Rag2 - Model RAGN12 Publications

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Sasaki T, et al.
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Sasaki T, Moro K, Kubota T, Kubota N, Kato T, Ohno H, Nakae S, Saito H, Koyasu S
(2019) Innate Lymphoid Cells in the Induction of Obesity. Cell Rep 28(1):202-217.e7
Gargani S, et al.
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Gargani S, Thévenet J, Yuan JE, Lefebvre B, Delalleau N, Gmyr V, Hubert T, Duhamel A, Pattou F, Kerr-Conte J
(2013) Adaptive changes of human islets to an obesogenic environment in the mouse. Diabetologia 56(2):350-8
Herndler-Brandstetter D, et al.
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Herndler-Brandstetter D, Ishigame H, Shinnakasu R, Plajer V, Stecher C, Zhao J, Lietzenmayer M, Kroehling L, Takumi A, Kometani K, Inoue T, Kluger Y, Kaech SM, Kurosaki T, Okada T, Flavell RA
(2018) KLRG1 Effector CD8 T Cells Lose KLRG1, Differentiate into All Memory T Cell Lineages, and Convey Enhanced Protective Immunity. Immunity 48(4):716-729.e8
Tran NT, et al.
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Tran NT, Sommermann T, Graf R, Trombke J, Pempe J, Petsch K, Kühn R, Rajewsky K, Chu VT
(2019) Efficient CRISPR/Cas9-Mediated Gene Knockin in Mouse Hematopoietic Stem and Progenitor Cells. Cell Rep 28(13):3510-3522.e5
Shen E, et al.
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Shen E, Rabe H, Luo L, Wang L, Wang Q, Yin J, Yang X, Liu W, Sido JM, Nakagawa H, Ao L, Kim HJ, Cantor H, Leavenworth JW
(2019) Control of Germinal Center Localization and Lineage Stability of Follicular Regulatory T Cells by the Blimp1 Transcription Factor. Cell Rep 29(7):1848-1861.e6
Bianchi JJ, et al.
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Bianchi JJ, Murigneux V, Bedora-Faure M, Lescale C, Deriano L
(2019) Breakage-Fusion-Bridge Events Trigger Complex Genome Rearrangements and Amplifications in Developmentally Arrested T Cell Lymphomas. Cell Rep 27(10):2847-2858.e4
Sinha SR, et al.
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Sinha SR, Haileselassie Y, Nguyen LP, Tropini C, Wang M, Becker LS, Sim D, Jarr K, Spear ET, Singh G, Namkoong H, Bittinger K, Fischbach MA, Sonnenburg JL, Habtezion A
(2020) Dysbiosis-Induced Secondary Bile Acid Deficiency Promotes Intestinal Inflammation. Cell Host Microbe 27(4):659-670.e5
Wagner M, et al.
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Wagner M, Ealey KN, Tetsu H, Kiniwa T, Motomura Y, Moro K, Koyasu S
(2020) Tumor-Derived Lactic Acid Contributes to the Paucity of Intratumoral ILC2s. Cell Rep 30(8):2743-2757.e5
Miyajima Y, et al.
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Miyajima Y, Ealey KN, Motomura Y, Mochizuki M, Takeno N, Yanagita M, Economides AN, Nakayama M, Koseki H, Moro K
(2020) Effects of BMP7 produced by group 2 innate lymphoid cells on adipogenesis. Int. Immunol. 32(6):407-419
Cubas R, et al.
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Cubas R, Moskalenko M, Cheung J, Yang M, McNamara E, Xiong H, Hoves S, Ries CH, Kim J, Gould S
(2018) Chemotherapy Combines Effectively with Anti-PD-L1 Treatment and Can Augment Antitumor Responses. J. Immunol. 201(8):2273-2286
Horton BL, et al.
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Horton BL, Williams JB, Cabanov A, Spranger S, Gajewski TF
(2018) Intratumoral CD8 T-cell Apoptosis Is a Major Component of T-cell Dysfunction and Impedes Antitumor Immunity. Cancer Immunol Res 6(1):14-24
Spranger S, et al.
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Spranger S, Dai D, Horton B, Gajewski TF
(2017) Tumor-Residing Batf3 Dendritic Cells Are Required for Effector T Cell Trafficking and Adoptive T Cell Therapy. Cancer Cell 31(5):711-723.e4
Bauché D, et al.
