TK-NOG Publications

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Filter publications by application: All ADMET Diabetes (Type 1) Diabetes (Type 2) Hepatitis-B Humanized Immunology Infectious Disease Malaria Metabolism PK/PD (pharmacokinetic/pharmacodynamic modeling) Safety Assessment Stem Cells/Regenerative Medicine/Tissue Engineering Tox & Safety Assessment Virology
Filter publications by model type: All Humanization

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Ruan X, et al.
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Ruan X, Li P, Chen Y, Shi Y, Pirooznia M, Seifuddin F, Suemizu H, Ohnishi Y, Yoneda N, Nishiwaki M, Shepherdson J, Suresh A, Singh K, Ma Y, Jiang CF, Cao H		 (2020) In vivo functional analysis of non-conserved human lncRNAs associated with cardiometabolic traits. Nat Commun 11(1):45
Chen PB, et al.
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Chen PB, Ding S, Zanghì G, Soulard V, DiMaggio PA, Fuchter MJ, Mecheri S, Mazier D, Scherf A, Malmquist NA		 (2016) Plasmodium falciparum PfSET7: enzymatic characterization and cellular localization of a novel protein methyltransferase in sporozoite, liver and erythrocytic stage parasites. Sci Rep 6:21802
Yamazaki H, et al.
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Yamazaki H, Suemizu H, Shimizu M, Igaya S, Shibata N, Nakamura M, Chowdhury G, Guengerich FP		 (2012) In vivo formation of dihydroxylated and glutathione conjugate metabolites derived from thalidomide and 5-Hydroxythalidomide in humanized TK-NOG mice. Chem. Res. Toxicol. 25(2):274-6
Tsukada A, et al.
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Tsukada A, Suemizu H, Murayama N, Takano R, Shimizu M, Nakamura M, Yamazaki H		 (2013) Plasma concentrations of melengestrol acetate in humans extrapolated from the pharmacokinetics established in in vivo experiments with rats and chimeric mice with humanized liver and physiologically based pharmacokinetic modeling. Regul. Toxicol. Pharmacol. 65(3):316-24
Yamazaki H, et al.
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Yamazaki H, Suemizu H, Murayama N, Utoh M, Shibata N, Nakamura M, Guengerich FP		 (2013) In vivo drug interactions of the teratogen thalidomide with midazolam: heterotropic cooperativity of human cytochrome P450 in humanized TK-NOG mice. Chem. Res. Toxicol. 26(3):486-9
Higuchi Y, et al.
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Higuchi Y, Kawai K, Yamazaki H, Nakamura M, Bree F, Guguen-Guillouzo C, Suemizu H		 (2014) The human hepatic cell line HepaRG as a possible cell source for the generation of humanized liver TK-NOG mice. Xenobiotica 44(2):146-53
Kim M, et al.
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Kim M, Choi B, Joo SY, Lee H, Lee JH, Lee KW, Lee S, Park JB, Lee SK, Kim SJ		 (2014) Generation of humanized liver mouse model by transplant of patient-derived fresh human hepatocytes. Transplant. Proc. 46(4):1186-90
Kai Y, et al.
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Kai Y, Hikita H, Tatsumi T, Nakabori T, Saito Y, Morishita N, Tanaka S, Nawa T, Oze T, Sakamori R, Yakushijin T, Hiramatsu N, Suemizu H, Takehara T		 (2015) Emergence of hepatitis C virus NS5A L31V plus Y93H variant upon treatment failure of daclatasvir and asunaprevir is relatively resistant to ledipasvir and NS5B polymerase nucleotide inhibitor GS-558093 in human hepatocyte chimeric mice. J. Gastroenterol. 50(11):1145-51
Nishiyama S, et al.
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Nishiyama S, Suemizu H, Shibata N, Guengerich FP, Yamazaki H		 (2015) Simulation of Human Plasma Concentrations of Thalidomide and Primary 5-Hydroxylated Metabolites Explored with Pharmacokinetic Data in Humanized TK-NOG Mice. Chem. Res. Toxicol. 28(11):2088-90
Higuchi Y, et al.
