CIEA NOG mouse® Publications

CIEA NOG mouse® Model Page

Filter publications by application: All Antibody-Dependent-Cellular Cytotoxicity (ADCC) Autoimmune Benign Tumors Breast Cancer Colon Cancer Differentiation Of HSC Into Hepatocytes Epstein-Barr Virus Gastric Cancer HIV HTLV-1 Hematopoietic Stem Cell Engraftment Hepatocellular Carcinoma (HCC) Humanized Immuno-Oncology Immunology Immunotherapy Induced Pluripotent Stem Cells (iPSCs) Infectious Disease Inflammation Leukemia Lung Cancer Lymphoma Melanoma Metastases Myeloma NK Neuroscience Oncology Pancreatic And Other Biliary Tract Cancers Patient Derived Xenograft (PDX) Prostate Cancer Regeneration Of Human Tissue Safety Assessment Stem Cells/Regenerative Medicine/Tissue Engineering T And/Or B Cell Function Therapeutic Efficacy Evaluation Transplantation Research And Graft Versus Host Disease (GVHD) Vaccine Research
Filter publications by model type: All Humanization

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Jespersen H, et al.
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Jespersen H, Lindberg MF, Donia M, Söderberg EMV, Andersen R, Keller U, Ny L, Svane IM, Nilsson LM, Nilsson JA
(2017) Clinical responses to adoptive T-cell transfer can be modeled in an autologous immune-humanized mouse model. Nat Commun 8(1):707
Humanization
Immunology, Humanized
Kametani Y, et al.
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Kametani Y, Katano I, Miyamoto A, Kikuchi Y, Ito R, Muguruma Y, Tsuda B, Habu S, Tokuda Y, Ando K, Ito M
(2017) NOG-hIL-4-Tg, a new humanized mouse model for producing tumor antigen-specific IgG antibody by peptide vaccination. PLoS ONE 12(6):e0179239
Humanization
Immunology, Oncology, Vaccine Research, Humanized
Patel S, et al.
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Patel S, Zhang Y, Cassinat B, Zassadowski F, Ferré N, Cuccuini W, Cayuela JM, Fenaux P, Bonnet D, Chomienne C, Louache F
(2012) Successful xenografts of AML3 samples in immunodeficient NOD/shi-SCID IL2Rγ⁻/⁻ mice. Leukemia 26(11):2432-5
Humanization
Immunology, Oncology, Leukemia, Humanized
Jin Y, et al.
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Jin Y, Yao Y, Chen L, Zhu X, Jin B, Shen Y, Li J, Du X, Lu Y, Jiang S, Pan J
(2016) Depletion of γ-catenin by Histone Deacetylase Inhibition Confers Elimination of CML Stem Cells in Combination with Imatinib. Theranostics 6(11):1947-62
Hematopoietic Stem Cell Engraftment, Oncology, Humanized
Nambu J, et al.
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Nambu J, Kobayashi T, Hashimoto M, Tashiro H, Sugino K, Shimamoto F, Kikuchi A, Ohdan H
(2016) h-prune affects anaplastic thyroid cancer invasion and metastasis. Oncol. Rep. 35(6):3445-52
Oncology
Fu J, et al.
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Fu J, Sen R, Masica DL, Karchin R, Pardoll D, Walter V, Hayes DN, Chung CH, Kim YJ
(2016) Autologous reconstitution of human cancer and immune system in vivo. Oncotarget
Oncology, Patient Derived Xenograft (PDX), Immuno-Oncology, Humanized
Ito R, et al.
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Ito R, Katano I, Kawai K, Yagoto M, Takahashi T, Ka Y, Ogura T, Takahashi R, Ito M
(2016) A novel xenogeneic graft-versus-host disease model for investigating the pathological role of human CD4+ or CD8+ T cells using immunodeficient NOG mice. Am. J. Transplant.
Ando S, et al.
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Ando S, Kawada JI, Watanabe T, Suzuki M, Sato Y, Torii Y, Asai M, Goshima F, Murata T, Shimizu N, Ito Y, Kimura H
(2016) Tofacitinib induces G1 cell-cycle arrest and inhibits tumor growth in Epstein-Barr virus-associated T and natural killer cell lymphoma cells. Oncotarget
Epstein-Barr Virus, Oncology, Lymphoma
Sugai K, et al.
