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Zhang YQ, et al.
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Zhang YQ, Resta S, Jung B, Barrett KE, Sarvetnick N
(2009) Upregulation of activin signaling in experimental colitis. Am. J. Physiol. Gastrointest. Liver Physiol. 297(4):G768-80
Paul G, et al.
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Paul G, Marchelletta RR, McCole DF, Barrett KE
(2012) Interferon-γ alters downstream signaling originating from epidermal growth factor receptor in intestinal epithelial cells: functional consequences for ion transport. J. Biol. Chem. 287(3):2144-55
McCole DF, et al.
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McCole DF, Rogler G, Varki N, Barrett KE
(2005) Epidermal growth factor partially restores colonic ion transport responses in mouse models of chronic colitis. Gastroenterology 129(2):591-608
Resta-Lenert SC, et al.
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Resta-Lenert SC, Barrett KE
(2009) Modulation of intestinal barrier properties by probiotics: role in reversing colitis. Ann. N. Y. Acad. Sci. 1165:175-82
Wilk JN, et al.
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Wilk JN, Bilsborough J, Viney JL
(2005) The mdr1a-/- mouse model of spontaneous colitis: a relevant and appropriate animal model to study inflammatory bowel disease. Immunol. Res. 31(2):151-9
Yau JL, et al.
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Yau JL, Noble J, Thomas S, Kerwin R, Morgan PE, Lightman S, Seckl JR, Pariante CM
(2007) The antidepressant desipramine requires the ABCB1 (Mdr1)-type p-glycoprotein to upregulate the glucocorticoid receptor in mice. Neuropsychopharmacology 32(12):2520-9
Bang B, et al.
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Bang B, Lichtenberger LM
(2016) Methods of Inducing Inflammatory Bowel Disease in Mice. Curr Protoc Pharmacol 72:5.58.1-42
Guner YS, et al.
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Guner YS, Franklin AL, Chokshi NK, Castle SL, Pontarelli E, Wang J, Wang L, Prasadarao NV, Upperman JS, Grishin AV, Ford HR
(2011) P-glycoprotein induction by breast milk attenuates intestinal inflammation in experimental necrotizing enterocolitis. Lab. Invest. 91(11):1668-79
Ho GT, et al.
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Ho GT, Aird RE, Liu B, Boyapati RK, Kennedy NA, Dorward DA, Noble CL, Shimizu T, Carter RN, Chew ET, Morton NM, Rossi AG, Sartor RB, Iredale JP, Satsangi J
(2017) MDR1 deficiency impairs mitochondrial homeostasis and promotes intestinal inflammation. Mucosal Immunol
Eisenbraun MD, et al.
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Eisenbraun MD, Mosley RL, Teitelbaum DH, Miller RA
(2000) Altered development of intestinal intraepithelial lymphocytes in P-glycoprotein-deficient mice. Dev. Comp. Immunol. 24(8):783-95
Barnett MP, et al.
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Barnett MP, Dommels YE, Butts CA, Zhu S, McNabb WC, Roy NC
(2016) Inoculation with enterococci does not affect colon inflammation in the multi-drug resistance 1a-deficient mouse model of IBD. BMC Gastroenterol 16:31
Lencioni KC, et al.
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Lencioni KC, Seamons A, Treuting PM, Maggio-Price L, Brabb T
(2008) Murine norovirus: an intercurrent variable in a mouse model of bacteria-induced inflammatory bowel disease. Comp. Med. 58(6):522-33
Torrence AE, et al.
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Torrence AE, Brabb T, Viney JL, Bielefeldt-Ohmann H, Treuting P, Seamons A, Drivdahl R, Zeng W, Maggio-Price L
(2008) Serum biomarkers in a mouse model of bacterial-induced inflammatory bowel disease. Inflamm. Bowel Dis. 14(4):480-90
Fort MM, et al.
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Fort MM, Mozaffarian A, Stöver AG, Correia Jda S, Johnson DA, Crane RT, Ulevitch RJ, Persing DH, Bielefeldt-Ohmann H, Probst P, Jeffery E, Fling SP, Hershberg RM
(2005) A synthetic TLR4 antagonist has anti-inflammatory effects in two murine models of inflammatory bowel disease. J. Immunol. 174(10):6416-23
Cooney JM, et al.