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Higuchi Y, Kawai K, Kanaki T, Yamazaki H, Chesné C, Guguen-Guillouzo C, Suemizu H		 (2016) Functional polymer-dependent 3D culture accelerates the differentiation of HepaRG cells into mature hepatocytes. Hepatol. Res. 46(10):1045-57
Kamimura H, et al.
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Kamimura H, Ito S, Chijiwa H, Okuzono T, Ishiguro T, Yamamoto Y, Nishinoaki S, Ninomiya SI, Mitsui M, Kalgutkar AS, Yamazaki H, Suemizu H		 (2017) Simulation of human plasma concentration-time profiles of the partial glucokinase activator PF-04937319 and its disproportionate N-demethylated metabolite using humanized chimeric mice and semi-physiological pharmacokinetic modeling. Xenobiotica 47(5):382-393
Shimizu M, et al.
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Shimizu M, Suemizu H, Mitsui M, Shibata N, Guengerich FP, Yamazaki H		 (2017) Metabolic profiles of pomalidomide in human plasma simulated with pharmacokinetic data in control and humanized-liver mice. Xenobiotica 47(10):844-848
Suzuki E, et al.
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Suzuki E, Koyama K, Nakai D, Goda R, Kuga H, Chiba K		 (2017) Observation of Clinically Relevant Drug Interaction in Chimeric Mice with Humanized Livers: The Case of Valproic Acid and Carbapenem Antibiotics. Eur J Drug Metab Pharmacokinet 42(6):965-972
Iwata H, et al.
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Iwata H, Goto M, Sakai N, Suemizu H, Yamazaki H		 (2019) Predictability of human pharmacokinetics of diisononyl phthalate (DINP) using chimeric mice with humanized liver. Xenobiotica 49(11):1311-1322
Ganesan M, et al.
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Ganesan M, Tikhanovich I, Vangimalla SS, Dagur RS, Wang W, Poluektova LI, Sun Y, Mercer DF, Tuma D, Weinman SA, Kharbanda KK, Osna NA		 (2018) Demethylase JMJD6 as a New Regulator of Interferon Signaling: Effects of HCV and Ethanol Metabolism. Cell Mol Gastroenterol Hepatol 5(2):101-112
Doi A, et al.
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Doi A, Hikita H, Kai Y, Tahata Y, Saito Y, Nakabori T, Yamada R, Kodama T, Sakamori R, Murayama A, Nitta S, Asahina Y, Suemizu H, Tatsumi T, Kato T, Takehara T		 (2019) Combinations of two drugs among NS3/4A inhibitors, NS5B inhibitors and non-selective antiviral agents are effective for hepatitis C virus with NS5A-P32 deletion in humanized-liver mice. J. Gastroenterol. 54(5):449-458
Uehara S, et al.
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Uehara S, Yoneda N, Higuchi Y, Yamazaki H, Suemizu H		 (2019) Metabolism of desloratadine by chimeric TK-NOG mice transplanted with human hepatocytes. Xenobiotica :1-8
Dagur RS, et al.
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Dagur RS, Wang W, Makarov E, Sun Y, Poluektova LY		 (2019) Establishment of the Dual Humanized TK-NOG Mouse Model for HIV-associated Liver Pathogenesis. J Vis Exp (151)
Michailidis E, et al.
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Michailidis E, Vercauteren K, Mancio-Silva L, Andrus L, Jahan C, Ricardo-Lax I, Zou C, Kabbani M, Park P, Quirk C, Pyrgaki C, Razooky B, Verhoye L, Zoluthkin I, Lu WY, Forbes SJ, Chiriboga L, Theise ND, Herzog RW, Suemizu H, Schneider WM, Shlomai A, Meuleman P, Bhatia SN, Rice CM, de Jong YP		 (2020) Expansion, in vivo-ex vivo cycling, and genetic manipulation of primary human hepatocytes. Proc. Natl. Acad. Sci. U.S.A. 117(3):1678-1688
Dagur RS, et al.
