For more than 30 years, Taconic has supported European researchers with cutting-edge animal models. Our humanised immune system (HIS) mice are advanced, translatable preclinical models designed to replicate key functions of the human immune system. Ideal for oncology, immuno-oncology and autoimmunity research, these models support translational evaluation of novel therapeutics. Trusted by leading scientists worldwide, our validated humanisation process is now available on-site in Leverkusen, Germany, giving European researchers access to the state-of-the-art humanised animal models with faster delivery and lower shipping costs.
Humanised Immune System Mice, Now Locally Humanised and Shipped from Our Facility in Leverkusen, Germany
Humanised Immune System Mice for Preclinical Studies
From the well-established CIEA NOG mouse® to the exclusive FcResolv® huNOG model, Taconic provides a comprehensive range of humanised mouse models to accelerate your studies. Our portfolio includes study ready HIS mice engrafted with human HSCs or PBMCs, a suite of custom humanisation capabilities, and on-site flow cytometry to improve the quality and consistency of your therapeutic study outcomes.
Sustainable Research Solutions for a Greener Future
Taconic’s localized HIS mouse humanisation in Leverkusen, Germany reduces shipping-related CO₂ emissions by more than 93%. By eliminating long-distance transit, we help advance your research while supporting a more sustainable, eco-conscious future for life sciences.
Faster Delivery for Better Animal Welfare
With local delivery to Europe from our Leverkusen, Germany facility, we are able to reduce shipping times for fragile humanised mice from 7 days to just 24 hours. Local humanisation also avoids double packing and unpacking, further minimising animal stress.
Benefits
- Local production of HIS mice: Securing your supply chain by having the entire process for HIS mice centrally available in Europe.
- Flexible HIS Offerings: Off-the-shelf and custom humanisations (PBMC and CD34+).
- On-site Flow Cytometry: Local immune profiling expertise.
- Improved Access: Faster, more reliable delivery, same Taconic quality.
- Sustainability and Welfare: Shorter transport, lower CO2 emissions, improved animal welfare.
- Cost-Effective Logistics: Avoid air shipment and benefit from existing European ground transportation networks.
- Simplified Importation: Local EU production streamlines processes.
- Local Scientific Support: European experts ready to collaborate.
Learn About our Leverkusen Humanised Centre of Excellence
Connect with an expert
Why Taconic?
Taconic Biosciences is a global leader in genetically engineered mouse models and colony management services. We support researchers in advancing their science with innovative, reliable solutions.
Learn More about our Fully Integrated Custom Model Generation and Colony Management Solutions.
Available Humanised Immune System Mice
Click each card to learn more.
huNOG
Summary
- • Species: Mouse
- • Strain Type: Congenic
- • Coat Color: Albino
- • Allele Type: Constitutive Knockout; Spontaneous Mutant
- • Genetic Background: NOD
Applications & Therapeutic Areas
- • Immunology
- • Oncology & Immuno-Oncology
- • Infectious Disease
- • Cell and Tissue Humanised
- • Inflammation
huNOG-EXL EA
(Early Access)
Summary
- • Species: Mouse
- • Strain Type: Congenic
- • Allele Type: Constitutive Knockout; Spontaneous Mutant; Random Transgenic
- • Coat Color: Albino
- • Genetic Background: NOD
Applications & Therapeutic Areas
- • Cell and Tissue Humanised
- • Immunology
- • Infectious Disease
- • Oncology & Immuno-Oncology
- • Inflammation
huNOG-EXL SA
(Standard Access)
Summary
- • Species: Mouse
- • Strain Type: Congenic
- • Allele Type: Constitutive Knockout; Spontaneous Mutant; Random Transgenic
- • Coat Color: Albino
- • Genetic Background: NOD
Applications & Therapeutic Areas
- • Cell and Tissue Humanised
- • Immunology
- • Inflammation
- • Infectious Disease
- • Oncology & Immuno-Oncology
huSelect™ Customized Humanisation Options
Humanised immune system (HIS) mice are critical tools for in vivo evaluation of biological therapeutic target efficacy. HIS mice require a human donor source of CD34+ hematopoietic stem cells (HSCs), but genetic variance across donors can lead to inconsistent outcomes.
Taconic has developed a suite of offerings to address the issue of donor-to-donor variability by utilizing our extensive and well-characterized CD34+HSC inventory and expertise in immune cell characterization. Suitable for use in any of our CD34+ humanised immune system models (huNOG-EXL, FcResolv® huNOG-EXL, huNOG, FcResolv® NOG) or in a model of your choice.
huSelect™ Service* | Description |
| Select CD34+ HSC donors based on one or more HLA criteria | Our extensive CD34+ HSC donor catalog supports a wide range of HLA types for to suit your study parameters. |
| Request a specific CD34+ HSC donor | Repeat studies using CD34+ donors from prior orders |
| Reserve CD34+ cells for future use | Ensure an ongoing supply of CD34+ cells from selected donors |
| Pre-characterized CD34+ HSC donors | A number of donors have been validated in huNOG-EXL mice and pre-characterized for human immune cell populations for four timepoints out to 30 weeks post-engraftment. Data available upon request. |
| On-demand analysis of immune cell characterization | Flow cytometry services for immune cell analysis of models prior to shipping or for customer-provided samples. A variety of panels are available. |
*All service options are subject to availability. Other restrictions may apply.
On-Demand Webinar
Accelerate Drug Discovery Using the Next Generation of Humanized Immune System (HIS) Mice
Watch this exclusive webinar to learn how next-gen humanized immune system mice accelerate drug development in cancer and autoimmunity. Explore solutions to common challenges like donor variability and see how Taconic’s new services can improve consistency and reduce preclinical costs.
View our Oncology and Immuno-Oncology Portfolio
Taconic Biosciences uniquely combines a broad portfolio of models, including advanced genetically engineered models (GEMs) and humanized mice with integrated IP access, with expertise in oncology model generation and breeding, all with an ecosystem of scientific support designed to always provide our customers with the best solution. Browse our catalog of readily available models for your next oncology study, explore our portfolio of super immunodeficient mice suitable for testing novel oncology drug candidates, or discuss your specific project needs with a scientist.
Featured Resources
Get In Touch
Request a Complimentary Consultation Today