Abb (H2-Ab1) - Model ABBN12

Abb (H2-Ab1) ABBN12 Constitutive Knockout Mouse Model
  • Cryopreserved
  • Mouse
  • Black
  • Not available for direct purchase by CRO
Model No.NomenclatureGenotype
ABBN12B6.129-H2-Ab1tm1Gru N12
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Overview

Nomenclature: B6.129-H2-Ab1tm1Gru N12

  • Contains a disruption of the H2-Ab1 gene
  • Expresses no A or E MHC class II molecules and therefore lacks most CD4+ T cells
  • Useful in transplantation, gene therapy and immunological disease research

Orders by weight: Taconic cannot accept orders by weight for this model. Please note that shipments may contain animals with a larger weight variation.

This model is cryopreserved and available for recovery. Models can typically be recovered and delivered to customers within 14-16 weeks after order receipt. Purchase of this model includes perpetual use rights and a deliverable of four mutant animals at the Murine Pathogen Free™ health standard along with a genotyping protocol. For models which include a recombinase gene or multiple alleles, all alleles will be provided, but individual animals may not contain all mutant alleles.

Taconic’s Colony Management experts can design a plan to grow your colony faster.

Genetics

Species:Mouse
Strain Type:Congenic
Allele Type:Constitutive Knockout
Coat Color:Black
Genetic Background:C57BL/6

Other Genetic Notes:

Wild type for Nnt mutation, carries Pde6brd1 mutation

Guides & Publications

Initial Publication: 

Grusby MJ, Johnson RS, Papaioannou VE, Glimcher LH. (1991) Depletion of CD4+ T-Cells in Major Histocompatibility Complex Class II - Deficient Mice. Science, 253(5026):1417-1420.

Applications & Therapeutic Areas

  • Autoimmune Disease
  • Immunology
  • Infectious Disease
  • Inflammation
  • Microbiome
  • Oncology & Immuno-Oncology
  • Vaccine Research

Transit, Housing & Welfare

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Abb (H2-Ab1) - Model ABBN12

Customers may purchase this model by signing the appropriate Terms of Sale (below) and providing a PO.
This model is sold under terms which grant perpetual use rights.

Pricing - USD

ABBN12

ItemCommercialNonprofit
Cryopreserved Model$23,100.00$17,325.00

Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.

Fees for Taconic Transit Cages™ and freight are in addition to the price above.

Pricing - EUR

ABBN12

ItemCommercialNonprofit
Cryopreserved Model€21.000,00€15.855,00

Cryopreserved models are invoiced upon shipment of recovered animals. Once orders are placed, the full purchase price will be applied if the order is canceled. For orders greater than 4 animals, please contact Taconic for options.

Fees for Taconic Transit Cages™ and freight are in addition to the price above.

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Get your Taconic Biosciences 2024 Pricing Guide today. Personalized, customizable, links to up-to-date health reports, and additional information on Taconic's products and services.