
|---|---|---|
| 22641-M | NTac:SD-Lrrk2em9358Tac | ko/ko |
| 22641-F | NTac:SD-Lrrk2em9358Tac | ko/ko |
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Overview
Nomenclature: NTac:SD-Lrrk2em9358Tac
Model 26641 is a constitutive knock-out of the Lrrk2 gene via CRISPR/Cas9-mediated gene editing.
- Developed in collaboration with The Michael J. Fox Foundation, this model contains a deletion of the Lrrk2 gene, encoding for the leucine-rich repeat kinase 2. Mutations in Lrrk2 are the most common monogenic cause of Parkinson's disease. This model is useful in understanding Lrrk2 biology.
- Lrrk2 mutations account for 5-6% of familial Parkinson's disease and 1-3% in sporadic PD. Collectively, these mutations result in the most common cause of PD, making this an important model for the study of Parkinson's disease.
Model Sponsor: The Michael J. Fox Foundation
Taconic Biosciences has partnered with The Michael J. Fox Foundation on a catalog of rodent models for Parkinson's Disease (PD) research.
Orders by weight: Taconic cannot accept orders by weight for this model. Please note that shipments may contain animals with a larger weight variation.
Ordering Note for controls: Model 26641 WT littermate controls are not available for this model due to the homozygous mating format. A recommended WT control option is to utilize the SD rat commercial animals.
Availability
As of April 1, 2018, The Michael J. Fox Foundation for Parkinson's Research (MJFF) has instituted a new ordering policy for this model in an effort to prevent delays in order fulfillment, ensure models are shipped at the desired age, and maintain affordable pricing for all researchers accessing MJFF models. To achieve these goals, the new MJFF policy dictates that no one group can deplete the MJFF-sponsored colony. As such, orders will be limited to a total quantity of approximately 15-20 per researcher per month. Average lead time and age range may vary based on quantity and sex requested. Researchers requiring orders above this amount should establish a dedicated colony for their own use, either by breeding in-house or contracting with Taconic. For questions or requests for an exemption to the order limit, please email tools@michaeljfox.org.
Origin
The strategy overview for the constitutive NTac:SD-Lrrk2em9358Tac rat via CRISPR/Cas9-mediated gene-editing:
Lrrk2 KO Strategy Overview
Genetics
Applications & Therapeutic Areas
- Neurobiology
- Parkinson's Disease
Transit, Housing & Welfare
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Diet
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Licensing
Label License Agreement and Conditions of Use for SD LRRK2 KO Rat Model #22641
The SD LRRK2 KO Rat Model ( "Model") is produced and distributed under rights to patents and/or intellectual property owned by or licensed to the Michael J. Fox Foundation ("MJFF") and Taconic. Taconic has rights to distribute the Model on behalf of MJFF. MJFF maintains ownership of the Model and permits the sale of such Model to each purchaser that agrees to the Terms and Conditions of the Sale and following terms of use:
- Title to the Model, any progeny and biological materials derived from the foregoing remains with MJFF.
- The Model may be bred or crossbred by purchaser.
- Purchaser shall inform MJFF of any crossbred animal generated ("Modified Progeny"), shall at MJFF's election deposit breeding pairs of each Modified Progeny with Taconic or another designee of MJFF and shall permit Taconic or another designee of MJFF to distribute the Modified Progeny on behalf of MJFF to non-profit institutions or for-profit institutions without any compensation to purchaser on terms similar to the terms and conditions by which purchaser received the Model. Purchaser assumes all liability for any claim or demand that Modified Progeny created by purchaser infringes on the intellectual property rights of any third party.
- The Model, progeny, or Modified Progeny may be used by non-profit institutions or for-profit institutions for research purposes only.
- The Model, any progeny, Modified Progeny or biological materials will not be used for commercial purposes.
- The Model, any progeny, Modified Progeny and biological materials derived from them will not be distributed to any third party.
- Purchaser assumes all risk from using the Model, any progeny, Modified Progeny and biological materials.
- To the extent permissible by law, purchaser indemnifies, defends, and holds harmless MJFF from any claim or demand that purchaser's use or transfer of the Model, any progeny, Modified Progeny or biological materials has caused harm, damage or liability.
Pricing - USD
Murine Pathogen Free (MPF) Health Standard
22641 Female
22641-F Genotype ko/ko
Available now
| Age in Weeks | Quantity 1 - 999 |
|---|---|
| 4 to 12 | US$250.00 |
22641 Male
22641-M Genotype ko/ko
Available now
| Age in Weeks | Quantity 1 - 999 |
|---|---|
| 4 to 12 | US$250.00 |
Pricing - EUR
Murine Pathogen Free (MPF) Health Standard
22641 Female
22641-F Genotype ko/ko
Available now
| Age in Weeks | Quantity 1 - 999 |
|---|---|
| 4 to 12 | 228,00 € |
22641 Male
22641-M Genotype ko/ko
Available now
| Age in Weeks | Quantity 1 - 999 |
|---|---|
| 4 to 12 | 228,00 € |
Pricing - DKK
Murine Pathogen Free (MPF) Health Standard
22641 Female
22641-F Genotype ko/ko
Available now
| Age in Weeks | Quantity 1 - 999 |
|---|---|
| 4 to 12 | kr.1.696,00 |
22641 Male
22641-M Genotype ko/ko
Available now
| Age in Weeks | Quantity 1 - 999 |
|---|---|
| 4 to 12 | kr.1.696,00 |
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Why Parkinson’s Disease Models are Essential for Drug Discovery
Parkinson's disease rat models are essential tools for advancing neurodegenerative research and accelerating drug discovery. These preclinical models mimic key pathological features of Parkinson’s, including dopaminergic neuron loss and α-synuclein aggregation. By enabling scientists to test therapeutic strategies in a controlled, reproducible environment, Parkinson's rat models help predict clinical efficacy and reduce translational risks. Taconic Biosciences offers genetically engineered Parkinson’s disease models that support the development of novel treatments targeting motor function and disease progression. Using validated rat models in Parkinson’s research is critical for identifying biomarkers, optimizing dosing, and meeting regulatory requirements.
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Customer Reviews and Testimonials—Hear From our Scientists
“Robust, well-validated pre-clinical models of Parkinson's disease are a necessary tool for understanding the biology and possible treatment of this complex disease. With dedicated project management and technical support, Taconic has been a reliable partner in The Michael J. Fox Foundation's efforts to provide the research community with important, field-enabling pre-clinical models. We look forward to continuing to partner with Taconic for custom model generation projects.”