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Sugai K, Fukuzawa R, Shofuda T, Fukusumi H, Kawabata S, Nishiyama Y, Higuchi Y, Kawai K, Isoda M, Kanematsu D, Hashimoto-Tamaoki T, Kohyama J, Iwanami A, Suemizu H, Ikeda E, Matsumoto M, Kanemura Y, Nakamura M, Okano H
(2016) Pathological classification of human iPSC-derived neural stem/progenitor cells towards safety assessment of transplantation therapy for CNS diseases. Mol Brain 9(1):85
Neuroscience, Stem Cells/Regenerative Medicine/Tissue Engineering, Induced Pluripotent Stem Cells (iPSCs)
Mamoru Ito, et al.
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Mamoru Ito, Hidefumi Hiramatsu, Kimio Kobayashi, Kazutomo Suzue, Mariko Kawahata, Kyoji Hioki, Yoshito Ueyama, Yoshio Koyanagi, Kazuo Sugamura, Kohichiro Tsuji, Toshio Heike, Tatsutoshi Nakahata
(2002) NOD/SCID/γ nullc mouse: an excellent recipient mouse model for engraftment of human cells Blood 2002 100:3175-3182
Humanized
Ziemke EK, et al.
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Ziemke EK, Dosch JS, Maust JD, Shettigar A, Sen A, Welling TH, Hardiman KM, Sebolt-Leopold JS
(2016) Sensitivity of KRAS-Mutant Colorectal Cancers to Combination Therapy That Cotargets MEK and CDK4/6. Clin. Cancer Res. 22(2):405-14
Colon Cancer
Marina Bacac, et al.
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Marina Bacac, Tanja Fauti, Sara Colombetti, Johannes Sam, Valeria Nicolini, Nathalie Steinhoff, Oliver Ast, Peter Bruenker, Ralf Hosse, Thomas Hofer, Ekkehard Moessner, Christiane Jaeger, Jose Saro, Vaios Karanikas, Christian Klein, Pablo Umaña
(2015) A novel T-cell bispecific antibody with potent in vitro and in vivo antitumour activity against solid tumours European Journal of Cancer
T And/Or B Cell Function
Ito M, et al.
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Ito M, Ueyama Y, Koyanagi Y, Nakahata T, Nomura T, Tamaoki N, Terashima K, Yamamoto N
(2003) NOG (NOD/Shi-scid, γcnull) mouse-HIV-1 and HTLV-1 infection model using NOG mice allowing an efficient transplantation of human cells Proc. Japanese Society of Animal Models for Human Diseases 19:23-30
HTLV-1
Valiulienė G, et al.
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Valiulienė G, Treigytė G, Savickienė J, Matuzevičius D, Alksnė M, Jarašienė-Burinskaja R, Bukelskienė V, Navakauskas D, Navakauskienė R
(2016) Histone modifications patterns in tissues and tumours from acute promyelocytic leukemia xenograft model in response to combined epigenetic therapy. Biomed. Pharmacother. 79:62-70
Leukemia
Kitadate A, et al.
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Kitadate A, Ikeda S, Teshima K, Ito M, Toyota I, Hasunuma N, Takahashi N, Miyagaki T, Sugaya M, Tagawa H
(2015) MicroRNA-16 mediates the regulation of a senescence-apoptosis switch in cutaneous T-cell and other non-Hodgkin lymphomas. Oncogene
Lymphoma, Metastases
Soleimani R, et al.
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Soleimani R, Heytens E, Darzynkiewicz Z, Oktay K
(2011) Mechanisms of chemotherapy-induced human ovarian aging: double strand DNA breaks and microvascular compromise. Aging (Albany NY) 3(8):782-93
Safety Assessment
Kanemura H, et al.
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Kanemura H, Go MJ, Nishishita N, Sakai N, Kamao H, Sato Y, Takahashi M, Kawamata S
(2013) Pigment epithelium-derived factor secreted from retinal pigment epithelium facilitates apoptotic cell death of iPSC. Sci Rep 3:2334
Safety Assessment
Takahashi M, et al.
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Takahashi M, Tsujimura N, Yoshino T, Hosokawa M, Otsuka K, Matsunaga T, Nakasono S
(2012) Assessment of benzene-induced hematotoxicity using a human-like hematopoietic lineage in NOD/Shi-scid/IL-2Rγnull mice. PLoS ONE 7(12):e50448
Safety Assessment
Nakamura T, et al.
