Humanized Immune System Mice for Preclinical Research

Our humanized immune system (HIS) mice are advanced, translatable preclinical models designed to replicate key functions of the human immune system. Ideal for immuno-oncology and cell therapy research, these models support translational evaluation of novel immunotherapies. Our portfolio includes genetically engineered strains for in-house humanization and study-ready HIS mice engrafted with human HSCs or PBMCs. From the well-established CIEA NOG mouse® to the exclusive FcResolv® huNOG model, Taconic provides a comprehensive range of humanized mouse models to accelerate your immunology studies. 

  NEW! Improve the quality and consistency of your studies by reducing donor-to-donor variability in CD34+ HSC engrafted models.
Learn More about our huSelect™ Custom Humanization Services!

Humanized Immune System Mice for Preclinical Studies

As drug discovery efforts rapidly shift towards increasingly complex and highly specific biologic therapeutics, sourcing appropriate in vivo models for preclinical work is becoming more challenging. Researchers are turning to our humanized models to help address their in vivo drug research challenges.

Humanized models are created by engrafting CD34+ hematopoietic stem cells (HSCs), peripheral blood mononuclear cells (PBMCs), or other human immune cells into an immunodeficient mouse. Taconic offers expert engraftment and a broad selection of NOG models to suit multiple application areas and project types. 

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Flow Cytometry Services

Leverage Taconic's cutting-edge flow cytometry services for accurate cell analysis. Our expert team and state-of-the-art technology ensure reliable results for your research.
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Locally Humanized Immune System Mice in Leverkusen, Germany

Humanized immune system mice now locally produced in Leverkusen for faster delivery and lower costs. Advanced, translatable models for oncology, immuno-oncology and autoimmunity research.

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Why Choose our Humanized Mice

Easiest Access to Humanized Immune System Mice

  • Start projects sooner with off-the-shelf huNOG and huNOG-EXL SA (Standard Access) inventory available within days, not months. 
  • Taconic humanized immune system (HIS) mice are distributed with no additional licensing requirements under clear for-profit terms of use and nonprofit terms of use. 
  • Taconic Biosciences is the only rodent model provider empowering customers to obtain models without an MTA or commercial use license.

Which huNOG-EXL model is right for you?

  • The Taconic portfolio of HIS mice includes the huNOG-EXL SA (Standard Access) model and the huNOG-EXL EA (Early Access) model. Each model supports different types of studies. Visit the the huNOG-EXL model page to learn the difference and determine which best suits your application.

The NOG Portfolio of super immunodeficient and humanized immune system mouse models

Taconic's NOG mice are severely immunodeficient mouse models which accept the engraftment of heterologous cells more readily than traditional immunodeficient models, making them exceptional hosts for the production of mice with human immune systems. Selection of the right HIS model starts with consideration of the human cell type(s) of interest. The diagram below indicates the predominant immune cells present in each model.

NOG EXL

Available Humanized Immune System Mice

Click each card to learn more.

b6129f1

huNOG


View Model

Summary

  • • Species: Mouse
  • • Strain Type: Congenic
  • • Coat Color: Albino
  • • Allele Type: Constitutive Knockout; Spontaneous Mutant
  • • Genetic Background: NOD

Applications & Therapeutic Areas

  • • Immunology
  • • Oncology & Immuno-Oncology
  • • Infectious Disease
  • • Cell and Tissue Humanized
  • • Inflammation

nude

huNOG-EXL EA
(Early Access)


View Model

Summary

  • • Species: Mouse
  • • Strain Type: Congenic
  • • Allele Type: Constitutive Knockout; Spontaneous Mutant; Random Transgenic
  • • Coat Color: Albino
  • • Genetic Background: NOD

Applications & Therapeutic Areas

  • • Cell and Tissue Humanized
  • • Immunology
  • • Infectious Disease
  • • Oncology & Immuno-Oncology
  • • Inflammation

nude

huNOG-EXL SA
(Standard Access)


View Model

Summary

  • • Species: Mouse
  • • Strain Type: Congenic
  • • Allele Type: Constitutive Knockout; Spontaneous Mutant; Random Transgenic
  • • Coat Color: Albino
  • • Genetic Background: NOD

Applications & Therapeutic Areas

  • • Cell and Tissue Humanized
  • • Immunology
  • • Inflammation
  • • Infectious Disease
  • • Oncology & Immuno-Oncology

