Sprague Dawley®

Sprague Dawley® Outbred Rat Model
  • Live
  • Rat
  • Male & Female Available
  • Albino
  • Available for direct purchase by CRO
Model No.NomenclatureGenotype
SD-FNTac:SD
SD-MNTac:SD
View:
Select One

Overview

Nomenclature: NTac:SD

  • Used in virtually all disciplines of biomedical research including toxicology and pharmacology.
  • Excellent reproductive performance makes the SD rat a good model for generating timed pregnant females.
  • Opportunist Free (OF) SD rats are useful as health sentinels, clean fosters or where co-housed with immunodeficient/genetically modified models.

Origin

The Sprague Dawley® outbred model was developed by Sprague Dawley, Inc. NIH received stock from Sprague Dawley, Inc in 1945. The rats are maintained as an outbred closed colony. Taconic received stock from the NIH Animal Genetic Resource in 1970. The rats were refreshed with NIH Genetic Resource stock in 1998.

Genetics

Species:Rat
Strain Type:Outbred or Mixed
Coat Color:Albino
Coat Color Loci: Tyrc
Genetic Background:SD
Coat Color Loci: Tyrc

Guides & Publications

Applications & Therapeutic Areas

  • ADMET
  • Cardiovascular Disease
  • Neuroscience
  • Safety Assessment

Transit, Housing & Welfare

Need more info? Click the live chat button or Contact Us

Packing Practices

Taconic standard practice is to recombine animals of different home cages and/or ages from a single model and sex during packing, except in specific cases where Taconic's animal welfare policy prohibits recombination due to aggression or other concerns.  When an order is fulfilled with animals from more than one week of birth, this standard practice results in animals from a range of birth weeks packed together in a single TTC. When an order is fulfilled with animals from genotyped models, this standard practice results in animals from different home cages packed together in a single TTC.

Customers who wish to keep animals from different weeks of birth separated should place orders with the special instruction "Divide and label by age."  Note that this special request can result in increased costs for additional Taconic Transit Cages, dividers and/or freight charges.

Taconic discourages other types of custom packing requests as they can have a negative impact on animal welfare. Learn more.

Murine Biospecimen Collection

mouse

Surgical Models and Services

mouse

Data

Average litter size: 10
SD Physiological Data Summary (April 2004; N=10/group):
ParameterUnitsSprague
Dawley® Males
Sprague
Dawley® Females
Serum ChemistryAvg ± S.D.   
Calciummg/dL12.3 ± 0.411.4 ± 3.5
Phosphorousmg/dL12.6 ± 1.112.4 ± 1.4
Glucosemg/dL82.4 ± 11.393.2 ± 10.3
Creatininemg/dL0.3 ± 0.10.3 ± 0.1
BUNmg/dL9.1 ± 1.413.6 ± 3.0
Total Bilirubinmg/dL0.1 ± 0.00.1 ± 0.0
ALKU/L227.7 ± 36.1142.5 ± 33.9
ALT U/LU/L29.3 ± 3.422.5 ± 3.9
Total Proteing/dL6.4 ± 0.26.7 ± 0.2
Blood Counts
Erythron   
Red Blood CellsX106/uL6.9 ± 0.37.7 ± 0.3
Nucleated RBCX106/uL00
Hemoglobing/dL14.5 ± 0.816.1 ± 0.6
Hematocrit%48.3 ± 2.351.2 ± 2.6
MCVfL69.9 ± 1.766.9 ± 0.9
MCHpG20.9 ± 1.321.0 ± 1.1
MCHC%29.9 ± 1.631.4 ± 1.9
Platelets   
PlateletsX103/uL1358.0 ± 123.81262.2 ± 278.4
Leukogram   
White Blood Cellsx103/uL9.4 ± 3.26.0 ± 1.5
Neutrophilx103/uL0.9 ± 0.50.4 ± 0.3
Bandsx103/uL00
Lymphocytex103/uL8.3 ± 2.95.5 ± 1.4
Monocytesx103/uL0.3 ± 0.30.1 ± 0.1
Eosinophilx103/uL00
Basophilsx103/uL00
Othersx103/uL00
Organ Weights   
Stomachg2.02 ± 0.121.54 ± 0.17
Ileumg6.19 ± 0.624.83 ± 0.35
Colong0.77 ± 0.370.85 ± 0.21
Lungsg1.69 ± 0.141.31 ± 0.19
Heartg1.24 ± 0.140.90 ± 0.10
Liverg11.37 ± 1.127.17 ± 0.62
Spleen/Pancreasg1.58 ± 0.151.17 ± 0.23
Kidney (L)g1.08 ± 0.10.82 ± 0.08
Kidney (R)g1.09 ± 0.090.85 ± 0.08
Testes (L)g1.33 ± 0.17-
Testes (R)g1.33 ± 0.14-
Ovary (L)g-0.08 ± 0.01
Ovary (R)g-0.08 ± 0.01
Urinalysis   
Glucosemg/dLNegativeNegative
Blood-NegativeNegative
pH-6.75 ± 0.356.7 ± 0.4
Proteinmg/dLN/AN/A
Specific Gravity-1.0195 ± 0.00681.0155 ± 0.0079
Phenotyping Procedures:

