TK-NOG Publications

TK-NOG Model Page

Filter publications by application: All ADMET Diabetes (Type 1) Diabetes (Type 2) Hepatitis-B Humanized Infectious Disease Metabolism PK/PD (pharmacokinetic/pharmacodynamic modeling) Safety Assessment Tox & Safety Assessment Virology
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Nishimura T, et al.
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Nishimura T, Nishimura T, Hu Y, Wu M, Pham E, Suemizu H, Elazar M, Liu M, Idilman R, Yurdaydin C, Angus P, Stedman C, Murphy B, Glenn J, Nakamura M, Nomura T, Chen Y, Zheng M, Fitch WL, Peltz G		 (2013) Using chimeric mice with humanized livers to predict human drug metabolism and a drug-drug interaction. J. Pharmacol. Exp. Ther. 344(2):388-96
ADMET, Metabolism, Safety Assessment, Tox & Safety Assessment, Humanized
Xu D, et al.
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Xu D, Wu M, Nishimura S, Nishimura T, Michie SA, Zheng M, Yang Z, Yates AJ, Day JS, Hillgren KM, Takeda ST, Guan Y, Guo Y, Peltz G		 (2015) Chimeric TK-NOG mice: a predictive model for cholestatic human liver toxicity. J. Pharmacol. Exp. Ther. 352(2):274-80
ADMET, Metabolism, Safety Assessment, Tox & Safety Assessment, Humanized
Yamazaki-Nishioka M, et al.
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Yamazaki-Nishioka M, Shimizu M, Suemizu H, Nishiwaki M, Mitsui M, Yamazaki H		 (2017) Human Plasma Metabolic Profiles of Benzydamine, a Flavin-containing Monooxygenase Probe Substrate, Simulated with Pharmacokinetic Data from Control and Humanized-liver Mice. Xenobiotica :1-26
Xu D, et al.
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Xu D, Nishimura T, Nishimura S, Zhang H, Zheng M, Guo YY, Masek M, Michie SA, Glenn J, Peltz G		 (2014) Fialuridine induces acute liver failure in chimeric TK-NOG mice: a model for detecting hepatic drug toxicity prior to human testing. PLoS Med. 11(4):e1001628
Tox & Safety Assessment
Uchida T, et al.
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Uchida T, Hiraga N, Imamura M, Tsuge M, Abe H, Hayes CN, Aikata H, Ishida Y, Tateno C, Yoshizato K, Ohdan H, Murakami K, Chayama K		 (2015) Human Cytotoxic T Lymphocyte-Mediated Acute Liver Failure and Rescue by Immunoglobulin in Human Hepatocyte Transplant TK-NOG Mice. J. Virol. 89(19):10087-96
Hashimoto H, et al.
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Hashimoto H, Mizushima T, Ogura T, Kagawa T, Tomiyama K, Takahashi R, Yagoto M, Kawai K, Chijiwa T, Nakamura M, Suemizu H		 (2016) Study on AAV-mediated gene therapy for diabetes in humanized liver mouse to predict efficacy in humans. Biochem. Biophys. Res. Commun. 478(3):1254-60
Diabetes (Type 1), Virology, Diabetes (Type 2)
Utoh M, et al.
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Utoh M, Suemizu H, Mitsui M, Kawano M, Toda A, Uehara S, Uno Y, Shimizu M, Sasaki E, Yamazaki H		 (2016) Human plasma concentrations of cytochrome P450 probe cocktails extrapolated from pharmacokinetics in mice transplanted with human hepatocytes and from pharmacokinetics in common marmosets using physiologically based pharmacokinetic modeling. Xenobiotica 46(12):1049-1055
Nakabori T, et al.
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Nakabori T, Hikita H, Murai K, Nozaki Y, Kai Y, Makino Y, Saito Y, Tanaka S, Wada H, Eguchi H, Takahashi T, Suemizu H, Sakamori R, Hiramatsu N, Tatsumi T, Takehara T		 (2016) Sodium taurocholate cotransporting polypeptide inhibition efficiently blocks hepatitis B virus spread in mice with a humanized liver. Sci Rep 6:27782
Infectious Disease, Hepatitis-B
Masami Hasegawa, et al.
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Masami Hasegawa, Kenji Kawai, Tetsuya Mitsui, Kenji Taniguchi, Makoto Monnai, Masatoshi Wakui, Mamoru Ito, Makoto Suematsu, Gary Peltz, Masato Nakamura, and Hiroshi Suemizu		 (2013) The Reconstituted ‘Humanized Liver’ in TK-NOG Mice is Mature and Functional Biochem Biophys Res Commun
Mamoru Ito, et al.
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Mamoru Ito, Hidefumi Hiramatsu, Kimio Kobayashi, Kazutomo Suzue, Mariko Kawahata, Kyoji Hioki, Yoshito Ueyama, Yoshio Koyanagi, Kazuo Sugamura, Kohichiro Tsuji, Toshio Heike, Tatsutoshi Nakahata		 (2002) NOD/SCID/γ nullc mouse: an excellent recipient mouse model for engraftment of human cells Blood 2002 100:3175-3182
Humanized
Suemizu H, et al.
