Neuroscience Portfolio

Taconic offers a diverse portfolio of rodent models and services for neuroscience research. Get easy access to exclusive neurodegenerative disease-specific models, aged up to 40+ weeks, available at study-ready quantities. We combine scientific support from PhD scientists, extensive phenotyping data, and customized breeding and aging services to accelerate your neuroscience research efforts.

Albino mouse standing

Timely Access to Neuroscience Models

A major challenge in neuroscience research and drug discovery is timely access to relevant animal models for use in screening drug candidates.

With access to the right model at the right stage of disease progression, your research projects can begin sooner and accelerate the time to data. Through our models portfolio, active partnerships and custom services, we remove common challenges to accessing disease-specific models.

Familial Alzheimer's Disease Models

Amyloid beta (Aβ) plaques and neurofibrillary tangles (NFTs) combined with deficits in learning and memory are hallmarks of Alzheimer’s Disease (AD). Understanding how plaques, tangles and neuroinflammation develop and discovering effective therapeutics that prevent these neurodegenerative processes are important factors for winning the battle against Alzheimer’s disease.

Taconic offers a variety of transgenic rodent models that develop plaques, tangles and neuroinflammation and which allow screening of novel drug candidates for treatments against Alzheimer’s and other neurodegenerative diseases.

Sporadic Alzheimer's Disease Models

Humanized Apolipoprotein E (APOE) mice

The Apoe gene is the strongest genetic risk factor for sporadic forms of late-onset Alzheimer Disease (AD). Taconic provides three humanized APOE mouse models that are useful for studying the role of human APOE polymorphism neurodegenerative disorders.

The association of specific APOE isoform expression with human neurodegenerative disorders has focused attention on the role of these APOE isoforms in lipoprotein receptor-dependent synaptic modulation. Targeting APOE and APOE receptor pathways represents promising therapeutic strategies to combat neurodegenerative diseases such as Alzheimer’s Disease.

APOE is a plasma protein involved in cholesterol transport with three human isoforms (E2, E3, and E4). Among the three isoforms APOE4 appears to drive amyloid pathology by inhibiting brain clearance of amyloid-β (Aβ) peptides and by promoting Aβ aggregation.

In the brain, APOE is primarily synthesized by astrocytes and microglia and is lipidated by the ABCA1 transporter to form lipoprotein particles. Lipidated APOE binds to soluble Aβ and facilitates Aβ uptake through cell surface receptors

Neuropsychiatric disorder models

Copy number variations (CNVs) are a type of genetic structural variation involving deletions or duplications of specific and relatively large (>1 kb) regions of DNA. Geneticists now recognize that CNVs and other rare structural variants contribute to the genetic basis of common diseases and disorders, including autism and schizophrenia.

Taconic offers neuropsychiatric disorder CNV models that develop distinct neurological and behavioral phenotypes. These models can be used to screen novel drug candidates for treating schizophrenia, autism spectrum disorders, epilepsy, and other neuropsychiatric disorders.

ALS rat model

The SOD1 Rat has been used extensively for drug discovery and basic research into ALS.

CRE-Luc reporter mouse platform

Taconic offers a panel of luciferase reporter mice to assay GPCR ligand binding and pathway activation in various tissues. Mice with CNS specific expression of CRE-Luc reporter can be used to isolate primary neurons (for in vitro studies) or for in vivo imaging studies to assay GPCR based signaling in the CNS. This platform can also provide rapid in vivo PK/PD profiling of compounds with quantitative data to compare pharmacological action.

Central Nervous System Trauma Model

Taconic offers the GFAP-Luc mouse which carries a luciferase reporter gene under the control of the GFAP promoter and provides an easy to use tool to study CNS damage. The reporter is inducible following injury to the CNS and the model is useful for studying changes in the health of the CNS.

Brain Inflammation Model

Taconic offers several models for use in Experimental Autoimmune Encephalomyelitis (EAE), which is widely studied as an animal model of CNS demyelinating diseases, including Multiple Sclerosis (MS) and acute disseminated encephalomyelitis.

Like MS, EAE is characterized by infiltration of immune cells into the central nervous system (CNS) and demyelination. The two most widely-used methods to induce EAE are:

  • Active induction by immunization
  • Passive induction through adoptive transfer

Read our Insight (below) to learn more about these approaches. 

Don't see what you're looking for? Request a custom model.

Genetically Engineered Animal Models | Taconic Biosciences

Explore custom animal model solution options designed and engineered to fit the specific needs of your research program

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Book a complimentary consultation or get support for an existing order

If you need immediate assistance, please contact Customer Service:

Taconic Corporate Offices

Phone: +1 (518) 697-3900
273 Hover Ave., Germantown, NY 12526

North American Customer Service

Phone: +1 (518) 697-3915 
Toll-free:  +1 (888) 822-6642

Hours: (Monday - Friday): 7 a.m. - 6 p.m. ET

European Customer Service

Phone (Europe and Denmark): +45 70 23 04 05 
Phone (Germany): +49 214 50 68 023 
Hours: (Monday - Friday): 7 a.m. - 5 p.m. CET

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