APP/PS1 (ARTE10) Alzheimer’s Mouse Model

Commonly referred to as APP/PS1 | Also known as: ARTE10, APP-PS1, APP/PSEN1, APP-PSEN1, Model 16347

The APP/PS1 (ARTE10) transgenic mouse model is a robust and highly translational tool for advancing Alzheimer’s disease research. Engineered on a C57BL/6 (B6) background, this model co-expresses human APP with the Swedish mutation and PSEN1 with the M146V mutation under the Thy1 promoter, leading to early and abundant β-amyloid plaque formation. With predictable onset and progression of amyloid pathology, low inter-animal variability, and high penetrance, APP/PS1 is ideal for evaluating amyloid-targeting therapies and imaging agents. Whether you're investigating disease mechanisms or testing therapeutic interventions, the APP/PS1 model offers the consistency and clinical relevance essential for preclinical neuroscience research.

  Application Areas: 

  • Neurobiology
  • Alzheimers Disease (AD)
  • Live
  • Mouse
  • Male & Female Available
  • Black
  • Available for direct purchase by CRO
  • Taconic Transgenic Model
Model No.NomenclatureGenotype
16347-FC57BL/6NTac.CBA-Tg(Thy1-PSEN1*M146V,-APP*Swe)10Artetg/tg
16347-MC57BL/6NTac.CBA-Tg(Thy1-PSEN1*M146V,-APP*Swe)10Artetg/tg
black lab mouse close-up isolated on white background
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Overview

Nomenclature: C57BL/6NTac.CBA-Tg(Thy1-PSEN1*M146V,-APP*Swe)10Arte

 

  • Transgenic line with two co-integrated constructs: Thy-1 promoter specific expression the transgene coding for the 695-amino acid isoform that harbors the Swedish mutation of human Alzheimer β-amyloid (Aβ) precursor protein, as well as human Presenilin 1 carrying the M146V mutation (PS1M146V).
    • Expresses high concentrations of human Aβ protein and develops human AD-like amyloid pathology due to genetic mutations within the human APP and PSEN1 genes. Aβ42 is the predominant insoluble species in this model.
Application:
  • APP/PS1 is an appropriate preclinical model for prolonged evaluation of amyloid-lowering therapies and has been successfully PET imaged in vivo and ex vivo using Pittsburgh compound B (PiB) tracers.
Aβ Pathology:
  • This model develops cerebral β-amyloidosis that mimics several β-amyloid characteristics of human AD neuropathology, which is associated with glial inflammation. The neuropathology is reported to progress rapidly and predictably, with up to 100%-penetrance and low inter-animal variability reported. In animals with advanced plaque deposition, cerebral amyloid angiopathy is also present.
  • Pattern and sequence of Aβ deposition: Aβ plaque formation first occurs in the anterior neocortex and subiculum in both homozygous and hemizygous animals as early as 3-months and 5-months respectively.
  • Quantification of Aβ plaque: Plaque load progressively increases with age of onset, rate, and maximum level of plaque deposition, which are transgene dose-related. Homozygous animals have higher amounts of both insoluble and soluble Aβ levels in the brain then hemizygous animals.
  • Sex differences in either homo- or hemizygous animals with regards to Aβ pathology have not been reported in this line.
Note:
  • The homozygous & hemizygous APP/PS1 animals are reported to possess a relatively low rate of premature mortality (15% and 0% at 12 months, respectively) with expected life expectancy beyond 20 months. At Taconic Biosciences, we have observed limited mortality post-weaning in the breeding colony, with some incidence of a tremor phenotype.

Orders by weight: Taconic cannot accept orders by weight for this model. Please note that shipments may contain animals with a larger weight variation.
 
Genetic Background: C57BL/6NTac background. The APP/PS1 model was backcrossed to C57BL/6NTac and is 100% congenic.
The transgene integration caused an approximate 200kB deletion, which includes the Nrg3 gene.

Recommended Controls
The recommended control for this model is C57BL/6NTac.

Origin

The APP/PS1 mouse model was developed by Taconic in association with Evotec. The APP/PS1 model was created by pronuclear co-injection of human cDNA constructs of Thy1-APPswe and Thy1-PS1M146V into B6CBF1 eggs and the founder line was selected based on amyloid plaque formation (Arte10-729). The two constructs were coinherited as a single transgene without segregation as assessed over several generations in backcrosses to C57BL/6. The colony is maintained via mating homozygous males and females.