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Nakamura T, Miyakawa Y, Miyamura A, Yamane A, Suzuki H, Ito M, Ohnishi Y, Ishiwata N, Ikeda Y, Tsuruzoe N
(2006) A novel nonpeptidyl human c-Mpl activator stimulates human megakaryopoiesis and thrombopoiesis. Blood 107(11):4300-7
Therapeutic Efficacy Evaluation
Ninomiya M, et al.
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Ninomiya M, Kiyoi H, Ito M, Hirose Y, Ito M, Naoe T
(2004) Retinoic acid syndrome in NOD/scid mice induced by injecting an acute promyelocytic leukemia cell line. Leukemia 18(3):442-8
Leukemia
Fujii E, et al.
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Fujii E, Kato A, Chen YJ, Matsubara K, Ohnishi Y, Suzuki M
(2014) Histopathological characteristics of human non-tumor thyroid tissues in a long-term model of adenomatous goiter xenografts in the NOD/Shi-scid, IL-2Rγ(null) mouse. Exp. Toxicol. Pathol. 66(4):203-9
Martel BC, et al.
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Martel BC, Blom L, Dyring-Andersen B, Skov L, Thestrup-Pedersen K, Skov S, Skak K, Poulsen LK
(2015) Human Atopic Dermatitis Skin-derived T Cells can Induce a Reaction in Mouse Keratinocytes in vivo. Scand. J. Immunol. 82(2):125-34
Autoimmune, Inflammation
Saito N, et al.
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Saito N, Yoshioka N, Abe R, Qiao H, Fujita Y, Hoshina D, Suto A, Kase S, Kitaichi N, Ozaki M, Shimizu H
(2013) Stevens-Johnson syndrome/toxic epidermal necrolysis mouse model generated by using PBMCs and the skin of patients. J. Allergy Clin. Immunol. 131(2):434-41.e1-9
Autoimmune, Inflammation
Doshi M, et al.
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Doshi M, Koyanagi M, Nakahara M, Saeki K, Saeki K, Yuo A
(2006) Identification of human neutrophils during experimentally induced inflammation in mice with transplanted CD34+ cells from human umbilical cord blood. Int. J. Hematol. 84(3):231-7
Autoimmune, Inflammation
Marg A, et al.
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Marg A, Escobar H, Gloy S, Kufeld M, Zacher J, Spuler A, Birchmeier C, Izsvák Z, Spuler S
(2014) Human satellite cells have regenerative capacity and are genetically manipulable. J. Clin. Invest. 124(10):4257-65
Regeneration Of Human Tissue
Wang C, et al.
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Wang C, Oshima M, Sashida G, Tomioka T, Hasegawa N, Mochizuki-Kashio M, Nakajima-Takagi Y, Kusunoki Y, Kyoizumi S, Imai K, Nakachi K, Iwama A
(2015) Non-Lethal Ionizing Radiation Promotes Aging-Like Phenotypic Changes of Human Hematopoietic Stem and Progenitor Cells in Humanized Mice. PLoS ONE 10(7):e0132041
Regeneration Of Human Tissue
Kato T, et al.
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Kato T, Hisasue M, Segawa K, Fujimoto A, Makiishi E, Neo S, Yasuno K, Kobayashi R, Tsuchiya R
(2013) Accumulation of xenotransplanted canine bone marrow cells in NOD/SCID/γc(null) mice with acute hepatitis induced by CCl4. J. Vet. Med. Sci. 75(7):847-55
Regeneration Of Human Tissue
Yahata T, et al.
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Yahata T, Takanashi T, Muguruma Y, Ibrahim AA, Matsuzawa H, Uno T, Sheng Y, Onizuka M, Ito M, Kato S, Ando K
(2011) Accumulation of oxidative DNA damage restricts the self-renewal capacity of human hematopoietic stem cells. Blood 118(11):2941-50
Regeneration Of Human Tissue
Ogawa D, et al.
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Ogawa D, Okada Y, Nakamura M, Kanemura Y, Okano HJ, Matsuzaki Y, Shimazaki T, Ito M, Ikeda E, Tamiya T, Nagao S, Okano H
(2009) Evaluation of human fetal neural stem/progenitor cells as a source for cell replacement therapy for neurological disorders: properties and tumorigenicity after long-term in vitro maintenance. J. Neurosci. Res. 87(2):307-17
Regeneration Of Human Tissue
Kishi Y, et al.
