Cyp3a (8-gene) Knockout Publications

Cyp3a (8-gene) Knockout Model Page

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Eisenmann ED, et al.
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Eisenmann ED, Fu Q, Muhowski EM, Jin Y, Uddin ME, Garrison DA, Weber RH, Woyach J, Byrd JC, Sparreboom A, Baker SD
(2021) Intentional Modulation of Ibrutinib Pharmacokinetics through CYP3A Inhibition. Cancer Res Commun 1(2):79-89
Jin Y, et al.
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Jin Y, Li Y, Uddin ME, Sparreboom A, Hu S
(2021) Rapid quantification of vincristine in mouse plasma using ESI-LC-MS/MS: Application to pharmacokinetic studies. J Chromatogr B Analyt Technol Biomed Life Sci 1168:122591
Liu K, et al.
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Liu K, Li F, Lu J, Gao Z, Klaassen CD, Ma X
(2014) Role of CYP3A in isoniazid metabolism in vivo. Drug Metab Pharmacokinet 29(2):219-22
Chang JH, et al.
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Chang JH, Ly J, Plise E, Zhang X, Messick K, Wright M, Cheong J
(2014) Differential effects of Rifampin and Ketoconazole on the blood and liver concentration of atorvastatin in wild-type and Cyp3a and Oatp1a/b knockout mice. Drug Metab Dispos 42(6):1067-73
Robillard KR, et al.
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Robillard KR, Chan GN, Zhang G, la Porte C, Cameron W, Bendayan R
(2014) Role of P-glycoprotein in the distribution of the HIV protease inhibitor atazanavir in the brain and male genital tract. Antimicrob Agents Chemother 58(3):1713-22
Li W, et al.
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Li W, Sparidans RW, Martins MLF, El-Lari M, Lebre MC, van Tellingen O, Beijnen JH, Schinkel AH
(2021) ABCB1 and ABCG2 Restrict Brain and Testis Accumulation and, Alongside CYP3A, Limit Oral Availability of the Novel TRK Inhibitor Selitrectinib. Mol Cancer Ther 20(6):1173-1182
van Herwaarden AE, et al.
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van Herwaarden AE, Wagenaar E, van der Kruijssen CM, van Waterschoot RA, Smit JW, Song JY, van der Valk MA, van Tellingen O, van der Hoorn JW, Rosing H, Beijnen JH, Schinkel AH
(2007) Knockout of cytochrome P450 3A yields new mouse models for understanding xenobiotic metabolism. J. Clin. Invest. 117(11):3583-92
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