A CD34⁺ humanized IL-6 NOG mouse model optimized for human myeloid cell development, enabling translational immuno-oncology research focused on tumor-associated macrophages, MDSCs, and myeloid-driven immune suppression in cancer. As a made-to-order model, lead times and immune responses may vary depending on donor sources.
hIL-6 huNOG
| Model No. | Nomenclature | Genotype |
|---|---|---|
| HSCCB-13686-M | NOD.Cg-Prkdcscid Il2rgtm1Sug Tg(CMV-IL6)1-1Jic/JicTac | sp/sp;ko/ko;tg/wt |
| HSCCB-13686-F | NOD.Cg-Prkdcscid Il2rgtm1Sug Tg(CMV-IL6)1-1Jic/JicTac | sp/sp;ko/y;tg/wt |
View:
Select One
- Description
- Data
- Price & Licensing
- Health Report
- Overview
- Genetics
- Guides & Publications
- Applications & Therapeutic Areas
- Transit, Housing & Welfare
- Diet
Overview
Nomenclature: NOD.Cg-Prkdcscid Il2rgtm1Sug Tg(CMV-IL6)1-1Jic/JicTac
- The hIL-6 huNOG mouse is a HIS mouse made by engrafting hematopoietic stem cells (HSCs) in the hIL-6 NOG strain.
- Made to order, with typical lead time of 20 weeks from order to delivery.
- Minimum purchase required. Human lymphocytes are present in peripheral blood, bone marrow and spleen.
- hIL-6 huNOG mice are a suitable control for NeoThy(TM) hIL-6 huNOG mice.
- Humanized immune system mice require special housing and husbandry. We recommend reviewing the the comprehensive document Taconic's Humanized Immune System Models: Licensing, Care & Resources and the Video: Care of HIS mice for experimental success prior to ordering.
IL-6 NOG Characteristics:
- Super immunodeficient NOG mouse expressing human IL-6 cytokine
- Enhanced expansion of human monocytes following human HSC engraftment
- May be useful for study of tumor-infiltrating macrophages
- May be suitable host for hIL-6 dependent multiple myeloma (MM) patient derived xenograft (PDX) and tumor samples.
- Applications in research involving cancer, immunology, regenerative medicine and human immune system engraftment
Orders by weight: Taconic cannot accept orders by weight for this model. Please note that shipments may contain animals with a larger weight variation.
Origin
The CIEA NOG mouse® was developed by Mamoru Ito of the Central Institute for Experimental Animals (CIEA) in Japan. The Prkdc scid mutation was identified by Mel Bosma of the Fox Chase Cancer Center in a C.B-17 congenic mouse population. This mutation was backcrossed onto the NOD/ShiJic strain at CIEA for at least eight generations. The Il2rg targeted mutation was developed by Dr. Kazuo Sugamura of Tohoku University by targeting the gene in ES cells derived from a 129 strain. Portions of exons 7 and 8 were replaced with a neo cassette. Targeted ES cells were injected into C57BL/6 blastocysts. Resultant chimeras were backcrossed onto the C57BL/6JJic background for at least eight generations. The CIEA NOG mouse® was developed by backcrossing the C57BL/6JJic-Il2rg line to the NOD/ShiJic-Prkdc scid line for a total of eight generations. The linearized hIL-6 transgene was injected into zygotes from NOD/Shi-IL2rg females x NOD/Shi-IL2rg males. The transgenic hIL-6 NOD/Shi-IL2rg mouse was crossed on to the NOG background to introduce the Prkdc scid mutation. The mice were backcrossed onto the NOG background three times. Taconic received stock in 2014, and the line was derived through embryo transfer.
Genetics
Guides & Publications
Initial Publication:
Hanazawa A, Ito R, Katano I, Kawai K, Goto M, Suemizu H, Kawakami Y, Ito M, Takahashi T. (2018) Generation of Human Immunosuppressive Myeloid Cell Populations in Human Interleukin-6 Transgenic NOG Mice. Front Immunol 9:152
Applications & Therapeutic Areas
- Oncology & Immuno-Oncology
- Immunology
- Infectious Diseases
- Immunogenicity
Transit, Housing & Welfare
Need more info? Click the live chat button or Contact Us
Diet
Data
Scientific Posters
See how The NeoThy™ Platform enables more physiologic immune responses
- Licensing
- Pricing - USD
- Pricing - EUR
- Pricing - DKK
- Pricing - USD Nonprofit
- Pricing - EUR Nonprofit
- Pricing - DKK Nonprofit
- Select my Health Standard
- Get Custom Pricing Guide
Licensing
Nonprofit users (excluding users at nonprofit foundations which are affiliated with a for-profit entity): For internal research purposes, the CIEA NOG mouse® Conditions of Use for nonprofit users apply. If you wish to perform sponsored research or fee-for-service contract research using the CIEA NOG mouse®, please inquire for access conditions.
For-profit users and users at foundations which are affiliated with for-profit entities: The CIEA NOG mouse® Conditions of Use for for-profit users apply.
