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Filter publications by model type: All Conditional knock out Humanization Knock in Knock out Targeted transgenic miRNA over-expression shRNA-mediatred gene knock down

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Metzger MW, et al.
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Metzger MW, Walser SM, Aprile-Garcia F, Dedic N, Chen A, Holsboer F, Arzt E, Wurst W, Deussing JM
(2017) Genetically dissecting P2rx7 expression within the central nervous system using conditional humanized mice. Purinergic Signal. 13(2):153-170
Targeted transgenic
Development
Steinbusch LK, et al.
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Steinbusch LK, Picard A, Bonnet MS, Basco D, Labouèbe G, Thorens B
(2016) Sex-Specific Control of Fat Mass and Counterregulation by Hypothalamic Glucokinase. Diabetes 65(10):2920-31
Conditional knock out
Metabolism, Neuroscience
Nanda SK, et al.
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Nanda SK, Lopez-Pelaez M, Arthur JS, Marchesi F, Cohen P
(2016) Suppression of IRAK1 or IRAK4 Catalytic Activity, but Not Type 1 IFN Signaling, Prevents Lupus Nephritis in Mice Expressing a Ubiquitin Binding-Defective Mutant of ABIN1. J. Immunol. 197(11):4266-4273
Knock in
Inflammation
Si S, et al.
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Si S, Nakajima-Takagi Y, Aoyama K, Oshima M, Saraya A, Sugishita H, Nakayama M, Ishikura T, Koseki H, Iwama A
(2016) Loss of Pcgf5 Affects Global H2A Monoubiquitination but Not the Function of Hematopoietic Stem and Progenitor Cells. PLoS ONE 11(5):e0154561
Targeted transgenic
Development
Qvist P, et al.
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Qvist P, Christensen JH, Vardya I, Rajkumar AP, Mørk A, Paternoster V, Füchtbauer EM, Pallesen J, Fryland T, Dyrvig M, Hauberg ME, Lundsberg B, Fejgin K, Nyegaard M, Jensen K, Nyengaard JR, Mors O, Didriksen M, Børglum AD
(2016) The Schizophrenia-Associated BRD1 Gene Regulates Behavior, Neurotransmission, and Expression of Schizophrenia Risk Enriched Gene Sets in Mice. Biol. Psychiatry
Conditional knock out
Neuroscience
Redelinghuys P, et al.
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Redelinghuys P, Whitehead L, Augello A, Drummond RA, Levesque JM, Vautier S, Reid DM, Kerscher B, Taylor JA, Nigrovic PA, Wright J, Murray GI, Willment JA, Hocking LJ, Fernandes MJ, De Bari C, Mcinnes IB, Brown GD
(2016) MICL controls inflammation in rheumatoid arthritis. Ann. Rheum. Dis. 75(7):1386-91
Conditional knock out
Inflammation
Liput DJ, et al.
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Liput DJ, Lu VB, Davis MI, Puhl HL, Ikeda SR
(2016) Rem2, a member of the RGK family of small GTPases, is enriched in nuclei of the basal ganglia. Sci Rep 6:25137
Conditional knock out
Neuroscience, Development
Kim J, et al.
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Kim J, Siverly AN, Chen D, Wang M, Yuan Y, Wang Y, Lee H, Zhang J, Muller WJ, Liang H, Gan B, Yang X, Sun Y, You MJ, Ma L
(2016) Ablation of miR-10b Suppresses Oncogene-Induced Mammary Tumorigenesis and Metastasis and Reactivates Tumor-Suppressive Pathways. Cancer Res. 76(21):6424-6435
Conditional knock out
Oncology
Oshima M, et al.
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Oshima M, Hasegawa N, Mochizuki-Kashio M, Muto T, Miyagi S, Koide S, Yabata S, Wendt GR, Saraya A, Wang C, Shimoda K, Suzuki Y, Iwama A
(2016) Ezh2 regulates the Lin28/let-7 pathway to restrict activation of fetal gene signature in adult hematopoietic stem cells. Exp. Hematol. 44(4):282-96.e3
Development
Szczepanek K, et al.
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Szczepanek K, Allegood J, Aluri H, Hu Y, Chen Q, Lesnefsky EJ
(2016) Acquired deficiency of tafazzin in the adult heart: Impact on mitochondrial function and response to cardiac injury. Biochim. Biophys. Acta 1861(4):294-300
shRNA-mediatred gene knock down
Cardiovascular
Ito G, et al.
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Ito G, Katsemonova K, Tonelli F, Lis P, Baptista MA, Shpiro N, Duddy G, Wilson S, Ho PW, Ho SL, Reith AD, Alessi DR
(2016) Phos-tag analysis of Rab10 phosphorylation by LRRK2: a powerful assay for assessing kinase function and inhibitors. Biochem. J. 473(17):2671-85
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Parkinson's
Connell JW, et al.
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Connell JW, Allison R, Reid E
(2016) Quantitative Gait Analysis Using a Motorized Treadmill System Sensitively Detects Motor Abnormalities in Mice Expressing ATPase Defective Spastin. PLoS ONE 11(3):e0152413
Knock in
Neuroscience
McMahon M, et al.
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McMahon M, Frangova TG, Henderson CJ, Wolf CR
(2016) Olaparib, Monotherapy or with Ionizing Radiation, Exacerbates DNA Damage in Normal Tissues: Insights from a New p21 Reporter Mouse. Mol. Cancer Res. 14(12):1195-1203
Knock in
Tox & Safety Assessment
Tanaka K, et al.
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Tanaka K, Kelly CE, Goh KY, Lim KB, Ibáñez CF
(2016) Death Domain Signaling by Disulfide-Linked Dimers of the p75 Neurotrophin Receptor Mediates Neuronal Death in the CNS. J. Neurosci. 36(20):5587-95
Knock in
Development
Mangels N, et al.
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Mangels N, Awwad K, Wettenmann A, Dos Santos LR, Frömel T, Fleming I
(2016) The soluble epoxide hydrolase determines cholesterol homeostasis by regulating AMPK and SREBP activity. Prostaglandins Other Lipid Mediat. 125:30-9
Conditional knock out
Metabolism
MacLeod AK, et al.
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MacLeod AK, McLaughlin LA, Henderson CJ, Wolf CR
(2017) Application of Mice Humanized for CYP2D6 to the Study of Tamoxifen Metabolism and Drug-Drug Interaction with Antidepressants. Drug Metab. Dispos. 45(1):17-22
Humanization
ADMET
Li K, et al.
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Li K, Wohlford-Lenane CL, Channappanavar R, Park JE, Earnest JT, Bair TB, Bates AM, Brogden KA, Flaherty HA, Gallagher T, Meyerholz DK, Perlman S, McCray PB
(2017) Mouse-adapted MERS coronavirus causes lethal lung disease in human DPP4 knockin mice. Proc. Natl. Acad. Sci. U.S.A. 114(15):E3119-E3128
Humanization
Infectious Disease
Alliegro M, et al.
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Alliegro M, Ferla R, Nusco E, De Leonibus C, Settembre C, Auricchio A
(2016) Low-dose Gene Therapy Reduces the Frequency of Enzyme Replacement Therapy in a Mouse Model of Lysosomal Storage Disease. Mol. Ther. 24(12):2054-2063
Targeted transgenic
Gene/Cell therapy
Ferla R, et al.
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Ferla R, Claudiani P, Cotugno G, Saccone P, De Leonibus E, Auricchio A
(2014) Similar therapeutic efficacy between a single administration of gene therapy and multiple administrations of recombinant enzyme in a mouse model of lysosomal storage disease. Hum. Gene Ther. 25(7):609-18
Targeted transgenic
Gene/Cell therapy
Strickson S, et al.
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Strickson S, Emmerich CH, Goh ETH, Zhang J, Kelsall IR, Macartney T, Hastie CJ, Knebel A, Peggie M, Marchesi F, Arthur JSC, Cohen P
(2017) Roles of the TRAF6 and Pellino E3 ligases in MyD88 and RANKL signaling. Proc. Natl. Acad. Sci. U.S.A. 114(17):E3481-E3489
Knock out
Immunology
Falkevall A, et al.
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Falkevall A, Mehlem A, Palombo I, Heller Sahlgren B, Ebarasi L, He L, Ytterberg AJ, Olauson H, Axelsson J, Sundelin B, Patrakka J, Scotney P, Nash A, Eriksson U
(2017) Reducing VEGF-B Signaling Ameliorates Renal Lipotoxicity and Protects against Diabetic Kidney Disease. Cell Metab. 25(3):713-726
Conditional knock out
Metabolic Syndrome
Liu P, et al.
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Liu P, Lee S, Knoll J, Rauch A, Ostermay S, Luther J, Malkusch N, Lerner UH, Zaiss MM, Neven M, Wittig R, Rauner M, David JP, Bertolino P, Zhang CX, Tuckermann JP
(2017) Loss of menin in osteoblast lineage affects osteocyte-osteoclast crosstalk causing osteoporosis. Cell Death Differ. 24(4):672-682
Targeted transgenic
Liu Y, et al.
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Liu Y, Zhang C, Li Z, Wang C, Jia J, Gao T, Hildebrandt G, Zhou D, Bondada S, Ji P, St Clair D, Liu J, Zhan C, Geiger H, Wang S, Liang Y
(2017) Latexin Inactivation Enhances Survival and Long-Term Engraftment of Hematopoietic Stem Cells and Expands the Entire Hematopoietic System in Mice. Stem Cell Reports 8(4):991-1004
Conditional knock out
Stem Cells/Regenerative Medicine/Tissue Engineering
Han H, et al.
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Han H, Yang B, Wang W
(2017) Angiomotin-like 2 interacts with and negatively regulates AKT. Oncogene
Conditional knock out
Oncology
Smith CW, et al.