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Cooney JM, Barnett MP, Dommels YE, Brewster D, Butts CA, McNabb WC, Laing WA, Roy NC
(2016) A combined omics approach to evaluate the effects of dietary curcumin on colon inflammation in the Mdr1a(-/-) mouse model of inflammatory bowel disease. J. Nutr. Biochem. 27:181-92
Pérez-Bosque A, et al.
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Pérez-Bosque A, Miró L, Maijó M, Polo J, Campbell J, Russell L, Crenshaw J, Weaver E, Moretó M
(2015) Dietary intervention with serum-derived bovine immunoglobulins protects barrier function in a mouse model of colitis. Am. J. Physiol. Gastrointest. Liver Physiol. 308(12):G1012-8
Nones K, et al.
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Nones K, Knoch B, Dommels YE, Paturi G, Butts C, McNabb WC, Roy NC
(2009) Multidrug resistance gene deficient (mdr1a-/-) mice have an altered caecal microbiota that precedes the onset of intestinal inflammation. J. Appl. Microbiol. 107(2):557-66
Maxwell JR, et al.
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Maxwell JR, Zhang Y, Brown WA, Smith CL, Byrne FR, Fiorino M, Stevens E, Bigler J, Davis JA, Rottman JB, Budelsky AL, Symons A, Towne JE
(2015) Differential Roles for Interleukin-23 and Interleukin-17 in Intestinal Immunoregulation. Immunity 43(4):739-50
Goralski KB, et al.
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Goralski KB, Hartmann G, Piquette-Miller M, Renton KW
(2003) Downregulation of mdr1a expression in the brain and liver during CNS inflammation alters the in vivo disposition of digoxin. Br. J. Pharmacol. 139(1):35-48
Pérez-Bosque A, et al.
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Pérez-Bosque A, Miró L, Maijó M, Polo J, Campbell JM, Russell L, Crenshaw JD, Weaver E, Moretó M
(2016) Oral Serum-Derived Bovine Immunoglobulin/Protein Isolate Has Immunomodulatory Effects on the Colon of Mice that Spontaneously Develop Colitis. PLoS ONE 11(5):e0154823
Dommels YE, et al.
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Dommels YE, Butts CA, Zhu S, Davy M, Martell S, Hedderley D, Barnett MP, McNabb WC, Roy NC
(2007) Characterization of intestinal inflammation and identification of related gene expression changes in mdr1a(-/-) mice. Genes Nutr 2(2):209-23
Glymenaki M, et al.
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Glymenaki M, Singh G, Brass A, Warhurst G, McBain AJ, Else KJ, Cruickshank SM
(2017) Compositional Changes in the Gut Mucus Microbiota Precede the Onset of Colitis-Induced Inflammation. Inflamm. Bowel Dis. 23(6):912-922
Barnett MP, et al.
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Barnett MP, Cooney JM, Dommels YE, Nones K, Brewster DT, Park Z, Butts CA, McNabb WC, Laing WA, Roy NC
(2013) Modulation of colonic inflammation in Mdr1a(-/-) mice by green tea polyphenols and their effects on the colon transcriptome and proteome. J. Nutr. Biochem. 24(10):1678-90
Glymenaki M, et al.
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Glymenaki M, Barnes A, Hagan SO, Warhurst G, McBain AJ, Wilson ID, Kell DB, Else KJ, Cruickshank SM
(2017) Stability in metabolic phenotypes and inferred metagenome profiles before the onset of colitis-induced inflammation. Sci Rep 7(1):8836
Willis CR, et al.
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Willis CR, Seamons A, Maxwell J, Treuting PM, Nelson L, Chen G, Phelps S, Smith CL, Brabb T, Iritani BM, Maggio-Price L
(2012) Interleukin-7 receptor blockade suppresses adaptive and innate inflammatory responses in experimental colitis. J Inflamm (Lond) 9(1):39
Paturi G, et al.
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Paturi G, Mandimika T, Butts CA, Zhu S, Roy NC, McNabb WC, Ansell J
(2012) Influence of dietary blueberry and broccoli on cecal microbiota activity and colon morphology in mdr1a(-/-) mice, a model of inflammatory bowel diseases. Nutrition 28(3):324-30
Bekker P, et al.
