Carries a disruption of multi-drug resistance genes Abcb1a (ATP-binding cassette, sub-family B (MDR/TAP), member 1A, a.k.a. Mdr1a) encoding p-glycoprotein 3
Mdr1a protein is expressed actively in the intestine and at the blood-brain and blood-testis barriers
p-glycoprotein 3 actively extrudes a wide range of drugs from cells and can confer multi-drug resistance to tumor cells
Lack the protective function of p-glycoprotein 3 and exhibits a functional deficiency in the blood-brain barrier
Useful in neurotoxicology, drug transport, chemotherapy, multi-drug resistance and oral bioavailability research
Susceptible to developing a severe, spontaneous intestinal inflammation phenotypically similiar to human inflammatory bowel disease (IBD)
Orders by weight: Taconic cannot accept orders by weight for this model. Please note that shipments may contain animals with a larger weight variation.
New data is now available for the Mdr1a spontaneous colitis model.
The Mdr1a mouse was developed in the laboratory of Alfred Schinkel of the Netherlands Cancer Institute. The model was created by targeting the Abcb1a gene in E14 ES cells. Resultant chimeras were backcrossed to FVB for seven (N7) generations. Taconic received stock in 1994 and derived the line by Caesarean transfer. The colony is maintained by incrossing homozygous mice.
Genetics:
Wildtype for Nnt mutation; carries Pde6brd1 mutation
Color:
Albino
Species:
Mouse
Initial Publication:
Schinkel AH, Smit JJM, van Tellingen O, Beijnen JH, Wagenaar E, van Deetmer L, Mol CAAM, van der Valk MA, Robanus-Maandag BC, te Tiele HPJ, Berns AJM, Borst P. (1994) Disruption of the Mouse mdr1a P-Glycoprotein Gene Leads to a Deficiency in the Blood Brain Barrier and to Increased Sensitivity to Drugs.Cell, 77:491-502.
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and the following terms of use:
Title to these Models and biological materials derived from them remains with Taconic.
The Models will be used for research purposes only.
The Models will not be bred or cross-bred except to obtain embryos or fetuses required for research purposes unless additional rights have been granted in writing by Taconic.
The Models and biological materials derived from them will not be distributed to third parties or used for commercial purposes.
Non-profit purchasers may not use this Model and/or biological materials derived from it in sponsored research or contract research studies unless it is purchased at the for-profit price.
Representative data for spontaneous colitis in MDR1A mice provided by Bolder BioPATH. Download the full data package, including protocol information, body weight change, endoscope scores and representative endoscopy images, disease activity scores, colon weights, histopathology scores and efficacy of anti-IL-12 treatment.
