About the webinar:
Alzheimer’s disease is the most common cause of dementia. It is associated with the build-up of small protein aggregates in the brain, termed β-amyloid plaques, ultimately leading to brain damage and memory loss. Overall, more women are affected by Alzheimer’s disease than men, but the reasons for these differences are not fully understood. Elucidating these differences is crucial for improving therapies aimed at reducing the detrimental impact of β-amyloid plaque buildup.
This study aimed to investigate sex-specific β-amyloid plaque dynamics in a female and male transgenic mouse model of Alzheimer’s disease. To enable this, we employed 3-dimensional imaging to map and quantify β-amyloid plaques throughout the intact mouse brain at different ages. We found that female transgenic mice develop β-amyloid plaques earlier and show a more rapid and widespread accumulation than their male counterparts in almost all parts of the brain.
In conclusion, our study provides the first quantitative assessment of sex differences in progressive β-amyloid plaque pathology across the entire brain in a mouse model of Alzheimer’s disease, offering insights that may guide future research and inform the development of sex-specific treatment strategies.
