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Ruan X, et al. Mouse over for full list |
(2020) | In vivo functional analysis of non-conserved human lncRNAs associated with cardiometabolic traits. | Nat Commun 11(1):45 | |||
Chen PB, et al. Mouse over for full list |
(2016) | Plasmodium falciparum PfSET7: enzymatic characterization and cellular localization of a novel protein methyltransferase in sporozoite, liver and erythrocytic stage parasites. | Sci Rep 6:21802 | |||
Yamazaki H, et al. Mouse over for full list |
(2012) | In vivo formation of dihydroxylated and glutathione conjugate metabolites derived from thalidomide and 5-Hydroxythalidomide in humanized TK-NOG mice. | Chem. Res. Toxicol. 25(2):274-6 | |||
Tsukada A, et al. Mouse over for full list |
(2013) | Plasma concentrations of melengestrol acetate in humans extrapolated from the pharmacokinetics established in in vivo experiments with rats and chimeric mice with humanized liver and physiologically based pharmacokinetic modeling. | Regul. Toxicol. Pharmacol. 65(3):316-24 | |||
Yamazaki H, et al. Mouse over for full list |
(2013) | In vivo drug interactions of the teratogen thalidomide with midazolam: heterotropic cooperativity of human cytochrome P450 in humanized TK-NOG mice. | Chem. Res. Toxicol. 26(3):486-9 | |||
Higuchi Y, et al. Mouse over for full list |
(2014) | The human hepatic cell line HepaRG as a possible cell source for the generation of humanized liver TK-NOG mice. | Xenobiotica 44(2):146-53 | |||
Kim M, et al. Mouse over for full list |
(2014) | Generation of humanized liver mouse model by transplant of patient-derived fresh human hepatocytes. | Transplant. Proc. 46(4):1186-90 | |||
Kai Y, et al. Mouse over for full list |
(2015) | Emergence of hepatitis C virus NS5A L31V plus Y93H variant upon treatment failure of daclatasvir and asunaprevir is relatively resistant to ledipasvir and NS5B polymerase nucleotide inhibitor GS-558093 in human hepatocyte chimeric mice. | J. Gastroenterol. 50(11):1145-51 | |||
Nishiyama S, et al. Mouse over for full list |
(2015) | Simulation of Human Plasma Concentrations of Thalidomide and Primary 5-Hydroxylated Metabolites Explored with Pharmacokinetic Data in Humanized TK-NOG Mice. | Chem. Res. Toxicol. 28(11):2088-90 | |||
Higuchi Y, et al. Mouse over for full list |
(2016) | Functional polymer-dependent 3D culture accelerates the differentiation of HepaRG cells into mature hepatocytes. | Hepatol. Res. 46(10):1045-57 | |||
Kamimura H, et al. Mouse over for full list |
(2017) | Simulation of human plasma concentration-time profiles of the partial glucokinase activator PF-04937319 and its disproportionate N-demethylated metabolite using humanized chimeric mice and semi-physiological pharmacokinetic modeling. | Xenobiotica 47(5):382-393 | |||
Shimizu M, et al. Mouse over for full list |
(2017) | Metabolic profiles of pomalidomide in human plasma simulated with pharmacokinetic data in control and humanized-liver mice. | Xenobiotica 47(10):844-848 | |||
Suzuki E, et al. Mouse over for full list |
(2017) | Observation of Clinically Relevant Drug Interaction in Chimeric Mice with Humanized Livers: The Case of Valproic Acid and Carbapenem Antibiotics. | Eur J Drug Metab Pharmacokinet 42(6):965-972 | |||
Iwata H, et al. Mouse over for full list |
(2019) | Predictability of human pharmacokinetics of diisononyl phthalate (DINP) using chimeric mice with humanized liver. | Xenobiotica 49(11):1311-1322 | |||
Ganesan M, et al. Mouse over for full list |
(2018) | Demethylase JMJD6 as a New Regulator of Interferon Signaling: Effects of HCV and Ethanol Metabolism. | Cell Mol Gastroenterol Hepatol 5(2):101-112 | |||
Doi A, et al. Mouse over for full list |