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Smith CW, Thomas SG, Raslan Z, Patel P, Byrne M, Lordkipanidzé M, Bem D, Meyaard L, Senis YA, Watson SP, Mazharian A
(2017) Mice Lacking the Inhibitory Collagen Receptor LAIR-1 Exhibit a Mild Thrombocytosis and Hyperactive Platelets. Arterioscler. Thromb. Vasc. Biol. 37(5):823-835
Knock out
Petit EI, et al.
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Petit EI, Michalak Z, Cox R, O'Tuathaigh CM, Clarke N, Tighe O, Talbot K, Blake D, Joel J, Shaw A, Sheardown SA, Morrison AD, Wilson S, Shapland EM, Henshall DC, Kew JN, Kirby BP, Waddington JL
(2017) Dysregulation of Specialized Delay/Interference-Dependent Working Memory Following Loss of Dysbindin-1A in Schizophrenia-Related Phenotypes. Neuropsychopharmacology 42(6):1349-1360
Neuroscience
Ly JQ, et al.
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Ly JQ, Messick K, Qin A, Takahashi RH, Choo EF
(2017) Utility of CYP3A4 and PXR-CAR-CYP3A4/3A7 Transgenic Mouse Models To Assess the Magnitude of CYP3A4 Mediated Drug-Drug Interactions. Mol. Pharm. 14(5):1754-1759
Humanization
Tox & Safety Assessment
Sergaki MC, et al.
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Sergaki MC, Ibáñez CF
(2017) GFRα1 Regulates Purkinje Cell Migration by Counteracting NCAM Function. Cell Rep 18(2):367-379
Knock in
Darling NJ, et al.
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Darling NJ, Toth R, Arthur JS, Clark K
(2017) Inhibition of SIK2 and SIK3 during differentiation enhances the anti-inflammatory phenotype of macrophages. Biochem. J. 474(4):521-537
Knock in
Immunology
Daumas S, et al.
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Daumas S, Hunter CJ, Mistry RB, Morè L, Privitera L, Cooper DD, Reyskens KM, Flynn HT, Morris RG, Arthur JS, Frenguelli BG
(2017) The Kinase Function of MSK1 Regulates BDNF Signaling to CREB and Basal Synaptic Transmission, But Is Not Required for Hippocampal Long-Term Potentiation or Spatial Memory. eNeuro 4(1)
Knock in
Neuroscience
You L, et al.
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You L, Zou J, Zhao H, Bertos NR, Park M, Wang E, Yang XJ
(2015) Deficiency of the chromatin regulator BRPF1 causes abnormal brain development. J. Biol. Chem. 290(11):7114-29
Knock out
Neuroscience
Valkova C, et al.
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Valkova C, Liebmann L, Krämer A, Hübner CA, Kaether C
(2017) The sorting receptor Rer1 controls Purkinje cell function via voltage gated sodium channels. Sci Rep 7:41248
Conditional knock out
Neuroscience
Hu J, et al.
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Hu J, Geyer A, Dziumbla S, Awwad K, Zeldin DC, Schunck WH, Popp R, Frömel T, Fleming I
(2017) Prostaglandins and Other Lipid Mediators (POLM), Special Issue of the 6th European workshop on lipid mediators: Role of Müller cell cytochrome P450 2c44 in murine retinal angiogenesis. Prostaglandins Other Lipid Mediat.
Conditional knock out
Cardiovascular
Chou AM, et al.
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Chou AM, Sem KP, Lam WJ, Ahmed S, Lim CY
(2017) Redundant functions of I-BAR family members, IRSp53 and IRTKS, are essential for embryonic development. Sci Rep 7:40485
Conditional knock out
Development
Marialuisa Alliegro, et al.
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Marialuisa Alliegro, Rita Ferla, Edoardo Nusco, Chiara De Leonibus, Carmine Settembre, Alberto Auricchio
(2016) Low-dose Gene Therapy Reduces the Frequency of Enzyme Replacement Therapy in a Mouse Model of Lysosomal Storage Disease Molecular Therapy; 24 12, 2054–2063. doi:10.1038/mt.2016.181
Targeted transgenic
Kornfeld JW, et al.
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Kornfeld JW, Baitzel C, Könner AC, Nicholls HT, Vogt MC, Herrmanns K, Scheja L, Haumaitre C, Wolf AM, Knippschild U, Seibler J, Cereghini S, Heeren J, Stoffel M, Brüning JC
(2013) Obesity-induced overexpression of miR-802 impairs glucose metabolism through silencing of Hnf1b. Nature 494(7435):111-5
Metabolism
Gebeshuber CA, et al.
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Gebeshuber CA, Kornauth C, Dong L, Sierig R, Seibler J, Reiss M, Tauber S, Bilban M, Wang S, Kain R, Böhmig GA, Moeller MJ, Gröne HJ, Englert C, Martinez J, Kerjaschki D
(2013) Focal segmental glomerulosclerosis is induced by microRNA-193a and its downregulation of WT1. Nat. Med. 19(4):481-7
Vink PM, et al.
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Vink PM, Smout WM, Driessen-Engels LJ, de Bruin AM, Delsing D, Krajnc-Franken MA, Jansen AJ, Rovers EF, van Puijenbroek AA, Kaptein A, Nolte MA, Garritsen A, van Eenennaam H
(2013) In vivo knockdown of TAK1 accelerates bone marrow proliferation/differentiation and induces systemic inflammation. PLoS ONE 8(3):e57348
Inflammation
Michalak EM, et al.
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Michalak EM, Nacerddine K, Pietersen A, Beuger V, Pawlitzky I, Cornelissen-Steijger P, Wientjens E, Tanger E, Seibler J, van Lohuizen M, Jonkers J
(2013) Polycomb group gene Ezh2 regulates mammary gland morphogenesis and maintains the luminal progenitor pool. Stem Cells 31(9):1910-20
Gerrits H, et al.
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Gerrits H, Paradé MC, Koonen-Reemst AM, Bakker NE, Timmer-Hellings L, Sollewijn Gelpke MD, Gossen JA
(2014) Reversible infertility in a liver receptor homologue-1 (LRH-1)-knockdown mouse model. Reprod. Fertil. Dev. 26(2):293-306
Molenaar JJ, et al.
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Molenaar JJ, Domingo-Fernández R, Ebus ME, Lindner S, Koster J, Drabek K, Mestdagh P, van Sluis P, Valentijn LJ, van Nes J, Broekmans M, Haneveld F, Volckmann R, Bray I, Heukamp L, Sprüssel A, Thor T, Kieckbusch K, Klein-Hitpass L, Fischer M, Vandesompele J, Schramm A, van Noesel MM, Varesio L, Speleman F, Eggert A, Stallings RL, Caron HN, Versteeg R, Schulte JH
(2012) LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression. Nat. Genet. 44(11):1199-206
Targeted transgenic
Oncology
Scheer N, et al.
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Scheer N, Snaith M, Wolf CR, Seibler J
(2013) Generation and utility of genetically humanized mouse models. Drug Discov. Today 18(23-24):1200-11
Humanization
Scheer N, et al.
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Scheer N, Wolf CR
(2014) Genetically humanized mouse models of drug metabolizing enzymes and transporters and their applications. Xenobiotica 44(2):96-108
Humanization
ADMET
Guo T, et al.
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Guo T, Marmol P, Moliner A, Björnholm M, Zhang C, Shokat KM, Ibanez CF
(2014) Adipocyte ALK7 links nutrient overload to catecholamine resistance in obesity. Elife 3:e03245
Metabolism
Smeets MF, et al.
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Smeets MF, DeLuca E, Wall M, Quach JM, Chalk AM, Deans AJ, Heierhorst J, Purton LE, Izon DJ, Walkley CR
(2014) The Rothmund-Thomson syndrome helicase RECQL4 is essential for hematopoiesis. J. Clin. Invest. 124(8):3551-65
Knock in
Hematopoietic Stem Cell Engraftment
Maddaluno L, et al.
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Maddaluno L, Rudini N, Cuttano R, Bravi L, Giampietro C, Corada M, Ferrarini L, Orsenigo F, Papa E, Boulday G, Tournier-Lasserve E, Chapon F, Richichi C, Retta SF, Lampugnani MG, Dejana E
(2013) EndMT contributes to the onset and progression of cerebral cavernous malformations. Nature 498(7455):492-6
Nilsson SR, et al.
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Nilsson SR, Celada P, Fejgin K, Thelin J, Nielsen J, Santana N, Heath CJ, Larsen PH, Nielsen V, Kent BA, Saksida LM, Stensbøl TB, Robbins TW, Bastlund JF, Bussey TJ, Artigas F, Didriksen M
(2016) A mouse model of the 15q13.3 microdeletion syndrome shows prefrontal neurophysiological dysfunctions and attentional impairment. Psychopharmacology (Berl.) 233(11):2151-63
Knock out
Neuroscience
Gass N, et al.
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Gass N, Weber-Fahr W, Sartorius A, Becker R, Didriksen M, Stensbøl TB, Bastlund JF, Meyer-Lindenberg A, Schwarz AJ
(2016) An acetylcholine alpha7 positive allosteric modulator rescues a schizophrenia-associated brain endophenotype in the 15q13.3 microdeletion, encompassing CHRNA7. Eur Neuropsychopharmacol 26(7):1150-60
Knock out
Behavior
Feith DJ, et al.
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Feith DJ, Shantz LM, Pegg AE
(2001) Targeted antizyme expression in the skin of transgenic mice reduces tumor promoter induction of ornithine decarboxylase and decreases sensitivity to chemical carcinogenesis. Cancer Res. 61(16):6073-81
Ziegler SF, et al.
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Ziegler SF, Wilkinson JE, Paeper B, Brunkow ME, Ramsdell F, Jeffery EW, Hjerrild KA, Clark LB, Yasayko SA, Galas D
(2001) Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Nat. Genet. 27(1):68-73
Asamoto M, et al.