Genetics

Species:Mouse
Strain Type:Congenic
Allele Type:Random Transgenic;Genetically Humanized
Coat Color:Black
Genetic Background:C57BL/6

Other Genetic Notes:

Wild type for Pde6brd1 mutation.

Guides & Publications

Initial Publication: Willuweit A.; Velden J.; Godemann R.; Manook A.; Jetzek F.; Tintrup H.; Kauselmann G.; Zevnik B.; Henriksen G.; Drzezga A.; Pohlner J.; Schoor M.; Kemp J.A.; von der Kammer H. (2009) Early-Onset and Robust Amyloid Pathology in a New Homozygous Mouse Model of Alzheimer’s Disease. PLoS ONE. 4 (11), e7931.

Other Publications:

  • Manook, A.; Yousefi, B. H.; Willuweit, A.; Platzer, S.; Reder, S.; Voss, A.; Huisman, M.; Settles, M.; Neff, F.; Velden, J.; Schoor, M.; Kammer, H. V. D.; Wester, H.-J.; Schwaiger, M.; Henriksen, G.; Drzezga, A. Small-Animal PET Imaging of Amyloid-Beta Plaques with [11C]PiB and Its Multi-Modal Validation in an APP/PS1 Mouse Model of Alzheimers Disease. PLoS ONE 2012, 7 (3).
  • Watanabe, T.; Hikichi, Y.; Willuweit, A.; Shintani, Y.; Horiguchi, T. FBL2 Regulates Amyloid Precursor Protein (APP) Metabolism by Promoting Ubiquitination-Dependent APP Degradation and Inhibition of APP Endocytosis. Journal of Neuroscience 2012, 32 (10), 3352–3365.
  • Yousefi, B. H.; Manook André; Drzezga, A.; Reutern, B. V.; Schwaiger, M.; Wester Hans-Jürgen; Henriksen, G. Synthesis and Evaluation of11C-Labeled Imidazo[2,1-b]Benzothiazoles (IBTs) as PET Tracers for Imaging β-Amyloid Plaques in Alzheimer’s Disease. Journal of Medicinal Chemistry 2011, 54 (4), 949–956.
  • Yousefi, B. H.; Drzezga, A.; Reutern, B. V.; Manook, A.; Schwaiger, M.; Wester, H.-J.; Henriksen, G. A Novel 18F-Labeled Imidazo[2,1-b]Benzothiazole (IBT) for High-Contrast PET Imaging of β-Amyloid Plaques. ACS Medicinal Chemistry Letters 2011, 2 (9), 673–677.
  • Yousefi, B. H.; Manook, A.; Reutern, B. V.; Schwaiger, M.; Drzezga, A.; Wester, H.-J.; Henriksen, G. Development of an Improved Radioiodinated 2-Phenylimidazo[1,2-a]Pyridine for Non-Invasive Imaging of Amyloid Plaques. MedChemComm 2012, 3 (7), 775.
  • Šišková, Z.; Justus, D.; Kaneko, H.; Friedrichs, D.; Henneberg, N.; Beutel, T.; Pitsch, J.; Schoch, S.; Becker, A.; Von Der Kammer, H.; Remy, S. Dendritic Structural Degeneration Is Functionally Linked to Cellular Hyperexcitability in a Mouse Model of Alzheimer’s Disease. Neuron 2014, 84 (5), 1023–1033.
See all publications

Applications & Therapeutic Areas

  • "Alzheimers Disease"
  • Genetically Humanized
  • Neuroscience

Transit, Housing & Welfare

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Animals >24 weeks of age may have the following physical characteristics, which are considered consistent for this model and for the animal's age:

  • Graying fur
  • Areas of thinning fur or evidence of barbering
  • Minor skin issue
  • Cataract

Packing Practices

Taconic standard practice is to recombine animals of different home cages and/or ages from a single model and sex during packing, except in specific cases where Taconic's animal welfare policy prohibits recombination due to aggression or other concerns.  When an order is fulfilled with animals from more than one week of birth, this standard practice results in animals from a range of birth weeks packed together in a single TTC. When an order is fulfilled with animals from genotyped models, this standard practice results in animals from different home cages packed together in a single TTC.

Customers who wish to keep animals from different weeks of birth separated should place orders with the special instruction "Divide and label by age."  Note that this special request can result in increased costs for additional Taconic Transit Cages, dividers and/or freight charges.

Taconic discourages other types of custom packing requests as they can have a negative impact on animal welfare. Learn more.