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Suemizu H, Nakamura M, Yamazaki H, Igaya S, Shimizu M, Shibata N, Chowdhury G, Guengerich FP		 (2012) In vivo Formation of Dihydroxylated and Glutathione Conjugate Metabolites derived from Thalidomide and 5-Hydroxythalidomide in Humanized TK-NOG mice Chem Res Toxicol. 25(2): 274-276
Suemizu H, et al.
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Suemizu H, Nakamura M, Yamazaki H, Shibata N, Guengerich FP, Murayama N, Utoh M		 (2013) In vivo Drug Interactions of the Teratogen Thalidomide with Midazolam: Heterotropic Cooperativity of Human Cytochrome P450 in Humanized TK-NOG Mice Chem Res Toxicol. 26(3):486-489
Xu D, et al.
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Xu D, Michie SA, Zheng M, Takeda S, Wu M, Peltz G		 (2015) Humanized thymidine kinase-NOG mice can be used to identify drugs that cause animal-specific hepatotoxicity: a case study with furosemide. J. Pharmacol. Exp. Ther. 354(1):73-8
Soulard V, et al.
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Soulard V, Bosson-Vanga H, Lorthiois A, Roucher C, Franetich JF, Zanghi G, Bordessoulles M, Tefit M, Thellier M, Morosan S, Le Naour G, Capron F, Suemizu H, Snounou G, Moreno-Sabater A, Mazier D		 (2015) Plasmodium falciparum full life cycle and Plasmodium ovale liver stages in humanized mice. Nat Commun 6:7690
Peltz G
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Peltz G		 (2013) Can ‘Humanized’ Mice Improve Drug Development in the 21st Century? Trends Pharmacol Sci. 34(5): 255-260
Nomura T, et al.
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Nomura T, Suemizu H, Nakamura M, Chen Y, Wu M, Liu M, Nishimura T, Hu Y, Zheng M, Pham E, Elazar M, Idilman R, Yurdaydin C, Angus P, Stedman C, Murphy B, Glenn J, Fitch WL, Peltzcorresponding G		 (2013) Using Chimeric Mice with Humanized Livers to Predict Human Drug Metabolism and a Drug-Drug Interaction J Pharmacol Exp Ther. 344(2):388-396
Miyaguchi T, et al.
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Miyaguchi T, Suemizu H, Shimizu M, Shida S, Nishiyama S, Takano R, Murayama N, Yamazaki H		 (2015) Human urine and plasma concentrations of bisphenol A extrapolated from pharmacokinetics established in in vivo experiments with chimeric mice with humanized liver and semi-physiological pharmacokinetic modeling. Regul. Toxicol. Pharmacol. 72(1):71-6
Kosaka K, et al.
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Kosaka K, Hiraga N, Imamura M, Yoshimi S, Murakami E, Nakahara T, Honda Y, Ono A, Kawaoka T, Tsuge M, Abe H, Hayes CN, Miki D, Aikata H, Ochi H, Ishida Y, Tateno C, Yoshizato K, Sasaki T, Chayama K		 (2013) A novel TK-NOG based humanized mouse model for the study of HBV and HCV infections. Biochem. Biophys. Res. Commun. 441(1):230-5
Kamimura H, et al.
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Kamimura H, Ito S, Nozawa K, Nakamura S, Chijiwa H, Nagatsuka S, Kuronuma M, Ohnishi Y, Suemizu H, Ninomiya S		 (2015) Formation of the accumulative human metabolite and human-specific glutathione conjugate of diclofenac in TK-NOG chimeric mice with humanized livers. Drug Metab. Dispos. 43(3):309-16
Hu Y, et al.
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Hu Y, Wu M, Nishimura T, Zheng M, Peltz G		 (2013) Human pharmacogenetic analysis in chimeric mice with 'humanized livers'. Pharmacogenet. Genomics 23(2):78-83
ADMET, Tox & Safety Assessment, PK/PD (pharmacokinetic/pharmacodynamic modeling), Humanized
Suemizu H, et al.
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Suemizu H, Kawai K, Nakamura M, Yamazaki H, Higuchi Y, Bree F, Guguen-Guillouzo C		 (2014) The human hepatic cell line HepaRG as a possible cell source for the generation of humanized liver TK-NOG mice Xenobiotica. 44(2):146-153
Grompe M, et al.
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Grompe M, Strom S		 (2013) Mice with human livers. Gastroenterology 145(6):1209-14
Cohen J
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Cohen J		 (2014) Toxicology. 'Humanized' mouse detects deadly drug side effects. Science 344(6181):244-5
Adachi K, et al.
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Adachi K, Suemizu H, Murayama N, Shimizu M, Yamazaki H		 (2015) Human biofluid concentrations of mono(2-ethylhexyl)phthalate extrapolated from pharmacokinetics in chimeric mice with humanized liver administered with di(2-ethylhexyl)phthalate and physiologically based pharmacokinetic modeling. Environ. Toxicol. Pharmacol. 39(3):1067-73