Author(s) |
(Date) |
Paper Title |
Citation |
Model Type |
Applications |
Full Text |
Lang J, et al. Mouse over for full list |
(2020) | Acid ceramidase of macrophages traps herpes simplex virus in multivesicular bodies and protects from severe disease. | Nat Commun 11(1):1338 | |||
Huynh TV, et al. Mouse over for full list |
(2019) | Lack of hepatic apoE does not influence early Aβ deposition: observations from a new APOE knock-in model. | Mol Neurodegener 14(1):37 | Alzheimer's | ||
Wosnitzka E, et al. Mouse over for full list |
(2020) | A New Mouse Line Reporting the Translation of Brain-Derived Neurotrophic Factor Using Green Fluorescent Protein. | eNeuro 7(1) | |||
Bouteau A, et al. Mouse over for full list |
(2019) | DC Subsets Regulate Humoral Immune Responses by Supporting the Differentiation of Distinct Tfh Cells. | Front Immunol 10:1134 | T And/Or B Cell Function | ||
Svensson KA, et al. Mouse over for full list |
(2017) | An Allosteric Potentiator of the Dopamine D1 Receptor Increases Locomotor Activity in Human D1 Knock-In Mice without Causing Stereotypy or Tachyphylaxis. | J. Pharmacol. Exp. Ther. 360(1):117-128 | Neuroscience | ||
Zhao HT, et al. Mouse over for full list |
(2018) | PMP22 antisense oligonucleotides reverse Charcot-Marie-Tooth disease type 1A features in rodent models. | J. Clin. Invest. 128(1):359-368 | Neuroscience | ||
Malinverno M, et al. Mouse over for full list |
(2019) | Endothelial cell clonal expansion in the development of cerebral cavernous malformations. | Nat Commun 10(1):2761 | |||
Rudyk O, et al. Mouse over for full list |
(2019) | Oxidation of PKGIα mediates an endogenous adaptation to pulmonary hypertension. | Proc. Natl. Acad. Sci. U.S.A. | Cardiovascular | ||
Kuehm LM, et al. Mouse over for full list |
(2019) | Checkpoint blockade immunotherapy enhances the frequency and effector function of murine tumor-infiltrating T cells but does not alter TCRβ diversity. | Cancer Immunol. Immunother. | T And/Or B Cell Function, Immunotherapy, Melanoma | ||
Kumawat K, et al. Mouse over for full list |
(2019) | LAIR-1 Limits Neutrophilic Airway Inflammation. | Front Immunol 10:842 | |||
Ahmad ST, et al. Mouse over for full list |
(2019) | Capicua regulates neural stem cell proliferation and lineage specification through control of Ets factors. | Nat Commun 10(1):2000 | Neuroscience, Oncology | ||
Abed M, et al. Mouse over for full list |
(2019) | The Gag protein PEG10 binds to RNA and regulates trophoblast stem cell lineage specification. | PLoS ONE 14(4):e0214110 | Development | ||
Bilanges B, et al. Mouse over for full list |
(2017) | Vps34 PI 3-kinase inactivation enhances insulin sensitivity through reprogramming of mitochondrial metabolism. | Nat Commun 8(1):1804 | Diabetes (Type 2) | ||
Stavrou S, et al. Mouse over for full list |
(2018) | DDX41 Recognizes RNA/DNA Retroviral Reverse Transcripts and Is Critical for In Vivo Control of Murine Leukemia Virus Infection | MBio 9(3) | Virology | ||
Aden K, et al. Mouse over for full list |
(2018) | ATG16L1 orchestrates interleukin-22 signaling in the intestinal epithelium via cGAS-STING. | J. Exp. Med. 215(11):2868-2886 | Gastrointestinal, Inflammation | ||
Zieger K, et al. Mouse over for full list |
(2018) | Ablation of kallikrein 7 (KLK7) in adipose tissue ameliorates metabolic consequences of high fat diet-induced obesity by counteracting adipose tissue inflammation in vivo. | Cell. Mol. Life Sci. 75(4):727-742 | Conditional knock out |
Metabolism | |
Hossain DMS, et al. Mouse over for full list |
(2018) | Dinaciclib induces immunogenic cell death and enhances anti-PD1-mediated tumor suppression. | J. Clin. Invest. 128(2):644-654 | CRISPR/Cas9 |
Immuno-Oncology | |
Sanclemente M, et al. Mouse over for full list |
(2018) | c-RAF Ablation Induces Regression of Advanced Kras/Trp53 Mutant Lung Adenocarcinomas by a Mechanism Independent of MAPK Signaling. | Cancer Cell 33(2):217-228.e4 | CRISPR/Cas9 |
Oncology, Lung Cancer | |
Uddin M, et al. Mouse over for full list |
(2018) | OTUD7A Regulates Neurodevelopmental Phenotypes in the 15q13.3 Microdeletion Syndrome. | Am. J. Hum. Genet. 102(2):278-295 | Knock out |
Neuroscience | |
McWilliams TG, et al. Mouse over for full list |
(2018) | Basal Mitophagy Occurs Independently of PINK1 in Mouse Tissues of High Metabolic Demand. | Cell Metab. 27(2):439-449.e5 | Targeted transgenic |
General | |
Berenjeno IM, et al. Mouse over for full list |
(2017) | Oncogenic PIK3CA induces centrosome amplification and tolerance to genome doubling. | Nat Commun 8(1):1773 | Conditional knock in |
Oncology | |
Johnston DGW, et al. Mouse over for full list |
(2017) | MicroRNA-21 Limits Uptake of Listeria monocytogenes by Macrophages to Reduce the Intracellular Niche and Control Infection. | Front Cell Infect Microbiol 7:201 | Conditional knock out |
Immunology | |
Qvist P, et al. Mouse over for full list |
(2017) | Mice heterozygous for an inactivated allele of the schizophrenia associated Brd1 gene display selective cognitive deficits with translational relevance to schizophrenia. | Neurobiol Learn Mem 141:44-52 | Knock out |
Neuroscience | |
Zhang Z, et al. Mouse over for full list |
(2017) | Macrophage 11β-HSD-1 deficiency promotes inflammatory angiogenesis. | J. Endocrinol. 234(3):291-299 | Conditional knock out |
Cardiovascular, Immunology | |
Zaccagnini G, et al. Mouse over for full list |
(2017) | Overexpression of miR-210 and its significance in ischemic tissue damage. | Sci Rep 7(1):9563 | miRNA over-expression |
Cardiovascular | |
McMahon M, et al. Mouse over for full list |
(2017) | Measuring in vivo responses to endogenous and exogenous oxidative stress using a novel Heme Oxygenase 1 reporter mouse. | J. Physiol. (Lond.) | Knock in |
Metabolism | |
Schenk RL, et al. Mouse over for full list |
(2017) | Characterisation of mice lacking all functional isoforms of the pro-survival BCL-2 family member A1 reveals minor defects in the haematopoietic compartment. | Cell Death Differ. 24(3):534-545 | Conditional knock out |
Cardiovascular, Hematopoietic Stem Cell Engraftment | |
Li H, et al. Mouse over for full list |
(2011) | In vivo genome editing restores haemostasis in a mouse model of haemophilia. | Nature 475(7355):217-21 | Targeted transgenic |
Gene/Cell therapy | |
Denechaud PD, et al. Mouse over for full list |
(2016) | E2F1 mediates sustained lipogenesis and contributes to hepatic steatosis. | J. Clin. Invest. 126(1):137-50 | Conditional knock out |
Metabolism | |
Metzger MW, et al. Mouse over for full list |
(2017) | Genetically dissecting P2rx7 expression within the central nervous system using conditional humanized mice. | Purinergic Signal. 13(2):153-170 | Targeted transgenic |
Development | |
Steinbusch LK, et al. Mouse over for full list |
