Orders by weight:
- Contains a disruption of the H2-Ab1 gene
- Expresses no A or E MHC class II molecules and therefore lacks most CD4+ T cells
- Useful in transplantation, gene therapy and immunological disease research
Taconic cannot accept orders by weight for this model. Please note that shipments may contain animals with a larger weight variation.
Genetic Background: C57BL/6 Background
Origin: The Abb mouse was developed in the laboratory of Michael J. Grusby et al. of the Harvard School of Public Health. The model was created by targeting the H2-Ab1 gene in ES-D3 cells and injecting the targeted ES cells into C57BL/6 blastocysts. Resultant chimeras were backcrossed to C57BL/6 for 4 generations (N4). Taconic received stock from Tufts University in December 1991, and the mice were backcrossed eight additional generations (N12) to C57BL/6NTac. The mice were derived by embryo transfer and intercrossed to homozygosity.
Genetics: Wild type for Nnt mutation, carries Pde6brd1 mutation
Grusby MJ, Johnson RS, Papaioannou VE, Glimcher LH. (1991) Depletion of CD4+ T-Cells in Major Histocompatibility Complex Class II - Deficient Mice
. Science, 253(5026):1417-1420