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Bauché D, Joyce-Shaikh B, Fong J, Villarino AV, Ku KS, Jain R, Lee YC, Annamalai L, Yearley JH, Cua DJ
(2020) IL-23 and IL-2 activation of STAT5 is required for optimal IL-22 production in ILC3s during colitis. Sci Immunol 5(46)
Lion M, et al.
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Lion M, Muhire B, Namiki Y, Tolstorukov MY, Oettinger MA
(2020) Alterations in chromatin at antigen receptor loci define lineage progression during B lymphopoiesis. Proc. Natl. Acad. Sci. U.S.A. 117(10):5453-5462
T And/Or B Cell Function
B. Joyce-Shaikh, et al.
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B. Joyce-Shaikh, D.J. Cua, D. Bauché
(2019) Induction and Analysis of Anti-CD40-induced Colitis in Mice Bio-protocol 9(3): e3153. DOI: 10.21769/BioProtoc.3153.
Gastrointestinal, Colitis, Crohn's Disease, Immunology, Inflammation
Frisbee AL, et al.
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Frisbee AL, Saleh MM, Young MK, Leslie JL, Simpson ME, Abhyankar MM, Cowardin CA, Ma JZ, Pramoonjago P, Turner SD, Liou AP, Buonomo EL, Petri WA
(2019) IL-33 drives group 2 innate lymphoid cell-mediated protection during Clostridium difficile infection. Nat Commun 10(1):2712
Immunology, Infectious Disease, Inflammation
Biswas A, et al.
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Biswas A, Shouval DS, Griffith A, Goettel JA, Field M, Kang YH, Konnikova L, Janssen E, Redhu NS, Thrasher AJ, Chatila T, Kuchroo VK, Geha RS, Notarangelo LD, Pai SY, Horwitz BH, Snapper SB
(2018) WASP-mediated regulation of anti-inflammatory macrophages is IL-10 dependent and is critical for intestinal homeostasis. Nat Commun 9(1):1779
Colitis, Inflammation
Fowler JA, et al.
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Fowler JA, Lwin ST, Drake MT, Edwards JR, Kyle RA, Mundy GR, Edwards CM
(2011) Host-derived adiponectin is tumor-suppressive and a novel therapeutic target for multiple myeloma and the associated bone disease. Blood 118(22):5872-82
Myeloma
Wang Z, et al.
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Wang Z, Aguilar EG, Luna JI, Dunai C, Khuat LT, Le CT, Mirsoian A, Minnar CM, Stoffel KM, Sturgill IR, Grossenbacher SK, Withers SS, Rebhun RB, Hartigan-O'Connor DJ, Méndez-Lagares G, Tarantal AF, Isseroff RR, Griffith TS, Schalper KA, Merleev A, Saha A, Maverakis E, Kelly K, Aljumaily R, Ibrahimi S, Mukherjee S, Machiorlatti M, Vesely SK, Longo DL, Blazar BR, Canter RJ, Murphy WJ, Monjazeb AM
(2019) Paradoxical effects of obesity on T cell function during tumor progression and PD-1 checkpoint blockade. Nat. Med. 25(1):141-151
Oncology
Bauché D, et al.
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Bauché D, Joyce-Shaikh B, Jain R, Grein J, Ku KS, Blumenschein WM, Ganal-Vonarburg SC, Wilson DC, McClanahan TK, Malefyt RW, Macpherson AJ, Annamalai L, Yearley JH, Cua DJ
(2018) LAG3 Regulatory T Cells Restrain Interleukin-23-Producing CX3CR1 Gut-Resident Macrophages during Group 3 Innate Lymphoid Cell-Driven Colitis. Immunity
Colitis, Immunology
Rogers R, et al.
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Rogers R, Eastham-Anderson J, DeVoss J, Lesch J, Yan D, Xu M, Solon M, Hotzel K, Diehl L, Webster JD
(2016) Image Analysis-Based Approaches for Scoring Mouse Models of Colitis. Vet. Pathol. 53(1):200-10
Karwacz K, et al.