(2016) | Sex-Specific Control of Fat Mass and Counterregulation by Hypothalamic Glucokinase. | Diabetes 65(10):2920-31 | Conditional knock out |
Metabolism, Neuroscience | |
Nanda SK, et al. Mouse over for full list |
(2016) | Suppression of IRAK1 or IRAK4 Catalytic Activity, but Not Type 1 IFN Signaling, Prevents Lupus Nephritis in Mice Expressing a Ubiquitin Binding-Defective Mutant of ABIN1. | J. Immunol. 197(11):4266-4273 | Knock in |
Inflammation | |
Si S, et al. Mouse over for full list |
(2016) | Loss of Pcgf5 Affects Global H2A Monoubiquitination but Not the Function of Hematopoietic Stem and Progenitor Cells. | PLoS ONE 11(5):e0154561 | Targeted transgenic |
Development | |
Qvist P, et al. Mouse over for full list |
(2016) | The Schizophrenia-Associated BRD1 Gene Regulates Behavior, Neurotransmission, and Expression of Schizophrenia Risk Enriched Gene Sets in Mice. | Biol. Psychiatry | Conditional knock out |
Neuroscience | |
Redelinghuys P, et al. Mouse over for full list |
(2016) | MICL controls inflammation in rheumatoid arthritis. | Ann. Rheum. Dis. 75(7):1386-91 | Conditional knock out |
Inflammation | |
Liput DJ, et al. Mouse over for full list |
(2016) | Rem2, a member of the RGK family of small GTPases, is enriched in nuclei of the basal ganglia. | Sci Rep 6:25137 | Conditional knock out |
Neuroscience, Development | |
Kim J, et al. Mouse over for full list |
(2016) | Ablation of miR-10b Suppresses Oncogene-Induced Mammary Tumorigenesis and Metastasis and Reactivates Tumor-Suppressive Pathways. | Cancer Res. 76(21):6424-6435 | Conditional knock out |
Oncology | |
Oshima M, et al. Mouse over for full list |
(2016) | Ezh2 regulates the Lin28/let-7 pathway to restrict activation of fetal gene signature in adult hematopoietic stem cells. | Exp. Hematol. 44(4):282-96.e3 | Development | ||
Szczepanek K, et al. Mouse over for full list |
(2016) | Acquired deficiency of tafazzin in the adult heart: Impact on mitochondrial function and response to cardiac injury. | Biochim. Biophys. Acta 1861(4):294-300 | shRNA-mediatred gene knock down |
Cardiovascular | |
Ito G, et al. Mouse over for full list |
(2016) | Phos-tag analysis of Rab10 phosphorylation by LRRK2: a powerful assay for assessing kinase function and inhibitors. | Biochem. J. 473(17):2671-85 | Knock in |
Parkinson's | |
Connell JW, et al. Mouse over for full list |
(2016) | Quantitative Gait Analysis Using a Motorized Treadmill System Sensitively Detects Motor Abnormalities in Mice Expressing ATPase Defective Spastin. | PLoS ONE 11(3):e0152413 | Knock in |
Neuroscience | |
McMahon M, et al. Mouse over for full list |
(2016) | Olaparib, Monotherapy or with Ionizing Radiation, Exacerbates DNA Damage in Normal Tissues: Insights from a New p21 Reporter Mouse. | Mol. Cancer Res. 14(12):1195-1203 | Knock in |
Tox & Safety Assessment | |
Tanaka K, et al. Mouse over for full list |
(2016) | Death Domain Signaling by Disulfide-Linked Dimers of the p75 Neurotrophin Receptor Mediates Neuronal Death in the CNS. | J. Neurosci. 36(20):5587-95 | Knock in |
Development | |
Mangels N, et al. Mouse over for full list |
(2016) | The soluble epoxide hydrolase determines cholesterol homeostasis by regulating AMPK and SREBP activity. | Prostaglandins Other Lipid Mediat. 125:30-9 | Conditional knock out |
Metabolism | |
MacLeod AK, et al. Mouse over for full list |
(2017) | Application of Mice Humanized for CYP2D6 to the Study of Tamoxifen Metabolism and Drug-Drug Interaction with Antidepressants. | Drug Metab. Dispos. 45(1):17-22 | Humanization |
ADMET | |
Li K, et al. Mouse over for full list |
(2017) | Mouse-adapted MERS coronavirus causes lethal lung disease in human DPP4 knockin mice. | Proc. Natl. Acad. Sci. U.S.A. 114(15):E3119-E3128 | Humanization |
Infectious Disease | |
Alliegro M, et al. Mouse over for full list |
(2016) | Low-dose Gene Therapy Reduces the Frequency of Enzyme Replacement Therapy in a Mouse Model of Lysosomal Storage Disease. | Mol. Ther. 24(12):2054-2063 | Targeted transgenic |
Gene/Cell therapy | |
Ferla R, et al. Mouse over for full list |
(2014) | Similar therapeutic efficacy between a single administration of gene therapy and multiple administrations of recombinant enzyme in a mouse model of lysosomal storage disease. | Hum. Gene Ther. 25(7):609-18 | Targeted transgenic |
Gene/Cell therapy | |
Strickson S, et al. Mouse over for full list |
(2017) | Roles of the TRAF6 and Pellino E3 ligases in MyD88 and RANKL signaling. | Proc. Natl. Acad. Sci. U.S.A. 114(17):E3481-E3489 | Knock out |
Immunology | |
Falkevall A, et al. Mouse over for full list |
(2017) | Reducing VEGF-B Signaling Ameliorates Renal Lipotoxicity and Protects against Diabetic Kidney Disease. | Cell Metab. 25(3):713-726 | Conditional knock out |
Metabolic Syndrome | |
Liu P, et al. Mouse over for full list |
(2017) | Loss of menin in osteoblast lineage affects osteocyte-osteoclast crosstalk causing osteoporosis. | Cell Death Differ. 24(4):672-682 | Targeted transgenic |
||
Liu Y, et al. Mouse over for full list |
(2017) | Latexin Inactivation Enhances Survival and Long-Term Engraftment of Hematopoietic Stem Cells and Expands the Entire Hematopoietic System in Mice. | Stem Cell Reports 8(4):991-1004 | Conditional knock out |
Stem Cells/Regenerative Medicine/Tissue Engineering | |
Han H, et al. Mouse over for full list |
(2017) | Angiomotin-like 2 interacts with and negatively regulates AKT. | Oncogene | Conditional knock out |
Oncology | |
Smith CW, et al. Mouse over for full list |
(2017) | Mice Lacking the Inhibitory Collagen Receptor LAIR-1 Exhibit a Mild Thrombocytosis and Hyperactive Platelets. | Arterioscler. Thromb. Vasc. Biol. 37(5):823-835 | Knock out |
||
Petit EI, et al. Mouse over for full list |
(2017) | Dysregulation of Specialized Delay/Interference-Dependent Working Memory Following Loss of Dysbindin-1A in Schizophrenia-Related Phenotypes. | Neuropsychopharmacology 42(6):1349-1360 | Neuroscience | ||
Ly JQ, et al. Mouse over for full list |
(2017) | Utility of CYP3A4 and PXR-CAR-CYP3A4/3A7 Transgenic Mouse Models To Assess the Magnitude of CYP3A4 Mediated Drug-Drug Interactions. | Mol. Pharm. 14(5):1754-1759 | Humanization |
Tox & Safety Assessment | |
Sergaki MC, et al. Mouse over for full list |
(2017) | GFRα1 Regulates Purkinje Cell Migration by Counteracting NCAM Function. | Cell Rep 18(2):367-379 | Knock in |
||
Darling NJ, et al. Mouse over for full list |
(2017) | Inhibition of SIK2 and SIK3 during differentiation enhances the anti-inflammatory phenotype of macrophages. | Biochem. J. 474(4):521-537 | Knock in |
Immunology | |
Daumas S, et al. Mouse over for full list |
(2017) | The Kinase Function of MSK1 Regulates BDNF Signaling to CREB and Basal Synaptic Transmission, But Is Not Required for Hippocampal Long-Term Potentiation or Spatial Memory. | eNeuro 4(1) | Knock in |