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Asamoto M, Hokaiwado N, Cho YM, Takahashi S, Ikeda Y, Imaida K, Shirai T
(2001) Prostate carcinomas developing in transgenic rats with SV40 T antigen expression under probasin promoter control are strictly androgen dependent. Cancer Res. 61(12):4693-700
Tanemura K, et al.
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Tanemura K, Murayama M, Akagi T, Hashikawa T, Tominaga T, Ichikawa M, Yamaguchi H, Takashima A
(2002) Neurodegeneration with tau accumulation in a transgenic mouse expressing V337M human tau. J. Neurosci. 22(1):133-41
Alzheimer's
Sakata Y, et al.
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Sakata Y, Kamei CN, Nakagami H, Bronson R, Liao JK, Chin MT
(2002) Ventricular septal defect and cardiomyopathy in mice lacking the transcription factor CHF1/Hey2. Proc. Natl. Acad. Sci. U.S.A. 99(25):16197-202
Wagenaar E, et al.
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Wagenaar E, Jonker JW, Beijnen JH, van der Valk MA, Scheffer GL, Scheper RJ, Elferink RP, Rosing H, Buitelaar M, Kuipers F, Schinkel AH., Plösch T
(2002) The breast cancer resistance protein protects against a major chlorophyll-derived dietary phototoxin and protoporphyria Proc Natl Acad Sci USA. 99(24):15649-54.
Breast Cancer
Engle SJ, et al.
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Engle SJ, Ormsby I, Pawlowski S, Boivin GP, Croft J, Balish E, Doetschman T
(2002) Elimination of colon cancer in germ-free transforming growth factor beta 1-deficient mice. Cancer Res. 62(22):6362-6
Colon Cancer
Eggan K, et al.
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Eggan K, Rode A, Jentsch I, Samuel C, Hennek T, Tintrup H, Zevnik B, Erwin J, Loring J, Jackson-Grusby L, Speicher MR, Kuehn R, Jaenisch R
(2002) Male and female mice derived from the same embryonic stem cell clone by tetraploid embryo complementation. Nat. Biotechnol. 20(5):455-9
Stem Cells/Regenerative Medicine/Tissue Engineering
Asamoto M, et al.
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Asamoto M, Hokaiwado N, Cho YM, Shirai T
(2002) Effects of genetic background on prostate and taste bud carcinogenesis due to SV40 T antigen expression under probasin gene promoter control. Carcinogenesis 23(3):463-7
Andreas S, et al.
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Andreas S, Schwenk F, Küter-Luks B, Faust N, Kühn R
(2002) Enhanced efficiency through nuclear localization signal fusion on phage PhiC31-integrase: activity comparison with Cre and FLPe recombinase in mammalian cells. Nucleic Acids Res. 30(11):2299-306
Anderson RE, et al.
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Anderson RE, Maude MB, McClellan M, Matthes MT, Yasumura D, LaVail MM
(2002) Low docosahexaenoic acid levels in rod outer segments of rats with P23H and S334ter rhodopsin mutations. Mol. Vis. 8:351-8
Zhang Y, et al.
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Zhang Y, Rauch U, Perez MT
(2003) Accumulation of neurocan, a brain chondroitin sulfate proteoglycan, in association with the retinal vasculature in RCS rats. Invest. Ophthalmol. Vis. Sci. 44(3):1252-61
Zhang Y, et al.
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Zhang Y, Arnér K, Ehinger B, Perez MT
(2003) Limitation of anatomical integration between subretinal transplants and the host retina. Invest. Ophthalmol. Vis. Sci. 44(1):324-31
Yu C, et al.
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Yu C, Staehling-Hampton K, Brunkow ME, Jonas M, Latham JA, Winkler DG, Sutherland MK, Geoghegan JC, Hayes T, Skonier JE, Shpektor D, Kovacevich BR, Appleby M
(2003) Osteocyte control of bone formation via sclerostin, a novel BMP antagonist. EMBO J. 22(23):6267-76
Tietge UJ, et al.
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Tietge UJ, Maugeais C, Cain W, Rader DJ
(2003) Acute inflammation increases selective uptake of HDL cholesteryl esters into adrenals of mice overexpressing human sPLA2. Am. J. Physiol. Endocrinol. Metab. 285(2):E403-11
Stricklett PK, et al.
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Stricklett PK, Taylor D, Nelson RD, Kohan DE
(2003) Thick ascending limb-specific expression of Cre recombinase. Am. J. Physiol. Renal Physiol. 285(1):F33-9
Seibler J, et al.
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Seibler J, Zevnik B, Küter-Luks B, Andreas S, Kern H, Hennek T, Rode A, Heimann C, Faust N, Kauselmann G, Schoor M, Jaenisch R, Rajewsky K, Kühn R, Schwenk F
(2003) Rapid generation of inducible mouse mutants. Nucleic Acids Res. 31(4):e12
Schwenk F, et al.
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Schwenk F, Zevnik B, Brüning J, Röhl M, Willuweit A, Rode A, Hennek T, Kauselmann G, Jaenisch R, Kühn R
(2003) Hybrid embryonic stem cell-derived tetraploid mice show apparently normal morphological, physiological, and neurological characteristics. Mol. Cell. Biol. 23(11):3982-9
Sagdullaev BT, et al.
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Sagdullaev BT, Aramant RB, Seiler MJ, Woch G, McCall MA
(2003) Retinal transplantation-induced recovery of retinotectal visual function in a rodent model of retinitis pigmentosa. Invest. Ophthalmol. Vis. Sci. 44(4):1686-95
Phan TG, et al.
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Phan TG, Amesbury M, Gardam S, Crosbie J, Hasbold J, Hodgkin PD, Basten A, Brink R
(2003) B cell receptor-independent stimuli trigger immunoglobulin (Ig) class switch recombination and production of IgG autoantibodies by anergic self-reactive B cells. J. Exp. Med. 197(7):845-60
Lozano J, et al.
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Lozano J, Xing R, Cai Z, Jensen HL, Trempus C, Mark W, Cannon R, Kolesnick R
(2003) Deficiency of kinase suppressor of Ras1 prevents oncogenic ras signaling in mice. Cancer Res. 63(14):4232-8
Lee JH, et al.
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Lee JH, Lau KF, Perkinton MS, Standen CL, Shemilt SJ, Mercken L, Cooper JD, McLoughlin DM, Miller CC
(2003) The neuronal adaptor protein X11alpha reduces Abeta levels in the brains of Alzheimer's APPswe Tg2576 transgenic mice. J. Biol. Chem. 278(47):47025-9
Alzheimer's
Kühn R, et al.
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Kühn R, Schwenk F
(2003) Conditional knockout mice. Methods Mol. Biol. 209:159-85
Wagenaar E, et al.
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Wagenaar E, Jonker JW, Van Eijl S, Schinkel AH.
(2003) Deficiency in the Organic Cation Transporters 1 and 2 (Oct1/Oct2 [Slc22a1/Slc22a2]) in Mice Abolishes Renal Secretion of Organic Cations Mol Cell Biol. 23(21):7902-7908.
Czipri M, et al.
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Czipri M, Otto JM, Cs-Szabó G, Kamath RV, Vermes C, Firneisz G, Kolman KJ, Watanabe H, Li Y, Roughley PJ, Yamada Y, Olsen BR, Glant TT
(2003) Genetic rescue of chondrodysplasia and the perinatal lethal effect of cartilage link protein deficiency. J. Biol. Chem. 278(40):39214-23
Crocker SJ, et al.
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Crocker SJ, Liston P, Anisman H, Lee CJ, Smith PD, Earl N, Thompson CS, Park DS, Korneluk RG, Robertson GS
(2003) Attenuation of MPTP-induced neurotoxicity and behavioural impairment in NSE-XIAP transgenic mice. Neurobiol. Dis. 12(2):150-61
Zhang W, et al.
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Zhang W, Purchio AF, Coffee R, West DB
(2004) Differential regulation of the human CYP3A4 promoter in transgenic mice and rats. Drug Metab. Dispos. 32(2):163-7
Otani K, et al.
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Otani K, Han DH, Ford EL, Garcia-Roves PM, Ye H, Horikawa Y, Bell GI, Holloszy JO, Polonsky KS
(2004) Calpain system regulates muscle mass and glucose transporter GLUT4 turnover. J. Biol. Chem. 279(20):20915-20
Lee JH, et al.
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Lee JH, Lau KF, Perkinton MS, Standen CL, Rogelj B, Falinska A, McLoughlin DM, Miller CC
(2004) The neuronal adaptor protein X11beta reduces amyloid beta-protein levels and amyloid plaque formation in the brains of transgenic mice. J. Biol. Chem. 279(47):49099-104
Hess JF, et al.
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Hess JF, Ransom RW, Zeng Z, Chang RS, Hey PJ, Warren L, Harrell CM, Murphy KL, Chen TB, Miller PJ, Lis E, Reiss D, Gibson RE, Markowitz MK, DiPardo RM, Su DS, Bock MG, Gould RJ, Pettibone DJ
(2004) Generation and characterization of a human bradykinin receptor B1 transgenic rat as a pharmacodynamic model. J. Pharmacol. Exp. Ther. 310(2):488-97
Griffin KJ, et al.
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Griffin KJ, Kirschner LS, Matyakhina L, Stergiopoulos S, Robinson-White A, Lenherr S, Weinberg FD, Claflin E, Meoli E, Cho-Chung YS, Stratakis CA
(2004) Down-regulation of regulatory subunit type 1A of protein kinase A leads to endocrine and other tumors. Cancer Res. 64(24):8811-5
Humanization
Oncology
García-Martínez LF, et al.