(2019) | Combinations of two drugs among NS3/4A inhibitors, NS5B inhibitors and non-selective antiviral agents are effective for hepatitis C virus with NS5A-P32 deletion in humanized-liver mice. | J. Gastroenterol. 54(5):449-458 | |||
Uehara S, et al. Mouse over for full list |
(2019) | Metabolism of desloratadine by chimeric TK-NOG mice transplanted with human hepatocytes. | Xenobiotica :1-8 | |||
Dagur RS, et al. Mouse over for full list |
(2019) | Establishment of the Dual Humanized TK-NOG Mouse Model for HIV-associated Liver Pathogenesis. | J Vis Exp (151) | |||
Michailidis E, et al. Mouse over for full list |
(2020) | Expansion, in vivo-ex vivo cycling, and genetic manipulation of primary human hepatocytes. | Proc. Natl. Acad. Sci. U.S.A. 117(3):1678-1688 | |||
Dagur RS, et al. Mouse over for full list |
(2018) | Human hepatocyte depletion in the presence of HIV-1 infection in dual reconstituted humanized mice. | Biol Open 7(2) | |||
Valérie Soulard Mouse over for full list |
(2016) | Modeling malaria parasites’ life cycle in humanized mice | Humanization |
Malaria | ||
Takebe T, et al. Mouse over for full list |
(2017) | Massive and Reproducible Production of Liver Buds Entirely from Human Pluripotent Stem Cells. | Cell Rep 21(10):2661-2670 | Stem Cells/Regenerative Medicine/Tissue Engineering, Humanized | ||
Fomin ME, et al. Mouse over for full list |
(2017) | Human fetal liver cultures support multiple cell lineages that can engraft immunodeficient mice. | Open Biol 7(12) | Immunology, Stem Cells/Regenerative Medicine/Tissue Engineering, Humanized | ||
Nishimura T, et al. Mouse over for full list |
(2013) | Using chimeric mice with humanized livers to predict human drug metabolism and a drug-drug interaction. | J. Pharmacol. Exp. Ther. 344(2):388-96 | ADMET, Infectious Disease, Metabolism, Safety Assessment, Tox & Safety Assessment, Humanized | ||
Xu D, et al. Mouse over for full list |
(2015) | Chimeric TK-NOG mice: a predictive model for cholestatic human liver toxicity. | J. Pharmacol. Exp. Ther. 352(2):274-80 | ADMET, Metabolism, Safety Assessment, Tox & Safety Assessment, Humanized | ||
Yamazaki-Nishioka M, et al. Mouse over for full list |
(2017) | Human Plasma Metabolic Profiles of Benzydamine, a Flavin-containing Monooxygenase Probe Substrate, Simulated with Pharmacokinetic Data from Control and Humanized-liver Mice. | Xenobiotica :1-26 | |||
Xu D, et al. Mouse over for full list |
(2014) | Fialuridine induces acute liver failure in chimeric TK-NOG mice: a model for detecting hepatic drug toxicity prior to human testing. | PLoS Med. 11(4):e1001628 | Tox & Safety Assessment | ||
Uchida T, et al. Mouse over for full list |
(2015) | Human Cytotoxic T Lymphocyte-Mediated Acute Liver Failure and Rescue by Immunoglobulin in Human Hepatocyte Transplant TK-NOG Mice. | J. Virol. 89(19):10087-96 | |||
Hashimoto H, et al. Mouse over for full list |
(2016) | Study on AAV-mediated gene therapy for diabetes in humanized liver mouse to predict efficacy in humans. | Biochem. Biophys. Res. Commun. 478(3):1254-60 | Diabetes (Type 1), Virology, Diabetes (Type 2) | ||
Utoh M, et al. Mouse over for full list |
(2016) | Human plasma concentrations of cytochrome P450 probe cocktails extrapolated from pharmacokinetics in mice transplanted with human hepatocytes and from pharmacokinetics in common marmosets using physiologically based pharmacokinetic modeling. | Xenobiotica 46(12):1049-1055 | |||
Nakabori T, et al. Mouse over for full list |
(2016) | Sodium taurocholate cotransporting polypeptide inhibition efficiently blocks hepatitis B virus spread in mice with a humanized liver. | Sci Rep 6:27782 | Infectious Disease, Hepatitis-B | ||
Yamazaki H, et al. Mouse over for full list |
