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A new and improved B6 Albino strain based on the C57BL/6NTac substrain.
Contains a mutation in the Tyr gene to introduce albinism
The Taconic B6 Albino is an ideal host for maintaining substrain specificity of ES cells derived from the C57BL/6NTac substrain
May be used as a blastocyst host for B6 ES cells with an agouti mutation
Can also be used as a genetic background for models in which a B6 background is needed with an albino coat, for example in imaging applications
Available only from Taconic!
Taconic cannot accept orders by weight for this model. Please note that shipments may contain animals with a larger weight variation.
Genetic Background: C57BL/6NTac Background
Origin: The B6 Albino model was developed by Taconic. The Tyr mutation is a constitutive knock in of a point mutation in which a G nucleotide located at position 369 in exon 1 has been replaced with C nucleotide, resulting in an amino acid substitution at position 103 (Cys>Ser). The F3 site flanked selection marker was removed by via Flp recombinase. This mutation was made in the C57BL/6NTac substrain. The line was intracrossed to homozygosity.
Availability: Production at Danish facilities ended on December 31, 2015. This model is produced in the U.S. and available to ship internationally.
Genetics: Use the Taconic B6 Albino as a blastocyst donor for agouti JM8A3 ES cells. Use of the Taconic B6 Albino as a blastocyst donor for JM8A3 ES cells permits detection of germline transmission by coat color in 100% of pups. G1 germline pups are heterozygous at one or two coat color loci.
Zevnik B, Uyttersprot NC, Perez AV, Bothe GW, Kern H, Kauselmann G. (2014) C57BL/6N albino/agouti mutant mice as embryo donors for efficient germline transmission of C57BL/6 ES cells. PLoS One. 2014 Mar 5;9(3):e90570