The CIEA NOG mouse® is produced and distributed under license rights to the following patents and trademarks:
- Japanese Patent No. 3,753,321
- US Patent No. 7,145,055; 5,464,764; 5,487,992; 5,627,059; 5,631,153; 5,789,215; 6,204,061; 6,653,113; 6,689,610
EP Patent No. 1,338,198 - Japanese Trademark Reg. No. 4,823,423
- US Trademark Reg. No. 3,118,040
- EU Trademark Reg. No. 3,736,758
Pricing - USD
Opportunist Free (OF) Health Standard
HSCCB-13686 Female
HSCCB-13686-F Genotype sp/sp;ko/ko;tg/wt
Cohorts are reserved upon order placement and will take 2-4 weeks to fulfill. An estimated lead time will be provided to you within 2-3 business days.
| Age in Weeks Post Engraftment | Quantity 6 - 500 |
|---|---|
| 2 to 24 | US$1,558.00 |
HSCCB-13686 Male
HSCCB-13686-M Genotype sp/sp;ko/y;tg/wt
Cohorts are reserved upon order placement and will take 2-4 weeks to fulfill. An estimated lead time will be provided to you within 2-3 business days.
| Age in Weeks Post Engraftment | Quantity 6 - 500 |
|---|---|
| 2 to 24 | US$1,558.00 |
Pricing - EUR
Opportunist Free (OF) Health Standard
HSCCB-13686 Female
HSCCB-13686-F Genotype sp/sp;ko/ko;tg/wt
Cohorts are reserved upon order placement and will take 2-4 weeks to fulfill. An estimated lead time will be provided to you within 2-3 business days.
| Age in Weeks Post Engraftment | Quantity 6 - 500 |
|---|---|
| 2 to 24 | 1.356,00 € |
HSCCB-13686 Male
HSCCB-13686-M Genotype sp/sp;ko/y;tg/wt
Cohorts are reserved upon order placement and will take 2-4 weeks to fulfill. An estimated lead time will be provided to you within 2-3 business days.
| Age in Weeks Post Engraftment | Quantity 6 - 500 |
|---|---|
| 2 to 24 | 1.356,00 € |
Pricing - DKK
Opportunist Free (OF) Health Standard
HSCCB-13686 Female
HSCCB-13686-F Genotype sp/sp;ko/ko;tg/wt
Cohorts are reserved upon order placement and will take 2-4 weeks to fulfill. An estimated lead time will be provided to you within 2-3 business days.
| Age in Weeks Post Engraftment | Quantity 6 - 500 |
|---|---|
| 2 to 24 | kr.10.112,00 |
HSCCB-13686 Male
HSCCB-13686-M Genotype sp/sp;ko/y;tg/wt
Cohorts are reserved upon order placement and will take 2-4 weeks to fulfill. An estimated lead time will be provided to you within 2-3 business days.
| Age in Weeks Post Engraftment | Quantity 6 - 500 |
|---|---|
| 2 to 24 | kr.10.112,00 |
Pricing - USD Nonprofit
Opportunist Free (OF) Health Standard
HSCCB-13686 Female
HSCCB-13686-F Genotype sp/sp;ko/ko;tg/wt
Cohorts are reserved upon order placement and will take 2-4 weeks to fulfill. An estimated lead time will be provided to you within 2-3 business days.
| Age in Weeks Post Engraftment | Quantity 6 - 500 |
|---|---|
| 2 to 24 | US$1,169.00 |
HSCCB-13686 Male
HSCCB-13686-M Genotype sp/sp;ko/y;tg/wt
Cohorts are reserved upon order placement and will take 2-4 weeks to fulfill. An estimated lead time will be provided to you within 2-3 business days.
| Age in Weeks Post Engraftment | Quantity 6 - 500 |
|---|---|
| 2 to 24 | US$1,167.00 |
Pricing - EUR Nonprofit
Opportunist Free (OF) Health Standard
HSCCB-13686 Female
HSCCB-13686-F Genotype sp/sp;ko/ko;tg/wt
Cohorts are reserved upon order placement and will take 2-4 weeks to fulfill. An estimated lead time will be provided to you within 2-3 business days.
| Age in Weeks Post Engraftment | Quantity 6 - 500 |
|---|---|
| 2 to 24 | 1.017,00 € |
HSCCB-13686 Male
HSCCB-13686-M Genotype sp/sp;ko/y;tg/wt
Cohorts are reserved upon order placement and will take 2-4 weeks to fulfill. An estimated lead time will be provided to you within 2-3 business days.
| Age in Weeks Post Engraftment | Quantity 6 - 500 |
|---|---|
| 2 to 24 | 1.017,00 € |
Pricing - DKK Nonprofit
Opportunist Free (OF) Health Standard
HSCCB-13686 Female
HSCCB-13686-F Genotype sp/sp;ko/ko;tg/wt
Cohorts are reserved upon order placement and will take 2-4 weeks to fulfill. An estimated lead time will be provided to you within 2-3 business days.
| Age in Weeks Post Engraftment | Quantity 6 - 500 |
|---|---|
| 2 to 24 | kr.7.584,00 |
HSCCB-13686 Male
HSCCB-13686-M Genotype sp/sp;ko/y;tg/wt
Cohorts are reserved upon order placement and will take 2-4 weeks to fulfill. An estimated lead time will be provided to you within 2-3 business days.
| Age in Weeks Post Engraftment | Quantity 6 - 500 |
|---|---|
| 2 to 24 | kr.7.584,00 |
Select my Health Standard
Need help choosing the right Taconic Biosciences health standard for your research?
Use the Health Standard Selector to enter your exclusion list. The tool will tell you which health standards meet your requirements.
Get custom pricing guide
View the production locations(s) and the accompanying current IHMS™ Health Report and Taconic Health Standard for this model
Schedule A Scientific Consultation
Connect directly with a member of our Scientific Solutions team who can help you select the most appropriate model and maximize your experimental success.
Related Models
Schedule A Scientific Consultation
Speak with a scientist who can help you select the most appropriate model and maximize your experimental success.