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Bekker P, Ebsworth K, Walters MJ, Berahovich RD, Ertl LS, Charvat TT, Punna S, Powers JP, Campbell JJ, Sullivan TJ, Jaen JC, Schall TJ
(2015) CCR9 Antagonists in the Treatment of Ulcerative Colitis. Mediators Inflamm. 2015:628340
Nones K, et al.
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Nones K, Dommels YE, Martell S, Butts C, McNabb WC, Park ZA, Zhu S, Hedderley D, Barnett MP, Roy NC
(2009) The effects of dietary curcumin and rutin on colonic inflammation and gene expression in multidrug resistance gene-deficient (mdr1a-/-) mice, a model of inflammatory bowel diseases. Br. J. Nutr. 101(2):169-81
Paik J, et al.
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Paik J, Fierce Y, Treuting PM, Brabb T, Maggio-Price L
(2013) High-fat diet-induced obesity exacerbates inflammatory bowel disease in genetically susceptible Mdr1a-/- male mice. J. Nutr. 143(8):1240-7
Bhardwaj EK, et al.
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Bhardwaj EK, Else KJ, Rogan MT, Warhurst G
(2014) Increased susceptibility to Trichuris muris infection and exacerbation of colitis in Mdr1a-/- mice. World J. Gastroenterol. 20(7):1797-806
Staley EM, et al.
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Staley EM, Schoeb TR, Lorenz RG
(2009) Differential susceptibility of P-glycoprotein deficient mice to colitis induction by environmental insults. Inflamm. Bowel Dis. 15(5):684-96
Hennenberg EM, et al.
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Hennenberg EM, Eyking A, Reis H, Cario E
(2017) MDR1A deficiency restrains tumor growth in murine colitis-associated carcinogenesis. PLoS ONE 12(7):e0180834
Haarberg KM, et al.
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Haarberg KM, Wymore Brand MJ, Overstreet AM, Hauck CC, Murphy PA, Hostetter JM, Ramer-Tait AE, Wannemuehler MJ
(2015) Orally administered extract from Prunella vulgaris attenuates spontaneous colitis in mdr1a(-/-) mice. World J Gastrointest Pharmacol Ther 6(4):223-37
Masunaga Y, et al.
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Masunaga Y, Noto T, Suzuki K, Takahashi K, Shimizu Y, Morokata T
(2007) Expression profiles of cytokines and chemokines in murine MDR1a-/- colitis. Inflamm. Res. 56(11):439-46
Tanner SM, et al.
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Tanner SM, Staley EM, Lorenz RG
(2013) Altered generation of induced regulatory T cells in the FVB.mdr1a-/- mouse model of colitis. Mucosal Immunol 6(2):309-23
Ey B, et al.
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Ey B, Eyking A, Klepak M, Salzman NH, Göthert JR, Rünzi M, Schmid KW, Gerken G, Podolsky DK, Cario E
(2013) Loss of TLR2 worsens spontaneous colitis in MDR1A deficiency through commensally induced pyroptosis. J. Immunol. 190(11):5676-88
Staley EM, et al.
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Staley EM, Dimmitt RA, Schoeb TR, Tanner SM, Lorenz RG
(2011) Critical role for P-glycoprotein expression in hematopoietic cells in the FVB.Mdr1a(-/-) model of colitis. J. Pediatr. Gastroenterol. Nutr. 53(6):666-73
Collett A, et al.
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Collett A, Higgs NB, Gironella M, Zeef LA, Hayes A, Salmo E, Haboubi N, Iovanna JL, Carlson GL, Warhurst G
(2008) Early molecular and functional changes in colonic epithelium that precede increased gut permeability during colitis development in mdr1a(-/-) mice. Inflamm. Bowel Dis. 14(5):620-31
Stephens RH, et al.
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Stephens RH, Tanianis-Hughes J, Higgs NB, Humphrey M, Warhurst G
(2002) Region-dependent modulation of intestinal permeability by drug efflux transporters: in vitro studies in mdr1a(-/-) mouse intestine. J. Pharmacol. Exp. Ther. 303(3):1095-101
Panwala CM, et al.
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Panwala CM, Jones JC, Viney JL
(1998) A novel model of inflammatory bowel disease: mice deficient for the multiple drug resistance gene, mdr1a, spontaneously develop colitis. J. Immunol. 161(10):5733-44
Banner KH, et al.