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Karwacz K, Miraldi ER, Pokrovskii M, Madi A, Yosef N, Wortman I, Chen X, Watters A, Carriero N, Awasthi A, Regev A, Bonneau R, Littman D, Kuchroo VK
(2017) Critical role of IRF1 and BATF in forming chromatin landscape during type 1 regulatory cell differentiation. Nat. Immunol. 18(4):412-421
Immunology
Shinkai Y, et al.
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Shinkai Y, Rathbun G, Lam KP, Oltz EM, Stewart V, Mendelsohn M, Charron J, Datta M, Young F, Stall AM
(1992) RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement. Cell 68(5):855-67
Zhang K, et al.
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Zhang K, Wong HN, Song B, Miller CN, Scheuner D, Kaufman RJ
(2005) The unfolded protein response sensor IRE1alpha is required at 2 distinct steps in B cell lymphopoiesis. J. Clin. Invest. 115(2):268-81
T And/Or B Cell Function
Xiao H, et al.
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Xiao H, Heeringa P, Hu P, Liu Z, Zhao M, Aratani Y, Maeda N, Falk RJ, Jennette JC
(2002) Antineutrophil cytoplasmic autoantibodies specific for myeloperoxidase cause glomerulonephritis and vasculitis in mice. J. Clin. Invest. 110(7):955-63
Witt CM, et al.
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Witt CM, Raychaudhuri S, Schaefer B, Chakraborty AK, Robey EA
(2005) Directed migration of positively selected thymocytes visualized in real time. PLoS Biol. 3(6):e160
Sommers CL, et al.
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Sommers CL, Lee J, Steiner KL, Gurson JM, Depersis CL, El-Khoury D, Fuller CL, Shores EW, Love PE, Samelson LE
(2005) Mutation of the phospholipase C-gamma1-binding site of LAT affects both positive and negative thymocyte selection. J. Exp. Med. 201(7):1125-34
Singh NJ, et al.
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Singh NJ, Chen C, Schwartz RH
(2006) The impact of T cell intrinsic antigen adaptation on peripheral immune tolerance. PLoS Biol. 4(11):e340
T And/Or B Cell Function
Min B, et al.
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Min B, Foucras G, Meier-Schellersheim M, Paul WE
(2004) Spontaneous proliferation, a response of naive CD4 T cells determined by the diversity of the memory cell repertoire. Proc. Natl. Acad. Sci. U.S.A. 101(11):3874-9
T And/Or B Cell Function
Milner JD, et al.
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Milner JD, Ward JM, Keane-Myers A, Paul WE
(2007) Lymphopenic mice reconstituted with limited repertoire T cells develop severe, multiorgan, Th2-associated inflammatory disease. Proc. Natl. Acad. Sci. U.S.A. 104(2):576-81
T And/Or B Cell Function
Krueger A, et al.
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Krueger A, von Boehmer H
(2007) Identification of a T lineage-committed progenitor in adult blood. Immunity 26(1):105-16
Kojima H, et al.
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Kojima H, Gu H, Nomura S, Caldwell CC, Kobata T, Carmeliet P, Semenza GL, Sitkovsky MV
(2002) Abnormal B lymphocyte development and autoimmunity in hypoxia-inducible factor 1alpha -deficient chimeric mice. Proc. Natl. Acad. Sci. U.S.A. 99(4):2170-4
Huang YH, et al.
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Huang YH, Li D, Winoto A, Robey EA
(2004) Distinct transcriptional programs in thymocytes responding to T cell receptor, Notch, and positive selection signals. Proc. Natl. Acad. Sci. U.S.A. 101(14):4936-41
T And/Or B Cell Function
Erlebacher A, et al.
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Erlebacher A, Zhang D, Parlow AF, Glimcher LH
(2004) Ovarian insufficiency and early pregnancy loss induced by activation of the innate immune system. J. Clin. Invest. 114(1):39-48
Erlebacher A, et al.
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Erlebacher A, Vencato D, Price KA, Zhang D, Glimcher LH
(2007) Constraints in antigen presentation severely restrict T cell recognition of the allogeneic fetus. J. Clin. Invest. 117(5):1399-411
Chan WF, et al.
