Taconic Biosciences at AALAS 2025

In their 1959 publication The Principles of Humane Experimental Technique, W.M.S. Russell and R.L. Burch introduced not only to guide current humane experimental methods but also a foundation for continuous innovation in scientific research practices. 

One unexpected but impactful innovation aligned with the 3Rs is Sales, Inventory, and Operations Planning (SIOP). Originally developed in 1983 by Oliver Wight for integrated business management, SIOP is a monthly five-step process designed to align sales forecasts, supply resources, and operational output with broader strategic objectives. In the context of laboratory animal production, this cross-functional planning model has become a powerful tool to reduce overproduction, improve efficiency, and support ethical research practices. 

Our organization has successfully implemented the SIOP framework, and it has become deeply embedded in our operations. Through consistent execution of the five-step cycle—data gathering, demand planning, supply planning, reconciliation, and executive alignment—we have achieved notable results of improving our production accuracy of over 90% and improving our On-Time and In-Full (OTIF) delivery hits.  These reflect precise alignment between anticipated and actual animal use while ensuring operational reliability and supply chain responsiveness. 

We support Reduction by narrowing the gap between animals produced and animals actually used.  This significantly decreases unnecessary breeding and resource waste.  Accurate planning enhances animal welfare by reducing environmental stressors and ensuring predictable, humane handling conditions. Operational efficiency opens bandwidth for investment in alternative models and emerging technologies, supporting long-term replacement strategies.  

Regular monitoring of unused animal rates and made-to-stock alignment provides measurable feedback on the process. A consistent downward trend in animals produced but not used is a key indicator of success.  While SIOP originated as a business efficiency model, its application in biomedical research operations demonstrates its value as a strategic tool for advancing both scientific quality and humane practice.

The integration of refined handling in rodent breeding facilities represents an evolution of both animal welfare and operational efficiency. Currently, the adoption of these techniques in larger breeding facilities is limited. Our approach incorporates refined handling techniques that focus on minimizing stress and enhancing the overall well-being of rodents. The process involves identifying and eliminating stressful stimuli, adopting refined handling methods such as cupping and tunnel handling, and incorporating these practices into the standard protocol. The initial step involves assessing current handling practices and identifying stressors. By understanding the elements that contribute to stress, facilities can effectively address these issues. This is followed by the creation and evaluation of refined handling protocols with a focus on mitigating stress and promoting positive interactions between handlers and rodents. Initial reluctance towards refined handling is expected, making employee training a critical component of this transition. Ensuring that staff are proficient in refined techniques is essential for consistency. Training includes both the technical aspects and highlights the importance of empathy and gentle handling. Feedback from staff as well as continuous monitoring will be utilized to measure the effectiveness of the methods and integrate necessary adjustments. This cycle ensures that handling techniques remain effective and are continuously improved based on observations and feedback. The transition to refined handling is expected to enhance animal welfare, reduce stress levels, and improve breeding outcomes, leading to healthier and more content rodents. Moreover, staff satisfaction is likely to increase as humane handling practices create a more positive and fulfilling work environment. The anticipated handler-animal bond resulting from refined handling is expected to produce less variation in study outcomes, thereby advancing scientific research. Here, we outline the steps and anticipated impacts of transitioning to refined handling in a large rodent breeding facility, emphasizing the importance of a structured, process-driven approach.