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Kishi Y, Tanaka Y, Shibata H, Nakamura S, Takeuchi K, Masuda S, Ikeda T, Muramatsu S, Hanazono Y
(2008) Variation in the incidence of teratomas after the transplantation of nonhuman primate ES cells into immunodeficient mice. Cell Transplant 17(9):1095-102
Regeneration Of Human Tissue
Yahata T, et al.
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Yahata T, Muguruma Y, Yumino S, Sheng Y, Uno T, Matsuzawa H, Ito M, Kato S, Hotta T, Ando K
(2008) Quiescent human hematopoietic stem cells in the bone marrow niches organize the hierarchical structure of hematopoiesis. Stem Cells 26(12):3228-36
Regeneration Of Human Tissue
Yamazaki H, et al.
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Yamazaki H, Suemizu H, Igaya S, Shimizu M, Shibata N, Nakamura M, Chowdhury G, Guengerich FP
(2011) In vivo formation of a glutathione conjugate derived from thalidomide in humanized uPA-NOG mice. Chem. Res. Toxicol. 24(3):287-9
Regeneration Of Human Tissue
Hasegawa M, et al.
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Hasegawa M, Kawai K, Mitsui T, Taniguchi K, Monnai M, Wakui M, Ito M, Suematsu M, Peltz G, Nakamura M, Suemizu H
(2011) The reconstituted 'humanized liver' in TK-NOG mice is mature and functional. Biochem. Biophys. Res. Commun. 405(3):405-10
Regeneration Of Human Tissue
Kikuchi-Arai M, et al.
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Kikuchi-Arai M, Murakami T, Utsunomiya H, Akahira J, Suzuki-Kakisaka H, Terada Y, Tachibana M, Hayasaka S, Ugajin T, Yaegashi N
(2010) Establishment of long-term model throughout regular menstrual cycles in immunodeficient mice. Am. J. Reprod. Immunol. 64(5):324-32
Regeneration Of Human Tissue
Masuda H, et al.
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Masuda H, Matsuzaki Y, Hiratsu E, Ono M, Nagashima T, Kajitani T, Arase T, Oda H, Uchida H, Asada H, Ito M, Yoshimura Y, Maruyama T, Okano H
(2010) Stem cell-like properties of the endometrial side population: implication in endometrial regeneration. PLoS ONE 5(4):e10387
Regeneration Of Human Tissue
Watanabe T, et al.
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Watanabe T, Hayashi H, Kita K, Kubota Y, Ogawa T
(2009) Ectopic porcine spermatogenesis in murine subcutis: tissue grafting versus cell-injection methods. Asian J. Androl. 11(3):317-23
Regeneration Of Human Tissue
Suemizu H, et al.
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Suemizu H, Hasegawa M, Kawai K, Taniguchi K, Monnai M, Wakui M, Suematsu M, Ito M, Peltz G, Nakamura M
(2008) Establishment of a humanized model of liver using NOD/Shi-scid IL2Rgnull mice. Biochem. Biophys. Res. Commun. 377(1):248-52
Regeneration Of Human Tissue
Terada Y, et al.
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Terada Y, Terunuma-Sato Y, Kakoi-Yoshimoto T, Hasegawa H, Ugajin T, Koyanagi Y, Ito M, Murakami T, Sasano H, Yaegashi N, Okamura K
(2008) Development of human Graafian follicles following transplantation of human ovarian tissue into NOD/SCID/gammac null mice. Am. J. Reprod. Immunol. 60(6):534-40
Regeneration Of Human Tissue
Ono M, et al.
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Ono M, Maruyama T, Masuda H, Kajitani T, Nagashima T, Arase T, Ito M, Ohta K, Uchida H, Asada H, Yoshimura Y, Okano H, Matsuzaki Y
(2007) Side population in human uterine myometrium displays phenotypic and functional characteristics of myometrial stem cells. Proc. Natl. Acad. Sci. U.S.A. 104(47):18700-5
Regeneration Of Human Tissue
Masuda H, et al.
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Masuda H, Maruyama T, Hiratsu E, Yamane J, Iwanami A, Nagashima T, Ono M, Miyoshi H, Okano HJ, Ito M, Tamaoki N, Nomura T, Okano H, Matsuzaki Y, Yoshimura Y
(2007) Noninvasive and real-time assessment of reconstructed functional human endometrium in NOD/SCID/gamma c(null) immunodeficient mice. Proc. Natl. Acad. Sci. U.S.A. 104(6):1925-30
Regeneration Of Human Tissue
Matsuura-Sawada R, et al.
