hG-CSF KI huNOG

The hG-CSF KI huNOG mouse is an immune humanized mouse model with robust human neutrophil reconstitution and function. Combining CD34+ human immune system engraftment with human G-CSF expression, this model supports translational research in innate immunity, inflammation, immuno-oncology, infectious disease, and neutrophil-targeted therapeutics

  • Live
  • Mouse
  • Male & Female Available
  • Albino
  • Available for direct purchase by CRO
Model No.NomenclatureGenotype
HSCCB-23225-FNOD.Cg-Csf3rtm1(CMV-CSF3) Prkdcscid Il2rgtm1Sug/JicTacki/ki;sp/sp;ko/ko
HSCCB-23225-MNOD.Cg-Csf3rtm1(CMV-CSF3) Prkdcscid Il2rgtm1Sug/JicTacki/ki;sp/sp;ko/y
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Overview

Nomenclature: NOD.Cg-Csf3rtm1(CMV-CSF3) Prkdcscid Il2rgtm1Sug/JicTac

The hG-CSF KI huNOG is a HIS mouse made by engrafting hematopoietic stem cells (HSCs) in the hG-CSF KI NOG strain (no. 23225).

  • CD16+ CD89+ mature human neutrophils are elevated at 4 weeks post engraftment.
  • The study window for this model is between 1 and 8 weeks post engraftment, however, some donors may allow for longer experimental windows.
  • Human CD45 engraftment is accelerated compared to NOG or NOG-EXL strains, with the majority of animals passing 25% chimerism at 4WPE.
  • All mice are made to order and can be purchased as male or female.
  • Humanized immune system mice require special housing and husbandry. We recommend reviewing the comprehensive document Taconic’s Humanized Immune System Models: Licensing, Care & Resources and the Video: Care of HIS mice for experimental success prior to ordering.
Orders by weight: Taconic cannot accept orders by weight for this model. Please note that shipments may contain animals with a larger weight variation.
 

Origin

The hG-CSF KI NOG mouse was developed by Ryoji Ito and colleagues at the Central Institute for Experimental Animals. To generate the model, a human granulocyte colony-stimulating factor (hG-CSF/CSF3) expression cassette driven by the CMV promoter was targeted into the murine Csf3r (G-CSF receptor) locus of the CIEA NOG mouse®. This strategy enabled systemic expression of human G-CSF while disrupting the endogenous mouse G-CSF receptor pathway, thereby preferentially supporting human neutrophil differentiation following engraftment with human hematopoietic stem cells. The colony is maintained by homozygous breeding.

Genetics

Species: Mouse
Strain Type: Congenic
Allele Type: Knock-In, Genetically Humanized, Targeted Replacement
Coat Color: Albino
Genetic Background: NOD

Guides & Publications

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Applications & Therapeutic Areas

  • Immunology
  • Oncology & Immuno-Oncology
  • Infectious Disease

Transit, Housing & Welfare

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Taconic packs humanized immune system mice as cagemates -  one engraftment lot per Taconic Transit Cage (TTC).  Taconic does not combine different lots into a single TTC. 

Data

Human Neutrophils
Individual Donors Data
4 weeks post engraftment

Human Neutrophils
3 Donors Combined
4 weeks post engraftment

Licensing

Nonprofit users (excluding users at nonprofit foundations which are affiliated with a for-profit entity): For internal research purposes, the CIEA NOG mouse® Conditions of Use for nonprofit users apply. If you wish to perform sponsored research or fee-for-service contract research using the CIEA NOG mouse®, please inquire for access conditions.

For-profit users and users at foundations which are affiliated with for-profit entities: The CIEA NOG mouse® Conditions of Use for for-profit users apply.

The CIEA NOG mouse® is produced and distributed under license rights to the following patents and trademarks:

  • Japanese Patent No. 3,753,321
  • US Patent No. 7,145,055; 5,464,764; 5,487,992; 5,627,059; 5,631,153; 5,789,215; 6,204,061; 6,653,113; 6,689,610
    EP Patent No. 1,338,198
  • Japanese Trademark Reg. No. 4,823,423
  • US Trademark Reg. No. 3,118,040
  • EU Trademark Reg. No. 3,736,758

Pricing - USD

OF Health Standard Available

 

Opportunist Free (OF) Health Standard

HSCCB-23225 Female

HSCCB-23225-F Genotype hu/hu;sp/sp;ko/ko

Age in Weeks Post EngraftmentQuantity 6 - 1000
1 to 5 US$1,481.00

HSCCB-23225 Male

HSCCB-23225-M Genotype hu/hu;sp/sp;ko/y

Age in Weeks Post EngraftmentQuantity 6 - 1000
1 to 5 US$1,481.00

Pricing - EUR

OF Health Standard Available

 

Opportunist Free (OF) Health Standard

HSCCB-23225 Female

HSCCB-23225-F Genotype hu/hu;sp/sp;ko/ko

Age in Weeks Post EngraftmentQuantity 6 - 1000
1 to 5 1.289,00 €

HSCCB-23225 Male

HSCCB-23225-M Genotype hu/hu;sp/sp;ko/y

Age in Weeks Post EngraftmentQuantity 6 - 1000
1 to 5 1.289,00 €

Pricing - DKK

OF Health Standard Available

 

Opportunist Free (OF) Health Standard

HSCCB-23225 Female

HSCCB-23225-F Genotype hu/hu;sp/sp;ko/ko

Age in Weeks Post EngraftmentQuantity 6 - 1000
1 to 5 kr.9.612,00

HSCCB-23225 Male

HSCCB-23225-M Genotype hu/hu;sp/sp;ko/y

Age in Weeks Post EngraftmentQuantity 6 - 1000
1 to 5 kr.9.612,00

Pricing - USD Nonprofit

OF Health Standard Available

 

Opportunist Free (OF) Health Standard

HSCCB-23225 Female

HSCCB-23225-F Genotype hu/hu;sp/sp;ko/ko

Age in Weeks Post EngraftmentQuantity 6 - 1000
1 to 5 US$1,288.00

HSCCB-23225 Male

HSCCB-23225-M Genotype hu/hu;sp/sp;ko/y

Age in Weeks Post EngraftmentQuantity 6 - 1000
1 to 5 US$1,288.00

Pricing - EUR Nonprofit

OF Health Standard Available

 

Opportunist Free (OF) Health Standard

HSCCB-23225 Female

HSCCB-23225-F Genotype hu/hu;sp/sp;ko/ko

Age in Weeks Post EngraftmentQuantity 6 - 1000
1 to 5 1.121,00 €

HSCCB-23225 Male

HSCCB-23225-M Genotype hu/hu;sp/sp;ko/y

Age in Weeks Post EngraftmentQuantity 6 - 1000
1 to 5 1.121,00 €

Pricing - DKK Nonprofit

OF Health Standard Available

 

Opportunist Free (OF) Health Standard

HSCCB-23225 Female

HSCCB-23225-F Genotype hu/hu;sp/sp;ko/ko

Age in Weeks Post EngraftmentQuantity 6 - 1000
1 to 5 kr.8.360,00

HSCCB-23225 Male

HSCCB-23225-M Genotype hu/hu;sp/sp;ko/y

Age in Weeks Post EngraftmentQuantity 6 - 1000
1 to 5 kr.8.360,00

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