Animal Receipt and Maintenance

A quantity of twenty rats (ten males and ten females) was submitted for testing, strain identified as Line Sprague Dawley® (NTac:SD), age 7 weeks. Rats were received at RBU 3, Taconic Biotechnology, Albany NY and acclimated for three days on irradiated NIH #31M Rodent Diet and sterilized water ad lib, sterile contact bedding (paper chip) and a 12:12 light:dark cycle. All animals appeared normal during this period and routine health surveillance of this colony detected no microbial pathogens. Rats were assigned study unique identification numbers (males 1-10, females 11-20).

 

Urinalysis

All rats were placed in metabolic cages and an overnight urine sample was collected. Urine analysis was performed using Multistix 10 SG (Bayer). Strips were read and recorded as per the manufacturer's instructions, and the results are presented in Table 2.

 

Clinical Chemistry and Hematology

A terminal blood sample was taken from Carbon Dioxide - anesthetized rats via cardiac puncture. The collected blood was divided into two samples. One sample was treated with EDTA and stored at 4°C for hematological evaluation. Another sample was allowed to clot at 4°C for 30 minutes, and then centrifuged at 7000rpm for 10 minutes, and the serum was decanted and frozen at -80°C for clinical chemistry analysis. A slide smear was made from a single drop of whole blood. Frozen serum, chilled whole blood and slides were delivered to LabCorp (RTP, NC) for analysis; the results are presented in Table 3. Unless otherwise indicated, serum chemistry data is generated from a Hitachi 717 automated analyzer and hematological data is generated from a Celldyne 3500. WBC differential counts are performed manually.

 

Necropsy and Organ Weights

All rats were euthanized and bodyweights were recorded. Representative tissues were collected, weighed, and immersion fixed in 10% Neutral Buffered Formalin. Tissues were delivered to the Taconic Anmed lab (Rockville, MD) for histological preparation and evaluation. Tabulation of organ weights is presented in Table 4. The pathologist’s summary and detailed histological descriptions follow.

 

Discussion

All animals were thrifty on arrival and appeared clinically normal. Locomotor behavior was normal and there were no visible lesions or discharges at the mucous membranes. All tissues appeared normal on gross necropsy evaluation and weights were within normal limits. There were no unusual findings upon collection of these tissues nor otherwise observed in the body cavities.

The overall profile of these rats is consistent with expectations of a general-purpose rat. None of the parameters are indicative of impaired system function.

One Year Growth Chart
Taconic Sprague Dawley® Rats Average Control Group Body Weight in Grams
One Year Toxicology Study (N=20)
Weeks of Age678910
Female152.71184.13209.71227.55241.11
Male163.01225.98276.15306.93336.53
Weeks of Age1112131415
Female256.33260.37271.94279.08291.5
Male361.71378.11396.8412.86431.21
Weeks of Age1617182226
Female295.22298.41303.42315.48335.41
Male441.56454.14461.01491.98514.05
Weeks of Age3034384246
Female350.74357.83368.19383.44392.05
Male528.94544.33556.88568.96568.41
Weeks of Age505458
Female408.44421.01426.79
Male579.1584.42577.79

For some applications, weight may be critical. For orders where weight is critical, please place orders by weight, not by age. Taconic can accept orders by weight for this model. For orders sourced from US or Denmark a production minimum 15 gram span is accepted. All weights are weights at time of packing. Mice and rats can lose weight in transit. Orders for specific weight spans will be assessed a nominal fee. More detail on weight order policies is available.

This chart is best viewed in landscape mode.
Please rotate your screen.

Loading...

n= 500 per sex at MPF, RF and EF health standards from all global colonies. Data collected 2013-15.
High and Low represent mean +/- 1 standard deviation.
Based on sample size the charts above represents ~68% of the population.
All growth curves represent animals housed in our barriers, at our standard density and fed NIH31-M diet. Variations at customer facilities will alter expected growth curves.
Growth charts are provided only as a guide, if a specific weight criteria is needed please order animals by weight.

Customize this chart by clicking the legend elements.

Licensing

Terms of Sale and Use for Sprague Dawley®

These models are sold subject to Taconic's Terms and Conditions for Taconic's Models, Products and Services

Pricing - USD

Opportunist Free (OF) Health Standard

SD Female

SD-F

Age in WeeksQuantity 1 - 999
3 to 4$74.00
5 to 6$78.00
7 to 8$87.00
9 to 10$106.00
11$120.00
12$135.00
13$151.00
14$165.00
15$180.00

Specialized Inventory

SD-FLQuantity 1 - 199
Female With Litter$286.00

Specialized Inventory

SD-TPQuantity 1 - 999
Timed Pregnant Female$372.00

Specialized Inventory

SD-UPQuantity 1 - 199
Untimed Pregnant Female$295.00

*Untimed pregnant requests are filled with late gestation pregnant females. Pups may be delivered in transit.