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Banner KH, Cattaneo C, Le Net JL, Popovic A, Collins D, Gale JD
(2004) Macroscopic, microscopic and biochemical characterisation of spontaneous colitis in a transgenic mouse, deficient in the multiple drug resistance 1a gene. Br. J. Pharmacol. 143(5):590-8
Resta-Lenert S, et al.
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Resta-Lenert S, Smitham J, Barrett KE
(2005) Epithelial dysfunction associated with the development of colitis in conventionally housed mdr1a-/- mice. Am. J. Physiol. Gastrointest. Liver Physiol. 289(1):G153-62
Schinkel AH, et al.
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Schinkel AH, Smit JJ, van Tellingen O, Beijnen JH, Wagenaar E, van Deemter L, Mol CA, van der Valk MA, Robanus-Maandag EC, te Riele HP
(1994) Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs. Cell 77(4):491-502
Zhou S, et al.
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Zhou S, Morris JJ, Barnes Y, Lan L, Schuetz JD, Sorrentino BP
(2002) Bcrp1 gene expression is required for normal numbers of side population stem cells in mice, and confers relative protection to mitoxantrone in hematopoietic cells in vivo. Proc. Natl. Acad. Sci. U.S.A. 99(19):12339-44
Schinkel AH, et al.
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Schinkel AH, Schuetz EG, Relling MV, Schuetz JD
(1996) P-glycoprotein: a major determinant of rifampicin-inducible expression of cytochrome P4503A in mice and humans Proc Natl Acad Sci USA. 93:4001-5
Schinkel AH, et al.
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Schinkel AH, Wagenaar E, Mol C A, van Deemter L
(1996) P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs. J Clin Invest. 97(11): 2517-2524
Sparreboom A, et al.
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Sparreboom A, van Asperen J, Mayer U, Schinkel AH, Smit JW, Meijer DK, Borst P, Nooijen WJ, Beijnen JH, van Tellingen O
(1997) Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine. Proc. Natl. Acad. Sci. U.S.A. 94(5):2031-5
Neudeck BL, et al.
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Neudeck BL, Loeb JM, Faith NG, Czuprynski CJ
(2004) Intestinal P Glycoprotein Acts as a Natural Defense Mechanism against Listeria monocytogenes Infect Immun. 72(7):3849-3854
Maggio-Price L, et al.
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Maggio-Price L, Bielefeldt-Ohmann H, Treuting P, Iritani BM, Zeng W, Nicks A, Tsang M, Shows D, Morrissey P, Viney JL
(2005) Dual infection with Helicobacter bilis and Helicobacter hepaticus in p-glycoprotein-deficient mdr1a-/- mice results in colitis that progresses to dysplasia. Am. J. Pathol. 166(6):1793-806
Maggio-Price L, et al.
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Maggio-Price L, Shows D, Waggie K, Burich A, Zeng W, Escobar S, Morrissey P, Viney JL
(2002) Helicobacter bilis infection accelerates and H. hepaticus infection delays the development of colitis in multiple drug resistance-deficient (mdr1a-/-) mice. Am. J. Pathol. 160(2):739-51
Cirrito JR, et al.
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Cirrito JR, Deane R, Fagan AM, Spinner ML, Parsadanian M, Finn MB, Jiang H, Prior JL, Sagare A, Bales KR, Paul SM, Zlokovic BV, Piwnica-Worms D, Holtzman DM
(2005) P-glycoprotein deficiency at the blood-brain barrier increases amyloid-beta deposition in an Alzheimer disease mouse model. J. Clin. Invest. 115(11):3285-90
Neudeck BL, et al.
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Neudeck BL, Loeb JM, Faith NG, Czuprynski CJ
(2004) Intestinal P glycoprotein acts as a natural defense mechanism against Listeria monocytogenes. Infect. Immun. 72(7):3849-54
Miyama T, et al.
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Miyama T, Takanaga H, Matsuo H, Yamano K, Yamamoto K, Iga T, Naito M, Tsuruo T, Ishizuka H, Kawahara Y, Sawada Y
(1998) P-glycoprotein-mediated transport of itraconazole across the blood-brain barrier. Antimicrob. Agents Chemother. 42(7):1738-44