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Matsuura-Sawada R, Murakami T, Ozawa Y, Nabeshima H, Akahira J, Sato Y, Koyanagi Y, Ito M, Terada Y, Okamura K
(2005) Reproduction of menstrual changes in transplanted human endometrial tissue in immunodeficient mice. Hum. Reprod. 20(6):1477-84
Regeneration Of Human Tissue
Schmittnaegel M, et al.
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Schmittnaegel M, Levitsky V, Hoffmann E, Georges G, Mundigl O, Klein C, Knoetgen H
(2015) Committing Cytomegalovirus-Specific CD8 T Cells to Eliminate Tumor Cells by Bifunctional Major Histocompatibility Class I Antibody Fusion Molecules. Cancer Immunol Res 3(7):764-76
Immunotherapy
Shimizu K, et al.
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Shimizu K, Mizuno T, Shinga J, Asakura M, Kakimi K, Ishii Y, Masuda K, Maeda T, Sugahara H, Sato Y, Matsushita H, Nishida K, Hanada K, Dorrie J, Schaft N, Bickham K, Koike H, Ando T, Nagai R, Fujii S
(2013) Vaccination with antigen-transfected, NKT cell ligand-loaded, human cells elicits robust in situ immune responses by dendritic cells. Cancer Res. 73(1):62-73
Immunotherapy
Shirakura Y, et al.
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Shirakura Y, Mizuno Y, Wang L, Imai N, Amaike C, Sato E, Ito M, Nukaya I, Mineno J, Takesako K, Ikeda H, Shiku H
(2012) T-cell receptor gene therapy targeting melanoma-associated antigen-A4 inhibits human tumor growth in non-obese diabetic/SCID/γcnull mice. Cancer Sci. 103(1):17-25
Immunotherapy
Lehmann S, et al.
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Lehmann S, Perera R, Grimm HP, Sam J, Colombetti S, Fauti T, Fahrni L, Schaller T, Freimoser-Grundschober A, Zielonka J, Stoma S, Rudin M, Klein C, Umana P, Gerdes C, Bacac M
(2016) In vivo imaging of the activity of CEA TCB, a novel T-cell bispecific antibody, reveals specific tumor targeting and fast induction of T-cell mediated tumor killing. Clin. Cancer Res.
Humanization
Oncology, Immunotherapy
Chijiwa T, et al.
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Chijiwa T, Kawai K, Noguchi A, Sato H, Hayashi A, Cho H, Shiozawa M, Kishida T, Morinaga S, Yokose T, Katayama M, Takenaka N, Suemizu H, Yamada R, Nakamura Y, Ohtsu T, Takano Y, Imai K, Miyagi Y, Nakamura M
(2015) Establishment of patient-derived cancer xenografts in immunodeficient NOG mice. Int. J. Oncol. 47(1):61-70
Patient Derived Xenograft (PDX)
Masaki A, et al.
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Masaki A, Ishida T, Suzuki S, Ito A, Mori F, Sato F, Narita T, Yamada T, Ri M, Kusumoto S, Komatsu H, Tanaka Y, Niimi A, Inagaki H, Iida S, Ueda R
(2013) Autologous Tax-specific CTL therapy in a primary adult T cell leukemia/lymphoma cell-bearing NOD/Shi-scid, IL-2Rγnull mouse model. J. Immunol. 191(1):135-44
Immunotherapy, Patient Derived Xenograft (PDX)
Joo KM, et al.
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Joo KM, Kim J, Jin J, Kim M, Seol HJ, Muradov J, Yang H, Choi YL, Park WY, Kong DS, Lee JI, Ko YH, Woo HG, Lee J, Kim S, Nam DH
(2013) Patient-specific orthotopic glioblastoma xenograft models recapitulate the histopathology and biology of human glioblastomas in situ. Cell Rep 3(1):260-73
Patient Derived Xenograft (PDX)
Zhang Y, et al.
