Oct1/2 Publications

Oct1/2 Model Page

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Morse BL, et al.
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Morse BL, Kolur A, Hudson LR, Hogan AT, Chen LH, Brackman RM, Sawada GA, Fallon JK, Smith PC, Hillgren KM
(2020) Pharmacokinetics of Organic Cation Transporter 1 (OCT1) Substrates in Oct1/2 Knockout Mice and Species Difference in Hepatic OCT1-Mediated Uptake. Drug Metab Dispos 48(2):93-105
ADMET
Morse BL, et al.
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Morse BL, Chen LH, Catlow JT, Fallon JK, Smith PC, Hillgren KM
(2021) Expansion of Knowledge on OCT1 Variant Activity and Using Oct1/2 Mice. Front Pharmacol 12:631793
ADMET
Ogasawara M, et al.
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Ogasawara M, Yamauchi K, Satoh Y, Yamaji R, Inui K, Jonker JW, Schinkel AH, Maeyama K
(2006) Recent advances in molecular pharmacology of the histamine systems: organic cation transporters as a histamine transporter and histamine metabolism. J. Pharmacol. Sci. 101(1):24-30
Kummer W, et al.
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Kummer W, Wiegand S, Akinci S, Wessler I, Schinkel AH, Wess J, Koepsell H, Haberberger RV, Lips KS
(2006) Role of acetylcholine and polyspecific cation transporters in serotonin-induced bronchoconstriction in the mouse. Respir. Res. 7:65
Kusuhara H, et al.
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Kusuhara H, Sugiyama Y
(2005) Active efflux across the blood-brain barrier: role of the solute carrier family. NeuroRx 2(1):73-85
Koepsell H, et al.
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Koepsell H, Lips K, Volk C
(2007) Polyspecific organic cation transporters: structure, function, physiological roles, and biopharmaceutical implications. Pharm. Res. 24(7):1227-51
Jonker JW, et al.
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Jonker JW, Wagenaar E, Van Eijl S, Schinkel AH.
(2003) Deficiency in the organic cation transporters 1 and 2 (Oct1/Oct2 [Slc22a1/Slc22a2]) in mice abolishes renal secretion of organic cations. Mol Cell Biol. 2003 Nov;23(21):7902-8.
Jonker JW, et al.
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Jonker JW, Wagenaar E, Mol CA, Buitelaar M, Koepsell H, Smit JW, Schinkel AH
(2001) Reduced hepatic uptake and intestinal excretion of organic cations in mice with a targeted disruption of the organic cation transporter 1 (Oct1 [Slc22a1]) gene. Mol. Cell. Biol. 21(16):5471-7
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