Transgenic HLA Mouse Models

Portfolio Overview

Transgenic mice that express human HLA molecules are used for cancer immunotherapy research in several ways. Example applications include evaluation of HLA-restricted CTL epitope responses in vivo, determining the immunogenicity of novel cancer vaccines, and to test expansion and response of chimeric antigen receptor T cells.

Cancer vaccines are a promising avenue for immunotherapy development. Like other vaccines, they often utilize rational design by epitope identification and selection. In silico modeling may be used to identify potential epitopes recognized by the human immune system, but in vivo confirmatory testing is frequently required to confirm immunogenicity.

One of the challenges in this area is that epitope recognition varies significantly from species to species, so animal models may not accurately model epitope binding by human HLAs. Our mice expressing human HLAs present one way to overcome this hurdle. These strains can be combined with syngeneic tumor modeling to test efficacy of cancer vaccines.

Taconic Biosciences offers a portfolio of human HLA mice covering key human HLA supertypes.

 

Key Human HLA Supertypes

HLA Class I
ModelStrain BackgroundDescription
HLA-A2.1 (CB6F1)C57BL/6 or CB6F1Expresses the chimeric HLA-A2.1 class I molecule (representing the HLA-A2 supertype) on the surface of T and B cells. Inquire for C57BL/6 version.
HLA-A11 (CB6F1)C57BL/6 or CB6F1Expresses the chimeric HLA-A11 class I molecule (representing the HLA-A3 supertype) on the surface of T and B cells. Inquire for C57BL/6 version.
HLA-A1 (CB6F1)C57BL/6 or CB6F1Expresses the chimeric HLA-A1 class I molecule (representing the HLA-A1 supertype) on the surface of T and B cells. Inquire for C57BL/6 version.
HLA-A24 (CB6F1)C57BL/6 or CB6F1Expresses the chimeric HLA-A24 class I molecule (representing the HLA-A24 supertype) on the surface of T and B cells. Inquire for C57BL/6 version.
HLA-B7 (C;B6)C57BL/6 or CB6F1Expresses the chimeric HLA-B7 class I molecule (representing the HLA-B7 supertype) on the surface of T and B cells. Inquire for C57BL/6 version.
HLA-B44 (CB6F1)C57BL/6 or CB6F1Expresses the chimeric HLA-B44 class I molecule (representing the HLA-B44 supertype) on the surface of T and B cells. Inquire for C57BL/6 version.
HLA CLASS II
Abb Knockout/ Transgenic HLA-DR4 C57BL/6Expresses the chimeric HLA-DR4 class II molecule on the surface of T and B cells

Custom crosses to immunodeficient models or other genetically modified strains are available. Inquire for details.

 

Custom Solutions For Oncology and Immuno-Oncology Research

Taconic Biosciences' globally recognized scientific project managers support your custom model design project from design to delivery. Each custom model design project develops along an agile framework, letting you reassess and retarget your model fluidly as new data becomes available. You can pause or postpone projects at any time, or even "back up" project milestones via cryopreservation.

Model Generation Solutions
& Breeding Services

  • Model Acquisition
  • Transition Mutant to Model
  • Scaled Breeding
  • Specialized Services
  • Distribution

Colony Management Solutions

  • Extensive Health Standard Options
  • True Gnotobiotic Profiles
  • Genetic Monitoring Programs
  • Scientific Leadership & Success Team
  • Custom Solutions for Every Partner

Featured Content

Get In Touch

Book a complimentary consultation or get support for an existing order

If you need immediate assistance, please contact Customer Service:

Taconic Corporate Offices

Email: info@taconic.com
Phone: +1 (518) 697-3900
273 Hover Ave., Germantown, NY 12526

North American Customer Service

Email: info@taconic.com
Phone: +1 (518) 697-3915 
Toll-free:  +1 (888) 822-6642

Hours: (Monday - Friday): 7 a.m. - 6 p.m. ET

European Customer Service

Email: info@taconic.com
Phone (Europe and Denmark): +45 70 23 04 05 
Phone (Germany): +49 214 50 68 023 
Hours: (Monday - Friday): 7 a.m. - 5 p.m. CET

Let's Get Social!

How can we help you?
Fill out the form to connect with us:

Welcome! Tell us a little about yourself