Neuroscience | |
You L, et al. Mouse over for full list |
(2015) | Deficiency of the chromatin regulator BRPF1 causes abnormal brain development. | J. Biol. Chem. 290(11):7114-29 | Knock out |
Neuroscience | |
Valkova C, et al. Mouse over for full list |
(2017) | The sorting receptor Rer1 controls Purkinje cell function via voltage gated sodium channels. | Sci Rep 7:41248 | Conditional knock out |
Neuroscience | |
Hu J, et al. Mouse over for full list |
(2017) | Prostaglandins and Other Lipid Mediators (POLM), Special Issue of the 6th European workshop on lipid mediators: Role of Müller cell cytochrome P450 2c44 in murine retinal angiogenesis. | Prostaglandins Other Lipid Mediat. | Conditional knock out |
Cardiovascular | |
Chou AM, et al. Mouse over for full list |
(2017) | Redundant functions of I-BAR family members, IRSp53 and IRTKS, are essential for embryonic development. | Sci Rep 7:40485 | Conditional knock out |
Development | |
Marialuisa Alliegro, et al. Mouse over for full list |
(2016) | Low-dose Gene Therapy Reduces the Frequency of Enzyme Replacement Therapy in a Mouse Model of Lysosomal Storage Disease | Molecular Therapy; 24 12, 2054–2063. doi:10.1038/mt.2016.181 | Targeted transgenic |
||
Kornfeld JW, et al. Mouse over for full list |
(2013) | Obesity-induced overexpression of miR-802 impairs glucose metabolism through silencing of Hnf1b. | Nature 494(7435):111-5 | Metabolism | ||
Gebeshuber CA, et al. Mouse over for full list |
(2013) | Focal segmental glomerulosclerosis is induced by microRNA-193a and its downregulation of WT1. | Nat. Med. 19(4):481-7 | |||
Vink PM, et al. Mouse over for full list |
(2013) | In vivo knockdown of TAK1 accelerates bone marrow proliferation/differentiation and induces systemic inflammation. | PLoS ONE 8(3):e57348 | Inflammation | ||
Michalak EM, et al. Mouse over for full list |
(2013) | Polycomb group gene Ezh2 regulates mammary gland morphogenesis and maintains the luminal progenitor pool. | Stem Cells 31(9):1910-20 | |||
Gerrits H, et al. Mouse over for full list |
(2014) | Reversible infertility in a liver receptor homologue-1 (LRH-1)-knockdown mouse model. | Reprod. Fertil. Dev. 26(2):293-306 | |||
Molenaar JJ, et al. Mouse over for full list |
(2012) | LIN28B induces neuroblastoma and enhances MYCN levels via let-7 suppression. | Nat. Genet. 44(11):1199-206 | Targeted transgenic |
Oncology | |
Scheer N, et al. Mouse over for full list |
(2013) | Generation and utility of genetically humanized mouse models. | Drug Discov. Today 18(23-24):1200-11 | Humanization |
||
Scheer N, et al. Mouse over for full list |
(2014) | Genetically humanized mouse models of drug metabolizing enzymes and transporters and their applications. | Xenobiotica 44(2):96-108 | Humanization |
ADMET | |
Guo T, et al. Mouse over for full list |
(2014) | Adipocyte ALK7 links nutrient overload to catecholamine resistance in obesity. | Elife 3:e03245 | Metabolism | ||
Smeets MF, et al. Mouse over for full list |
(2014) | The Rothmund-Thomson syndrome helicase RECQL4 is essential for hematopoiesis. | J. Clin. Invest. 124(8):3551-65 | Knock in |
Hematopoietic Stem Cell Engraftment | |
Maddaluno L, et al. Mouse over for full list |
(2013) | EndMT contributes to the onset and progression of cerebral cavernous malformations. | Nature 498(7455):492-6 | |||
Didriksen M, et al. Mouse over for full list |
(2016) | Persistent gating deficit and increased sensitivity to NMDA receptor antagonism after puberty in a new mouse model of the human 22q11.2 microdeletion syndrome: a study in male mice. | J Psychiatry Neurosci 41(5):150381 | Knock out |
Behavior, Neuroscience | |
Thelin J, et al. Mouse over for full list |
(2016) | The translationally relevant mouse model of the 15q13.3 microdeletion syndrome reveals deficits in neuronal spike firing matching clinical neurophysiological biomarkers seen in schizophrenia. | Acta Physiol (Oxf) | Knock out |
Behavior, Neuroscience | |
Nilsson SR, et al. Mouse over for full list |
(2016) | A mouse model of the 15q13.3 microdeletion syndrome shows prefrontal neurophysiological dysfunctions and attentional impairment. | Psychopharmacology (Berl.) 233(11):2151-63 | Knock out |
Neuroscience | |
Gass N, et al. Mouse over for full list |
(2016) | An acetylcholine alpha7 positive allosteric modulator rescues a schizophrenia-associated brain endophenotype in the 15q13.3 microdeletion, encompassing CHRNA7. | Eur Neuropsychopharmacol 26(7):1150-60 | Knock out |
Behavior | |
Feith DJ, et al. Mouse over for full list |
(2001) | Targeted antizyme expression in the skin of transgenic mice reduces tumor promoter induction of ornithine decarboxylase and decreases sensitivity to chemical carcinogenesis. | Cancer Res. 61(16):6073-81 | |||
Ziegler SF, et al. Mouse over for full list |
(2001) | Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. | Nat. Genet. 27(1):68-73 | |||
Asamoto M, et al. Mouse over for full list |
(2001) | Prostate carcinomas developing in transgenic rats with SV40 T antigen expression under probasin promoter control are strictly androgen dependent. | Cancer Res. 61(12):4693-700 | |||
Tanemura K, et al. Mouse over for full list |
(2002) | Neurodegeneration with tau accumulation in a transgenic mouse expressing V337M human tau. | J. Neurosci. 22(1):133-41 | Alzheimer's | ||
Sakata Y, et al. Mouse over for full list |
(2002) | Ventricular septal defect and cardiomyopathy in mice lacking the transcription factor CHF1/Hey2. | Proc. Natl. Acad. Sci. U.S.A. 99(25):16197-202 | |||
Wagenaar E, et al. Mouse over for full list |
(2002) | The breast cancer resistance protein protects against a major chlorophyll-derived dietary phototoxin and protoporphyria | Proc Natl Acad Sci USA. 99(24):15649-54. | Breast Cancer | ||
Engle SJ, et al. Mouse over for full list |
(2002) | Elimination of colon cancer in germ-free transforming growth factor beta 1-deficient mice. | Cancer Res. 62(22):6362-6 | Colon Cancer | ||
Eggan K, et al. Mouse over for full list |
(2002) | Male and female mice derived from the same embryonic stem cell clone by tetraploid embryo complementation. | Nat. Biotechnol. 20(5):455-9 | Stem Cells/Regenerative Medicine/Tissue Engineering | ||
Asamoto M, et al. Mouse over for full list |
(2002) | Effects of genetic background on prostate and taste bud carcinogenesis due to SV40 T antigen expression under probasin gene promoter control. | Carcinogenesis 23(3):463-7 | |||
Andreas S, et al. Mouse over for full list |
(2002) | Enhanced efficiency through nuclear localization signal fusion on phage PhiC31-integrase: activity comparison with Cre and FLPe recombinase in mammalian cells. | Nucleic Acids Res. 30(11):2299-306 | |||
Anderson RE, et al. Mouse over for full list |