(2016) | Assessment of Protein Binding of 5-Hydroxythalidomide Bioactivated in Humanized Mice with Human P450 3A-Chromosome or Hepatocytes by Two-Dimensional Electrophoresis/Accelerator Mass Spectrometry. | Chem. Res. Toxicol. 29(8):1279-81 | |||
Yamazaki H, et al. Mouse over for full list |
(2016) | Combining Chimeric Mice with Humanized Liver, Mass Spectrometry, and Physiologically-Based Pharmacokinetic Modeling in Toxicology. | Chem. Res. Toxicol. | ADMET, Safety Assessment, Tox & Safety Assessment | ||
Masami Hasegawa, et al. Mouse over for full list |
(2013) | The Reconstituted ‘Humanized Liver’ in TK-NOG Mice is Mature and Functional | Biochem Biophys Res Commun | |||
Mamoru Ito, et al. Mouse over for full list |
(2002) | NOD/SCID/γ nullc mouse: an excellent recipient mouse model for engraftment of human cells | Blood 2002 100:3175-3182 | Humanized | ||
Suemizu H, et al. Mouse over for full list |
(2012) | In vivo Formation of Dihydroxylated and Glutathione Conjugate Metabolites derived from Thalidomide and 5-Hydroxythalidomide in Humanized TK-NOG mice | Chem Res Toxicol. 25(2): 274-276 | |||
Suemizu H, et al. Mouse over for full list |
(2013) | In vivo Drug Interactions of the Teratogen Thalidomide with Midazolam: Heterotropic Cooperativity of Human Cytochrome P450 in Humanized TK-NOG Mice | Chem Res Toxicol. 26(3):486-489 | |||
Xu D, et al. Mouse over for full list |
(2015) | Humanized thymidine kinase-NOG mice can be used to identify drugs that cause animal-specific hepatotoxicity: a case study with furosemide. | J. Pharmacol. Exp. Ther. 354(1):73-8 | |||
Soulard V, et al. Mouse over for full list |
(2015) | Plasmodium falciparum full life cycle and Plasmodium ovale liver stages in humanized mice. | Nat Commun 6:7690 | |||
Peltz G Mouse over for full list |
(2013) | Can ‘Humanized’ Mice Improve Drug Development in the 21st Century? | Trends Pharmacol Sci. 34(5): 255-260 | |||
Nomura T, et al. Mouse over for full list |
(2013) | Using Chimeric Mice with Humanized Livers to Predict Human Drug Metabolism and a Drug-Drug Interaction | J Pharmacol Exp Ther. 344(2):388-396 | |||
Miyaguchi T, et al. Mouse over for full list |
(2015) | Human urine and plasma concentrations of bisphenol A extrapolated from pharmacokinetics established in in vivo experiments with chimeric mice with humanized liver and semi-physiological pharmacokinetic modeling. | Regul. Toxicol. Pharmacol. 72(1):71-6 | |||
Kosaka K, et al. Mouse over for full list |
(2013) | A novel TK-NOG based humanized mouse model for the study of HBV and HCV infections. | Biochem. Biophys. Res. Commun. 441(1):230-5 | |||
Kamimura H, et al. Mouse over for full list |
(2015) | Formation of the accumulative human metabolite and human-specific glutathione conjugate of diclofenac in TK-NOG chimeric mice with humanized livers. | Drug Metab. Dispos. 43(3):309-16 | |||
Hu Y, et al. Mouse over for full list |
(2013) | Human pharmacogenetic analysis in chimeric mice with 'humanized livers'. | Pharmacogenet. Genomics 23(2):78-83 | ADMET, Tox & Safety Assessment, PK/PD (pharmacokinetic/pharmacodynamic modeling), Humanized | ||
Suemizu H, et al. Mouse over for full list |
(2014) | The human hepatic cell line HepaRG as a possible cell source for the generation of humanized liver TK-NOG mice | Xenobiotica. 44(2):146-153 | |||
Grompe M, et al. Mouse over for full list |
(2013) | Mice with human livers. | Gastroenterology 145(6):1209-14 | |||
Cohen J Mouse over for full list |
(2014) | Toxicology. 'Humanized' mouse detects deadly drug side effects. | Science 344(6181):244-5 | |||
Adachi K, et al. Mouse over for full list |
(2015) | Human biofluid concentrations of mono(2-ethylhexyl)phthalate extrapolated from pharmacokinetics in chimeric mice with humanized liver administered with di(2-ethylhexyl)phthalate and physiologically based pharmacokinetic modeling. | Environ. Toxicol. Pharmacol. 39(3):1067-73 |