Tau - Model 2508

Tau (Model 2508) Random Transgenic Mouse Model
  • Live
  • Mouse
  • Male & Female Available
  • Various
  • Available for direct purchase by CRO
Model No.NomenclatureGenotype
2508-FSTOCKTg(Prnp-MAPT*P301L)JNPL3Hlmctg/tg
2508-MSTOCKTg(Prnp-MAPT*P301L)JNPL3Hlmctg/tg
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Overview

Nomenclature: STOCKTg(Prnp-MAPT*P301L)JNPL3Hlmc

  • Carries the transgene for the human P301L mutation of the microtubule-associated protein tau gene (MAPT) and expresses mutant human TAU protein
  • Aggregates of filaments of TAU result in Neurofibrillary tangles (NFT) which are associated with Alzheimer's disease, Pick disease and other neurological syndromes
  • Develops behavioral and motor disturbances related to development of NFT
  • Model 2508 is homozygous for the transgene and develops a phenotype that mimics human tauopathies in a more rapid time frame than hemizygous mice
  • Useful for studying Alzheimer's disease, Pick's disease and other neurological syndromes associated with NFT
  • This model is on a C57BL/6, DBA/2, SW mixed background.
  • The appropriate wild type control stock is model #18392.
  • Pink eyed animals, associated with certain coat colors, and the Pde6brd1 retinal degeneration mutation can cause light sensitivity and/or blindness in some animals. This may impact the results of behavioral testing. Upon request, animals can be screened for eye color, coat color, and/or rd1 homozygosity for an additional fee.
Orders by weight: Taconic cannot accept orders by weight for this model. Please note that shipments may contain animals with a larger weight variation.

Origin

The Tau mouse was developed in the laboratory of Mike Hutton at the Mayo Clinic. The model was created by microinjecting transgenic constructs containing the P301L mutation of the microtubule associated tau gene and mouse prion promoter into B6D2F1 x SW zygotes. The resultant mice from Founder Line JNPL3 were mated to B6D2F1. Taconic received stock in December 2000. The mice were derived by embryo transfer and mated to SW and B6D2F1 hybrids and embryo transfer derived. Offspring from both backgrounds were combined and were mated to B6D2F1 mice to produce hemizygous and wild type mice. Hemizygous Tau mice were intercrossed to generate homozygous Tau mice. A genetic refresh was initiated in part to generate a suitable wild type control stock. Homozygous 2508 Tau females were mated to Swiss Webster males. Hemizygous males from this cross were mated to B6D2F1 females. Wild type offspring from this second cross were used to establish control model #18392, whereas hemizygous males and females were intracrossed to generate homozygous mice to re-establish model #2508. The colony is maintained by mating homozygous females and males.

Genetics

Species:Mouse
Strain Type:Outbred or Mixed
Allele Type:Random Transgenic;Genetically Humanized
Coat Color:Various
Genetic Background:Mixed

Other Genetic Notes:

Wildtype for Nnt mutation; carries Pde6brd1 mutation

Guides & Publications

Initial Publication: Lewis J, McGowan E, Rockwood J, Melrose H, Nacaraju P, Van Slegtenhorst M, Gwinn-Hardy K, Murphy MP, Baker M, Yu X, Duff K, Hardy J, Corral A, Lin W-L, Yen S-H, Dickson DW, Davies P, Hutton M. (2000) Neurofibrillary Tangles, Amyotrophy and Progressive Motor Disturbance in Mice Expressing Mutant (P301L) Tau Protein. Nat Genet, 25(4):402-406.

Applications & Therapeutic Areas

  • "Alzheimers Disease"
  • Genetically Humanized
  • Neuroscience

Transit, Housing & Welfare

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2508 males are packed as cagemates without recombination of animals from different cages into a single Taconic Transit Cage (TTC). We recommed that the customers do NOT recombine 2508 males from different Taconic Transit Cages into the same cage at or after unpacking.  

Packing Practices

Taconic standard practice is to recombine animals of different home cages and/or ages from a single model and sex during packing, except in specific cases where Taconic's animal welfare policy prohibits recombination due to aggression or other concerns.  When an order is fulfilled with animals from more than one week of birth, this standard practice results in animals from a range of birth weeks packed together in a single TTC. When an order is fulfilled with animals from genotyped models, this standard practice results in animals from different home cages packed together in a single TTC.

Customers who wish to keep animals from different weeks of birth separated should place orders with the special instruction "Divide and label by age."  Note that this special request can result in increased costs for additional Taconic Transit Cages, dividers and/or freight charges.

Genetically Engineered Animal Models

mouse

Tau - Model 2508

Conditions of Use for Taconic Transgenic Models™

Taconic Transgenic Models™ (Models) are produced and distributed under rights to patents and intellectual property licensed from various institutions. Taconic sells the Models to purchasers, grants to each purchaser a right under Taconic's rights in such licensed patents and intellectual property to use the purchased Model in consideration of purchasers' acknowledgement of and agreement to the Terms and Conditions for Taconic Models, Products and Services and the following terms of use:

  • Title to these Models and biological materials derived from them remains with Taconic.
  • The Models will be used for research purposes only.
  • The Models will not be bred or cross-bred except to obtain embryos or fetuses required for research purposes unless additional rights have been granted in writing by Taconic.
  • The Models and biological materials derived from them will not be distributed to third parties or used for commercial purposes.
  • Non-profit purchasers may not use this Model and/or biological materials derived from it in sponsored research or contract research studies unless it is purchased at the for-profit price.

Pricing - USD

Murine Pathogen Free (MPF) Health Standard

2508 Female

2508-F Genotype tg/tg

Age in WeeksQuantity 1 - 999
3 to 10$556.00

2508 Male

2508-M Genotype tg/tg

Age in WeeksQuantity 1 - 999
3 to 10$556.00

Pricing - EUR

Murine Pathogen Free (MPF) Health Standard

2508 Female

2508-F Genotype tg/tg

Age in WeeksQuantity 1 - 999
3 to 10€486,00

2508 Male

2508-M Genotype tg/tg

Age in WeeksQuantity 1 - 999
3 to 10€486,00

Pricing - USD Nonprofit

Murine Pathogen Free (MPF) Health Standard

2508 Female

2508-F Genotype tg/tg

Age in WeeksQuantity 1 - 999
3 to 10$500.00

2508 Male

2508-M Genotype tg/tg

Age in WeeksQuantity 1 - 999
3 to 10$500.00

Pricing - EUR Nonprofit

Murine Pathogen Free (MPF) Health Standard

2508 Female

2508-F Genotype tg/tg

Age in WeeksQuantity 1 - 999
3 to 10€437,00

2508 Male

2508-M Genotype tg/tg

Age in WeeksQuantity 1 - 999
3 to 10€437,00

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