On-Demand Webinar

B6 Mice for Research: A Guide to Black 6 Mouse Substrains & Applications

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Speaker

Lisa Goldberg, PhD LinkedIn
Director, Scientific Solutions

Regina DeLellis

Lisa Goldberg, PhD, is the Director of Scientific Solutions at Taconic Biosciences. She joined Taconic in 2021 as part of the Colony Management Solutions Strategy Design Group before moving into the Scientific Solutions team. Prior to joining Taconic, Dr. Goldberg received a bachelor's degree in neuroscience from Vassar College before pursuing her graduate training at Boston University School of Medicine, where she completed her PhD in biomedical pharmacology and neuroscience. During graduate school and her post-doctoral studies, Dr. Goldberg focused on investigating the genetic underpinnings of addiction-associated traits using forward genetics and genetically modified mouse models. Dr. Goldberg has published numerous scientific articles leveraging the reduced complexity of B6 substrain mice to identify genetic variants underlying neurobehavioral traits, such as drug sensitivity1,2, drug withdrawal2-4, binge eating5, and nociception6. Dr. Goldberg has more than 14 years of experience with the management and behavioral analyses of genetically engineered mouse models.

  1. Goldberg L, Yao E, Kelliher J, et al. A quantitative trait variant in Gabra2 underlies increased methamphetamine stimulant sensitivity. Genes Brain Behav. 2021 Nov;20(8):e12774. https://doi/10.1111/gbb.12774
  2. Seemiller L, Goldberg L, Smith P, et al. Genetic differences in nicotine sensitivity and metabolism in C57BL/6J and NOD/ShiLtJ mouse strains. Neuropharmacology. 2022 Dec 15:221:109279. https://doi/10.1016 
  3. Goldberg L, Kutlu M, Zeid D, Seemiller L et al. Systems genetic analysis of nicotine withdrawal deficits in hippocampus‐dependent learning. Genes Brain Behav. 2021 Apr 2:e12734. https://doi/10.1111/gbb.12734
  4. Goldberg L, Baskin B, Beierle J, et al. Atp1a2 and Kcnj9 are candidate genes underlying sensitivity to oxycodone-induced locomotor activation and withdrawal-induced anxiety-like behaviors in C57BL/6 substrains. Genes Brain Behav. 2025 Feb;24(1):e70009. https://doi/10.1111/gbb.70009
  5. Goldberg L, Kirkpatrick S, Yazdani N, et al. Casein kinase 1‐epsilon deletion increases mu opioid receptor‐dependent behaviors and binge eating 1. Genes Brain Behav. 2017 Sep;16(7):725-738. https://doi/10.1111/gbb.12397
  6. Bryant C, Bagdas D, Goldberg L. C57BL/6 substrain differences in inflammatory and neuropathic nociception and genetic mapping of a major quantitative trait locus underlying acute thermal nociception. Mol Pain. 2019 Jan-Dec:15:1744806918825046. https://doi/10.1177/1744806918825046

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