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Dagur RS, Wang W, Cheng Y, Makarov E, Ganesan M, Suemizu H, Gebhart CL, Gorantla S, Osna N, Poluektova LY		 (2018) Human hepatocyte depletion in the presence of HIV-1 infection in dual reconstituted humanized mice. Biol Open 7(2)
Valérie Soulard
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Valérie Soulard		 (2016) Modeling malaria parasites’ life cycle in humanized mice
Humanization
 Malaria
Takebe T, et al.
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Takebe T, Sekine K, Kimura M, Yoshizawa E, Ayano S, Koido M, Funayama S, Nakanishi N, Hisai T, Kobayashi T, Kasai T, Kitada R, Mori A, Ayabe H, Ejiri Y, Amimoto N, Yamazaki Y, Ogawa S, Ishikawa M, Kiyota Y, Sato Y, Nozawa K, Okamoto S, Ueno Y, Taniguchi H		 (2017) Massive and Reproducible Production of Liver Buds Entirely from Human Pluripotent Stem Cells. Cell Rep 21(10):2661-2670
Stem Cells/Regenerative Medicine/Tissue Engineering, Humanized
Fomin ME, et al.
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Fomin ME, Beyer AI, Muench MO		 (2017) Human fetal liver cultures support multiple cell lineages that can engraft immunodeficient mice. Open Biol 7(12)
Immunology, Stem Cells/Regenerative Medicine/Tissue Engineering, Humanized
Nishimura T, et al.
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Nishimura T, Nishimura T, Hu Y, Wu M, Pham E, Suemizu H, Elazar M, Liu M, Idilman R, Yurdaydin C, Angus P, Stedman C, Murphy B, Glenn J, Nakamura M, Nomura T, Chen Y, Zheng M, Fitch WL, Peltz G		 (2013) Using chimeric mice with humanized livers to predict human drug metabolism and a drug-drug interaction. J. Pharmacol. Exp. Ther. 344(2):388-96
ADMET, Infectious Disease, Metabolism, Safety Assessment, Tox & Safety Assessment, Humanized
Xu D, et al.
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Xu D, Wu M, Nishimura S, Nishimura T, Michie SA, Zheng M, Yang Z, Yates AJ, Day JS, Hillgren KM, Takeda ST, Guan Y, Guo Y, Peltz G		 (2015) Chimeric TK-NOG mice: a predictive model for cholestatic human liver toxicity. J. Pharmacol. Exp. Ther. 352(2):274-80
ADMET, Metabolism, Safety Assessment, Tox & Safety Assessment, Humanized
Yamazaki-Nishioka M, et al.
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Yamazaki-Nishioka M, Shimizu M, Suemizu H, Nishiwaki M, Mitsui M, Yamazaki H		 (2017) Human Plasma Metabolic Profiles of Benzydamine, a Flavin-containing Monooxygenase Probe Substrate, Simulated with Pharmacokinetic Data from Control and Humanized-liver Mice. Xenobiotica :1-26
Xu D, et al.
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Xu D, Nishimura T, Nishimura S, Zhang H, Zheng M, Guo YY, Masek M, Michie SA, Glenn J, Peltz G		 (2014) Fialuridine induces acute liver failure in chimeric TK-NOG mice: a model for detecting hepatic drug toxicity prior to human testing. PLoS Med. 11(4):e1001628
Tox & Safety Assessment
Uchida T, et al.
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Uchida T, Hiraga N, Imamura M, Tsuge M, Abe H, Hayes CN, Aikata H, Ishida Y, Tateno C, Yoshizato K, Ohdan H, Murakami K, Chayama K		 (2015) Human Cytotoxic T Lymphocyte-Mediated Acute Liver Failure and Rescue by Immunoglobulin in Human Hepatocyte Transplant TK-NOG Mice. J. Virol. 89(19):10087-96
Hashimoto H, et al.
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Hashimoto H, Mizushima T, Ogura T, Kagawa T, Tomiyama K, Takahashi R, Yagoto M, Kawai K, Chijiwa T, Nakamura M, Suemizu H		 (2016) Study on AAV-mediated gene therapy for diabetes in humanized liver mouse to predict efficacy in humans. Biochem. Biophys. Res. Commun. 478(3):1254-60
Diabetes (Type 1), Virology, Diabetes (Type 2)
Utoh M, et al.
