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A new and improved B6 Albino strain based on the C57BL/6NTac substrain.
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Contains a mutation in the Tyr gene to introduce albinism
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The Taconic B6 Albino is an ideal host for maintaining substrain specificity of ES cells derived from the C57BL/6NTac substrain
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May be used as a blastocyst host for B6 ES cells with an agouti mutation
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Can also be used as a genetic background for models in which a B6 background is needed with an albino coat, for example in imaging applications
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Available only from Taconic!
Orders by weight: Taconic cannot accept orders by weight for this model. Please note that shipments may contain animals with a larger weight variation.
Genetic Background:
C57BL/6NTac Background Origin:
The B6 Albino model was developed by Taconic. The Tyr mutation is a constitutive knock in of a point mutation in which a G nucleotide located at position 369 in exon 1 has been replaced with C nucleotide, resulting in an amino acid substitution at position 103 (Cys>Ser). The F3 site flanked selection marker was removed by via Flp recombinase. This mutation was made in the C57BL/6NTac substrain. The line was intracrossed to homozygosity. Availability:
Production at Danish facilities ended on December 31, 2015. This model is produced in the U.S. and available to ship internationally. Genetics:
Use the Taconic B6 Albino as a blastocyst donor for agouti JM8A3 ES cells. Use of the Taconic B6 Albino as a blastocyst donor for JM8A3 ES cells permits detection of germline transmission by coat color in 100% of pups. G1 germline pups are heterozygous at one or two coat color loci. Color:
Albino Species:
Mouse Initial Publication:
Zevnik B, Uyttersprot NC, Perez AV, Bothe GW, Kern H, Kauselmann G. (2014) C57BL/6N albino/agouti mutant mice as embryo donors for efficient germline transmission of C57BL/6 ES cells.
PLoS One. 2014 Mar 5;9(3):e90570.
