Rag2 - Model RAG2

Rag2 (Model RAG2) Constitutive Knockout Mouse Model
  • Cryopreserved
  • Mouse
  • White-Bellied Black Agouti
  • Not available for direct purchase by CRO
Model No.NomenclatureGenotype
RAG2129S6/SvEvTac-Rag2tm1Fwa
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Overview

Nomenclature: 129S6/SvEvTac-Rag2tm1Fwa

  • Contains a disruption of the recombination activating gene 2 (Rag2)
  • Homozygous mice exhibit total inability to initiate V(D)J rearrangement and fail to generate mature T or B lymphocytes.
  • Useful for vaccine development, transplantation studies and hematopoiesis research.
  • The 129S6 strain was the original strain in which the Rag2 targeted mutation was created

Availability

This model is cryopreserved and available for cryorecovery. You may wish to consider other models with this same mutation which are available from live colonies, models RAGN12 and 601

This model is cryopreserved and available for recovery. Models can typically be recovered and delivered to customers within 14-16 weeks after order receipt. Purchase of this model includes perpetual use rights and a deliverable of four mutant animals at the Murine Pathogen Free™ health standard along with a genotyping protocol. For models which include a recombinase gene or multiple alleles, all alleles will be provided, but individual animals may not contain all mutant alleles.

Taconic’s Colony Management experts can design a plan to grow your colony faster.

Genetics

Species:Mouse
Strain Type:Inbred
Allele Type:Constitutive Knockout
Coat Color:White-Bellied Black Agouti
Genetic Background:129

Other Genetic Notes:

Wild type for Nnt mutation; carries mutated Disc1

Guides & Publications

Initial Publication: Shinkai, Y, Rathbun, G, Lam, KP, Oltz, EM, Stewart, V, Mendelsohn, M, Charron, J, Datta, M, Young, F, Stall, AM, and Alt, FW. (1992) RAG-2-Deficient Mice Lack Mature Lymphocytes Owing to Inability to Initiate V(D)J Rearrangement, Cell, 68: 855-867.

Applications & Therapeutic Areas

  • Immunology
  • Oncology & Immuno-Oncology
  • Inflammation

Transit, Housing & Welfare

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Data

Hematology reference data provided courtesy of ArcticLAS
.

Rag2 - Model RAG2

Customers may purchase this model by signing the appropriate Terms of Sale (below) and providing a PO.
This model is sold under terms which grant perpetual use rights.

Pricing - USD

RAG2

ItemCommercialNonprofit
Cryopreserved Model$23,100.00$17,325.00

Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.

Fees for Taconic Transit Cages™ and freight are in addition to the price above.

Pricing - EUR

RAG2

ItemCommercialNonprofit
Cryopreserved Model€21.000,00€15.855,00

Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.

Fees for Taconic Transit Cages™ and freight are in addition to the price above.

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