The hG-CSF KI NOG mouse is a next-generation humanized mouse model designed to support robust human neutrophil development and function following CD34+ cell engraftment. This model enables translational research in innate immunity, inflammation, immuno-oncology, infectious disease, and neutrophil-targeted therapeutics.
hG-CSF KI NOG Mouse
| Model No. | Nomenclature | Genotype |
|---|---|---|
| 23225-F | NOD.Cg-Csf3rtm1(CMV-CSF3) Prkdcscid Il2rgtm1Sug/JicTac | ki/ki;sp/sp;ko/ko |
| 23225-M | NOD.Cg-Csf3rtm1(CMV-CSF3) Prkdcscid Il2rgtm1Sug/JicTac | ki/ki;sp/sp;ko/y |
G-CSF huNOG mice are made to order and can be shipped as early as 1 week post engraftment
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- Description
- Data
- Price & Licensing
- Health Report
- Overview
- Genetics
- Guides & Publications
- Applications & Therapeutic Areas
- Transit, Housing & Welfare
- Diet
Overview
Nomenclature: NOD.Cg-Csf3rtm1(CMV-CSF3) Prkdcscid Il2rgtm1Sug/JicTac
The hG-CSF KI NOG is a super immunodeficient NOG mouse that has the Human Granulocyte Colony-Stimulating Factor (hG-CSF) gene knocked into the murine G-CSF receptor locus, disrupting the murine G-CSF.
- Amenable to immune system humanization via engraftment of human hematopoietic stem cells (HSCs).
- Immunodeficient model lacking mature T, B, and NK cells, with reduced murine neutrophils, reduced complement activity, dysfunctional macrophages and dysfunctional dendritic cells.
- Excellent model for a variety of xenograft and human cell engraftment studies.
- Applications in research involving Immunology, Oncology & Immuno-Oncology and Infectious Disease
Orders by weight: Taconic cannot accept orders by weight for this model. Please note that shipments may contain animals with a larger weight variation.
Origin
The hG-CSF KI NOG mouse was developed by Ryoji Ito and colleagues at the Central Institute for Experimental Animals. To generate the model, a human granulocyte colony-stimulating factor (hG-CSF/CSF3) expression cassette driven by the CMV promoter was targeted into the murine Csf3r (G-CSF receptor) locus of the CIEA NOG mouse®. This strategy enabled systemic expression of human G-CSF while disrupting the endogenous mouse G-CSF receptor pathway, thereby preferentially supporting human neutrophil differentiation following engraftment with human hematopoietic stem cells. The colony is maintained by homozygous breeding.
Genetics
Guides & Publications
Applications & Therapeutic Areas
- Immunology
- Oncology & Immuno-Oncology
- Infectious Disease
Transit, Housing & Welfare
Taconic standard practice is to recombine animals of different home cages and/or ages from a single model and sex during packing, except in specific cases where Taconic's animal welfare policy prohibits recombination due to aggression or other concerns. When an order is fulfilled with animals from more than one week of birth, this standard practice results in animals from a range of birth weeks packed together in a single TTC. When an order is fulfilled with animals from genotyped models, this standard practice results in animals from different home cages packed together in a single TTC.
Customers who wish to keep animals from different weeks of birth separated should place orders with the special instruction "Divide and label by age." Note that this special request can result in increased costs for additional Taconic Transit Cages, dividers and/or freight charges.
Taconic discourages other types of custom packing requests as they can have a negative impact on animal welfare. Learn more.
Diet
Data
Human Neutrophils
Individual Donors Data
4 weeks post engraftment
Human Neutrophils
3 Donors Combined
4 weeks post engraftment
- Licensing
- Pricing - USD
- Pricing - EUR
- Pricing - DKK
- Pricing - USD Nonprofit
- Pricing - EUR Nonprofit
- Pricing - DKK Nonprofit
- Select my Health Standard
- Get Custom Pricing Guide
Licensing
Nonprofit users (excluding users at nonprofit foundations which are affiliated with a for-profit entity): For internal research purposes, the CIEA NOG mouse® Conditions of Use for nonprofit users apply. If you wish to perform sponsored research or fee-for-service contract research using the CIEA NOG mouse®, please inquire for access conditions.
For-profit users and users at foundations which are affiliated with for-profit entities: The CIEA NOG mouse® Conditions of Use for for-profit users apply.
The CIEA NOG mouse® is produced and distributed under license rights to the following patents and trademarks:
- Japanese Patent No. 3,753,321
- US Patent No. 7,145,055; 5,464,764; 5,487,992; 5,627,059; 5,631,153; 5,789,215; 6,204,061; 6,653,113; 6,689,610
EP Patent No. 1,338,198 - Japanese Trademark Reg. No. 4,823,423
- US Trademark Reg. No. 3,118,040
- EU Trademark Reg. No. 3,736,758
Pricing - USD
Opportunist Free (OF) Health Standard
23225 Female
23225-F Genotype hu/hu;sp/sp;ko/ko
| Age in Weeks | Quantity 1 - 1000 |
|---|---|
| 3 to 10 | US$425.00 |
23225 Male
23225-M Genotype hu/hu;sp/sp;ko/y
| Age in Weeks | Quantity 1 - 1000 |
|---|---|
| 3 to 10 | US$425.00 |
Pricing - EUR
Opportunist Free (OF) Health Standard
23225 Female
23225-F Genotype hu/hu;sp/sp;ko/ko
| Age in Weeks | Quantity 1 - 1000 |
|---|---|
| 3 to 10 | 370,00 € |
23225 Male
23225-M Genotype hu/hu;sp/sp;ko/y
| Age in Weeks | Quantity 1 - 1000 |
|---|---|
| 3 to 10 | 370,00 € |
Pricing - DKK
Opportunist Free (OF) Health Standard
23225 Female
23225-F Genotype hu/hu;sp/sp;ko/ko
| Age in Weeks | Quantity 1 - 1000 |
|---|---|
| 3 to 10 | kr.2.759,00 |
23225 Male
23225-M Genotype hu/hu;sp/sp;ko/y
| Age in Weeks | Quantity 1 - 1000 |
|---|---|
| 3 to 10 | kr.2.759,00 |
Pricing - USD Nonprofit
Opportunist Free (OF) Health Standard
23225 Female
23225-F Genotype hu/hu;sp/sp;ko/ko
| Age in Weeks | Quantity 1 - 1000 |
|---|---|
| 3 to 10 | US$213.00 |
23225 Male
23225-M Genotype hu/hu;sp/sp;ko/y
| Age in Weeks | Quantity 1 - 1000 |
|---|---|
| 3 to 10 | US$213.00 |
Pricing - EUR Nonprofit
Opportunist Free (OF) Health Standard
23225 Female
23225-F Genotype hu/hu;sp/sp;ko/ko
| Age in Weeks | Quantity 1 - 1000 |
|---|---|
| 3 to 10 | 186,00 € |
23225 Male
23225-M Genotype hu/hu;sp/sp;ko/y
| Age in Weeks | Quantity 1 - 1000 |
|---|---|
| 3 to 10 | 186,00 € |
Pricing - DKK Nonprofit
Opportunist Free (OF) Health Standard
23225 Female
23225-F Genotype hu/hu;sp/sp;ko/ko
| Age in Weeks | Quantity 1 - 1000 |
|---|---|
| 3 to 10 | kr.1.383,00 |
23225 Male
23225-M Genotype hu/hu;sp/sp;ko/y
| Age in Weeks | Quantity 1 - 1000 |
|---|---|
| 3 to 10 | kr.1.383,00 |
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