Alzheimer's Disease Mouse Models for Drug Discovery & Therapeutic Research

Taconic offers state-of-the-art Alzheimer’s disease models that enhance our scientific understanding of disease progression and advance drug discovery efforts.

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Key Features of Our Alzheimer’s Disease Mouse Models 

Taconic Biosciences offers genetically engineered Alzheimer’s disease (AD) mouse models that replicate key features such as β-amyloid plaques, tau pathology, cognitive decline, and neuroinflammation. These highly translatable models are key in advancing preclinical research and drug discovery efforts. Designed for precision and reliability, models have been validated for use in therapeutic development. With ready-to-use cohorts, custom model generation capabilities including targeted transgenesis, and expert scientific support, Taconic empowers researchers to achieve breakthroughs in Alzheimer’s disease treatment. Contact us today to find the right model for your study.

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Blood–Brain Barrier Transport Platform

Evaluate receptor‑mediated CNS delivery in physiologically and disease‑relevant in vivo systems. Assess transport biology, brain exposure, and biodistribution across established and emerging RMT pathways.

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Why Alzheimer’s Disease Models are Critical for Drug Discovery

Animal models are essential for understanding Alzheimer’s disease mechanisms, testing potential therapies, and bridging the gap between discovery and clinical success. Mouse models play a crucial role in replicating key features of AD, including β-amyloid accumulation, tau pathology, and neuroinflammation, allowing researchers to study disease progression and evaluate novel treatments. By providing a controlled, reproducible system to test drug efficacy and safety before human trials, these models help accelerate the development of effective therapeutics. Taconic Biosciences offers a diverse portfolio of Alzheimer’s disease mouse models, supporting researchers in their mission to combat this devastating disease.

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Benefits of Taconic’s Transgenic Models for Alzheimer’s Disease

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The APPSWE (Tg2576) mouse model from Taconic Biosciences is a cornerstone in Alzheimer's research and has been critical in preclinical investigations for several FDA-approved drugs, including donepezil, galantamine, and memantine.

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Recent studies using Taconic mice have demonstrated the potential of M1 positive allosteric modulators (PAMs) like PQCA in combination therapies. This approach could improve cognitive function while reducing the severe side effects associated with traditional cholinesterase inhibitors.

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With hallmark Alzheimer's disease phenotypes such as amyloid plaque accumulation and cognitive deficits, Taconic’s mouse models are vital tools for researchers seeking to develop next-generation treatments that address both disease progression and symptom management.

On-Demand Webinar

Improving Preclinical Neuroscience Study Design with AlzPED Data

Watch this webinar to learn more about best practices for rigorous preclinical screening and testing of candidate therapeutics for neurodegenerative diseases.

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Partner with Us to Drive Alzheimer's Discoveries

Research Success Stories and Case Studies

Customer Reviews and Testimonials

"Taconic Biosciences has been an invaluable resource for the entire Alzheimer's disease (AD) research community. As an academic researcher that builds animal models of sporadic AD I cannot possibly supply the communities needs for these models but instead depend on Taconic to fulfill this role. My hope is that as new and improved models become characterized and validated that the research community at large will supply these models to Taconic to manage and distribute."

Patrick Sullivan, PhD, Associate Professor of Geriatrics at major university

"Cure Alzheimer's Fund is working closely with Taconic on our Genes to Therapies program, which supports investigations of gene variants impacting risk of Alzheimer's through funded research and the development of specialized genetically engineered mouse strains. The team at Taconic has provided excellent project management and technical support and are vital partners for the success of a complex project involving many custom strains and academic research labs.”

Cure Alzheimer's Fund

New gene therapy for the treatment of Alzheimer's Disease

An interesting new clinical trial is testing a gene therapy for Alzheimer’s Disease (AD) that has proven to reduce amyloid burden in mouse and non-human primate models of the disease.

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Therapeutic Area Database

Neurology Model Publications Database

Explore our AD Neurology Model Publications Database for the latest resources on AD models, pathology, and therapeutic insights. Stay informed with curated publications from leading studies. 

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Scientific Insight

Alzheimer's Disease: Steps towards more translational research models

More translational preclinical research models of Alzheimer’s Disease are needed to continue developing treatments for this disease.

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Scientific Poster

Alzheimer's Disease in 3D: Characterization of Plaques and Neuroinflammation with AD Mouse Models Using Innovative Tissue Clearing and Imaging Techniques

View this poster to see proof-of-concept ex vivo 3D imaging, showcasing the characterization of β-amyloid plaque distribution and densities, along with other pathological markers in ARTE10 (APP-PS1) and APPSWE (Tg2576) mouse brains across different ages. 

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Scientific Poster

Collaboration with Transpharmation Unveils Early Alzheimer's Biomarkers: Using the ARTE10 (APP-PS1) Mouse Model at 5 Months

Explore early Alzheimer's biomarkers and behaviors at 5 months using the ARTE10 mouse model data at 5 months. Taconic and Transpharmation scientists reveal key findings and future research directions, characterizing ARTE10 across three time points from early to late amyloid progression.

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Frequently Asked Alzheimer's Mouse Model Questions

Learn more about using mouse models in your Alzheimer's Disease research. 

These are genetically modified or induced mouse models designed to replicate key pathological features of Alzheimer’s disease (AD), such as amyloid-beta plaques, tau tangles, and cognitive decline.

Mice share genetic and biological similarities with humans, and their shorter lifespan allows for studying disease progression efficiently.

These models help researchers understand disease mechanisms, test new therapies, and evaluate the efficacy and safety of potential treatments.

Standardize age, gender, environment, diet, and test conditions to ensure reproducibility.

Yes, many strains are available as cryopreserved embryos or sperm, allowing for on-demand recovery and reducing colony maintenance costs. Cryopreservation ensures strain availability, genetic stability, and cost-effective colony management.

Partner with Us to Drive Alzheimer's Discoveries