News Release
Rensselaer, NY, June 19, 2025 – As drug discovery efforts shift towards increasingly complex and highly specific biologic therapeutics, finding the appropriate in vivo models for preclinical work becomes more challenging. More than ever, researchers are turning to CD34+ human hematopoietic stem cell (HSC)-engrafted mouse models that functionally recapitulate many aspects of the human immune system. However, natural variations among human HSC donors often occur, leading to data variability and poor reproducibility.
To address this, Taconic Biosciences has launched huSelect™ Custom Humanization Services, which enables researchers to harness the power of humanized immune system models that are more reliable, consistent, and clinically relevant.
Taconic’s huSelect™ suite offers:
- HLA-Driven Donor Selection: Choose CD34+ donors from Taconic inventory based on specific HLA types tailored to immunogenicity study requirements
- Donor Consistency: Conduct repeat studies with previously profiled donors or reserve specific donor cells for future experiments
- Pre-characterized Donors: Access CD34+ HSCs that have been pre-validated, with immune profiling data available at multiple post-engraftment timepoints in huNOG-EXL mice
- Custom Immune Profiling: Flow cytometry services to assess immune cell reconstitution on CD34+ engrafted mice, either pre-shipment or from researcher-provided samples.
“The huSelect portfolio of services was developed to give researchers the tools they need to conduct reliable, reproducible and clinically relevant immuno-oncology, autoimmune, and infectious disease studies with humanized immune system mice,” said Monika Buczek, PhD, Director, Humanized Immune Model Core at Taconic Biosciences. “By creating custom models with carefully selected CD34+ donor criteria, researchers can reduce donor-to-donor variability and improve the quality and consistency of their therapeutic study outcomes.”
For more information or to secure preferred donors, visit http://www.taconic.com/huselect.
"The huSelect portfolio of services was developed to give researchers the tools they need to conduct reliable, reproducible and clinically relevant immuno-oncology, autoimmune, and infectious disease studies with humanized immune system mice."
Monika Buczek, PhD
Director, Humanized Immune Model Core
About Taconic Biosciences, Inc.
Taconic Biosciences is a fully licensed, global leader in genetically engineered rodent models and services. Founded in 1952, Taconic provides the best animal solutions enabling customers to acquire, custom-generate, breed, precondition, test, and distribute valuable research models worldwide. Specialists in genetically engineered mouse and rat models, microbiome, immuno-oncology mouse models, and integrated model design and breeding services, Taconic operates service laboratories and breeding facilities in the U.S. and Europe, maintains distributor relationships in Asia and has global shipping capabilities to provide animal models almost anywhere in the world.
Media Contact:
Michael Seiler, PhD
Vice President, Commercial
marketing@taconic.com