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Utoh M, Suemizu H, Mitsui M, Kawano M, Toda A, Uehara S, Uno Y, Shimizu M, Sasaki E, Yamazaki H		 (2016) Human plasma concentrations of cytochrome P450 probe cocktails extrapolated from pharmacokinetics in mice transplanted with human hepatocytes and from pharmacokinetics in common marmosets using physiologically based pharmacokinetic modeling. Xenobiotica 46(12):1049-1055
Nakabori T, et al.
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Nakabori T, Hikita H, Murai K, Nozaki Y, Kai Y, Makino Y, Saito Y, Tanaka S, Wada H, Eguchi H, Takahashi T, Suemizu H, Sakamori R, Hiramatsu N, Tatsumi T, Takehara T		 (2016) Sodium taurocholate cotransporting polypeptide inhibition efficiently blocks hepatitis B virus spread in mice with a humanized liver. Sci Rep 6:27782
Infectious Disease, Hepatitis-B
Yamazaki H, et al.
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Yamazaki H, Suemizu H, Kazuki Y, Oofusa K, Kuribayashi S, Shimizu M, Ninomiya S, Horie T, Shibata N, Guengerich FP		 (2016) Assessment of Protein Binding of 5-Hydroxythalidomide Bioactivated in Humanized Mice with Human P450 3A-Chromosome or Hepatocytes by Two-Dimensional Electrophoresis/Accelerator Mass Spectrometry. Chem. Res. Toxicol. 29(8):1279-81
Yamazaki H, et al.
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Yamazaki H, Suemizu H, Mitsui M, Shimizu M, Guengerich FP		 (2016) Combining Chimeric Mice with Humanized Liver, Mass Spectrometry, and Physiologically-Based Pharmacokinetic Modeling in Toxicology. Chem. Res. Toxicol.
ADMET, Safety Assessment, Tox & Safety Assessment
Masami Hasegawa, et al.
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Masami Hasegawa, Kenji Kawai, Tetsuya Mitsui, Kenji Taniguchi, Makoto Monnai, Masatoshi Wakui, Mamoru Ito, Makoto Suematsu, Gary Peltz, Masato Nakamura, and Hiroshi Suemizu		 (2013) The Reconstituted ‘Humanized Liver’ in TK-NOG Mice is Mature and Functional Biochem Biophys Res Commun
Mamoru Ito, et al.
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Mamoru Ito, Hidefumi Hiramatsu, Kimio Kobayashi, Kazutomo Suzue, Mariko Kawahata, Kyoji Hioki, Yoshito Ueyama, Yoshio Koyanagi, Kazuo Sugamura, Kohichiro Tsuji, Toshio Heike, Tatsutoshi Nakahata		 (2002) NOD/SCID/γ nullc mouse: an excellent recipient mouse model for engraftment of human cells Blood 2002 100:3175-3182
Humanized
Suemizu H, et al.
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Suemizu H, Nakamura M, Yamazaki H, Igaya S, Shimizu M, Shibata N, Chowdhury G, Guengerich FP		 (2012) In vivo Formation of Dihydroxylated and Glutathione Conjugate Metabolites derived from Thalidomide and 5-Hydroxythalidomide in Humanized TK-NOG mice Chem Res Toxicol. 25(2): 274-276
Suemizu H, et al.
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Suemizu H, Nakamura M, Yamazaki H, Shibata N, Guengerich FP, Murayama N, Utoh M		 (2013) In vivo Drug Interactions of the Teratogen Thalidomide with Midazolam: Heterotropic Cooperativity of Human Cytochrome P450 in Humanized TK-NOG Mice Chem Res Toxicol. 26(3):486-489
Xu D, et al.
