Neurobiology Video Series

Neuroscience research is evolving rapidly, bringing new opportunities and challenges in disease modeling, colony management, breeding strategy, and translational discovery. In this video series, Taconic's scientific experts share practical insights drawn from their hands-on experience supporting researchers in biotech, pharmaceutical, and academic organizations.

Episode 1

What's New in Alzheimer's Disease Modeling?

Alzheimer's disease is highly heterogeneous, making it difficult for any single preclinical model to capture the full complexity of human disease biology and therapeutic response. In this episode, Dr. Janell Richardson explores emerging approaches to Alzheimer's disease modeling and discusses how advanced preclinical platforms can help researchers investigate genotype-dependent differences and improve translational relevance.


Video

Episode 2—Coming Soon

Why Are Neurological Mouse Models So Difficult to Breed?

Producing study-ready cohorts of neurological disease models often requires careful planning around breeding performance, phenotype development, aging, and attrition. In this episode, Dr. Caroline Mallick-Wood shares insights for anticipating these challenges and designing breeding programs that support neuroscience research.


Video

Episode 3

When Breeding Neuroscience In Vivo Models Doesn’t Go As Planned

Even the most carefully designed neurological disease breeding programs can face unexpected challenges that threaten study timelines, cohort availability, and research outcomes. In this episode, Dr. Gretchen Kusek shares practical strategies for anticipating risk, managing biological variability, and building contingency plans that help keep complex neuroscience research programs on track.


Additional Resources

APOE4 x APP/PS1 (ARTE10) Alzheimer's Mouse Model

Human APOE4 Alzheimer's mouse model combining APOE4 targeted replacement genetics with APP/PS1 (ARTE10) amyloid pathology for preclinical research.
Black Mouse

Mice and Rat Models for Neurobiology Research

Taconic provides easy access to models and services for the study of neuronal disease and signaling, many of which are available exclusively from Taconic with rights to use.
Neurobiology

APOE3xARTE10 & APOE4xARTE10 APP/PS1 Alzheimer’s Models

Evaluate amyloid pathology, plaque-associated glial response, and APOE genotype effects using APOE3xARTE10 and APOE4xARTE10 human APOE APP/PS1 Alzheimer’s disease models.
Neurobiology

Interested in Learning More? Ask an Expert


Featured Experts

Jessica Ramadhin

Sarah Sterlace, PhD  LinkedIn

Director, Portfolio Management Neurobiology and Rare Disease

Dr. Sarah Sterlace helps make innovative in vivo models and services accessible to neuroscience researchers around the world. With extensive experience translating complex research challenges into practical solutions, she partners with scientists across biotech, pharmaceutical, and academic organizations to advance preclinical discovery. Through these conversations, Sarah helps viewers explore emerging research approaches, model selection strategies, and opportunities to accelerate scientific progress.


Jessica Ramadhin

Janell Richardson, PhD  LinkedIn

Director, R&D

Dr. Janell Richardson leads the development of innovative research models and technologies that help advance translational science. Her work focuses on creating solutions that enable researchers to investigate complex disease biology with greater precision and confidence. In this series, Janell explores emerging approaches to Alzheimer's disease modeling and discusses how advanced preclinical platforms can help scientists better understand genotype-dependent disease mechanisms and therapeutic responses.