(2002) | Low docosahexaenoic acid levels in rod outer segments of rats with P23H and S334ter rhodopsin mutations. | Mol. Vis. 8:351-8 | |||
Zhang Y, et al. Mouse over for full list |
(2003) | Accumulation of neurocan, a brain chondroitin sulfate proteoglycan, in association with the retinal vasculature in RCS rats. | Invest. Ophthalmol. Vis. Sci. 44(3):1252-61 | |||
Zhang Y, et al. Mouse over for full list |
(2003) | Limitation of anatomical integration between subretinal transplants and the host retina. | Invest. Ophthalmol. Vis. Sci. 44(1):324-31 | |||
Yu C, et al. Mouse over for full list |
(2003) | Osteocyte control of bone formation via sclerostin, a novel BMP antagonist. | EMBO J. 22(23):6267-76 | |||
Tietge UJ, et al. Mouse over for full list |
(2003) | Acute inflammation increases selective uptake of HDL cholesteryl esters into adrenals of mice overexpressing human sPLA2. | Am. J. Physiol. Endocrinol. Metab. 285(2):E403-11 | |||
Stricklett PK, et al. Mouse over for full list |
(2003) | Thick ascending limb-specific expression of Cre recombinase. | Am. J. Physiol. Renal Physiol. 285(1):F33-9 | |||
Seibler J, et al. Mouse over for full list |
(2003) | Rapid generation of inducible mouse mutants. | Nucleic Acids Res. 31(4):e12 | |||
Schwenk F, et al. Mouse over for full list |
(2003) | Hybrid embryonic stem cell-derived tetraploid mice show apparently normal morphological, physiological, and neurological characteristics. | Mol. Cell. Biol. 23(11):3982-9 | |||
Sagdullaev BT, et al. Mouse over for full list |
(2003) | Retinal transplantation-induced recovery of retinotectal visual function in a rodent model of retinitis pigmentosa. | Invest. Ophthalmol. Vis. Sci. 44(4):1686-95 | |||
Phan TG, et al. Mouse over for full list |
(2003) | B cell receptor-independent stimuli trigger immunoglobulin (Ig) class switch recombination and production of IgG autoantibodies by anergic self-reactive B cells. | J. Exp. Med. 197(7):845-60 | |||
Lozano J, et al. Mouse over for full list |
(2003) | Deficiency of kinase suppressor of Ras1 prevents oncogenic ras signaling in mice. | Cancer Res. 63(14):4232-8 | |||
Lee JH, et al. Mouse over for full list |
(2003) | The neuronal adaptor protein X11alpha reduces Abeta levels in the brains of Alzheimer's APPswe Tg2576 transgenic mice. | J. Biol. Chem. 278(47):47025-9 | Alzheimer's | ||
Kühn R, et al. Mouse over for full list |
(2003) | Conditional knockout mice. | Methods Mol. Biol. 209:159-85 | |||
Wagenaar E, et al. Mouse over for full list |
(2003) | Deficiency in the Organic Cation Transporters 1 and 2 (Oct1/Oct2 [Slc22a1/Slc22a2]) in Mice Abolishes Renal Secretion of Organic Cations | Mol Cell Biol. 23(21):7902-7908. | |||
Czipri M, et al. Mouse over for full list |
(2003) | Genetic rescue of chondrodysplasia and the perinatal lethal effect of cartilage link protein deficiency. | J. Biol. Chem. 278(40):39214-23 | |||
Crocker SJ, et al. Mouse over for full list |
(2003) | Attenuation of MPTP-induced neurotoxicity and behavioural impairment in NSE-XIAP transgenic mice. | Neurobiol. Dis. 12(2):150-61 | |||
Zhang W, et al. Mouse over for full list |
(2004) | Differential regulation of the human CYP3A4 promoter in transgenic mice and rats. | Drug Metab. Dispos. 32(2):163-7 | |||
Otani K, et al. Mouse over for full list |
(2004) | Calpain system regulates muscle mass and glucose transporter GLUT4 turnover. | J. Biol. Chem. 279(20):20915-20 | |||
Lee JH, et al. Mouse over for full list |
(2004) | The neuronal adaptor protein X11beta reduces amyloid beta-protein levels and amyloid plaque formation in the brains of transgenic mice. | J. Biol. Chem. 279(47):49099-104 | |||
Hess JF, et al. Mouse over for full list |
(2004) | Generation and characterization of a human bradykinin receptor B1 transgenic rat as a pharmacodynamic model. | J. Pharmacol. Exp. Ther. 310(2):488-97 | |||
Griffin KJ, et al. Mouse over for full list |
(2004) | Down-regulation of regulatory subunit type 1A of protein kinase A leads to endocrine and other tumors. | Cancer Res. 64(24):8811-5 | Humanization |
Oncology | |
García-Martínez LF, et al. Mouse over for full list |
(2004) | A novel mutation in CD83 results in the development of a unique population of CD4+ T cells. | J. Immunol. 173(5):2995-3001 | |||
Finkle D, et al. Mouse over for full list |
(2004) | HER2-targeted therapy reduces incidence and progression of midlife mammary tumors in female murine mammary tumor virus huHER2-transgenic mice. | Clin. Cancer Res. 10(7):2499-511 | |||
Butler AE, et al. Mouse over for full list |
(2004) | Diabetes due to a progressive defect in beta-cell mass in rats transgenic for human islet amyloid polypeptide (HIP Rat): a new model for type 2 diabetes. | Diabetes 53(6):1509-16 | Autoimmune | ||
Seibler J, et al. Mouse over for full list |
(2005) | Single copy shRNA configuration for ubiquitous gene knockdown in mice. | Nucleic Acids Res. 33(7):e67 | |||
Jonker JW, et al. Mouse over for full list |
(2005) | Contribution of the ABC transporters Bcrp1 and Mdr1a/1b to the side population phenotype in mammary gland and bone marrow of mice. | Stem Cells 23(8):1059-65 | Stem Cells/Regenerative Medicine/Tissue Engineering | ||
Irvine RA, et al. Mouse over for full list |
(2005) | Generation and characterization of endonuclease G null mice. | Mol. Cell. Biol. 25(1):294-302 | |||
Andrews ZB, et al. Mouse over for full list |
(2005) | Uncoupling protein-2 is critical for nigral dopamine cell survival in a mouse model of Parkinson's disease. | J. Neurosci. 25(1):184-91 | Parkinson's | ||
Stanley LA, et al. Mouse over for full list |
(2006) | PXR and CAR: nuclear receptors which play a pivotal role in drug disposition and chemical toxicity. | Drug Metab. Rev. 38(3):515-97 | |||
Plum L, et al. Mouse over for full list |
(2006) | Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity. | J. Clin. Invest. 116(7):1886-901 | |||
Organisciak D, et al. Mouse over for full list |
(2006) | Genetic, age and light mediated effects on crystallin protein expression in the retina. | Photochem. Photobiol. 82(4):1088-96 | |||
Ma Y, et al. Mouse over for full list |
(2006) | Distinct subtypes of somatostatin-containing neocortical interneurons revealed in transgenic mice. | J. Neurosci. 26(19):5069-82 | |||
Lee G, et al. Mouse over for full list |
(2006) | Targeted gene deletion demonstrates that the cell adhesion molecule ICAM-4 is critical for erythroblastic island formation. | Blood 108(6):2064-71 | |||
Krimm RF Mouse over for full list |
(2006) | Mice lacking the p75 receptor fail to acquire a normal complement of taste buds and geniculate ganglion neurons by adulthood. | Anat Rec A Discov Mol Cell Evol Biol 288(12):1294-302 | |||
Cheng S, et al. Mouse over for full list |
(2006) | Matrix metalloproteinase 2 and basement membrane integrity: a unifying mechanism for progressive renal injury. | FASEB J. 20(11):1898-900 | |||
