Line 10681 was developed in the laboratory of Chenjian Li at Cornell. The model was created through pronuclear injection of human gene LRRK2 with the G2019S mutation into NTac:SD zygotes. Founder line 571 was bred to NTac:SD. The colony is maintained by mating a wild type female with a hemizygous male to produce hemizygous pups. Taconic received stock from Cornell in 2010 and derived the rats through embryo transfer derivation.
Initial characterization of this model is in progress.
Nonprofit users may purchase rats off the shelf for research purposes under a simple label license (no signatures required). For-profit users must first execute a license agreement with Cornell University.
Conditions of Use for Parkinson's Disease Rat Models for Nonprofit Users:
For licensing information, contact:
Cornell Center for Technology Enterprise and Commercialization
Attention: Executive Director
395 Pine Tree Road, Suite 310
Ithaca, NY 14850
Cite: Docket D4184 (LRRK2) and D5203 (alpha-synuclein)