APP/PS1 (ARTE10) Alzheimer’s Mouse Model

Conditions of Use for Taconic Transgenic Models™

Taconic Transgenic Models™ (Models) are produced and distributed under rights to patents and intellectual property licensed from various institutions. Taconic sells the Models to purchasers, grants to each purchaser a right under Taconic's rights in such licensed patents and intellectual property to use the purchased Model in consideration of purchasers' acknowledgement of and agreement to the Terms and Conditions for Taconic Models, Products and Services and the following terms of use:

  • Title to these Models and biological materials derived from them remains with Taconic.
  • The Models will be used for research purposes only.
  • The Models will not be bred or cross-bred except to obtain embryos or fetuses required for research purposes unless additional rights have been granted in writing by Taconic.
  • The Models and biological materials derived from them will not be distributed to third parties or used for commercial purposes.
  • Non-profit purchasers may not use this Model and/or biological materials derived from it in sponsored research or contract research studies unless it is purchased at the for-profit price.

Pricing - USD

MPF Health Standard Available

 

Murine Pathogen Free (MPF) Health Standard

16347 Female

16347-F Genotype tg/tg

Pilot-sized cohorts are readily available. Large cohort requests have a minimum 8-week lead time. An estimated lead time will be provided to you within 2-3 business days.

Age in WeeksQuantity 1 - 999
3 to 12 US$558.00
13 to 28 US$631.00
29 to 60 US$699.00

Specialized Inventory

16347-RF Genotype tg/tgQuantity 1 - 199
retired female breeder US$699.00

16347 Male

16347-M Genotype tg/tg

Pilot-sized cohorts are readily available. Large cohort requests have a minimum 8-week lead time. An estimated lead time will be provided to you within 2-3 business days.

Age in WeeksQuantity 1 - 999
3 to 12 US$558.00
13 to 28 US$583.00
29 to 60 US$699.00

Specialized Inventory

16347-RM Genotype tg/tgQuantity 1 - 199
retired male breeder US$699.00

Pricing - EUR

MPF Health Standard Available

 

Murine Pathogen Free (MPF) Health Standard

16347 Female

16347-F Genotype tg/tg

Pilot-sized cohorts are readily available. Large cohort requests have a minimum 8-week lead time. An estimated lead time will be provided to you within 2-3 business days.

Age in WeeksQuantity 1 - 999
3 to 12 508,00 €
13 to 28 574,00 €
29 to 60 636,00 €

Specialized Inventory

16347-RF Genotype tg/tgQuantity 1 - 199
retired female breeder 636,00 €

16347 Male

16347-M Genotype tg/tg

Pilot-sized cohorts are readily available. Large cohort requests have a minimum 8-week lead time. An estimated lead time will be provided to you within 2-3 business days.

Age in WeeksQuantity 1 - 999
3 to 12 508,00 €
13 to 28 530,00 €
29 to 60 636,00 €

Specialized Inventory

16347-RM Genotype tg/tgQuantity 1 - 199
retired male breeder 636,00 €

Pricing - DKK

MPF Health Standard Available

 

Murine Pathogen Free (MPF) Health Standard

16347 Female

16347-F Genotype tg/tg

Pilot-sized cohorts are readily available. Large cohort requests have a minimum 8-week lead time. An estimated lead time will be provided to you within 2-3 business days.

Age in WeeksQuantity 1 - 999
3 to 12 kr.3.778,00
13 to 28 kr.4.272,00
29 to 60 kr.4.733,00

Specialized Inventory

16347-RF Genotype tg/tgQuantity 1 - 199
retired female breeder kr.4.733,00

16347 Male

16347-M Genotype tg/tg

Pilot-sized cohorts are readily available. Large cohort requests have a minimum 8-week lead time. An estimated lead time will be provided to you within 2-3 business days.

Age in WeeksQuantity 1 - 999
3 to 12 kr.3.778,00
13 to 28 kr.3.945,00
29 to 60 kr.4.733,00

Specialized Inventory

16347-RM Genotype tg/tgQuantity 1 - 199
retired male breeder kr.4.733,00

Pricing - USD Nonprofit

MPF Health Standard Available

 

Murine Pathogen Free (MPF) Health Standard

16347 Female

16347-F Genotype tg/tg

Pilot-sized cohorts are readily available. Large cohort requests have a minimum 8-week lead time. An estimated lead time will be provided to you within 2-3 business days.

Age in WeeksQuantity 1 - 999
3 to 12 US$280.00
13 to 28 US$343.00
29 to 60 US$422.00

Specialized Inventory

16347-RF Genotype tg/tgQuantity 1 - 199
retired female breeder US$422.00

16347 Male

16347-M Genotype tg/tg

Pilot-sized cohorts are readily available. Large cohort requests have a minimum 8-week lead time. An estimated lead time will be provided to you within 2-3 business days.