SD Male

SD-M

Age in WeeksQuantity 1 - 999
3 to 4$65.00
5 to 6$67.00
7 to 8$98.00
9 to 10$126.00
11$140.00
12$168.00
13$184.00
14$198.00
15$227.00

Murine Pathogen Free (MPF) Health Standard

SD Female

SD-F

Age in WeeksQuantity 1 - 999
3 to 4$33.00
5 to 6$35.00
7 to 8$52.00
9 to 10$54.00
11$60.00
12$68.00
13$77.00
14$84.00
15$91.00

Specialized Inventory

SD-FLQuantity 1 - 199
Female With Litter$191.00

Specialized Inventory

SD-RFQuantity 1 - 199
Retired Female Breeder$60.00

Specialized Inventory

SD-TPQuantity 1 - 999
Timed Pregnant Female$207.00

Specialized Inventory

SD-UPQuantity 1 - 199
Untimed Pregnant Female$151.00

*Untimed pregnant requests are filled with late gestation pregnant females. Pups may be delivered in transit.

SD Male

SD-M

Age in WeeksQuantity 1 - 999
3 to 4$33.00
5 to 6$35.00
7 to 8$53.00
9 to 10$64.00
11$78.00
12$89.00
13$102.00
14$113.00
15$131.00
16$140.00
17$151.00

Specialized Inventory

SD-RMQuantity 1 - 199
Retired Male Breeder$74.00

Pricing - EUR

Opportunist Free (OF) Health Standard

SD Female

SD-F

Age in WeeksQuantity 1 - 999
3 to 4€67,00
5 to 6€95,00
7 to 8€110,00
9 to 10€134,00
11€147,00
12€164,00
13€180,00
14€194,00
15€210,00
16€224,00
17€240,00

Specialized Inventory

SD-FLQuantity 1 - 199
Female With Litter€297,00

SD Male

SD-M

Age in WeeksQuantity 1 - 999
3 to 4€67,00
5 to 6€97,00
7 to 8€128,00
9 to 10€163,00
11€176,00
12€193,00
13€209,00
14€223,00
15€238,00
16€254,00
17€268,00

Murine Pathogen Free (MPF) Health Standard

SD Female

SD-F

Age in WeeksQuantity 1 - 199Quantity 200 - 999
3 to 4€27,00€22,00
5 to 6€34,00€31,00
7 to 8€36,00€31,00
9 to 10€49,00€45,00
11€61,00€59,00
12€69,00€68,00
13€79,00€78,00
14€86,00€86,00

Specialized Inventory

SD-FLQuantity 1 - 199
Female With Litter€286,00

Specialized Inventory

SD-RFQuantity 1 - 199
Retired Female Breeder€112,00

Specialized Inventory

SD-TPQuantity 1 - 999
Timed Pregnant Female€335,00

Specialized Inventory

SD-UPQuantity 1 - 199
Untimed Pregnant Female€233,00

*Untimed pregnant requests are filled with late gestation pregnant females. Pups may be delivered in transit.

SD Male

SD-M

Age in WeeksQuantity 1 - 199Quantity 200 - 999
3 to 4€27,00€24,00
5 to 6€36,00€34,00
7 to 8€53,00€47,00
9 to 10€68,00€61,00
11€78,00€69,00
12€86,00€79,00
13€97,00€86,00
14€106,00€94,00

Specialized Inventory

SD-RMQuantity 1 - 199
Retired Male Breeder€112,00

Select my Health Standard

Need help choosing the right Taconic Biosciences health standard for your research?

Use the Health Standard Selector to enter your exclusion list. The tool will tell you which health standards meet your requirements.

Get custom pricing guide

2024 Pricing Guide Now Available

Get your Taconic Biosciences 2024 Pricing Guide today. Personalized, customizable, links to up-to-date health reports, and additional information on Taconic's products and services.

Schedule A Scientific Consultation

Speak with a PhD-level Field Application Scientist who can help you select the most appropriate model and maximize your experimental success.

Want to Get in Touch?

Chat with us or reach out to our global team

phone

Webinar On-Demand

ON-DEMAND WEBINAR | Breed Vs. Buy: What's The Right Choice For Your Lab?

Webinar On-Demand

ON-DEMAND WEBINAR | The Laboratory Rat: Biology, Reproduction, and Unique Applications

2024 Pricing Guide Now Available

Get your Taconic Biosciences 2024 Pricing Guide today. Personalized, customizable, links to up-to-date health reports, and additional information on Taconic's products and services.

Smart Select Program

Trial an Animal Model for Quality & Compatibility Assurance

As longtime facilitators of animal-based research, we understand the importance of aligning your project goals and procurement priorities to support advancements in your research. 

  • Evaluate a specific model strain, before making any financial investment
  • Request up to 20 animals from one of the strains listed below, to test for quality, consistency, and suitability for your experimental purpose
  • Enjoy free ground shipping, where applicable (see table for more details)*