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García-Martínez LF, Appleby MW, Staehling-Hampton K, Andrews DM, Chen Y, McEuen M, Tang P, Rhinehart RL, Proll S, Paeper B, Brunkow ME, Grandea AG, Howard ED, Walker DE, Charmley P, Jonas M, Shaw S, Latham JA, Ramsdell F
(2004) A novel mutation in CD83 results in the development of a unique population of CD4+ T cells. J. Immunol. 173(5):2995-3001
Finkle D, et al.
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Finkle D, Quan ZR, Asghari V, Kloss J, Ghaboosi N, Mai E, Wong WL, Hollingshead P, Schwall R, Koeppen H, Erickson S
(2004) HER2-targeted therapy reduces incidence and progression of midlife mammary tumors in female murine mammary tumor virus huHER2-transgenic mice. Clin. Cancer Res. 10(7):2499-511
Butler AE, et al.
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Butler AE, Jang J, Gurlo T, Carty MD, Soeller WC, Butler PC
(2004) Diabetes due to a progressive defect in beta-cell mass in rats transgenic for human islet amyloid polypeptide (HIP Rat): a new model for type 2 diabetes. Diabetes 53(6):1509-16
Autoimmune
Seibler J, et al.
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Seibler J, Küter-Luks B, Kern H, Streu S, Plum L, Mauer J, Kühn R, Brüning JC, Schwenk F
(2005) Single copy shRNA configuration for ubiquitous gene knockdown in mice. Nucleic Acids Res. 33(7):e67
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Jonker JW, Freeman J, Bolscher E, Musters S, Alvi AJ, Titley I, Schinkel AH, Dale TC
(2005) Contribution of the ABC transporters Bcrp1 and Mdr1a/1b to the side population phenotype in mammary gland and bone marrow of mice. Stem Cells 23(8):1059-65
Stem Cells/Regenerative Medicine/Tissue Engineering
Irvine RA, et al.
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Irvine RA, Adachi N, Shibata DK, Cassell GD, Yu K, Karanjawala ZE, Hsieh CL, Lieber MR
(2005) Generation and characterization of endonuclease G null mice. Mol. Cell. Biol. 25(1):294-302
Andrews ZB, et al.
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Andrews ZB, Horvath B, Barnstable CJ, Elsworth J, Elseworth J, Yang L, Beal MF, Roth RH, Matthews RT, Horvath TL
(2005) Uncoupling protein-2 is critical for nigral dopamine cell survival in a mouse model of Parkinson's disease. J. Neurosci. 25(1):184-91
Parkinson's
Stanley LA, et al.
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Stanley LA, Horsburgh BC, Ross J, Scheer N, Wolf CR
(2006) PXR and CAR: nuclear receptors which play a pivotal role in drug disposition and chemical toxicity. Drug Metab. Rev. 38(3):515-97
Plum L, et al.
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Plum L, Ma X, Hampel B, Balthasar N, Coppari R, Münzberg H, Shanabrough M, Burdakov D, Rother E, Janoschek R, Alber J, Belgardt BF, Koch L, Seibler J, Schwenk F, Fekete C, Suzuki A, Mak TW, Krone W, Horvath TL, Ashcroft FM, Brüning JC
(2006) Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity. J. Clin. Invest. 116(7):1886-901
Organisciak D, et al.
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Organisciak D, Darrow R, Gu X, Barsalou L, Crabb JW
(2006) Genetic, age and light mediated effects on crystallin protein expression in the retina. Photochem. Photobiol. 82(4):1088-96
Ma Y, et al.
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Ma Y, Hu H, Berrebi AS, Mathers PH, Agmon A
(2006) Distinct subtypes of somatostatin-containing neocortical interneurons revealed in transgenic mice. J. Neurosci. 26(19):5069-82
Lee G, et al.
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Lee G, Lo A, Short SA, Mankelow TJ, Spring F, Parsons SF, Yazdanbakhsh K, Mohandas N, Anstee DJ, Chasis JA
(2006) Targeted gene deletion demonstrates that the cell adhesion molecule ICAM-4 is critical for erythroblastic island formation. Blood 108(6):2064-71
Krimm RF
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Krimm RF
(2006) Mice lacking the p75 receptor fail to acquire a normal complement of taste buds and geniculate ganglion neurons by adulthood. Anat Rec A Discov Mol Cell Evol Biol 288(12):1294-302
Cheng S, et al.
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Cheng S, Pollock AS, Mahimkar R, Olson JL, Lovett DH
(2006) Matrix metalloproteinase 2 and basement membrane integrity: a unifying mechanism for progressive renal injury. FASEB J. 20(11):1898-900
Yaradanakul A, et al.
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Yaradanakul A, Feng S, Shen C, Lariccia V, Lin MJ, Yang J, Kang T M , Dong P, Yin HL, Albanesi JP, Hilgemann DW
(2007) Dual control of cardiac Na+ Ca2+ exchange by PIP(2): electrophysiological analysis of direct and indirect mechanisms. J. Physiol. (Lond.) 582(Pt 3):991-1010
van Herwaarden AE, et al.
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van Herwaarden AE, Wagenaar E, Beijnen JH, Smit JW, van Tellingen O, van der Valk MA, Rosing H, van der Kruijssen CM, van Waterschoot RA, Song JY, van der Hoorn JW, Schinkel AH.
(2007) Knockout of cytochrome P450 3A yields new mouse models for understanding xenobiotic metabolism J Clin Invest. 117(11):3583-92.
Woodruff ML, et al.
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Woodruff ML, Olshevskaya EV, Savchenko AB, Peshenko IV, Barrett R, Bush RA, Sieving PA, Fain GL, Dizhoor AM
(2007) Constitutive excitation by Gly90Asp rhodopsin rescues rods from degeneration caused by elevated production of cGMP in the dark. J. Neurosci. 27(33):8805-15
Thomas BB, et al.
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Thomas BB, Samant DM, Seiler MJ, Aramant RB, Sheikholeslami S, Zhang K, Chen Z, Sadda SR
(2007) Behavioral evaluation of visual function of rats using a visual discrimination apparatus. J. Neurosci. Methods 162(1-2):84-90
Thomas BB, et al.
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Thomas BB, Seiler MJ, Aramant RB, Samant D, Qiu G, Vyas N, Arai S, Chen Z, Sadda SR
(2007) Visual functional effects of constant blue light in a retinal degenerate rat model. Photochem. Photobiol. 83(3):759-65
Seibler J, et al.
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Seibler J, Kleinridders A, Küter-Luks B, Niehaves S, Brüning JC, Schwenk F
(2007) Reversible gene knockdown in mice using a tight, inducible shRNA expression system. Nucleic Acids Res. 35(7):e54
Schmitt I, et al.
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Schmitt I, Linden M, Khazneh H, Evert BO, Breuer P, Klockgether T, Wuellner U
(2007) Inactivation of the mouse Atxn3 (ataxin-3) gene increases protein ubiquitination. Biochem. Biophys. Res. Commun. 362(3):734-9
Qiu G, et al.
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Qiu G, Seiler MJ, Thomas BB, Wu K, Radosevich M, Sadda SR
(2007) Revisiting nestin expression in retinal progenitor cells in vitro and after transplantation in vivo. Exp. Eye Res. 84(6):1047-59
Peng Q, et al.
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Peng Q, Thomas BB, Aramant RB, Chen Z, Sadda SR, Seiler MJ
(2007) Structure and function of embryonic rat retinal sheet transplants. Curr. Eye Res. 32(9):781-9
Park JM, et al.
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Park JM, Kanaoka Y, Eguchi N, Aritake K, Grujic S, Materi AM, Buslon VS, Tippin BL, Kwong AM, Salido E, French SW, Urade Y, Lin HJ
(2007) Hematopoietic prostaglandin D synthase suppresses intestinal adenomas in ApcMin/+ mice. Cancer Res. 67(3):881-9
Li N, et al.
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Li N, Cui Z, Fang F, Lee JY, Ballatori N
(2007) Heterodimerization, trafficking and membrane topology of the two proteins, Ost alpha and Ost beta, that constitute the organic solute and steroid transporter. Biochem. J. 407(3):363-72
Cheatham MA, et al.
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Cheatham MA, Zheng J, Huynh KH, Du GG, Edge RM, Anderson CT, Zuo J, Ryan AF, Dallos P
(2007) Evaluation of an independent prestin mouse model derived from the 129S1 strain. Audiol. Neurootol. 12(6):378-90
Bemis JC, et al.
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Bemis JC, Alejandro NF, Nazarenko DA, Brooks AI, Baggs RB, Gasiewicz TA
(2007) TCDD-induced alterations in gene expression profiles of the developing mouse paw do not influence morphological differentiation of this potential target tissue. Toxicol. Sci. 95(1):240-8
Xu D, et al.
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Xu D, Rowland SE, Clark P, Giroux A, Côté B, Guiral S, Salem M, Ducharme Y, Friesen RW, Méthot N, Mancini J, Audoly L, Riendeau D
(2008) MF63 [2-(6-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-isophthalonitrile], a selective microsomal prostaglandin E synthase-1 inhibitor, relieves pyresis and pain in preclinical models of inflammation. J. Pharmacol. Exp. Ther. 326(3):754-63
Seiler MJ, et al.
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Seiler MJ, Thomas BB, Chen Z, Arai S, Chadalavada S, Mahoney MJ, Sadda SR, Aramant RB
(2008) BDNF-treated retinal progenitor sheets transplanted to degenerate rats: improved restoration of visual function. Exp. Eye Res. 86(1):92-104
Scheer N, et al.
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Scheer N, Ross J, Rode A, Zevnik B, Niehaves S, Faust N, Wolf CR
(2008) A novel panel of mouse models to evaluate the role of human pregnane X receptor and constitutive androstane receptor in drug response. J. Clin. Invest. 118(9):3228-39
Pettigrew LC, et al.