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Chan WF, Perez-Diez A, Razavy H, Anderson CC
(2007) The ability of natural tolerance to be applied to allogeneic tissue: determinants and limits. Biol. Direct 2:10
Acuff HB, et al.
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Acuff HB, Carter KJ, Fingleton B, Gorden DL, Matrisian LM
(2006) Matrix metalloproteinase-9 from bone marrow-derived cells contributes to survival but not growth of tumor cells in the lung microenvironment. Cancer Res. 66(1):259-66
Zúñiga-Pflücker JC, et al.
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Zúñiga-Pflücker JC, Jiang D, Schwartzberg PL, Lenardo MJ
(1994) Sublethal gamma-radiation induces differentiation of CD4-/CD8- into CD4+/CD8+ thymocytes without T cell receptor beta rearrangement in recombinase activation gene 2-/- mice. J. Exp. Med. 180(4):1517-21
Yang L, et al.
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Yang L, Bailey L, Baltimore D, Wang P
(2006) Targeting lentiviral vectors to specific cell types in vivo. Proc. Natl. Acad. Sci. U.S.A. 103(31):11479-84
Suzue K, et al.
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Suzue K, Reinherz EL, Koyasu S
(2001) Critical role of NK but not NKT cells in acute rejection of parental bone marrow cells in F1 hybrid mice. Eur. J. Immunol. 31(11):3147-52
NK
Shinkai Y, et al.
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Shinkai Y, Koyasu S, Nakayama K, Murphy KM, Loh DY, Reinherz EL, Alt FW
(1993) Restoration of T cell development in RAG-2-deficient mice by functional TCR transgenes. Science 259(5096):822-5
T And/Or B Cell Function
Schulz RJ, et al.
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Schulz RJ, Parkes A, Mizoguchi E, Bhan AK, Koyasu S
(1996) Development of CD4-CD8- alpha beta TCR+NK1.1+ T lymphocytes: thymic selection by self antigen. J. Immunol. 157(10):4379-89
Liu D, et al.
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Liu D, Hornsby PJ
(2007) Fibroblast stimulation of blood vessel development and cancer cell invasion in a subrenal capsule xenograft model: stress-induced premature senescence does not increase effect. Neoplasia 9(5):418-26
Iritani BM, et al.
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Iritani BM, Delrow J, Grandori C, Gomez I, Klacking M, Carlos LS, Eisenman RN
(2002) Modulation of T-lymphocyte development, growth and cell size by the Myc antagonist and transcriptional repressor Mad1. EMBO J. 21(18):4820-30
Horton RM, et al.
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Horton RM, Karachunski PI, Conti-Fine BM
(1995) PCR screening of transgenic RAG-2 "knockout" immunodeficient mice. BioTechniques 19(5):690-1
Gill N, et al.
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Gill N, Rosenthal KL, Ashkar AA
(2005) NK and NKT cell-independent contribution of interleukin-15 to innate protection against mucosal viral infection. J. Virol. 79(7):4470-8
NK
Dandekar AA, et al.
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Dandekar AA, Anghelina D, Perlman S
(2004) Bystander CD8 T-cell-mediated demyelination is interferon-gamma-dependent in a coronavirus model of multiple sclerosis. Am. J. Pathol. 164(2):363-9
T And/Or B Cell Function
Chen J, et al.
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Chen J, Shinkai Y, Young F, Alt FW
(1994) Probing immune functions in RAG-deficient mice. Curr. Opin. Immunol. 6(2):313-9
Chen J, et al.
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Chen J, Lansford R, Stewart V, Young F, Alt FW
(1993) RAG-2-deficient blastocyst complementation: an assay of gene function in lymphocyte development. Proc. Natl. Acad. Sci. U.S.A. 90(10):4528-32
Looney MR, et al.
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Looney MR, Su X, Van Ziffle JA, Lowell CA, Matthay MA
(2006) Neutrophils and their Fc gamma receptors are essential in a mouse model of transfusion-related acute lung injury. J. Clin. Invest. 116(6):1615-23
Erlebacher A, et al.
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Erlebacher A, Lukens AK, Glimcher LH
(2002) Intrinsic susceptibility of mouse trophoblasts to natural killer cell-mediated attack in vivo. Proc. Natl. Acad. Sci. U.S.A. 99(26):16940-5
Immunology
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