Commonly referred to as SLC3A2; CD98; MDU1; 4F2HC; 4T2HC; NACAE; CD98HC; 4F2 | Also known as: C57BL/6NTac-Slc3a2tm1.1(SLC3A2*)Tac
hCD98hc Mouse
A humanized CD98hc mouse model for evaluation of CD98hc-engineered central nervous system therapeutics. CD98 heavy chain (CD98hc, encoded by SLC3A2) is a multifunctional transmembrane protein that forms heterodimers with light chains to regulate amino acid transport and integrin signaling. It is vital for cell proliferation, adhesion, and survival, and is frequently overexpressed in cancers and used as a receptor for antibody-mediated drug delivery across the blood-brain barrier (BBB). This model may be useful for receptor-mediated transcytosis of therapeutics across to the blood-brain barrier.
Application Areas:
| Model No. | Nomenclature | Genotype |
|---|---|---|
| 23662-F | C57BL/6NTac-Slc3a2tm1.1(SLC3A2*)Tac | HOM |
| 23662-M | C57BL/6NTac-Slc3a2tm1.1(SLC3A2*)Tac | HOM |
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- Data
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- Overview
- Genetics
- Applications & Therapeutic Areas
- Transit, Housing & Welfare
- Diet
Overview
Nomenclature: C57BL/6NTac-Slc3a2tm1.1(SLC3A2*)Tac
A humanized CD98hc mouse model for evaluation of CD98hc-engineered central nervous system therapeutics. CD98 heavy chain (CD98hc, encoded by SLC3A2) is a multifunctional transmembrane protein that forms heterodimers with light chains to regulate amino acid transport and integrin signaling. It is vital for cell proliferation, adhesion, and survival, and is frequently overexpressed in cancers and used as a receptor for antibody-mediated drug delivery across the blood-brain barrier (BBB). This model may be useful for receptor-mediated transcytosis of therapeutics across to the blood-brain barrier.
Orders by weight: Taconic cannot accept orders by weight for this model. Please note that shipments may contain animals with a larger weight variation.
Recommended Controls
The recommended control for this model is C57BL/6NTac.
Origin
This model was developed by Taconic Biosciences. The mouse genomic region spanning Exon 2 to Exon 10 was selected for replacement with the corresponding human sequence. Codons A100–P107 (exon 2) and A526 (exon 10), which are conserved between species, were retained in their mouse form to maintain sequence continuity.
Genetics
Applications & Therapeutic Areas
- Immunology
- Neurobiology
- Alzheimer's Disease (AD)
- Parkinson's Disease (PD)
- Dementia
- Multiple Sclerosis
Transit, Housing & Welfare
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Diet
- Services
Data
Gene expression analysis of mouse and human CD98hc in homozygous and heterozygous hCD98hc mouse tissues
- Licensing
- Pricing - USD
- Pricing - EUR
- Pricing - DKK
- Pricing - USD Nonprofit
- Pricing - EUR Nonprofit
- Pricing - DKK Nonprofit
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Licensing
License fees are waived for breeding projects conducted at Taconic
Conditions of Use for Taconic Transgenic Models™
Taconic Transgenic Models™ (Models) are produced and distributed under rights to patents and intellectual property licensed from various institutions. Taconic sells the Models to purchasers, grants to each purchaser a right under Taconic's rights in such licensed patents and intellectual property to use the purchased Model in consideration of purchasers' acknowledgement of and agreement to the Terms and Conditions for Taconic Models, Products and Services and the following terms of use:
- Title to these Models and biological materials derived from them remains with Taconic.
- The Models will be used for research purposes only.
- The Models will not be bred or cross-bred except to obtain embryos or fetuses required for research purposes unless additional rights have been granted in writing by Taconic.
- The Models and biological materials derived from them will not be distributed to third parties or used for commercial purposes.
- Non-profit purchasers may not use this Model and/or biological materials derived from it in sponsored research or contract research studies unless it is purchased at the for-profit price.
Pricing - USD
Murine Pathogen Free (MPF) Health Standard
23662 Female
23662-F Genotype hu/hu
| Age in Weeks | Quantity 1 - 999 |
|---|---|
| 3 to 10 | US$365.00 |
23662 Male
23662-M Genotype hu/hu
| Age in Weeks | Quantity 1 - 999 |
|---|---|
| 3 to 10 | US$365.00 |
Pricing - EUR
Murine Pathogen Free (MPF) Health Standard
23662 Female
23662-F Genotype hu/hu
| Age in Weeks | Quantity 1 - 999 |
|---|---|
| 3 to 10 | 344,00 € |
23662 Male
23662-M Genotype hu/hu
| Age in Weeks | Quantity 1 - 999 |
|---|---|
| 3 to 10 | 344,00 € |
Pricing - DKK
Murine Pathogen Free (MPF) Health Standard
23662 Female
23662-F Genotype hu/hu
| Age in Weeks | Quantity 1 - 999 |
|---|---|
| 3 to 10 | kr.2.570,00 |
23662 Male
23662-M Genotype hu/hu
| Age in Weeks | Quantity 1 - 999 |
|---|---|
| 3 to 10 | kr.2.570,00 |
Pricing - USD Nonprofit
Murine Pathogen Free (MPF) Health Standard
23662 Female
23662-F Genotype hu/hu
| Age in Weeks | Quantity 1 - 999 |
|---|---|
| 3 to 10 | US$185.00 |
23662 Male
23662-M Genotype hu/hu
| Age in Weeks | Quantity 1 - 999 |
|---|---|
| 3 to 10 | US$185.00 |
Pricing - EUR Nonprofit
Murine Pathogen Free (MPF) Health Standard
23662 Female
23662-F Genotype hu/hu
| Age in Weeks | Quantity 1 - 999 |
|---|---|
| 3 to 10 | 174,00 € |
23662 Male
23662-M Genotype hu/hu
| Age in Weeks | Quantity 1 - 999 |
|---|---|
| 3 to 10 | 174,00 € |
Pricing - DKK Nonprofit
Murine Pathogen Free (MPF) Health Standard
23662 Female
23662-F Genotype hu/hu
| Age in Weeks | Quantity 1 - 999 |
|---|---|
| 3 to 10 | kr.1.303,00 |
23662 Male
23662-M Genotype hu/hu
| Age in Weeks | Quantity 1 - 999 |
|---|---|
| 3 to 10 | kr.1.303,00 |
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