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B6 Albino

Targeted Replacement

B6 Albino Targeted Replacement Mouse Model
EZcohort® Models
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This model is available for immediate cryorecovery.

C57BL/6NTac Background

  • Model #
  • Genotype
  • Nomenclature
  • 11971
    C57BL/6NTac-Tyrtm1Arte
  • A new and improved B6 Albino strain based on the C57BL/6NTac substrain.
  • Contains a mutation in the Tyr gene to introduce albinism
  • The Taconic B6 Albino is an ideal host for maintaining substrain specificity of ES cells derived from the C57BL/6NTac substrain
  • May be used as a blastocyst host for B6 ES cells with an agouti mutation
  • Can also be used as a genetic background for models in which a B6 background is needed with an albino coat, for example in imaging applications
  • Available only from Taconic!

B6 Albino Germline

Orders by weight: Taconic cannot accept orders by weight for this model. Please note that shipments may contain animals with a larger weight variation.

Genetic Background:

C57BL/6NTac Background

Origin:

The B6 Albino model was developed by Taconic. The Tyr mutation is a constitutive knock in of a point mutation in which a G nucleotide located at position 369 in exon 1 has been replaced with C nucleotide, resulting in an amino acid substitution at position 103 (Cys>Ser). The F3 site flanked selection marker was removed by via Flp recombinase. This mutation was made in the C57BL/6NTac substrain. The line was intracrossed to homozygosity.


Availability:

Production at Danish facilities ended on December 31, 2015. This model is produced in the U.S. and available to ship internationally.

Genetics:

Use the Taconic B6 Albino as a blastocyst donor for agouti JM8A3 ES cells.   Use of the Taconic B6 Albino as a blastocyst donor for JM8A3 ES cells permits detection of germline transmission by coat color in 100% of pups. G1 germline pups are heterozygous at one or two coat color loci.


Color:

Albino

Species:

Mouse

Initial Publication:

Zevnik B, Uyttersprot NC, Perez AV, Bothe GW, Kern H, Kauselmann G. (2014) C57BL/6N albino/agouti mutant mice as embryo donors for efficient germline transmission of C57BL/6 ES cells. PLoS One. 2014 Mar 5;9(3):e90570.



To purchase this EZcohort model, sign the terms of sale (choose from the list below) and email it directly to info@taconic.com with a purchase order for the purchase price:

This model is sold under terms which grant perpetual use rights.