Age in WeeksQuantity 1 - 999
3 to 12 US$280.00
13 to 28 US$343.00
29 to 60 US$422.00

Specialized Inventory

16347-RM Genotype tg/tgQuantity 1 - 199
retired male breeder US$422.00

Pricing - EUR Nonprofit

MPF Health Standard Available

 

Murine Pathogen Free (MPF) Health Standard

16347 Female

16347-F Genotype tg/tg

Pilot-sized cohorts are readily available. Large cohort requests have a minimum 8-week lead time. An estimated lead time will be provided to you within 2-3 business days.

Age in WeeksQuantity 1 - 999
3 to 12 254,00 €
13 to 28 313,00 €
29 to 60 384,00 €

Specialized Inventory

16347-RF Genotype tg/tgQuantity 1 - 199
retired female breeder 384,00 €

16347 Male

16347-M Genotype tg/tg

Pilot-sized cohorts are readily available. Large cohort requests have a minimum 8-week lead time. An estimated lead time will be provided to you within 2-3 business days.

Age in WeeksQuantity 1 - 999
3 to 12 254,00 €
13 to 28 313,00 €
29 to 60 384,00 €

Specialized Inventory

16347-RM Genotype tg/tgQuantity 1 - 199
retired male breeder 384,00 €

Pricing - DKK Nonprofit

MPF Health Standard Available

 

Murine Pathogen Free (MPF) Health Standard

16347 Female

16347-F Genotype tg/tg

Pilot-sized cohorts are readily available. Large cohort requests have a minimum 8-week lead time. An estimated lead time will be provided to you within 2-3 business days.

Age in WeeksQuantity 1 - 999
3 to 12 kr.1.893,00
13 to 28 kr.2.325,00
29 to 60 kr.2.859,00

Specialized Inventory

16347-RF Genotype tg/tgQuantity 1 - 199
retired female breeder kr.2.859,00

16347 Male

16347-M Genotype tg/tg

Pilot-sized cohorts are readily available. Large cohort requests have a minimum 8-week lead time. An estimated lead time will be provided to you within 2-3 business days.

Age in WeeksQuantity 1 - 999
3 to 12 kr.1.893,00
13 to 28 kr.2.325,00
29 to 60 kr.2.859,00

Specialized Inventory

16347-RM Genotype tg/tgQuantity 1 - 199
retired male breeder kr.2.859,00

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Learn How the APP/PS1 (ARTE10) Alzheimer’s Mouse Model is Used in Research

Scientific Poster

Collaboration with Transpharmation Unveils Early Alzheimer's Biomarkers: Using the ARTE10 (APP-PS1) Mouse Model Data

Explore early Alzheimer's biomarkers and behaviors using ARTE10 mouse model data. Discover key findings and future research directions.
Learn More

Webinar On-Demand

ARTE10 (APP-PS1) & APPSWE

Characterization of Alzheimer’s Disease Progression in Mouse Models Using 3D Intact Tissue Clearing and Imaging Technologies

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Webinar On-Demand

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ARTE10 (APP-PS1) Mouse

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Why Use B6 (C57BL/6) Mice for Your Research Studies?

Black 6 (C57BL/6) mice are the preferred choice for many researchers because of their proven track record in various research applications. These genetically uniform mice ensure that your experiments are not affected by genetic variability, allowing for clear and reliable data. Whether working in genetics, pharmacology, or other areas, B6 mice deliver exceptional quality and consistency, making them the gold standard for preclinical studies.

When it comes to B6 mice, Taconic Biosciences is your trusted partner. With decades of experience in breeding and maintaining high-quality mouse models, Taconic ensures that every Black 6 (C57BL/6) mouse meets the strictest standards for genetic purity and health. Researchers can count on Taconic’s rigorous breeding programs and quality control procedures to provide genetically accurate, healthy mice for their studies.

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Free Animal Model Trial: Quality & Compatibility Assurance

To help alleviate uncertainty in selecting a new model, we offer a free animal trial program that allows you to test the quality, consistency, and availability of Taconic’s rodent models. Pilot our most popular mouse or rat models in your facility at no cost to your organization with the Smart Select program. 

  • Evaluate a specific model strain, before making any financial investment
  • Request up to 20 animals from one of the strains listed here to test for quality, consistency, and suitability for your experimental purpose
  • Enjoy free ground shipping, where applicable (see table for more details)
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