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Xu D, Michie SA, Zheng M, Takeda S, Wu M, Peltz G		 (2015) Humanized thymidine kinase-NOG mice can be used to identify drugs that cause animal-specific hepatotoxicity: a case study with furosemide. J. Pharmacol. Exp. Ther. 354(1):73-8
Soulard V, et al.
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Soulard V, Bosson-Vanga H, Lorthiois A, Roucher C, Franetich JF, Zanghi G, Bordessoulles M, Tefit M, Thellier M, Morosan S, Le Naour G, Capron F, Suemizu H, Snounou G, Moreno-Sabater A, Mazier D		 (2015) Plasmodium falciparum full life cycle and Plasmodium ovale liver stages in humanized mice. Nat Commun 6:7690
Peltz G
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Peltz G		 (2013) Can ‘Humanized’ Mice Improve Drug Development in the 21st Century? Trends Pharmacol Sci. 34(5): 255-260
Nomura T, et al.
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Nomura T, Suemizu H, Nakamura M, Chen Y, Wu M, Liu M, Nishimura T, Hu Y, Zheng M, Pham E, Elazar M, Idilman R, Yurdaydin C, Angus P, Stedman C, Murphy B, Glenn J, Fitch WL, Peltzcorresponding G		 (2013) Using Chimeric Mice with Humanized Livers to Predict Human Drug Metabolism and a Drug-Drug Interaction J Pharmacol Exp Ther. 344(2):388-396
Miyaguchi T, et al.
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Miyaguchi T, Suemizu H, Shimizu M, Shida S, Nishiyama S, Takano R, Murayama N, Yamazaki H		 (2015) Human urine and plasma concentrations of bisphenol A extrapolated from pharmacokinetics established in in vivo experiments with chimeric mice with humanized liver and semi-physiological pharmacokinetic modeling. Regul. Toxicol. Pharmacol. 72(1):71-6
Kosaka K, et al.
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Kosaka K, Hiraga N, Imamura M, Yoshimi S, Murakami E, Nakahara T, Honda Y, Ono A, Kawaoka T, Tsuge M, Abe H, Hayes CN, Miki D, Aikata H, Ochi H, Ishida Y, Tateno C, Yoshizato K, Sasaki T, Chayama K		 (2013) A novel TK-NOG based humanized mouse model for the study of HBV and HCV infections. Biochem. Biophys. Res. Commun. 441(1):230-5
Kamimura H, et al.
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Kamimura H, Ito S, Nozawa K, Nakamura S, Chijiwa H, Nagatsuka S, Kuronuma M, Ohnishi Y, Suemizu H, Ninomiya S		 (2015) Formation of the accumulative human metabolite and human-specific glutathione conjugate of diclofenac in TK-NOG chimeric mice with humanized livers. Drug Metab. Dispos. 43(3):309-16
Hu Y, et al.
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Hu Y, Wu M, Nishimura T, Zheng M, Peltz G		 (2013) Human pharmacogenetic analysis in chimeric mice with 'humanized livers'. Pharmacogenet. Genomics 23(2):78-83
ADMET, Tox & Safety Assessment, PK/PD (pharmacokinetic/pharmacodynamic modeling), Humanized
Suemizu H, et al.
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Suemizu H, Kawai K, Nakamura M, Yamazaki H, Higuchi Y, Bree F, Guguen-Guillouzo C		 (2014) The human hepatic cell line HepaRG as a possible cell source for the generation of humanized liver TK-NOG mice Xenobiotica. 44(2):146-153
Grompe M, et al.
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Grompe M, Strom S		 (2013) Mice with human livers. Gastroenterology 145(6):1209-14
Cohen J
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Cohen J		 (2014) Toxicology. 'Humanized' mouse detects deadly drug side effects. Science 344(6181):244-5
Adachi K, et al.
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Adachi K, Suemizu H, Murayama N, Shimizu M, Yamazaki H		 (2015) Human biofluid concentrations of mono(2-ethylhexyl)phthalate extrapolated from pharmacokinetics in chimeric mice with humanized liver administered with di(2-ethylhexyl)phthalate and physiologically based pharmacokinetic modeling. Environ. Toxicol. Pharmacol. 39(3):1067-73