Tau - Model 2508

Genetic Background:

C57BL/6, DBA/2, SW mixed background

Origin:

The Tau mouse was developed in the laboratory of Mike Hutton at the Mayo Clinic. The model was created by microinjecting transgenic constructs containing the P301L mutation of the microtubule associated tau gene and mouse prion promoter into B6D2F1 x SW zygotes. The resultant mice from Founder Line JNPL3 were mated to B6D2F1. Taconic received stock in December 2000. The mice were derived by embryo transfer and mated to SW and B6D2F1 hybrids and embryo transfer derived. Offspring from both backgrounds were combined and were mated to B6D2F1 mice to produce hemizygous and wild type mice. Hemizygous Tau mice were intercrossed to generate homozygous Tau mice. A genetic refresh was initiated in part to generate a suitable wild type control stock. Homozygous 2508 Tau females were mated to Swiss Webster males. Hemizygous males from this cross were mated to B6D2F1 females. Wild type offspring from this second cross were used to establish control model #18392, whereas hemizygous males and females were intracrossed to generate homozygous mice to re-establish model #2508. The colony is maintained by mating homozygous females and males.

Genetics:

Wildtype for Nnt mutation; carries Pde6b^rd1 mutation

Color:

Various

Species:

Mouse

Initial Publication:

Lewis J, McGowan E, Rockwood J, Melrose H, Nacaraju P, Van Slegtenhorst M, Gwinn-Hardy K, Murphy MP, Baker M, Yu X, Duff K, Hardy J, Corral A, Lin W-L, Yen S-H, Dickson DW, Davies P, Hutton M. (2000) Neurofibrillary Tangles, Amyotrophy and Progressive Motor Disturbance in Mice Expressing Mutant (P301L) Tau Protein. Nat Genet, 25(4):402-406.

Animal Diet:

NIH #31M Rodent Diet

Conditions of Use for Taconic Transgenic Models™
Taconic Transgenic Models™ (Models) are produced and distributed under rights to patents and intellectual property licensed from various institutions. Taconic sells the Models to purchasers, grants to each purchaser a right under Taconic's rights in such licensed patents and intellectual property to use the purchased Model in consideration of purchasers' acknowledgement of and agreement to the Terms and Conditions for Taconic Models, Products and Services and the following terms of use:

• Title to these Models and biological materials derived from them remains with Taconic.
• The Models will be used for research purposes only.
• The Models will not be bred or cross-bred except to obtain embryos or fetuses required for research purposes unless additional rights have been granted in writing by Taconic.
• The Models and biological materials derived from them will not be distributed to third parties or used for commercial purposes.
• Non-profit purchasers may not use this Model and/or biological materials derived from it in sponsored research or contract research studies unless it is purchased at the for-profit price.

View the production locations(s) and the accompanying current IHMS™ Health Report and Taconic Health Standard for this model