Abb/B2m

Constitutive Knockout

Abb/B2m Constitutive Knockout Mouse Model
EZcohort® Models
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This model is available for immediate cryorecovery.

C57BL/6 Background

  • Model #
  • Genotype
  • Nomenclature
  • 4080
    B6.129-H2-Ab1tm1Gru B2mtm1Jae N17
  • Contains a disruption of the H2-Ab1 gene
  • Expresses no A or E MHC class II molecules and therefore lacks most CD4+ T cells
  • Useful in transplantation, gene therapy and immunological disease research

Origin:

The Abb/B2m multiple targeted mutation model was generated through the mating of B2m and Abb lines from the Jaenisch laboratory at the Whitehead Institute and the Glimcher lab at Harvard University, respectively. Abb mice at three backcrosses (N3) onto C57BL/6 were mated to B2m at eight backcrosses (N8) onto C57BL/6 in 1992 by Laurie Glimcher. The mice were then backcrossed to N17. Taconic received stock through the NIAID repository and embryo transfer derived the line in 1996. The line was maintained through mating of double homozygotes.

Genetics:

Wild type for Nnt mutation

Color:

Black

Species:

Mouse

Initial Publication:

Grusby MJ, Auchincloss H Jr, Lee R, Johnson RS, Spencer JP, Zijlstra M, Jaenisch R, Papaioannou VE, Glimcher LH. (1993) Mice lacking major histocompatibility complex class I and class II moleculesProc Natl Acad Sci USA, 90(9):3913-3917.


To purchase this EZcohort model, sign the Teams of Sale (choose from the list below) and email it directly to legal@taconic.com:

This model is sold under terms which grant perpetual use rights.
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