Yaradanakul A, et al. Mouse over for full list |
(2007) | Dual control of cardiac Na+ Ca2+ exchange by PIP(2): electrophysiological analysis of direct and indirect mechanisms. | J. Physiol. (Lond.) 582(Pt 3):991-1010 | |||
van Herwaarden AE, et al. Mouse over for full list |
(2007) | Knockout of cytochrome P450 3A yields new mouse models for understanding xenobiotic metabolism | J Clin Invest. 117(11):3583-92. | |||
Woodruff ML, et al. Mouse over for full list |
(2007) | Constitutive excitation by Gly90Asp rhodopsin rescues rods from degeneration caused by elevated production of cGMP in the dark. | J. Neurosci. 27(33):8805-15 | |||
Thomas BB, et al. Mouse over for full list |
(2007) | Behavioral evaluation of visual function of rats using a visual discrimination apparatus. | J. Neurosci. Methods 162(1-2):84-90 | |||
Thomas BB, et al. Mouse over for full list |
(2007) | Visual functional effects of constant blue light in a retinal degenerate rat model. | Photochem. Photobiol. 83(3):759-65 | |||
Seibler J, et al. Mouse over for full list |
(2007) | Reversible gene knockdown in mice using a tight, inducible shRNA expression system. | Nucleic Acids Res. 35(7):e54 | |||
Schmitt I, et al. Mouse over for full list |
(2007) | Inactivation of the mouse Atxn3 (ataxin-3) gene increases protein ubiquitination. | Biochem. Biophys. Res. Commun. 362(3):734-9 | |||
Qiu G, et al. Mouse over for full list |
(2007) | Revisiting nestin expression in retinal progenitor cells in vitro and after transplantation in vivo. | Exp. Eye Res. 84(6):1047-59 | |||
Peng Q, et al. Mouse over for full list |
(2007) | Structure and function of embryonic rat retinal sheet transplants. | Curr. Eye Res. 32(9):781-9 | |||
Park JM, et al. Mouse over for full list |
(2007) | Hematopoietic prostaglandin D synthase suppresses intestinal adenomas in ApcMin/+ mice. | Cancer Res. 67(3):881-9 | |||
Li N, et al. Mouse over for full list |
(2007) | Heterodimerization, trafficking and membrane topology of the two proteins, Ost alpha and Ost beta, that constitute the organic solute and steroid transporter. | Biochem. J. 407(3):363-72 | |||
Cheatham MA, et al. Mouse over for full list |
(2007) | Evaluation of an independent prestin mouse model derived from the 129S1 strain. | Audiol. Neurootol. 12(6):378-90 | |||
Bemis JC, et al. Mouse over for full list |
(2007) | TCDD-induced alterations in gene expression profiles of the developing mouse paw do not influence morphological differentiation of this potential target tissue. | Toxicol. Sci. 95(1):240-8 | |||
Xu D, et al. Mouse over for full list |
(2008) | MF63 [2-(6-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-isophthalonitrile], a selective microsomal prostaglandin E synthase-1 inhibitor, relieves pyresis and pain in preclinical models of inflammation. | J. Pharmacol. Exp. Ther. 326(3):754-63 | |||
Seiler MJ, et al. Mouse over for full list |
(2008) | BDNF-treated retinal progenitor sheets transplanted to degenerate rats: improved restoration of visual function. | Exp. Eye Res. 86(1):92-104 | |||
Scheer N, et al. Mouse over for full list |
(2008) | A novel panel of mouse models to evaluate the role of human pregnane X receptor and constitutive androstane receptor in drug response. | J. Clin. Invest. 118(9):3228-39 | |||
Pettigrew LC, et al. Mouse over for full list |
(2008) | Focal cerebral ischemia in the TNFalpha-transgenic rat. | J Neuroinflammation 5:47 | |||
Pennesi ME, et al. Mouse over for full list |
(2008) | The relationship of photoreceptor degeneration to retinal vascular development and loss in mutant rhodopsin transgenic and RCS rats. | Exp. Eye Res. 87(6):561-70 | |||
Menke DB, et al. Mouse over for full list |
(2008) | Dual hindlimb control elements in the Tbx4 gene and region-specific control of bone size in vertebrate limbs. | Development 135(15):2543-53 | |||
Lu H, et al. Mouse over for full list |
(2008) | Characterization of organic anion transporting polypeptide 1b2-null mice: essential role in hepatic uptake/toxicity of phalloidin and microcystin-LR. | Toxicol. Sci. 103(1):35-45 | |||
Koch L, et al. Mouse over for full list |
(2008) | Central insulin action regulates peripheral glucose and fat metabolism in mice. | J. Clin. Invest. 118(6):2132-47 | |||
Herold MJ, et al. Mouse over for full list |
(2008) | Inducible and reversible gene silencing by stable integration of an shRNA-encoding lentivirus in transgenic rats. | Proc. Natl. Acad. Sci. U.S.A. 105(47):18507-12 | |||
Gwack Y, et al. Mouse over for full list |
(2008) | Hair loss and defective T- and B-cell function in mice lacking ORAI1. | Mol. Cell. Biol. 28(17):5209-22 | T And/Or B Cell Function | ||
Gutierrez JA, et al. Mouse over for full list |
(2008) | Ghrelin octanoylation mediated by an orphan lipid transferase. | Proc. Natl. Acad. Sci. U.S.A. 105(17):6320-5 | |||
Guenther C, et al. Mouse over for full list |
(2008) | Shaping skeletal growth by modular regulatory elements in the Bmp5 gene. | PLoS Genet. 4(12):e1000308 | |||
Christoph T, et al. Mouse over for full list |
(2008) | Investigation of TRPV1 loss-of-function phenotypes in transgenic shRNA expressing and knockout mice. | Mol. Cell. Neurosci. 37(3):579-89 | shRNA-mediatred gene knock down |
||
Chi LY, et al. Mouse over for full list |
(2008) | The dual role of tumor necrosis factor-alpha in the pathophysiology of spinal cord injury. | Neurosci. Lett. 438(2):174-9 | |||
Ballatori N, et al. Mouse over for full list |
(2008) | Ostalpha-Ostbeta is required for bile acid and conjugated steroid disposition in the intestine, kidney, and liver. | Am. J. Physiol. Gastrointest. Liver Physiol. 295(1):G179-G186 | |||
Willuweit A, et al. Mouse over for full list |
(2009) | Early-onset and robust amyloid pathology in a new homozygous mouse model of Alzheimer's disease. | PLoS ONE 4(11):e7931 | Alzheimer's | ||
van de Steeg E, et al. Mouse over for full list |
(2009) | Methotrexate pharmacokinetics in transgenic mice with liver-specific expression of human organic anion-transporting polypeptide 1B1 (SLCO1B1). | Drug Metab. Dispos. 37(2):277-81 | |||
van Waterschoot RA, et al. Mouse over for full list |
(2009) | Intestinal cytochrome P450 3A plays an important role in the regulation of detoxifying systems in the liver. | FASEB J. 23(1):224-31 | |||
Robert A. B. van Waterschoot, et al. Mouse over for full list |
(2009) | Inhibition and Stimulation of Intestinal and Hepatic CYP3A Activity: Studies in Humanized CYP3A4 Transgenic Mice Using Triazolam | DMD 37:2305–2313, 2009 | |||
Stanley LA, et al. Mouse over for full list |
(2009) | Drug transporters: gatekeepers controlling access of xenobiotics to the cellular interior. | Drug Metab. Rev. 41(1):27-65 | |||
Roebuck BD, et al. Mouse over for full list |
