ApoB100

ApoB100 Random Transgenic Mouse Model
  • Live
  • Mouse
  • Male & Female Available
  • Black
  • Available for direct purchase by CRO
Model No.NomenclatureGenotype
1004-FB6.SJL-Tg(APOB)1102Sgy N20+?tg/wt
1004-MB6.SJL-Tg(APOB)1102Sgy N20+?tg/wt
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Overview

Nomenclature: B6.SJL-Tg(APOB)1102Sgy N20+?

  • Expresses high levels of human apolipoprotein B100
  • ApoB100 mice show elevated serum levels of LDL cholesterol
  • When fed a high fat diet, will develop significant foam cell accumulation underlying the endothelium and within the media, and develop significantly more complex atherosclerotic lesions than control animals
  • Useful for identifying and evaluating compounds to reduce elevated levels of LDL cholesterol and the risk of atherosclerosis
  • Also useful for studies of lipid transport and atherosclerosis
Orders by weight: Taconic cannot accept orders by weight for this model. Please note that shipments may contain animals with a larger weight variation.

Origin

The ApoB100 mouse was developed by MacRae F. Linton et. al. of the Gladstone Institute of Cardiovascular Disease. The model was created by microinjecting the human apolipoprotein B100 gene into C57BL/6J x SJL zygotes. The resultant mice were backcrossed to C57BL/6 for 4 generations (N4). Taconic received stock from Xenogen Biosciences in May 1996. The mice are maintained by backcrossing hemizygous ApoB100 mice with C57BL/6NTac inbred mice.

Genetics

Species:Mouse
Strain Type:Congenic
Allele Type:Random Transgenic;Genetically Humanized
Coat Color:Black
Genetic Background:C57BL/6

Other Genetic Notes:

Wild type for Nnt mutation

Guides & Publications

Initial Publication: Linton MF, Farese RV, Chiesa G, Grass DS, Chin P, Hammer RE, Hobbs HH, Young SG. (1993). Transgenic Mice Expressing High Plasma Concentrations of Human Apolipoproteins B100 and Lipoprotein (a). J Clin Invest, 92: 3029-3037.

Applications & Therapeutic Areas

  • Cardiovascular Disease
  • Genetically Humanized
  • Metabolic Disease
  • Microbiome

Transit, Housing & Welfare

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Packing Practices

Taconic standard practice is to recombine animals of different home cages and/or ages from a single model and sex during packing, except in specific cases where Taconic's animal welfare policy prohibits recombination due to aggression or other concerns.  When an order is fulfilled with animals from more than one week of birth, this standard practice results in animals from a range of birth weeks packed together in a single TTC. When an order is fulfilled with animals from genotyped models, this standard practice results in animals from different home cages packed together in a single TTC.

Customers who wish to keep animals from different weeks of birth separated should place orders with the special instruction "Divide and label by age."  Note that this special request can result in increased costs for additional Taconic Transit Cages, dividers and/or freight charges.

ApoB100

Conditions of Use for Taconic Transgenic Models™

Taconic Transgenic Models™ (Models) are produced and distributed under rights to patents and intellectual property licensed from various institutions. Taconic sells the Models to purchasers, grants to each purchaser a right under Taconic's rights in such licensed patents and intellectual property to use the purchased Model in consideration of purchasers' acknowledgement of and agreement to the Terms and Conditions for Taconic Models, Products and Services and the following terms of use:

  • Title to these Models and biological materials derived from them remains with Taconic.
  • The Models will be used for research purposes only.
  • The Models will not be bred or cross-bred except to obtain embryos or fetuses required for research purposes unless additional rights have been granted in writing by Taconic.
  • The Models and biological materials derived from them will not be distributed to third parties or used for commercial purposes.
  • Non-profit purchasers may not use this Model and/or biological materials derived from it in sponsored research or contract research studies unless it is purchased at the for-profit price.

Pricing - USD

Murine Pathogen Free (MPF) Health Standard

1004 Female

1004-F Genotype tg/wt

Age in WeeksQuantity 1 - 999
3 to 10$604.00

1004 Male

1004-M Genotype tg/wt

Age in WeeksQuantity 1 - 999
3 to 10$604.00

Pricing - EUR

Murine Pathogen Free (MPF) Health Standard

1004 Female

1004-F Genotype tg/wt

Age in WeeksQuantity 1 - 999
3 to 10€522,00

1004 Male

1004-M Genotype tg/wt

Age in WeeksQuantity 1 - 999
3 to 10€522,00

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