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Zhang Y, Patel S, Abdelouahab H, Wittner M, Willekens C, Shen S, Betems A, Joulin V, Opolon P, Bawa O, Pasquier F, Ito M, Fujii N, Gonin P, Solary E, Vainchenker W, Coppo P, De Botton S, Louache F
(2012) CXCR4 inhibitors selectively eliminate CXCR4-expressing human acute myeloid leukemia cells in NOG mouse model. Cell Death Dis 3:e396
Patient Derived Xenograft (PDX)
Mori F, et al.
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Mori F, Ishida T, Ito A, Sato F, Masaki A, Takino H, Ri M, Kusumoto S, Komatsu H, Ueda R, Inagaki H, Iida S
(2012) Potent antitumor effects of bevacizumab in a microenvironment-dependent human lymphoma mouse model. Blood Cancer J 2(4):e67
Patient Derived Xenograft (PDX)
Kobayashi S, et al.
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Kobayashi S, Yamada-Okabe H, Suzuki M, Natori O, Kato A, Matsubara K, Jau Chen Y, Yamazaki M, Funahashi S, Yoshida K, Hashimoto E, Watanabe Y, Mutoh H, Ashihara M, Kato C, Watanabe T, Yoshikubo T, Tamaoki N, Ochiya T, Kuroda M, Levine AJ, Yamazaki T
(2012) LGR5-positive colon cancer stem cells interconvert with drug-resistant LGR5-negative cells and are capable of tumor reconstitution. Stem Cells 30(12):2631-44
Patient Derived Xenograft (PDX)
Fujii E, et al.
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Fujii E, Suzuki M, Matsubara K, Watanabe M, Chen YJ, Adachi K, Ohnishi Y, Tanigawa M, Tsuchiya M, Tamaoki N
(2008) Establishment and characterization of in vivo human tumor models in the NOD/SCID/gamma(c)(null) mouse. Pathol. Int. 58(9):559-67
Patient Derived Xenograft (PDX)
Tsuiji K, et al.
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Tsuiji K, Takeda T, Li B, Kondo A, Ito M, Yaegashi N
(2010) Establishment of a novel xenograft model for human uterine leiomyoma in immunodeficient mice. Tohoku J. Exp. Med. 222(1):55-61
Benign Tumors
Kubo A, et al.
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Kubo A, Ohmura M, Wakui M, Harada T, Kajihara S, Ogawa K, Suemizu H, Nakamura M, Setou M, Suematsu M
(2011) Semi-quantitative analyses of metabolic systems of human colon cancer metastatic xenografts in livers of superimmunodeficient NOG mice. Anal Bioanal Chem 400(7):1895-904
Metastases
Nakamura M, et al.
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Nakamura M, Suemizu H
(2008) Novel metastasis models of human cancer in NOG mice. Curr. Top. Microbiol. Immunol. 324:167-77
Metastases
Gomez-Casal R, et al.
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Gomez-Casal R, Bhattacharya C, Epperly MW, Basse PH, Wang H, Wang X, Proia DA, Greenberger JS, Socinski MA, Levina V
(2015) The HSP90 Inhibitor Ganetespib Radiosensitizes Human Lung Adenocarcinoma Cells. Cancers (Basel) 7(2):876-907
Lung Cancer
Gad H, et al.
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Gad H, Koolmeister T, Jemth AS, Eshtad S, Jacques SA, Ström CE, Svensson LM, Schultz N, Lundbäck T, Einarsdottir BO, Saleh A, Göktürk C, Baranczewski P, Svensson R, Berntsson RP, Gustafsson R, Strömberg K, Sanjiv K, Jacques-Cordonnier MC, Desroses M, Gustavsson AL, Olofsson R, Johansson F, Homan EJ, Loseva O, Bräutigam L, Johansson L, Höglund A, Hagenkort A, Pham T, Altun M, Gaugaz FZ, Vikingsson S, Evers B, Henriksson M, Vallin KS, Wallner OA, Hammarström LG, Wiita E, Almlöf I, Kalderén C, Axelsson H, Djureinovic T, Puigvert JC, Häggblad M, Jeppsson F, Martens U, Lundin C, Lundgren B, Granelli I, Jensen AJ, Artursson P, Nilsson JA, Stenmark P, Scobie M, Berglund UW, Helleday T
(2014) MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool. Nature 508(7495):215-21
Lung Cancer, Patient Derived Xenograft (PDX), Therapeutic Efficacy Evaluation
Bacac M, et al.
