Orders by weight:
Carries the transgene for the human P301L mutation of the microtubule-associated protein tau gene (MAPT) and expresses no TAU protein
Aggregates of filaments of TAU result in Neurofibrillary tangles (NFT) which are associated with Alzheimers disease, Pick disease and other neurological syndromes
Develops behavioral and motor disturbances related to development of NFT
Model 2508 is homozygous for the transgene and develops a phenotype that mimics human tauopathies in a more rapid time frame than the hemizygous model
Useful for studying Alzheimer's disease, Pick's disease and other neurological syndromes associated with NFT
- Model is on a C57BL/6, DBA/2, SW Mixed Background
Taconic cannot accept orders by weight for this model. Please note that shipments may contain animals with a larger weight variation.
Genetic Background: C57BL/6, DBA/2, SW Mixed Background
Origin: The Tau mouse was developed in the laboratory of Mike Hutton at the Mayo Clinic. The model was created by microinjecting transgenic constructs containing the P301L mutation of the microtubule associated tau gene and mouse prion promoter into B6D2F1 x SW zygotes. The resultant mice from Founder Line JNPL3 were mated to B6D2F1. Taconic received stock in December 2000. The mice were derived by embryo transfer and mated to SW and B6D2F1 hybrids and embryo transfer derived. Offspring from both backgrounds were combined and are mated to B6D2F1 mice to produce hemizygous and wild type mice (1638). Hemizygous Tau mice were intercrossed to generate homozygous Tau mice. The homozygous colony is maintained by incrossing homozygotes.
Genetics: Wildtype for Nnt mutation; carries Pde6brd1 mutation
Lewis J, McGowan E, Rockwood J, Melrose H, Nacaraju P, Van Slegtenhorst M, Gwinn-Hardy K, Murphy MP, Baker M, Yu X, Duff K, Hardy J, Corral A, Lin W-L, Yen S-H, Dickson DW, Davies P, Hutton M. (2000) Neurofibrillary Tangles, Amyotrophy and Progressive Motor Disturbance in Mice Expressing Mutant (P301L) Tau Protein. Nat Genet, 25(4):402-406