B6 Albino

Targeted Replacement

B6 Albino Targeted Replacement Mouse Model

C57BL/6NTac Background

  • Model #
  • Genotype
  • Nomenclature
  • 11971-F
    ki/ki
    C57BL/6NTac-Tyrtm1Arte
  • 11971-M
    ki/ki
    C57BL/6NTac-Tyrtm1Arte
  • A new and improved B6 Albino strain based on the C57BL/6NTac substrain.
  • Contains a mutation in the Tyr gene to introduce albinism
  • The Taconic B6 Albino is an ideal host for maintaining substrain specificity of ES cells derived from the C57BL/6NTac substrain
  • May be used as a blastocyst host for B6 ES cells with an agouti mutation
  • Can also be used as a genetic background for models in which a B6 background is needed with an albino coat, for example in imaging applications
  • Available only from Taconic!

B6 Albino Germline

Orders by weight: Taconic cannot accept orders by weight for this model. Please note that shipments may contain animals with a larger weight variation.

Genetic Background:

C57BL/6NTac Background

Origin:

The B6 Albino model was developed by Taconic. The Tyr mutation is a constitutive knock in of a point mutation in which a G nucleotide located at position 369 in exon 1 has been replaced with C nucleotide, resulting in an amino acid substitution at position 103 (Cys>Ser). The F3 site flanked selection marker was removed by via Flp recombinase. This mutation was made in the C57BL/6NTac substrain. The line was intracrossed to homozygosity.

Availability:

Production at Danish facilities ended on December 31, 2015. This model is produced in the U.S. and available to ship internationally.

Genetics:

Use the Taconic B6 Albino as a blastocyst donor for agouti JM8A3 ES cells.   Use of the Taconic B6 Albino as a blastocyst donor for JM8A3 ES cells permits detection of germline transmission by coat color in 100% of pups. G1 germline pups are heterozygous at one or two coat color loci.

Color:

Albino

Species:

Mouse

Initial Publication:

Zevnik B, Uyttersprot NC, Perez AV, Bothe GW, Kern H, Kauselmann G. (2014) C57BL/6N albino/agouti mutant mice as embryo donors for efficient germline transmission of C57BL/6 ES cells. PLoS One. 2014 Mar 5;9(3):e90570.


Conditions of Use for Emerging Models
Emerging Models are produced and distributed under rights to patents and intellectual property licensed from various institutions. Taconic sells the Models to purchasers, grants to each purchaser a right under Taconic's rights in such licensed patents and intellectual property to use the purchased Model in consideration of purchasers' acknowledgement of and agreement to the Terms and Conditions of Sale and the following terms of use:
  • Title to these Models and biological materials derived from them remains with Taconic Biosciences, Inc.
  • The Models will be used for research purposes only.
  • The Models will not be bred or cross-bred except to obtain embryos or fetuses required for research purposes unless a breeding or cross-breeding agreement has been legally executed. Please contact Taconic Customer Service for details.
  • The Models and biological materials derived from them will not be distributed to third parties or used for commercial purposes.
  • Non-profit purchasers may not use this Model and/or biological materials derived from it in sponsored research or contract research studies unless it is purchased at the for-profit price.
Conditions of Use - Printable Version