(2009) | Transgenic expression of aflatoxin aldehyde reductase (AKR7A1) modulates aflatoxin B1 metabolism but not hepatic carcinogenesis in the rat. | Toxicol. Sci. 109(1):41-9 | |||
Preitner F, et al. Mouse over for full list |
(2009) | Glut9 is a major regulator of urate homeostasis and its genetic inactivation induces hyperuricosuria and urate nephropathy. | Proc. Natl. Acad. Sci. U.S.A. 106(36):15501-6 | |||
Ooe N, et al. Mouse over for full list |
(2009) | Functional characterization of basic helix-loop-helix-PAS type transcription factor NXF in vivo: putative involvement in an "on demand" neuroprotection system. | J. Biol. Chem. 284(2):1057-63 | |||
Otto C, et al. Mouse over for full list |
(2009) | GPR30 does not mediate estrogenic responses in reproductive organs in mice. | Biol. Reprod. 80(1):34-41 | |||
Niel L, et al. Mouse over for full list |
(2009) | Sexual differentiation of the spinal nucleus of the bulbocavernosus is not mediated solely by androgen receptors in muscle fibers. | Endocrinology 150(7):3207-13 | |||
Lee HW, et al. Mouse over for full list |
(2009) | Collecting duct-specific Rh C glycoprotein deletion alters basal and acidosis-stimulated renal ammonia excretion. | Am. J. Physiol. Renal Physiol. 296(6):F1364-75 | |||
Kotnik K, et al. Mouse over for full list |
(2009) | Inducible transgenic rat model for diabetes mellitus based on shRNA-mediated gene knockdown. | PLoS ONE 4(4):e5124 | |||
Kopanja D, et al. Mouse over for full list |
(2009) | Proliferation defects and genome instability in cells lacking Cul4A. | Oncogene 28(26):2456-65 | |||
Diveu C, et al. Mouse over for full list |
(2009) | IL-27 blocks RORc expression to inhibit lineage commitment of Th17 cells. | J. Immunol. 182(9):5748-56 | |||
Chabory E, et al. Mouse over for full list |
(2009) | Epididymis seleno-independent glutathione peroxidase 5 maintains sperm DNA integrity in mice. | J. Clin. Invest. 119(7):2074-85 | |||
Yang R, et al. Mouse over for full list |
(2011) | RNAi-mediated germline knockdown of FABP4 increases body weight but does not improve the deranged nutrient metabolism of diet-induced obese mice. | Int J Obes (Lond) 35(2):217-25 | |||
Evita van de Steeg, et al. Mouse over for full list |
(2010) | Organic anion transporting polypeptide 1a/1b–knockout mice provide insights into hepatic handling of bilirubin, bile acids, and drugs | J Clin Invest. 2010 Aug 2; 120(8): 2942–2952. | |||
Beijnen JH, et al. Mouse over for full list |
(2010) | Effects of cytochrome P450 3A (CYP3A) and the drug transporters P-glycoprotein (MDR1/ABCB1) and MRP2 (ABCC2) on the pharmacokinetics of lopinavirbph_759 1224..1 | Br J Pharmacol. 160(5):1224-1233. | |||
Verkoczy L, et al. Mouse over for full list |
(2010) | Autoreactivity in an HIV-1 broadly reactive neutralizing antibody variable region heavy chain induces immunologic tolerance. | Proc. Natl. Acad. Sci. U.S.A. 107(1):181-6 | |||
Thomas BB, et al. Mouse over for full list |
(2010) | Modulatory influence of stimulus parameters on optokinetic head-tracking response. | Neurosci. Lett. 479(2):92-6 | |||
Seiler MJ, et al. Mouse over for full list |
(2010) | Three-dimensional optical coherence tomography imaging of retinal sheet implants in live rats. | J. Neurosci. Methods 188(2):250-7 | |||
Seibler J, et al. Mouse over for full list |
(2010) | Transgenic RNAi applications in the mouse. | Meth. Enzymol. 477:367-86 | |||
Seiler MJ, et al. Mouse over for full list |
(2010) | Visual restoration and transplant connectivity in degenerate rats implanted with retinal progenitor sheets. | Eur. J. Neurosci. 31(3):508-20 | |||
Scheer N, et al. Mouse over for full list |
(2010) | In vivo responses of the human and murine pregnane X receptor to dexamethasone in mice. | Drug Metab. Dispos. 38(7):1046-53 | |||
Ross J, et al. Mouse over for full list |
(2010) | Human constitutive androstane receptor (CAR) and pregnane X receptor (PXR) support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogens phenobarbital and chlordane in vivo. | Toxicol. Sci. 116(2):452-66 | |||
Ramchandani VA, et al. Mouse over for full list |
(2010) | A genetic determinant of the striatal dopamine response to alcohol in men. | Mol. Psychiatry 16(8):809-17 | |||
Ludwig A, et al. Mouse over for full list |
(2010) | Flotillin microdomains interact with the cortical cytoskeleton to control uropod formation and neutrophil recruitment. | J. Cell Biol. 191(4):771-81 | |||
Lee HW, et al. Mouse over for full list |
(2010) | Effect of intercalated cell-specific Rh C glycoprotein deletion on basal and metabolic acidosis-stimulated renal ammonia excretion. | Am. J. Physiol. Renal Physiol. 299(2):F369-79 | |||
Lang CH, et al. Mouse over for full list |
(2010) | Skeletal muscle protein balance in mTOR heterozygous mice in response to inflammation and leucine. | Am. J. Physiol. Endocrinol. Metab. 298(6):E1283-94 | |||
He G, et al. Mouse over for full list |
(2010) | Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease. | Nature 467(7311):95-8 | Alzheimer's | ||
Bouskila M, et al. Mouse over for full list |
(2010) | Allosteric regulation of glycogen synthase controls glycogen synthesis in muscle. | Cell Metab. 12(5):456-66 | |||
Wullschleger S, et al. Mouse over for full list |
(2011) | Role of TAPP1 and TAPP2 adaptor binding to PtdIns(3,4)P2 in regulating insulin sensitivity defined by knock-in analysis. | Biochem. J. 434(2):265-74 | |||
Soustek MS, et al. Mouse over for full list |
(2011) | Characterization of a transgenic short hairpin RNA-induced murine model of Tafazzin deficiency. | Hum. Gene Ther. 22(7):865-71 | |||
Schackmann RC, et al. Mouse over for full list |
(2011) | Cytosolic p120-catenin regulates growth of metastatic lobular carcinoma through Rock1-mediated anoikis resistance. | J. Clin. Invest. 121(8):3176-88 | |||
Pearce LR, et al. Mouse over for full list |
(2011) | Protor-1 is required for efficient mTORC2-mediated activation of SGK1 in the kidney. | Biochem. J. 436(1):169-79 | |||
Out C, et al. Mouse over for full list |
(2011) | Liver receptor homolog-1 is critical for adequate up-regulation of Cyp7a1 gene transcription and bile salt synthesis during bile salt sequestration. | Hepatology 53(6):2075-85 | |||
Mi S, et al. Mouse over for full list |
(2011) | Death receptor 6 negatively regulates oligodendrocyte survival, maturation and myelination. | Nat. Med. 17(7):816-21 | |||
Kwak SP, et al. Mouse over for full list |
(2011) | Target Validation for Huntington’s Disease | Neurobiology of Huntington's Disease: Applications to Drug Discovery. | Huntington’s Disease | ||
Jordan SD, et al. Mouse over for full list |
(2011) | Obesity-induced overexpression of miRNA-143 inhibits insulin-stimulated AKT activation and impairs glucose metabolism. | Nat. Cell Biol. 13(4):434-46 | |||