NIH Nude

FcResolv® huNOG


View Model

Summary

  • • Species: Mouse
  • • Strain Type: Congenic
  • • Allele Type: Constitutive Knockout; Spontaneous Mutant
  • • Coat Color: Albino
  • • Genetic Background: NOD

Applications & Therapeutic Areas

  • • Cell and Tissue Humanized
  • • Immunology
  • • Infectious Disease
  • • Autoimmune Disease
  • • Oncology & Immuno-Oncology

cryo

FcResolv® huNOG-EXL EA (Early Access)


View Model

Summary

  • • Species: Mouse
  • • Strain Type: Congenic
  • • Allele Type: Constitutive Knockout; Spontaneous Mutant; Random Transgenic
  • • Coat Color: Albino
  • • Genetic Background: NOD

Applications & Therapeutic Areas

  • • Oncology & Immuno-Oncology
  • • Immunology
  • • Inflammation
  • • Cell and Tissue Humanized
  • • Infectious Disease

C.B-17 scid

FcResolv® huNOG-EXL SA (Standard Access)


View Model

Summary

  • • Species: Mouse
  • • Strain Type: Congenic
  • • Allele Type: Constitutive Knockout; Spontaneous Mutant; Random Transgenic
  • • Coat Color: Albino
  • • Genetic Background: NOD

Applications & Therapeutic Areas

  • • Oncology & Immuno-Oncology
  • • Immunology
  • • Inflammation
  • • Cell and Tissue Humanized
  • • Infectious Disease

b6129f1

huPBMC-NOG


View Model

Summary

  • • Species: Mouse
  • • Strain Type: Congenic
  • • Allele Type: Constitutive Knockout; Spontaneous Mutant
  • • Coat Color: Albino
  • • Genetic Background: NOD

Applications & Therapeutic Areas

  • • Cell and Tissue Humanized
  • • Immunology
  • • Inflammation
  • • Oncology & Immuno-Oncology

b6129f1

huPBMC-B2m-NOG


View Model

Summary

  • • Species: Mouse
  • • Strain Type: Congenic
  • • Allele Type: Constitutive Knockout; Spontaneous Mutant
  • • Coat Color: Albino
  • • Genetic Background: NOD

Applications & Therapeutic Areas

  • • Oncology & Immuno-Oncology
  • • Cell and Tissue Humanized

NEW! Taconic huSelect™ services for CD34+ humanized immune system models

Taconic offers a suite of custom humanization capabilities to improve quality and consistency of therapeutic study outcomes by reducing donor-to-donor variability.

  • Ideal for researchers carrying out pre-clinical studies who want to improve project outcomes to accelerate therapeutics to market.
  • Suitable for use in any of our CD34+ humanized immune system models (huNOG-EXL, FcResolv huNOG-EXL, huNOG, FcResolv NOG) or in a model of your choice.

huSelect Customized Humanization Options


huSelect Service*


Description

Select CD34+ HSC donors based on one or more HLA criteriaOur extensive CD34+ HSC donor catalog supports a wide range of HLA types for to suit your study parameters.
Request a specific CD34+ HSC donorRepeat studies using CD34+ donors from prior orders
Reserve CD34+ cells for future useEnsure an ongoing supply of CD34+ cells from selected donors
Pre-characterized CD34+ HSC donorsA number of donors have been validated in huNOG-EXL mice and pre-characterized for human immune cell populations for four timepoints out to 30 weeks post-engraftment. Data available upon request.
On-demand analysis of immune cell characterizationFlow cytometry services for immune cell analysis of models prior to shipping or for customer-provided samples. A variety of panels are available.

*All service options are subject to availability. Other restrictions may apply.

Why Humanized Immune System Mice Are Critical for Preclinical Immuno-Oncology Research

Humanized Immune System mice are vital for preclinical immuno-oncology studies because they enable in vivo evaluation of human-specific immune responses to cancer therapies. These models support developing and testing immune checkpoint inhibitors, CAR-T cells, and other targeted immunotherapies. By mimicking human tumor-immune system interactions, humanized mice provide more predictive data on efficacy and safety than traditional murine models. This accelerates translational research and reduces the risk of failure in clinical trials.

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mice

Research Success Stories and Case Studies

Customer Reviews and Testimonials

On-Demand Webinar

Accelerate Drug Discovery Using the Next Generation of Humanized Immune System (HIS) Mice

Watch this exclusive webinar to learn how next-gen humanized immune system mice accelerate drug development in cancer and autoimmunity. Explore solutions to common challenges like donor variability and see how Taconic’s new services can improve consistency and reduce preclinical costs.  