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Pettigrew LC, Kindy MS, Scheff S, Springer JE, Kryscio RJ, Li Y, Grass DS
(2008) Focal cerebral ischemia in the TNFalpha-transgenic rat. J Neuroinflammation 5:47
Pennesi ME, et al.
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Pennesi ME, Nishikawa S, Matthes MT, Yasumura D, LaVail MM
(2008) The relationship of photoreceptor degeneration to retinal vascular development and loss in mutant rhodopsin transgenic and RCS rats. Exp. Eye Res. 87(6):561-70
Menke DB, et al.
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Menke DB, Guenther C, Kingsley DM
(2008) Dual hindlimb control elements in the Tbx4 gene and region-specific control of bone size in vertebrate limbs. Development 135(15):2543-53
Lu H, et al.
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Lu H, Choudhuri S, Ogura K, Csanaky IL, Lei X, Cheng X, Song PZ, Klaassen CD
(2008) Characterization of organic anion transporting polypeptide 1b2-null mice: essential role in hepatic uptake/toxicity of phalloidin and microcystin-LR. Toxicol. Sci. 103(1):35-45
Koch L, et al.
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Koch L, Wunderlich FT, Seibler J, Könner AC, Hampel B, Irlenbusch S, Brabant G, Kahn CR, Schwenk F, Brüning JC
(2008) Central insulin action regulates peripheral glucose and fat metabolism in mice. J. Clin. Invest. 118(6):2132-47
Herold MJ, et al.
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Herold MJ, van den Brandt J, Seibler J, Reichardt HM
(2008) Inducible and reversible gene silencing by stable integration of an shRNA-encoding lentivirus in transgenic rats. Proc. Natl. Acad. Sci. U.S.A. 105(47):18507-12
Gwack Y, et al.
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Gwack Y, Srikanth S, Oh-Hora M, Hogan PG, Lamperti ED, Yamashita M, Gelinas C, Neems DS, Sasaki Y, Feske S, Prakriya M, Rajewsky K, Rao A
(2008) Hair loss and defective T- and B-cell function in mice lacking ORAI1. Mol. Cell. Biol. 28(17):5209-22
T And/Or B Cell Function
Gutierrez JA, et al.
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Gutierrez JA, Solenberg PJ, Perkins DR, Willency JA, Knierman MD, Jin Z, Witcher DR, Luo S, Onyia JE, Hale JE
(2008) Ghrelin octanoylation mediated by an orphan lipid transferase. Proc. Natl. Acad. Sci. U.S.A. 105(17):6320-5
Guenther C, et al.
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Guenther C, Pantalena-Filho L, Kingsley DM
(2008) Shaping skeletal growth by modular regulatory elements in the Bmp5 gene. PLoS Genet. 4(12):e1000308
Christoph T, et al.
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Christoph T, Bahrenberg G, De Vry J, Englberger W, Erdmann VA, Frech M, Kögel B, Röhl T, Schiene K, Schröder W, Seibler J, Kurreck J
(2008) Investigation of TRPV1 loss-of-function phenotypes in transgenic shRNA expressing and knockout mice. Mol. Cell. Neurosci. 37(3):579-89
shRNA-mediatred gene knock down
Chi LY, et al.
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Chi LY, Yu J, Zhu H, Li XG, Zhu SG, Kindy MS
(2008) The dual role of tumor necrosis factor-alpha in the pathophysiology of spinal cord injury. Neurosci. Lett. 438(2):174-9
Ballatori N, et al.
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Ballatori N, Fang F, Christian WV, Li N, Hammond CL
(2008) Ostalpha-Ostbeta is required for bile acid and conjugated steroid disposition in the intestine, kidney, and liver. Am. J. Physiol. Gastrointest. Liver Physiol. 295(1):G179-G186
Willuweit A, et al.
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Willuweit A, Velden J, Godemann R, Manook A, Jetzek F, Tintrup H, Kauselmann G, Zevnik B, Henriksen G, Drzezga A, Pohlner J, Schoor M, Kemp JA, von der Kammer H
(2009) Early-onset and robust amyloid pathology in a new homozygous mouse model of Alzheimer's disease. PLoS ONE 4(11):e7931
Alzheimer's
van de Steeg E, et al.
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van de Steeg E, van der Kruijssen CM, Wagenaar E, Burggraaff JE, Mesman E, Kenworthy KE, Schinkel AH
(2009) Methotrexate pharmacokinetics in transgenic mice with liver-specific expression of human organic anion-transporting polypeptide 1B1 (SLCO1B1). Drug Metab. Dispos. 37(2):277-81
van Waterschoot RA, et al.
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van Waterschoot RA, Rooswinkel RW, Wagenaar E, van der Kruijssen CM, van Herwaarden AE, Schinkel AH
(2009) Intestinal cytochrome P450 3A plays an important role in the regulation of detoxifying systems in the liver. FASEB J. 23(1):224-31
Robert A. B. van Waterschoot, et al.
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Robert A. B. van Waterschoot, Rogier W. Rooswinkel, Rolf W. Sparidans, Antonius E. van Herwaarden, Jos H. Beijnen, and Alfred H. Schinkel
(2009) Inhibition and Stimulation of Intestinal and Hepatic CYP3A Activity: Studies in Humanized CYP3A4 Transgenic Mice Using Triazolam DMD 37:2305–2313, 2009
Stanley LA, et al.
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Stanley LA, Horsburgh BC, Ross J, Scheer N, Wolf CR
(2009) Drug transporters: gatekeepers controlling access of xenobiotics to the cellular interior. Drug Metab. Rev. 41(1):27-65
Roebuck BD, et al.
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Roebuck BD, Johnson DN, Sutter CH, Egner PA, Scholl PF, Friesen MD, Baumgartner KJ, Ware NM, Bodreddigari S, Groopman JD, Kensler TW, Sutter TR
(2009) Transgenic expression of aflatoxin aldehyde reductase (AKR7A1) modulates aflatoxin B1 metabolism but not hepatic carcinogenesis in the rat. Toxicol. Sci. 109(1):41-9
Preitner F, et al.
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Preitner F, Bonny O, Laverrière A, Rotman S, Firsov D, Da Costa A, Metref S, Thorens B
(2009) Glut9 is a major regulator of urate homeostasis and its genetic inactivation induces hyperuricosuria and urate nephropathy. Proc. Natl. Acad. Sci. U.S.A. 106(36):15501-6
Ooe N, et al.
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Ooe N, Motonaga K, Kobayashi K, Saito K, Kaneko H
(2009) Functional characterization of basic helix-loop-helix-PAS type transcription factor NXF in vivo: putative involvement in an "on demand" neuroprotection system. J. Biol. Chem. 284(2):1057-63
Otto C, et al.
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Otto C, Fuchs I, Kauselmann G, Kern H, Zevnik B, Andreasen P, Schwarz G, Altmann H, Klewer M, Schoor M, Vonk R, Fritzemeier KH
(2009) GPR30 does not mediate estrogenic responses in reproductive organs in mice. Biol. Reprod. 80(1):34-41
Niel L, et al.
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Niel L, Shah AH, Lewis GA, Mo K, Chatterjee D, Fernando SM, Hong MH, Chang WY, Vollmayr P, Rosen J, Miner JN, Monks DA
(2009) Sexual differentiation of the spinal nucleus of the bulbocavernosus is not mediated solely by androgen receptors in muscle fibers. Endocrinology 150(7):3207-13
Lee HW, et al.
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Lee HW, Verlander JW, Bishop JM, Igarashi P, Handlogten ME, Weiner ID
(2009) Collecting duct-specific Rh C glycoprotein deletion alters basal and acidosis-stimulated renal ammonia excretion. Am. J. Physiol. Renal Physiol. 296(6):F1364-75
Kotnik K, et al.
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Kotnik K, Popova E, Todiras M, Mori MA, Alenina N, Seibler J, Bader M
(2009) Inducible transgenic rat model for diabetes mellitus based on shRNA-mediated gene knockdown. PLoS ONE 4(4):e5124
Kopanja D, et al.
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Kopanja D, Stoyanova T, Okur MN, Huang E, Bagchi S, Raychaudhuri P
(2009) Proliferation defects and genome instability in cells lacking Cul4A. Oncogene 28(26):2456-65
Diveu C, et al.
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Diveu C, McGeachy MJ, Boniface K, Stumhofer JS, Sathe M, Joyce-Shaikh B, Chen Y, Tato CM, McClanahan TK, de Waal Malefyt R, Hunter CA, Cua DJ, Kastelein RA
(2009) IL-27 blocks RORc expression to inhibit lineage commitment of Th17 cells. J. Immunol. 182(9):5748-56
Chabory E, et al.
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Chabory E, Damon C, Lenoir A, Kauselmann G, Kern H, Zevnik B, Garrel C, Saez F, Cadet R, Henry-Berger J, Schoor M, Gottwald U, Habenicht U, Drevet JR, Vernet P
(2009) Epididymis seleno-independent glutathione peroxidase 5 maintains sperm DNA integrity in mice. J. Clin. Invest. 119(7):2074-85
Yang R, et al.
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Yang R, Castriota G, Chen Y, Cleary MA, Ellsworth K, Shin MK, Tran JL, Vogt TF, Wu M, Xu S, Yang X, Zhang BB, Berger JP, Qureshi SA
(2011) RNAi-mediated germline knockdown of FABP4 increases body weight but does not improve the deranged nutrient metabolism of diet-induced obese mice. Int J Obes (Lond) 35(2):217-25
Evita van de Steeg, et al.
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Evita van de Steeg, Els Wagenaar, Cornelia M.M. van der Kruijssen, Johanna E.C. Burggraaff, Dirk R. de Waart, Ronald P.J. Oude Elferink, Kathryn E. Kenworthy, and Alfred H. Schinkel
(2010) Organic anion transporting polypeptide 1a/1b–knockout mice provide insights into hepatic handling of bilirubin, bile acids, and drugs J Clin Invest. 2010 Aug 2; 120(8): 2942–2952.