Inagaki A, et al. Mouse over for full list |
(2011) | Meiotic functions of RAD18. | J. Cell. Sci. 124(Pt 16):2837-50 | |||
Hasegawa M, et al. Mouse over for full list |
(2011) | Quantitative prediction of human pregnane X receptor and cytochrome P450 3A4 mediated drug-drug interaction in a novel multiple humanized mouse line. | Mol. Pharmacol. 80(3):518-28 | |||
Gleason CE, et al. Mouse over for full list |
(2011) | Polyubiquitin binding to optineurin is required for optimal activation of TANK-binding kinase 1 and production of interferon β. | J. Biol. Chem. 286(41):35663-74 | |||
Fre S, et al. Mouse over for full list |
(2011) | Notch Lineages and Activity in Intestinal Stem Cells Determined by a New Set of Knock-In Mice | PLoS One. 2011; 6(10): e25785. | |||
Bouskila M, et al. Mouse over for full list |
(2011) | TTBK2 kinase substrate specificity and the impact of spinocerebellar-ataxia-causing mutations on expression, activity, localization and development. | Biochem. J. 437(1):157-67 | |||
Bentz S, et al. Mouse over for full list |
(2011) | Lack of transketolase-like (TKTL) 1 aggravates murine experimental colitis. | Am. J. Physiol. Gastrointest. Liver Physiol. 300(4):G598-607 | |||
Bangs F, et al. Mouse over for full list |
(2011) | Generation of mice with functional inactivation of talpid3, a gene first identified in chicken. | Development 138(15):3261-72 | |||
Acehan D, et al. Mouse over for full list |
(2011) | Cardiac and skeletal muscle defects in a mouse model of human Barth syndrome. | J. Biol. Chem. 286(2):899-908 | |||
van de Steeg E, et al. Mouse over for full list |
(2012) | Complete OATP1B1 and OATP1B3 deficiency causes human Rotor syndrome by interrupting conjugated bilirubin reuptake into the liver. | J. Clin. Invest. 122(2):519-28 | |||
van de Steeg E, et al. Mouse over for full list |
(2012) | Influence of human OATP1B1, OATP1B3, and OATP1A2 on the pharmacokinetics of methotrexate and paclitaxel in humanized transgenic mice. | Clin. Cancer Res. 19(4):821-32 | |||
Sprüssel A, et al. Mouse over for full list |
(2012) | Lysine-specific demethylase 1 restricts hematopoietic progenitor proliferation and is essential for terminal differentiation. | Leukemia 26(9):2039-51 | Leukemia | ||
Scheer N, et al. Mouse over for full list |
(2012) | Generation and characterization of novel cytochrome P450 Cyp2c gene cluster knockout and CYP2C9 humanized mouse lines. | Mol. Pharmacol. 82(6):1022-9 | Humanization |
ADMET | |
Scheer N, et al. Mouse over for full list |
(2012) | Generation and characterization of a novel multidrug resistance protein 2 humanized mouse line. | Drug Metab. Dispos. 40(11):2212-8 | Humanization |
ADMET | |
Scheer N, et al. Mouse over for full list |
(2012) | Modeling human cytochrome P450 2D6 metabolism and drug-drug interaction by a novel panel of knockout and humanized mouse lines. | Mol. Pharmacol. 81(1):63-72 | Humanization |
ADMET | |
Robinson LJ, et al. Mouse over for full list |
(2012) | Gene disruption of the calcium channel Orai1 results in inhibition of osteoclast and osteoblast differentiation and impairs skeletal development. | Lab. Invest. 92(7):1071-83 | |||
Prysyazhna O, et al. Mouse over for full list |
(2012) | Single atom substitution in mouse protein kinase G eliminates oxidant sensing to cause hypertension. | Nat. Med. 18(2):286-90 | |||
Phoon CK, et al. Mouse over for full list |
(2012) | Tafazzin knockdown in mice leads to a developmental cardiomyopathy with early diastolic dysfunction preceding myocardial noncompaction. | J Am Heart Assoc 1(2) | shRNA-mediatred gene knock down |
Cardiovascular | |
Miller AL, et al. Mouse over for full list |
(2012) | Opposing roles of membrane and soluble forms of the receptor for advanced glycation end products in primary respiratory syncytial virus infection. | J. Infect. Dis. 205(8):1311-20 | |||
Neff F, et al. Mouse over for full list |
(2012) | Small-Animal PET Imaging of Amyloid-Beta Plaques with [ 11C]PiB and Its Multi-Modal Validation in an APP/PS1 Mouse Model of Alzheimer’s Disease | PLoS ONE 7(3): e31310. | |||
Mayerl S, et al. Mouse over for full list |
(2012) | Impact of Oatp1c1 deficiency on thyroid hormone metabolism and action in the mouse brain. | Endocrinology 153(3):1528-37 | |||
MacKenzie KF, et al. Mouse over for full list |
(2012) | PGE(2) induces macrophage IL-10 production and a regulatory-like phenotype via a protein kinase A-SIK-CRTC3 pathway. | J. Immunol. 190(2):565-77 | |||
Cook DR, et al. Mouse over for full list |
(2012) | The Ect2 Rho Guanine Nucleotide Exchange Factor Is Essential for Early Mouse Development and Normal Cell Cytokinesis and Migration | Genes & Cancer April 19, 2012 | |||
Stadler P, et al. Mouse over for full list |
(2013) | Industrialization of Functional Mouse Genomics Technologies for Biopharmaceutical Drug Discovery and Development | Modern Biopharmaceuticals: Recent Success Stories. | |||
Scheer N, et al. Mouse over for full list |
(2013) | Xenobiotic receptor humanized mice and their utility. | Drug Metab. Rev. 45(1):110-21 | Humanization |
ADMET | |
Rohm M, et al. Mouse over for full list |
(2013) | Transcriptional cofactor TBLR1 controls lipid mobilization in white adipose tissue. | Cell Metab. 17(4):575-85 | |||
Judit Remenyi, et al. Mouse over for full list |
(2013) | miR-132/212 Knockout Mice Reveal Roles for These miRNAs in Regulating Cortical Synaptic Transmission and Plasticity | PLoS ONE 8(4): e62509. | miRNA over-expression |
Neuroscience | |
Yong-Seok Oh, et al. Mouse over for full list |
(2013) | SMARCA3, a Chromatin-Remodeling Factor, Is Required for p11-Dependent Antidepressant Action | Cell , Volume 152 , Issue 4 , 831 - 843 | Conditional knock out |
Neuroscience | |
Murakami K, et al. Mouse over for full list |
(2013) | In vivo analysis of kallikrein-related peptidase 6 (KLK6) function in oligodendrocyte development and the expression of myelin proteins. | Neuroscience 236:1-11 | Neuroscience | ||
Mizuno Y, et al. Mouse over for full list |
(2013) | Tysnd1 deficiency in mice interferes with the peroxisomal localization of PTS2 enzymes, causing lipid metabolic abnormalities and male infertility. | PLoS Genet. 9(2):e1003286 | |||
Milenkovic D, et al. Mouse over for full list |
(2013) | TWINKLE is an essential mitochondrial helicase required for synthesis of nascent D-loop strands and complete mtDNA replication. | Hum. Mol. Genet. 22(10):1983-93 | |||
McMillan SJ, et al. Mouse over for full list |
(2013) | Siglec-E is a negative regulator of acute pulmonary neutrophil inflammation and suppresses CD11b β2-integrin-dependent signaling. | Blood 121(11):2084-94 | |||
Law AL, et al. Mouse over for full list |
(2013) | Lamellipodin and the Scar/WAVE complex cooperate to promote cell migration in vivo. | J. Cell Biol. 203(4):673-89 | |||