VIew Now

Scientific Poster

Evaluation of a human peripheral blood NK humanized hIL-15 mouse model lacking murine Fc gamma receptor

Learn how FcResolv® hIL-15 NOG mice minimize FcγR interaction with IgG therapeutics, supporting NK cell engraftment studies with 12+ week persistence.
View Now

White Paper

An Introduction to Humanized Immune System Mouse Models

Discover how humanized immune system mouse models recapitulate key aspects of human biology. Explore methods, benefits, and strain selection for your research.
Read Now

Scientific Poster

Advancing Cancer Research with Next Generation NOG Mice

Learn how preclinical immune therapy evaluation, using humanized mouse models with patient-derived tumors, advance tumor-immune research and cancer therapy development.

View Now
insight

Learn How Our Humanized Immune System Mice Are Used in Research

Visit our Resources page to find more webinars, insights, and white papers to learn more and help navigate the possibilities for humanized immune system mouse model utility and applications. 

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Select One

On-Demand Webinar

Accelerating Drug Discovery Using the Next Generation of Humanized Immune System Mice

Discover how next-gen humanized immune system mice improve reliability, reduce costs, and accelerate drug development in cancer and autoimmune research.

Watch Now

On-Demand Webinar

An Introduction to Humanized Immune System (HIS) Mice

Learn the fundamentals of Humanized Immune System (HIS) mice, including NOG models, humanization methods, and their applications in immuno-oncology and beyond.
Watch Now

On-Demand Webinar

Validation of Humanized Immune System Mice as a Model for Human Innate Immune Response

Explore how humanized immune system (HIS) mice advance TLR4-targeted drug discovery, overcoming species limitations in preclinical innate immunity studies.
Watch Now

Insight

NOG-EXL mouse model from Taconic outperforms NSG-SGM3 in new study

Read about the new paper from scientists at the University of Pennsylvania and Taconic showing improved outcomes in glioblastoma research using the NOG-EXL mouse model.
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Insight

huNOG-EXL models as a valuable tool in prostate cancer studies

In a study published in Molecular Cancer Research, investigators found that huNOG and huNOG-EXL models from Taconic can be used to successfully model prostate cancer to help develop effective treatment.
Read Now

Insight

Humanized Mouse Models for Drug Discovery: The NOG Portfolio

Explore how humanized NOG mouse models advance drug discovery. Learn about HSC and PBMC engraftment, immune system humanization, and selecting the right model for preclinical research.
Read Now

Frequently Asked Humanized Mouse Model Questions

Learn more about using our humanized mouse models in your preclinical research. 

Humanized immune system (HIS) mouse models are immunodeficient mice engrafted with human hematopoietic cells or tissues. These models support human immune cell development and function, enabling researchers to study human-specific immune responses in vivo.

Humanized mice are essential for preclinical studies because they mimic aspects of the human immune system. They are widely used to evaluate immunotherapies, infectious disease treatments, and autoimmune disorders with greater translational relevance than traditional mouse models.

Taconic offers several next-generation HIS models, including huNOG, huNOG-EXL, and huNOG-EXL SA. These models provide varying levels of myeloid and lymphoid cell reconstitution to support different research needs, such as oncology, infectious disease, and inflammation.

Taconic’s HIS models feature extended engraftment duration, improved immune cell reconstitution, and lower rates of graft-versus-host disease (GvHD). These advantages make them ideal for long-term studies and reduce variability in experimental outcomes.

Taconic HIS mice are developed by engrafting immunodeficient mouse strains with human CD34+ hematopoietic stem cells. The cells engraft and differentiate in vivo, establishing a functional human immune system within the mouse.

Get Expert Guidance on Humanized Mouse Models

Looking for the right humanized immune system (HIS) model for your study? Fill out the form to request a complimentary scientific consultation with one of our PhD model design experts. 

If you need immediate assistance, please contact Customer Service:

Taconic Corporate Offices

Email: info@taconic.com

Phone: +1 (518) 697-3900

273 Hover Ave., Germantown, NY 12526

North American Customer Service

Email: info@taconic.com

Phone:
+1 (518) 697-3915 

Toll-free:
+1 (888) 822-6642


Hours:
(Monday - Friday): 7 a.m. - 6 p.m. ET

European Customer Service

Email: info@taconic.com

Phone (Europe and Denmark):
+45 70 23 04 05 

Phone (Germany):
+49 214 50 68 023 

Hours: (Monday - Friday):
7 a.m. - 5 p.m. CET