Tau - Model 2508 Publications

Tau - Model 2508 Model Page

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Li S, et al.
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Li S, Shi S, Luo B, Xia F, Ha Y, Merkley KH, Motamedi M, Zhang W, Liu H
(2022) Tauopathy induces degeneration and impairs regeneration of sensory nerves in the cornea. Exp Eye Res 215:108900
Pace MC, et al.
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Pace MC, Xu G, Fromholt S, Howard J, Crosby K, Giasson BI, Lewis J, Borchelt DR
(2018) Changes in proteome solubility indicate widespread proteostatic disruption in mouse models of neurodegenerative disease. Acta Neuropathol 136(6):919-938
Nam E, et al.
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Nam E, Lee YB, Moon C, Chang KA
(2020) Serum Tau Proteins as Potential Biomarkers for the Assessment of Alzheimer's Disease Progression. Int J Mol Sci 21(14)
Melchior B, et al.
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Melchior B, Mittapalli GK, Lai C, Duong-Polk K, Stewart J, Güner B, Hofilena B, Tjitro A, Anderson SD, Herman DS, Dellamary L, Swearingen CJ, Sunil KC, Yazici Y
(2019) Tau pathology reduction with SM07883, a novel, potent, and selective oral DYRK1A inhibitor: A potential therapeutic for Alzheimer's disease. Aging Cell 18(5):e13000
Xia F, et al.
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Xia F, Ha Y, Shi S, Li Y, Li S, Luisi J, Kayed R, Motamedi M, Liu H, Zhang W
(2021) Early alterations of neurovascular unit in the retina in mouse models of tauopathy. Acta Neuropathol Commun 9(1):51
Neuroscience
Chung S, et al.
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Chung S, Yang J, Kim HJ, Hwang EM, Lee W, Suh K, Choi H, Mook-Jung I
(2021) Plexin-A4 mediates amyloid-β-induced tau pathology in Alzheimer's disease animal model. Prog Neurobiol :102075
Alzheimer's
Kang S, et al.
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Kang S, Kim J, Chang KA
(2021) Spatial memory deficiency early in 6xTg Alzheimer's disease mouse model. Sci Rep 11(1):1334
Alzheimer's
Wu Q, et al.
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Wu Q, Bai Y, Li W, Congdon EE, Liu W, Lin Y, Ji C, Gan WB, Sigurdsson EM
(2021) Increased neuronal activity in motor cortex reveals prominent calcium dyshomeostasis in tauopathy mice. Neurobiol Dis 147:105165
Neuroscience
Davidowitz EJ, et al.
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Davidowitz EJ, Krishnamurthy PK, Lopez P, Jimenez H, Adrien L, Davies P, Moe JG
(2020) In Vivo Validation of a Small Molecule Inhibitor of Tau Self-Association in htau Mice. J. Alzheimers Dis. 73(1):147-161
Alzheimer's
Chai X, et al.
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Chai X, Wu S, Murray TK, Kinley R, Cella CV, Sims H, Buckner N, Hanmer J, Davies P, O'Neill MJ, Hutton ML, Citron M
(2011) Passive immunization with anti-Tau antibodies in two transgenic models: reduction of Tau pathology and delay of disease progression. J. Biol. Chem. 286(39):34457-67
Neuroscience, Alzheimer's
Bi M, et al.
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Bi M, Ittner A, Ke YD, Götz J, Ittner LM
(2011) Tau-targeted immunization impedes progression of neurofibrillary histopathology in aged P301L tau transgenic mice. PLoS ONE 6(12):e26860
Neuroscience, Alzheimer's
Asuni AA, et al.
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Asuni AA, Boutajangout A, Quartermain D, Sigurdsson EM
(2007) Immunotherapy targeting pathological tau conformers in a tangle mouse model reduces brain pathology with associated functional improvements. J. Neurosci. 27(34):9115-29
Neuroscience, Alzheimer's
Lasagna-Reeves CA, et al.
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Lasagna-Reeves CA, Sengupta U, Castillo-Carranza D, Gerson JE, Guerrero-Munoz M, Troncoso JC, Jackson GR, Kayed R
(2014) The formation of tau pore-like structures is prevalent and cell specific: possible implications for the disease phenotypes. Acta Neuropathol Commun 2:56
Neuroscience, Alzheimer's
Nilson AN, et al.
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Nilson AN, English KC, Gerson JE, Whittle TB, Crain CN, Xue J, Sengupta U, Castillo-Carranza DL, Zhang W, Gupta P, Kayed R
(2016) Tau Oligomers Associate with Inflammation in the Brain and Retina of Tauopathy Mice and in Neurodegenerative Diseases. J. Alzheimers Dis.
Neuroscience, Alzheimer's
Castillo-Carranza DL, et al.
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Castillo-Carranza DL, Sengupta U, Guerrero-Muñoz MJ, Lasagna-Reeves CA, Gerson JE, Singh G, Estes DM, Barrett AD, Dineley KT, Jackson GR, Kayed R
(2014) Passive immunization with Tau oligomer monoclonal antibody reverses tauopathy phenotypes without affecting hyperphosphorylated neurofibrillary tangles. J. Neurosci. 34(12):4260-72
Neuroscience, Alzheimer's
Lewis J, et al.
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Lewis J, McGowan E, Rockwood J, Melrose H, Nacharaju P, Van Slegtenhorst M, Gwinn-Hardy K, Paul Murphy M, Baker M, Yu X, Duff K, Hardy J, Corral A, Lin WL, Yen SH, Dickson DW, Davies P, Hutton M
(2000) Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein. Nat. Genet. 25(4):402-5
Halverson RA, et al.
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Halverson RA, Lewis J, Frausto S, Hutton M, Muma NA
(2005) Tau protein is cross-linked by transglutaminase in P301L tau transgenic mice. J. Neurosci. 25(5):1226-33
Chen F, et al.
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Chen F, Wollmer MA, Hoerndli F, Münch G, Kuhla B, Rogaev EI, Tsolaki M, Papassotiropoulos A, Götz J
(2004) Role for glyoxalase I in Alzheimer's disease. Proc. Natl. Acad. Sci. U.S.A. 101(20):7687-92
Alzheimer's
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