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Bacac M, Fauti T, Sam J, Colombetti S, Weinzierl T, Ouaret D, Bodmer W, Lehmann S, Hofer T, Hosse RJ, Moessner E, Ast O, Bruenker P, Grau-Richards S, Schaller T, Seidl A, Gerdes C, Perro M, Nicolini V, Steinhoff N, Dudal S, Neumann S, von Hirschheydt T, Jaeger C, Saro J, Karanikas V, Klein C, Umaña P
(2016) A Novel Carcinoembryonic Antigen T-Cell Bispecific Antibody (CEA TCB) for the Treatment of Solid Tumors. Clin. Cancer Res. 22(13):3286-97
Humanization
Oncology, Colon Cancer, Immunotherapy, Immuno-Oncology, Humanized
Hamada K, et al.
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Hamada K, Monnai M, Kawai K, Nishime C, Kito C, Miyazaki N, Ohnishi Y, Nakamura M, Suemizu H
(2008) Liver metastasis models of colon cancer for evaluation of drug efficacy using NOD/Shi-scid IL2Rgammanull (NOG) mice. Int. J. Oncol. 32(1):153-9
Colon Cancer, Metastases, Differentiation Of HSC Into Hepatocytes, Therapeutic Efficacy Evaluation
Handa K, et al.
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Handa K, Ohmura M, Nishime C, Hishiki T, Nagahata Y, Kawai K, Suemizu H, Nakamura M, Wakui M, Kitagawa Y, Suematsu M, Tsukada K
(2010) Phosphorescence-assisted microvascular O(2) measurements reveal alterations of oxygen demand in human metastatic colon cancer in the liver of superimmunodeficient NOG mice. Adv. Exp. Med. Biol. 662:423-9
Colon Cancer, Metastases
Kimura O, et al.
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Kimura O, Takahashi T, Ishii N, Inoue Y, Ueno Y, Kogure T, Fukushima K, Shiina M, Yamagiwa Y, Kondo Y, Inoue J, Kakazu E, Iwasaki T, Kawagishi N, Shimosegawa T, Sugamura K
(2010) Characterization of the epithelial cell adhesion molecule (EpCAM)+ cell population in hepatocellular carcinoma cell lines. Cancer Sci. 101(10):2145-55
Hepatocellular Carcinoma (HCC)
Nishime C, et al.
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Nishime C, Kawai K, Yamamoto T, Katano I, Monnai M, Goda N, Mizushima T, Suemizu H, Nakamura M, Murata M, Suematsu M, Wakui M
(2015) Innate Response to Human Cancer Cells with or without IL-2 Receptor Common γ-Chain Function in NOD Background Mice Lacking Adaptive Immunity. J. Immunol. 195(4):1883-90
Colon Cancer, Metastases, Pancreatic And Other Biliary Tract Cancers
Tamai K, et al.
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Tamai K, Nakamura M, Mizuma M, Mochizuki M, Yokoyama M, Endo H, Yamaguchi K, Nakagawa T, Shiina M, Unno M, Muramoto K, Sato I, Satoh K, Sugamura K, Tanaka N
(2014) Suppressive expression of CD274 increases tumorigenesis and cancer stem cell phenotypes in cholangiocarcinoma. Cancer Sci. 105(6):667-74
Immunotherapy, Pancreatic And Other Biliary Tract Cancers
Matsuda Y, et al.
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Matsuda Y, Yoshimura H, Ueda J, Naito Z, Korc M, Ishiwata T
(2014) Nestin delineates pancreatic cancer stem cells in metastatic foci of NOD/Shi-scid IL2Rγ(null) (NOG) mice. Am. J. Pathol. 184(3):674-85
Metastases, Pancreatic And Other Biliary Tract Cancers
Suemizu H, et al.
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Suemizu H, Monnai M, Ohnishi Y, Ito M, Tamaoki N, Nakamura M
(2007) Identification of a key molecular regulator of liver metastasis in human pancreatic carcinoma using a novel quantitative model of metastasis in NOD/SCID/gammacnull (NOG) mice. Int. J. Oncol. 31(4):741-51
Metastases, Pancreatic And Other Biliary Tract Cancers
Gritsman K, et al.
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Gritsman K, Yuzugullu H, Von T, Yan H, Clayton L, Fritsch C, Maira SM, Hollingworth G, Choi C, Khandan T, Paktinat M, Okabe RO, Roberts TM, Zhao JJ
(2014) Hematopoiesis and RAS-driven myeloid leukemia differentially require PI3K isoform p110α. J. Clin. Invest. 124(4):1794-809
Leukemia
Veomett N, et al.