Beijnen JH, et al.
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Beijnen JH, Rooswinkel RW, van Waterschoot RAB, ter Heine R, Waagenar E, van der Kruijssen CMM, Huitema ADR, Schinkel AH.
(2010) Effects of cytochrome P450 3A (CYP3A) and the drug transporters P-glycoprotein (MDR1/ABCB1) and MRP2 (ABCC2) on the pharmacokinetics of lopinavirbph_759 1224..1 Br J Pharmacol. 160(5):1224-1233.
Verkoczy L, et al.
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Verkoczy L, Diaz M, Holl TM, Ouyang YB, Bouton-Verville H, Alam SM, Liao HX, Kelsoe G, Haynes BF
(2010) Autoreactivity in an HIV-1 broadly reactive neutralizing antibody variable region heavy chain induces immunologic tolerance. Proc. Natl. Acad. Sci. U.S.A. 107(1):181-6
Thomas BB, et al.
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Thomas BB, Shi D, Khine K, Kim LA, Sadda SR
(2010) Modulatory influence of stimulus parameters on optokinetic head-tracking response. Neurosci. Lett. 479(2):92-6
Seiler MJ, et al.
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Seiler MJ, Rao B, Aramant RB, Yu L, Wang Q, Kitayama E, Pham S, Yan F, Chen Z, Keirstead HS
(2010) Three-dimensional optical coherence tomography imaging of retinal sheet implants in live rats. J. Neurosci. Methods 188(2):250-7
Seibler J, et al.
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Seibler J, Schwenk F
(2010) Transgenic RNAi applications in the mouse. Meth. Enzymol. 477:367-86
Seiler MJ, et al.
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Seiler MJ, Aramant RB, Thomas BB, Peng Q, Sadda SR, Keirstead HS
(2010) Visual restoration and transplant connectivity in degenerate rats implanted with retinal progenitor sheets. Eur. J. Neurosci. 31(3):508-20
Scheer N, et al.
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Scheer N, Ross J, Kapelyukh Y, Rode A, Wolf CR
(2010) In vivo responses of the human and murine pregnane X receptor to dexamethasone in mice. Drug Metab. Dispos. 38(7):1046-53
Ross J, et al.
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Ross J, Plummer SM, Rode A, Scheer N, Bower CC, Vogel O, Henderson CJ, Wolf CR, Elcombe CR
(2010) Human constitutive androstane receptor (CAR) and pregnane X receptor (PXR) support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogens phenobarbital and chlordane in vivo. Toxicol. Sci. 116(2):452-66
Ramchandani VA, et al.
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Ramchandani VA, Umhau J, Pavon FJ, Ruiz-Velasco V, Margas W, Sun H, Damadzic R, Eskay R, Schoor M, Thorsell A, Schwandt ML, Sommer WH, George DT, Parsons LH, Herscovitch P, Hommer D, Heilig M
(2010) A genetic determinant of the striatal dopamine response to alcohol in men. Mol. Psychiatry 16(8):809-17
Ludwig A, et al.
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Ludwig A, Otto GP, Riento K, Hams E, Fallon PG, Nichols BJ
(2010) Flotillin microdomains interact with the cortical cytoskeleton to control uropod formation and neutrophil recruitment. J. Cell Biol. 191(4):771-81
Lee HW, et al.
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Lee HW, Verlander JW, Bishop JM, Nelson RD, Handlogten ME, Weiner ID
(2010) Effect of intercalated cell-specific Rh C glycoprotein deletion on basal and metabolic acidosis-stimulated renal ammonia excretion. Am. J. Physiol. Renal Physiol. 299(2):F369-79
Lang CH, et al.
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Lang CH, Frost RA, Bronson SK, Lynch CJ, Vary TC
(2010) Skeletal muscle protein balance in mTOR heterozygous mice in response to inflammation and leucine. Am. J. Physiol. Endocrinol. Metab. 298(6):E1283-94
He G, et al.
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He G, Luo W, Li P, Remmers C, Netzer WJ, Hendrick J, Bettayeb K, Flajolet M, Gorelick F, Wennogle LP, Greengard P
(2010) Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease. Nature 467(7311):95-8
Alzheimer's
Bouskila M, et al.
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Bouskila M, Hunter RW, Ibrahim AF, Delattre L, Peggie M, van Diepen JA, Voshol PJ, Jensen J, Sakamoto K
(2010) Allosteric regulation of glycogen synthase controls glycogen synthesis in muscle. Cell Metab. 12(5):456-66
Wullschleger S, et al.
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Wullschleger S, Wasserman DH, Gray A, Sakamoto K, Alessi DR
(2011) Role of TAPP1 and TAPP2 adaptor binding to PtdIns(3,4)P2 in regulating insulin sensitivity defined by knock-in analysis. Biochem. J. 434(2):265-74
Soustek MS, et al.
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Soustek MS, Falk DJ, Mah CS, Toth MJ, Schlame M, Lewin AS, Byrne BJ
(2011) Characterization of a transgenic short hairpin RNA-induced murine model of Tafazzin deficiency. Hum. Gene Ther. 22(7):865-71
Schackmann RC, et al.
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Schackmann RC, van Amersfoort M, Haarhuis JH, Vlug EJ, Halim VA, Roodhart JM, Vermaat JS, Voest EE, van der Groep P, van Diest PJ, Jonkers J, Derksen PW
(2011) Cytosolic p120-catenin regulates growth of metastatic lobular carcinoma through Rock1-mediated anoikis resistance. J. Clin. Invest. 121(8):3176-88
Pearce LR, et al.
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Pearce LR, Sommer EM, Sakamoto K, Wullschleger S, Alessi DR
(2011) Protor-1 is required for efficient mTORC2-mediated activation of SGK1 in the kidney. Biochem. J. 436(1):169-79
Out C, et al.
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Out C, Hageman J, Bloks VW, Gerrits H, Sollewijn Gelpke MD, Bos T, Havinga R, Smit MJ, Kuipers F, Groen AK
(2011) Liver receptor homolog-1 is critical for adequate up-regulation of Cyp7a1 gene transcription and bile salt synthesis during bile salt sequestration. Hepatology 53(6):2075-85
Mi S, et al.
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Mi S, Lee X, Hu Y, Ji B, Shao Z, Yang W, Huang G, Walus L, Rhodes K, Gong BJ, Miller RH, Pepinsky RB
(2011) Death receptor 6 negatively regulates oligodendrocyte survival, maturation and myelination. Nat. Med. 17(7):816-21
Kwak SP, et al.
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Kwak SP, Wang JKT, Howland DS.
(2011) Target Validation for Huntington’s Disease Neurobiology of Huntington's Disease: Applications to Drug Discovery.
Huntington’s Disease
Jordan SD, et al.
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(2011) Obesity-induced overexpression of miRNA-143 inhibits insulin-stimulated AKT activation and impairs glucose metabolism. Nat. Cell Biol. 13(4):434-46
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Inagaki A, Sleddens-Linkels E, Wassenaar E, Ooms M, van Cappellen WA, Hoeijmakers JH, Seibler J, Vogt TF, Shin MK, Grootegoed JA, Baarends WM
(2011) Meiotic functions of RAD18. J. Cell. Sci. 124(Pt 16):2837-50
Hasegawa M, et al.
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Hasegawa M, Kapelyukh Y, Tahara H, Seibler J, Rode A, Krueger S, Lee DN, Wolf CR, Scheer N
(2011) Quantitative prediction of human pregnane X receptor and cytochrome P450 3A4 mediated drug-drug interaction in a novel multiple humanized mouse line. Mol. Pharmacol. 80(3):518-28
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Gleason CE, Ordureau A, Gourlay R, Arthur JS, Cohen P
(2011) Polyubiquitin binding to optineurin is required for optimal activation of TANK-binding kinase 1 and production of interferon β. J. Biol. Chem. 286(41):35663-74
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Fre S, Hannezo E, Sale S, Huyghe M, Lafkas D, Kissel H, Louvi A, Greve J, Louvard D, Artavanis-Tsakonas S.
(2011) Notch Lineages and Activity in Intestinal Stem Cells Determined by a New Set of Knock-In Mice PLoS One. 2011; 6(10): e25785.
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Bouskila M, Esoof N, Gay L, Fang EH, Deak M, Begley MJ, Cantley LC, Prescott A, Storey KG, Alessi DR
(2011) TTBK2 kinase substrate specificity and the impact of spinocerebellar-ataxia-causing mutations on expression, activity, localization and development. Biochem. J. 437(1):157-67
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Bentz S, Pesch T, Wolfram L, de Vallière C, Leucht K, Fried M, Coy JF, Hausmann M, Rogler G
(2011) Lack of transketolase-like (TKTL) 1 aggravates murine experimental colitis. Am. J. Physiol. Gastrointest. Liver Physiol. 300(4):G598-607
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Bangs F, Antonio N, Thongnuek P, Welten M, Davey MG, Briscoe J, Tickle C
(2011) Generation of mice with functional inactivation of talpid3, a gene first identified in chicken. Development 138(15):3261-72
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Acehan D, Vaz F, Houtkooper RH, James J, Moore V, Tokunaga C, Kulik W, Wansapura J, Toth MJ, Strauss A, Khuchua Z
(2011) Cardiac and skeletal muscle defects in a mouse model of human Barth syndrome. J. Biol. Chem. 286(2):899-908
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van de Steeg E, Stránecký V, Hartmannová H, Nosková L, Hřebíček M, Wagenaar E, van Esch A, de Waart DR, Oude Elferink RP, Kenworthy KE, Sticová E, al-Edreesi M, Knisely AS, Kmoch S, Jirsa M, Schinkel AH
(2012) Complete OATP1B1 and OATP1B3 deficiency causes human Rotor syndrome by interrupting conjugated bilirubin reuptake into the liver. J. Clin. Invest. 122(2):519-28
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van de Steeg E, van Esch A, Wagenaar E, Kenworthy KE, Schinkel AH
(2012) Influence of human OATP1B1, OATP1B3, and OATP1A2 on the pharmacokinetics of methotrexate and paclitaxel in humanized transgenic mice. Clin. Cancer Res. 19(4):821-32
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Sprüssel A, Schulte JH, Weber S, Necke M, Händschke K, Thor T, Pajtler KW, Schramm A, König K, Diehl L, Mestdagh P, Vandesompele J, Speleman F, Jastrow H, Heukamp LC, Schüle R, Dührsen U, Buettner R, Eggert A, Göthert JR
(2012) Lysine-specific demethylase 1 restricts hematopoietic progenitor proliferation and is essential for terminal differentiation. Leukemia 26(9):2039-51
Leukemia
Scheer N, et al.
