TSG-p53® - Model P53N12 Publications

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Toledo F, et al.
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Toledo F, Liu CW, Lee CJ, Wahl GM
(2006) RMCE-ASAP: a gene targeting method for ES and somatic cells to accelerate phenotype analyses. Nucleic Acids Res. 34(13):e92
Pritchard JB, et al.
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Pritchard JB, French JE, Davis BJ, Haseman JK
(2003) The role of transgenic mouse models in carcinogen identification. Environ. Health Perspect. 111(4):444-54
Johansson FK, et al.
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Johansson FK, Brodd J, Eklöf C, Ferletta M, Hesselager G, Tiger CF, Uhrbom L, Westermark B
(2004) Identification of candidate cancer-causing genes in mouse brain tumors by retroviral tagging. Proc. Natl. Acad. Sci. U.S.A. 101(31):11334-7
Oncology
Hursting SD, et al.
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Hursting SD, Perkins SN, Haines DC, Ward JM, Phang JM
(1995) Chemoprevention of spontaneous tumorigenesis in p53-knockout mice. Cancer Res. 55(18):3949-53
Hursting SD, et al.
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Hursting SD, Perkins SN, Donehower LA, Davis BJ
(2001) Cancer prevention studies in p53-deficient mice. Toxicol Pathol 29(1):137-41
Horn TL, et al.
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Horn TL, Cwik MJ, Morrissey RL, Kapetanovic I, Crowell JA, Booth TD, McCormick DL
(2007) Oncogenicity evaluation of resveratrol in p53(+/-) (p53 knockout) mice. Food Chem. Toxicol. 45(1):55-63
Oncology
Harvey M, et al.
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Harvey M, Sands AT, Weiss RS, Hegi ME, Wiseman RW, Pantazis P, Giovanella BC, Tainsky MA, Bradley A, Donehower LA
(1993) In vitro growth characteristics of embryo fibroblasts isolated from p53-deficient mice. Oncogene 8(9):2457-67
Fukasawa K, et al.
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Fukasawa K, Choi T, Kuriyama R, Rulong S, Vande Woude GF
(1996) Abnormal centrosome amplification in the absence of p53. Science 271(5256):1744-7
Ferguson DO, et al.
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Ferguson DO, Sekiguchi JM, Chang S, Frank KM, Gao Y, DePinho RA, Alt FW
(2000) The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations. Proc. Natl. Acad. Sci. U.S.A. 97(12):6630-3
Donehower LA, et al.
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Donehower LA, Harvey M, Slagle BL, McArthur MJ, Montgomery CA, Butel JS, Bradley A
(1992) Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature 356(6366):215-21
Crumrine RC, et al.
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Crumrine RC, Thomas AL, Morgan PF
(1994) Attenuation of p53 expression protects against focal ischemic damage in transgenic mice. J. Cereb. Blood Flow Metab. 14(6):887-91
Bielas JH, et al.
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Bielas JH, Heddle JA
(2003) Elevated mutagenesis and decreased DNA repair at a transgene are associated with proliferation but not apoptosis in p53-deficient cells. Proc. Natl. Acad. Sci. U.S.A. 100(22):12853-8
Baxter EW, et al.
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Baxter EW, Blyth K, Donehower LA, Cameron ER, Onions DE, Neil JC
(1996) Moloney murine leukemia virus-induced lymphomas in p53-deficient mice: overlapping pathways in tumor development? J. Virol. 70(4):2095-100
Leukemia