Constitutive Knockout

Abb/B2m Constitutive Knockout Mouse Model
EZcohort® Models
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This model is available for immediate cryorecovery.

C57BL/6 Background

  • Model #
  • Genotype
  • Nomenclature
  • 4080
    B6.129-H2-Ab1tm1Gru B2mtm1Jae N17
  • Contains a disruption of the H2-Ab1 gene
  • Expresses no A or E MHC class II molecules and therefore lacks most CD4+ T cells
  • Useful in transplantation, gene therapy and immunological disease research


The Abb/B2m multiple targeted mutation model was generated through the mating of B2m and Abb lines from the Jaenisch laboratory at the Whitehead Institute and the Glimcher lab at Harvard University, respectively. Abb mice at three backcrosses (N3) onto C57BL/6 were mated to B2m at eight backcrosses (N8) onto C57BL/6 in 1992 by Laurie Glimcher. The mice were then backcrossed to N17. Taconic received stock through the NIAID repository and embryo transfer derived the line in 1996. The line was maintained through mating of double homozygotes.


Wild type for Nnt mutation





Initial Publication:

Grusby MJ, Auchincloss H Jr, Lee R, Johnson RS, Spencer JP, Zijlstra M, Jaenisch R, Papaioannou VE, Glimcher LH. (1993) Mice lacking major histocompatibility complex class I and class II moleculesProc Natl Acad Sci USA, 90(9):3913-3917.

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