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Scheer N, Kapelyukh Y, Chatham L, Rode A, Buechel S, Wolf CR
(2012) Generation and characterization of novel cytochrome P450 Cyp2c gene cluster knockout and CYP2C9 humanized mouse lines. Mol. Pharmacol. 82(6):1022-9
Humanization
ADMET
Scheer N, et al.
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Scheer N, Balimane P, Hayward MD, Buechel S, Kauselmann G, Wolf CR
(2012) Generation and characterization of a novel multidrug resistance protein 2 humanized mouse line. Drug Metab. Dispos. 40(11):2212-8
Humanization
ADMET
Scheer N, et al.
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Scheer N, Kapelyukh Y, McEwan J, Beuger V, Stanley LA, Rode A, Wolf CR
(2012) Modeling human cytochrome P450 2D6 metabolism and drug-drug interaction by a novel panel of knockout and humanized mouse lines. Mol. Pharmacol. 81(1):63-72
Humanization
ADMET
Robinson LJ, et al.
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Robinson LJ, Mancarella S, Songsawad D, Tourkova IL, Barnett JB, Gill DL, Soboloff J, Blair HC
(2012) Gene disruption of the calcium channel Orai1 results in inhibition of osteoclast and osteoblast differentiation and impairs skeletal development. Lab. Invest. 92(7):1071-83
Prysyazhna O, et al.
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Prysyazhna O, Rudyk O, Eaton P
(2012) Single atom substitution in mouse protein kinase G eliminates oxidant sensing to cause hypertension. Nat. Med. 18(2):286-90
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Phoon CK, Acehan D, Schlame M, Stokes DL, Edelman-Novemsky I, Yu D, Xu Y, Viswanathan N, Ren M
(2012) Tafazzin knockdown in mice leads to a developmental cardiomyopathy with early diastolic dysfunction preceding myocardial noncompaction. J Am Heart Assoc 1(2)
shRNA-mediatred gene knock down
Cardiovascular
Miller AL, et al.
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Miller AL, Sims GP, Brewah YA, Rebelatto MC, Kearley J, Benjamin E, Keller AE, Brohawn P, Herbst R, Coyle AJ, Humbles AA, Kolbeck R
(2012) Opposing roles of membrane and soluble forms of the receptor for advanced glycation end products in primary respiratory syncytial virus infection. J. Infect. Dis. 205(8):1311-20
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Neff F, Schwaiger M, Schoor M, Manook A, Yousefi BH, Willuweit A, Platzer S, Reder S, Voss A, Huisman M, Settles M, Velden J, von der Kammer H, Wester HJ, Henriksen G, Drzezg A.
(2012) Small-Animal PET Imaging of Amyloid-Beta Plaques with [ 11C]PiB and Its Multi-Modal Validation in an APP/PS1 Mouse Model of Alzheimer’s Disease PLoS ONE 7(3): e31310.
Mayerl S, et al.
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Mayerl S, Visser TJ, Darras VM, Horn S, Heuer H
(2012) Impact of Oatp1c1 deficiency on thyroid hormone metabolism and action in the mouse brain. Endocrinology 153(3):1528-37
MacKenzie KF, et al.
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MacKenzie KF, Clark K, Naqvi S, McGuire VA, Nöehren G, Kristariyanto Y, van den Bosch M, Mudaliar M, McCarthy PC, Pattison MJ, Pedrioli PG, Barton GJ, Toth R, Prescott A, Arthur JS
(2012) PGE(2) induces macrophage IL-10 production and a regulatory-like phenotype via a protein kinase A-SIK-CRTC3 pathway. J. Immunol. 190(2):565-77
Cook DR, et al.
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Cook DR, Solski PA, Bultman SJ, Gunther Kauselmann G, Schoor M, Kuehn R, Friedman LS, Cowley DO, Van Dyke T, Yeh JJ, Johnson L, Der CJ.
(2012) The Ect2 Rho Guanine Nucleotide Exchange Factor Is Essential for Early Mouse Development and Normal Cell Cytokinesis and Migration Genes & Cancer April 19, 2012
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Stadler P, Seibler J, Schwenk F.
(2013) Industrialization of Functional Mouse Genomics Technologies for Biopharmaceutical Drug Discovery and Development Modern Biopharmaceuticals: Recent Success Stories.
Scheer N, et al.
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Scheer N, Roland Wolf C
(2013) Xenobiotic receptor humanized mice and their utility. Drug Metab. Rev. 45(1):110-21
Humanization
ADMET
Rohm M, et al.
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Rohm M, Sommerfeld A, Strzoda D, Jones A, Sijmonsma TP, Rudofsky G, Wolfrum C, Sticht C, Gretz N, Zeyda M, Leitner L, Nawroth PP, Stulnig TM, Berriel Diaz M, Vegiopoulos A, Herzig S
(2013) Transcriptional cofactor TBLR1 controls lipid mobilization in white adipose tissue. Cell Metab. 17(4):575-85
Judit Remenyi, et al.
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Judit Remenyi, Mirjam W. M. van den Bosch, Oleg Palygin, Rajen B. Mistry, Colin McKenzie, Andrew Macdonald, Gyorgy Hutvagner, J. Simon C. Arthur, Bruno G. Frenguelli, Yuriy Pankratov
(2013) miR-132/212 Knockout Mice Reveal Roles for These miRNAs in Regulating Cortical Synaptic Transmission and Plasticity PLoS ONE 8(4): e62509.
miRNA over-expression
Neuroscience
Yong-Seok Oh, et al.
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Yong-Seok Oh, Pu Gao, Ko-Woon Lee, Ilaria Ceglia, Ji-Seon Seo, Xiaozhu Zhang, Jung-Hyuck Ahn, Brian T. Chait, Dinshaw J. Patel, Yong Kim, Paul Greengard
(2013) SMARCA3, a Chromatin-Remodeling Factor, Is Required for p11-Dependent Antidepressant Action Cell , Volume 152 , Issue 4 , 831 - 843
Conditional knock out
Neuroscience
Murakami K, et al.
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Murakami K, Jiang YP, Tanaka T, Bando Y, Mitrovic B, Yoshida S
(2013) In vivo analysis of kallikrein-related peptidase 6 (KLK6) function in oligodendrocyte development and the expression of myelin proteins. Neuroscience 236:1-11
Neuroscience
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(2013) Tysnd1 deficiency in mice interferes with the peroxisomal localization of PTS2 enzymes, causing lipid metabolic abnormalities and male infertility. PLoS Genet. 9(2):e1003286
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Milenkovic D, Matic S, Kühl I, Ruzzenente B, Freyer C, Jemt E, Park CB, Falkenberg M, Larsson NG
(2013) TWINKLE is an essential mitochondrial helicase required for synthesis of nascent D-loop strands and complete mtDNA replication. Hum. Mol. Genet. 22(10):1983-93
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McMillan SJ, Sharma RS, McKenzie EJ, Richards HE, Zhang J, Prescott A, Crocker PR
(2013) Siglec-E is a negative regulator of acute pulmonary neutrophil inflammation and suppresses CD11b β2-integrin-dependent signaling. Blood 121(11):2084-94
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Law AL, Vehlow A, Kotini M, Dodgson L, Soong D, Theveneau E, Bodo C, Taylor E, Navarro C, Perera U, Michael M, Dunn GA, Bennett D, Mayor R, Krause M
(2013) Lamellipodin and the Scar/WAVE complex cooperate to promote cell migration in vivo. J. Cell Biol. 203(4):673-89
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Hughes J, Frago S, Bühnemann C, Carter EJ, Hassan AB
(2013) Maternal transmission of a humanised Igf2r allele results in an Igf2 dependent hypomorphic and non-viable growth phenotype. PLoS ONE 8(2):e57270
Humanization
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Hu Y, Lee X, Shao Z, Apicco D, Huang G, Gong BJ, Pepinsky RB, Mi S
(2013) A DR6/p75(NTR) complex is responsible for β-amyloid-induced cortical neuron death. Cell Death Dis 4:e579
Alzheimer's
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Furlan A, Lübke M, Adameyko I, Lallemend F, Ernfors P
(2013) The transcription factor Hmx1 and growth factor receptor activities control sympathetic neurons diversification. EMBO J. 32(11):1613-25
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Zhang J, Clark K, Lawrence T, Peggie MW, Cohen P
(2014) An unexpected twist to the activation of IKKβ: TAK1 primes IKKβ for activation by autophosphorylation. Biochem. J. 461(3):531-7
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Zevnik B, Uyttersprot NC, Perez AV, Bothe GW, Kern H, Kauselmann G
(2014) C57BL/6N albino/agouti mutant mice as embryo donors for efficient germline transmission of C57BL/6 ES cells. PLoS ONE 9(3):e90570
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Weber B, Schuster S, Zysset D, Rihs S, Dickgreber N, Schürch C, Riether C, Siegrist M, Schneider C, Pawelski H, Gurzeler U, Ziltener P, Genitsch V, Tacchini-Cottier F, Ochsenbein A, Hofstetter W, Kopf M, Kaufmann T, Oxenius A, Reith W, Saurer L, Mueller C
(2014) TREM-1 deficiency can attenuate disease severity without affecting pathogen clearance. PLoS Pathog. 10(1):e1003900
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Waldschmitt N, Berger E, Rath E, Sartor RB, Weigmann B, Heikenwalder M, Gerhard M, Janssen KP, Haller D
(2014) C/EBP homologous protein inhibits tissue repair in response to gut injury and is inversely regulated with chronic inflammation. Mucosal Immunol 7(6):1452-66
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Vajda F, Jordi N, Dalkara D, Joly S, Christ F, Tews B, Schwab ME, Pernet V
(2015) Cell type-specific Nogo-A gene ablation promotes axonal regeneration in the injured adult optic nerve. Cell Death Differ. 22(2):323-35
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Stubbert D, Prysyazhna O, Rudyk O, Scotcher J, Burgoyne JR, Eaton P
(2014) Protein kinase G Iα oxidation paradoxically underlies blood pressure lowering by the reductant hydrogen sulfide. Hypertension 64(6):1344-51
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Scheer N, McLaughlin LA, Rode A, Macleod AK, Henderson CJ, Wolf CR
(2014) Deletion of 30 murine cytochrome p450 genes results in viable mice with compromised drug metabolism. Drug Metab. Dispos. 42(6):1022-30
Knock out
ADMET
Salphati L, et al.