Kim HY, et al. Mouse over for full list |
(2009) | Basolateral expression of the ammonia transporter family member Rh C glycoprotein in the mouse kidney. | Am. J. Physiol. Renal Physiol. 296(3):F543-55 | |||
Hughes J, et al. Mouse over for full list |
(2013) | Maternal transmission of a humanised Igf2r allele results in an Igf2 dependent hypomorphic and non-viable growth phenotype. | PLoS ONE 8(2):e57270 | Humanization |
||
Hu Y, et al. Mouse over for full list |
(2013) | A DR6/p75(NTR) complex is responsible for β-amyloid-induced cortical neuron death. | Cell Death Dis 4:e579 | Alzheimer's | ||
Furlan A, et al. Mouse over for full list |
(2013) | The transcription factor Hmx1 and growth factor receptor activities control sympathetic neurons diversification. | EMBO J. 32(11):1613-25 | |||
Zhang J, et al. Mouse over for full list |
(2014) | An unexpected twist to the activation of IKKβ: TAK1 primes IKKβ for activation by autophosphorylation. | Biochem. J. 461(3):531-7 | |||
Zevnik B, et al. Mouse over for full list |
(2014) | C57BL/6N albino/agouti mutant mice as embryo donors for efficient germline transmission of C57BL/6 ES cells. | PLoS ONE 9(3):e90570 | Autoimmune | ||
Weber B, et al. Mouse over for full list |
(2014) | TREM-1 deficiency can attenuate disease severity without affecting pathogen clearance. | PLoS Pathog. 10(1):e1003900 | |||
Waldschmitt N, et al. Mouse over for full list |
(2014) | C/EBP homologous protein inhibits tissue repair in response to gut injury and is inversely regulated with chronic inflammation. | Mucosal Immunol 7(6):1452-66 | |||
Vajda F, et al. Mouse over for full list |
(2015) | Cell type-specific Nogo-A gene ablation promotes axonal regeneration in the injured adult optic nerve. | Cell Death Differ. 22(2):323-35 | |||
Stubbert D, et al. Mouse over for full list |
(2014) | Protein kinase G Iα oxidation paradoxically underlies blood pressure lowering by the reductant hydrogen sulfide. | Hypertension 64(6):1344-51 | |||
Scheer N, et al. Mouse over for full list |
(2014) | Deletion of 30 murine cytochrome p450 genes results in viable mice with compromised drug metabolism. | Drug Metab. Dispos. 42(6):1022-30 | Knock out |
ADMET | |
Salphati L, et al. Mouse over for full list |
(2014) | Evaluation of organic anion transporting polypeptide 1B1 and 1B3 humanized mice as a translational model to study the pharmacokinetics of statins. | Drug Metab. Dispos. 42(8):1301-13 | |||
Oosting M, et al. Mouse over for full list |
(2014) | Human TLR10 is an anti-inflammatory pattern-recognition receptor. | Proc. Natl. Acad. Sci. U.S.A. 111(42):E4478-84 | |||
McMillan SJ, et al. Mouse over for full list |
(2014) | Siglec-F-dependent negative regulation of allergen-induced eosinophilia depends critically on the experimental model. | Immunol. Lett. 160(1):11-6 | |||
Metodiev MD, et al. Mouse over for full list |
(2014) | NSUN4 is a dual function mitochondrial protein required for both methylation of 12S rRNA and coordination of mitoribosomal assembly. | PLoS Genet. 10(2):e1004110 | |||
Mayerl S, et al. Mouse over for full list |
(2014) | Transporters MCT8 and OATP1C1 maintain murine brain thyroid hormone homeostasis. | J. Clin. Invest. 124(5):1987-99 | |||
Luisier R, et al. Mouse over for full list |
(2014) | Phenobarbital induces cell cycle transcriptional responses in mouse liver humanized for constitutive androstane and pregnane x receptors. | Toxicol. Sci. 139(2):501-11 | Humanization |
ADMET | |
Kraus M, et al. Mouse over for full list |
(2015) | Protein kinase N3 deficiency impedes PI3-kinase pathway-driven leukemogenesis without affecting normal hematopoiesis. | Leukemia 29(1):255-8 | Leukemia | ||
Kühl I, et al. Mouse over for full list |
(2014) | POLRMT does not transcribe nuclear genes. | Nature 514(7521):E7-11 | |||
Jun LS, et al. Mouse over for full list |
(2014) | A novel humanized GLP-1 receptor model enables both affinity purification and Cre-LoxP deletion of the receptor. | PLoS ONE 9(4):e93746 | |||
Itoh M, et al. Mouse over for full list |
(2014) | The structural and functional organization of the podocyte filtration slits is regulated by Tjp1/ZO-1. | PLoS ONE 9(9):e106621 | |||
Hultin S, et al. Mouse over for full list |
(2014) | AmotL2 links VE-cadherin to contractile actin fibres necessary for aortic lumen expansion. | Nat Commun 5:3743 | |||
Houde VP, et al. Mouse over for full list |
(2014) | Investigation of LKB1 Ser431 phosphorylation and Cys433 farnesylation using mouse knockin analysis reveals an unexpected role of prenylation in regulating AMPK activity. | Biochem. J. 458(1):41-56 | |||
Hoegg-Beiler MB, et al. Mouse over for full list |
(2014) | Disrupting MLC1 and GlialCAM and ClC-2 interactions in leukodystrophy entails glial chloride channel dysfunction. | Nat Commun 5:3475 | |||
Henderson CJ, et al. Mouse over for full list |
(2014) | In vivo regulation of human glutathione transferase GSTP by chemopreventive agents. | Cancer Res. 74(16):4378-87 | |||
Hansbro PM, et al. Mouse over for full list |
(2014) | Importance of mast cell Prss31/transmembrane tryptase/tryptase-γ in lung function and experimental chronic obstructive pulmonary disease and colitis. | J. Biol. Chem. 289(26):18214-27 | |||
Edwards JP, et al. Mouse over for full list |
(2014) | Release of active TGF-β1 from the latent TGF-β1/GARP complex on T regulatory cells is mediated by integrin β8. | J. Immunol. 193(6):2843-9 | |||
Charles RL, et al. Mouse over for full list |
(2014) | Protection from hypertension in mice by the Mediterranean diet is mediated by nitro fatty acid inhibition of soluble epoxide hydrolase. | Proc. Natl. Acad. Sci. U.S.A. 111(22):8167-72 | Knock in |
||
Bombail V, et al. Mouse over for full list |
(2014) | Prevention of 5-hydroxytryptamine2C receptor RNA editing and alternate splicing in C57BL/6 mice activates the hypothalamic-pituitary-adrenal axis and alters mood. | Eur. J. Neurosci. 40(11):3663-73 | |||
Bestas B, et al. Mouse over for full list |
(2014) | Splice-correcting oligonucleotides restore BTK function in X-linked agammaglobulinemia model. | J. Clin. Invest. 124(9):4067-81 | |||
Althoff K, et al. Mouse over for full list |
(2015) | A Cre-conditional MYCN-driven neuroblastoma mouse model as an improved tool for preclinical studies. | Oncogene 34(26):3357-68 | Targeted transgenic |
Oncology | |
van Herwaarden AE, et al. Mouse over for full list |
(2005) | Midazolam and cyclosporin a metabolism in transgenic mice with liver-specific expression of human CYP3A4. | Drug Metab. Dispos. 33(7):892-5 | |||
Vlaming ML, et al. Mouse over for full list |
(2006) | Carcinogen and anticancer drug transport by Mrp2 in vivo: studies using Mrp2 (Abcc2) knockout mice. | J. Pharmacol. Exp. Ther. 318(1):319-27 | Knock out |
ADMET |
Welcome! Tell us a little about yourself