Also known as: Tfrc, TFRC, Tfr, hTfr, CD71, hCD71, Tfr1, hTfr1, SLC3A2, CD98, MDU1, 4F2HC, 4T2HC, NACAE, CD98HC, 4F2, hCD98hc, TFR1xCD98hc, TFRCxCD98
hTFRC x hCD98hc Mouse
Use Model 23872 to compare TFRC- and CD98hc-directed delivery strategies, investigate dual-receptor approaches, or establish a common humanized receptor background for disease-relevant studies.
Application Areas:
| Model No. | Nomenclature | Genotype |
|---|---|---|
| 23872-M | C57BL/6N-Tfrctm1(TFRC)Tac Slc3a2tm1(SLC3A2)Tac | HOMxHOM |
| 23872-F | C57BL/6N-Tfrctm1(TFRC)Tac Slc3a2tm1(SLC3A2)Tac | HOMxHOM |
License fees are waived for custom breeding projects conducted at Taconic involving this model.
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Overview
Nomenclature: C57BL/6N-Tfrctm1(TFRC)Tac Slc3a2tm1(SLC3A2)Tac
The hTFRC x hCD98hc mouse is a double-humanized model designed to support in vivo evaluation of therapeutic constructs engineered to engage human transferrin receptor 1 (hTFRC/TfR1/CD71), human CD98 heavy chain (hCD98hc/SLC3A2), or both receptor targets. By placing both humanized receptors in a C57BL/6NTac background, Model 23872 supports direct comparison of alternative receptor-mediated transport strategies without introducing differences from separate host backgrounds.
The model is intended as an experimental platform for assessing construct-dependent CNS exposure, biodistribution, pharmacokinetics, target engagement, and downstream biological response when the appropriate study endpoints are included. Therapeutic performance remains dependent on construct design, receptor epitope, affinity, valency, payload, dose, route, and study conditions.
Why Use the Double-Humanized Model?
- Compare TFRC- and CD98hc-directed constructs in the same genetic background.
- Evaluate dual-targeted constructs designed to engage both human receptor targets.
- Investigate receptor-strategy differences in exposure, persistence, biodistribution, cellular access, or target engagement using fit-for-purpose endpoints.
- Create a common receptor-humanized background for crosses with disease-associated or proprietary genetics.
- Use one platform when a program may evaluate TFRC, CD98hc, or combined receptor strategies over time.
- Enhance efficacy by preferentially targeting multiple cell types
- Capitalize on differing kinetics by comparing efficacy and/or accessing different targets in the same pathway
Orders by weight: Taconic cannot accept orders by weight for this model. Please note that shipments may contain animals with a larger weight variation.
Recommended Controls
The recommended control for this model is C57BL/6NTac.
Origin
Model 23872 was generated by crossing Taconic's hTFRC Mouse, Model 23236, with Taconic's hCD98hc Mouse, Model 23662, to create a double-humanized TFRC x hCD98hc line. The line has since been backcrossed for multiple generations and is congenic on the C57BL/6NTac background.
Genetics
Guides & Publications
Applications & Therapeutic Areas
- Alzheimer's Disease
- Immunology
- Metabolic Disease
- Neuroscience & Neurodegeneration
- Oncology & Immuno-Oncology
- Parkinson's Disease
- Psychiatric Disorders
- Rare Diseases
Transit, Housing & Welfare
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Diet
Data
Constitutive Humanization of the Slc3a2 Extracellular Domain
The mouse Slc3a2 genomic region spanning codons V108 (exon 2) to V525 (exon 10) was replaced with the corresponding human sequence encoding the CD98hc extracellular domain. Flanking codons conserved between species (A100–P107 and A526) were retained in mouse form. Following removal of the selection cassette, the humanized allele is expressed under the control of the endogenous mouse Slc3a2 promoter, preserving the native expression pattern. One residual recombination site remains in a non-conserved region.
Constitutive Humanization of the Tfrc Extracellular Domain
The extracellular domain of mouse Tfrc was replaced with the corresponding human sequence (NCBI reference transcripts NM_011638.4, mouse; NM_001128148.1, human), producing a chimeric receptor with mouse cytoplasmic and transmembrane domains and the human extracellular domain. Following removal of the selection markers, the humanized allele is expressed under the control of the endogenous mouse Tfrc promoter, preserving the native expression pattern. Residual recombination sites remain in non-conserved regions.
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Licensing
License fees are waived for breeding projects conducted at Taconic
Conditions of Use for Taconic Transgenic Models™
Taconic Transgenic Models™ (Models) are produced and distributed under rights to patents and intellectual property licensed from various institutions. Taconic sells the Models to purchasers, grants to each purchaser a right under Taconic's rights in such licensed patents and intellectual property to use the purchased Model in consideration of purchasers' acknowledgement of and agreement to the Terms and Conditions for Taconic Models, Products and Services and the following terms of use:
- Title to these Models and biological materials derived from them remains with Taconic.
- The Models will be used for research purposes only.
- The Models will not be bred or cross-bred except to obtain embryos or fetuses required for research purposes unless additional rights have been granted in writing by Taconic.
- The Models and biological materials derived from them will not be distributed to third parties or used for commercial purposes.
- Non-profit purchasers may not use this Model and/or biological materials derived from it in sponsored research or contract research studies unless it is purchased at the for-profit price.
View the production locations(s) and the accompanying current IHMS™ Health Report and Taconic Health Standard for this model
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