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Salphati L, Chu X, Chen L, Prasad B, Dallas S, Evers R, Mamaril-Fishman D, Geier EG, Kehler J, Kunta J, Mezler M, Laplanche L, Pang J, Rode A, Soars MG, Unadkat JD, van Waterschoot RA, Yabut J, Schinkel AH, Scheer N
(2014) Evaluation of organic anion transporting polypeptide 1B1 and 1B3 humanized mice as a translational model to study the pharmacokinetics of statins. Drug Metab. Dispos. 42(8):1301-13
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Oosting M, Cheng SC, Bolscher JM, Vestering-Stenger R, Plantinga TS, Verschueren IC, Arts P, Garritsen A, van Eenennaam H, Sturm P, Kullberg BJ, Hoischen A, Adema GJ, van der Meer JW, Netea MG, Joosten LA
(2014) Human TLR10 is an anti-inflammatory pattern-recognition receptor. Proc. Natl. Acad. Sci. U.S.A. 111(42):E4478-84
McMillan SJ, et al.
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McMillan SJ, Richards HE, Crocker PR
(2014) Siglec-F-dependent negative regulation of allergen-induced eosinophilia depends critically on the experimental model. Immunol. Lett. 160(1):11-6
Metodiev MD, et al.
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Metodiev MD, Spåhr H, Loguercio Polosa P, Meharg C, Becker C, Altmueller J, Habermann B, Larsson NG, Ruzzenente B
(2014) NSUN4 is a dual function mitochondrial protein required for both methylation of 12S rRNA and coordination of mitoribosomal assembly. PLoS Genet. 10(2):e1004110
Mayerl S, et al.
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Mayerl S, Müller J, Bauer R, Richert S, Kassmann CM, Darras VM, Buder K, Boelen A, Visser TJ, Heuer H
(2014) Transporters MCT8 and OATP1C1 maintain murine brain thyroid hormone homeostasis. J. Clin. Invest. 124(5):1987-99
Luisier R, et al.
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Luisier R, Lempiäinen H, Scherbichler N, Braeuning A, Geissler M, Dubost V, Müller A, Scheer N, Chibout SD, Hara H, Picard F, Theil D, Couttet P, Vitobello A, Grenet O, Grasl-Kraupp B, Ellinger-Ziegelbauer H, Thomson JP, Meehan RR, Elcombe CR, Henderson CJ, Wolf CR, Schwarz M, Moulin P, Terranova R, Moggs JG
(2014) Phenobarbital induces cell cycle transcriptional responses in mouse liver humanized for constitutive androstane and pregnane x receptors. Toxicol. Sci. 139(2):501-11
Humanization
ADMET
Kraus M, et al.
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Kraus M, Dolinski B, Rosahl TW, Magee JA
(2015) Protein kinase N3 deficiency impedes PI3-kinase pathway-driven leukemogenesis without affecting normal hematopoiesis. Leukemia 29(1):255-8
Leukemia
Kühl I, et al.
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Kühl I, Kukat C, Ruzzenente B, Milenkovic D, Mourier A, Miranda M, Koolmeister C, Falkenberg M, Larsson NG
(2014) POLRMT does not transcribe nuclear genes. Nature 514(7521):E7-11
Jun LS, et al.
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Jun LS, Showalter AD, Ali N, Dai F, Ma W, Coskun T, Ficorilli JV, Wheeler MB, Michael MD, Sloop KW
(2014) A novel humanized GLP-1 receptor model enables both affinity purification and Cre-LoxP deletion of the receptor. PLoS ONE 9(4):e93746
Itoh M, et al.
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Itoh M, Nakadate K, Horibata Y, Matsusaka T, Xu J, Hunziker W, Sugimoto H
(2014) The structural and functional organization of the podocyte filtration slits is regulated by Tjp1/ZO-1. PLoS ONE 9(9):e106621
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Hultin S, Zheng Y, Mojallal M, Vertuani S, Gentili C, Balland M, Milloud R, Belting HG, Affolter M, Helker CS, Adams RH, Herzog W, Uhlen P, Majumdar A, Holmgren L
(2014) AmotL2 links VE-cadherin to contractile actin fibres necessary for aortic lumen expansion. Nat Commun 5:3743
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Houde VP, Ritorto MS, Gourlay R, Varghese J, Davies P, Shpiro N, Sakamoto K, Alessi DR
(2014) Investigation of LKB1 Ser431 phosphorylation and Cys433 farnesylation using mouse knockin analysis reveals an unexpected role of prenylation in regulating AMPK activity. Biochem. J. 458(1):41-56
Hoegg-Beiler MB, et al.
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Hoegg-Beiler MB, Sirisi S, Orozco IJ, Ferrer I, Hohensee S, Auberson M, Gödde K, Vilches C, de Heredia ML, Nunes V, Estévez R, Jentsch TJ
(2014) Disrupting MLC1 and GlialCAM and ClC-2 interactions in leukodystrophy entails glial chloride channel dysfunction. Nat Commun 5:3475
Henderson CJ, et al.
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Henderson CJ, McLaren AW, Wolf CR
(2014) In vivo regulation of human glutathione transferase GSTP by chemopreventive agents. Cancer Res. 74(16):4378-87
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Hansbro PM, Hamilton MJ, Fricker M, Gellatly SL, Jarnicki AG, Zheng D, Frei SM, Wong GW, Hamadi S, Zhou S, Foster PS, Krilis SA, Stevens RL
(2014) Importance of mast cell Prss31/transmembrane tryptase/tryptase-γ in lung function and experimental chronic obstructive pulmonary disease and colitis. J. Biol. Chem. 289(26):18214-27
Edwards JP, et al.
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Edwards JP, Thornton AM, Shevach EM
(2014) Release of active TGF-β1 from the latent TGF-β1/GARP complex on T regulatory cells is mediated by integrin β8. J. Immunol. 193(6):2843-9
Charles RL, et al.
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Charles RL, Rudyk O, Prysyazhna O, Kamynina A, Yang J, Morisseau C, Hammock BD, Freeman BA, Eaton P
(2014) Protection from hypertension in mice by the Mediterranean diet is mediated by nitro fatty acid inhibition of soluble epoxide hydrolase. Proc. Natl. Acad. Sci. U.S.A. 111(22):8167-72
Knock in
Bombail V, et al.
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Bombail V, Qing W, Chapman KE, Holmes MC
(2014) Prevention of 5-hydroxytryptamine2C receptor RNA editing and alternate splicing in C57BL/6 mice activates the hypothalamic-pituitary-adrenal axis and alters mood. Eur. J. Neurosci. 40(11):3663-73
Bestas B, et al.
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(2014) Splice-correcting oligonucleotides restore BTK function in X-linked agammaglobulinemia model. J. Clin. Invest. 124(9):4067-81
Althoff K, et al.
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Althoff K, Beckers A, Bell E, Nortmeyer M, Thor T, Sprüssel A, Lindner S, De Preter K, Florin A, Heukamp LC, Klein-Hitpass L, Astrahantseff K, Kumps C, Speleman F, Eggert A, Westermann F, Schramm A, Schulte JH
(2015) A Cre-conditional MYCN-driven neuroblastoma mouse model as an improved tool for preclinical studies. Oncogene 34(26):3357-68
Targeted transgenic
Oncology
van Herwaarden AE, et al.
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van Herwaarden AE, Smit JW, Sparidans RW, Wagenaar E, van der Kruijssen CM, Schellens JH, Beijnen JH, Schinkel AH
(2005) Midazolam and cyclosporin a metabolism in transgenic mice with liver-specific expression of human CYP3A4. Drug Metab. Dispos. 33(7):892-5
Vlaming ML, et al.
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Vlaming ML, Mohrmann K, Wagenaar E, de Waart DR, Elferink RP, Lagas JS, van Tellingen O, Vainchtein LD, Rosing H, Beijnen JH, Schellens JH, Schinkel AH
(2006) Carcinogen and anticancer drug transport by Mrp2 in vivo: studies using Mrp2 (Abcc2) knockout mice. J. Pharmacol. Exp. Ther. 318(1):319-27
Knock out
ADMET