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Veomett N, Dao T, Liu H, Xiang J, Pankov D, Dubrovsky L, Whitten JA, Park SM, Korontsvit T, Zakhaleva V, Casey E, Curcio M, Kharas MG, O'Reilly RJ, Liu C, Scheinberg DA
(2014) Therapeutic efficacy of an Fc-enhanced TCR-like antibody to the intracellular WT1 oncoprotein. Clin. Cancer Res. 20(15):4036-46
Immunotherapy, Leukemia
Rudolph D, et al.
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Rudolph D, Impagnatiello MA, Blaukopf C, Sommer C, Gerlich DW, Roth M, Tontsch-Grunt U, Wernitznig A, Savarese F, Hofmann MH, Albrecht C, Geiselmann L, Reschke M, Garin-Chesa P, Zuber J, Moll J, Adolf GR, Kraut N
(2015) Efficacy and mechanism of action of volasertib, a potent and selective inhibitor of Polo-like kinases, in preclinical models of acute myeloid leukemia. J. Pharmacol. Exp. Ther. 352(3):579-89
Leukemia
Maeda N, et al.
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Maeda N, Ohashi T, Chagan-Yasutan H, Hattori T, Takahashi Y, Harigae H, Hasegawa H, Yamada Y, Fujii M, Maenaka K, Uede T
(2015) Osteopontin-integrin interaction as a novel molecular target for antibody-mediated immunotherapy in adult T-cell leukemia. Retrovirology 12:99
Immunotherapy, Leukemia
Haji Y, et al.
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Haji Y, Suzuki M, Moriya K, So T, Hozumi K, Mizuma M, Unno M, Ishii N
(2014) Activation of Notch1 promotes development of human CD8(+) single positive T cells in humanized mice. Biochem. Biophys. Res. Commun. 447(2):346-51
Leukemia
Hertlein E, et al.
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Hertlein E, Beckwith KA, Lozanski G, Chen TL, Towns WH, Johnson AJ, Lehman A, Ruppert AS, Bolon B, Andritsos L, Lozanski A, Rassenti L, Zhao W, Jarvinen TM, Senter L, Croce CM, Symer DE, de la Chapelle A, Heerema NA, Byrd JC
(2013) Characterization of a new chronic lymphocytic leukemia cell line for mechanistic in vitro and in vivo studies relevant to disease. PLoS ONE 8(10):e76607
Leukemia
Muguruma Y, et al.
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Muguruma Y, Matsushita H, Yahata T, Yumino S, Tanaka Y, Miyachi H, Ogawa Y, Kawada H, Ito M, Ando K
(2011) Establishment of a xenograft model of human myelodysplastic syndromes. Haematologica 96(4):543-51
Leukemia
Kuwatsuka Y, et al.
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Kuwatsuka Y, Minami M, Minami Y, Sugimoto K, Hayakawa F, Miyata Y, Abe A, Goff DJ, Kiyoi H, Naoe T
(2011) The mTOR inhibitor, everolimus (RAD001), overcomes resistance to imatinib in quiescent Ph-positive acute lymphoblastic leukemia cells. Blood Cancer J 1(5):e17
Leukemia
Kato I, et al.
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Kato I, Niwa A, Heike T, Fujino H, Saito MK, Umeda K, Hiramatsu H, Ito M, Morita M, Nishinaka Y, Adachi S, Ishikawa F, Nakahata T
(2011) Identification of hepatic niche harboring human acute lymphoblastic leukemic cells via the SDF-1/CXCR4 axis. PLoS ONE 6(11):e27042
Leukemia
Dewan MZ, et al.
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Dewan MZ, Takamatsu N, Hidaka T, Hatakeyama K, Nakahata S, Fujisawa J, Katano H, Yamamoto N, Morishita K
(2008) Critical role for TSLC1 expression in the growth and organ infiltration of adult T-cell leukemia cells in vivo. J. Virol. 82(23):11958-63
Leukemia
Saitoh Y, et al.
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Saitoh Y, Yamamoto N, Dewan MZ, Sugimoto H, Martinez Bruyn VJ, Iwasaki Y, Matsubara K, Qi X, Saitoh T, Imoto I, Inazawa J, Utsunomiya A, Watanabe T, Masuda T, Yamamoto N, Yamaoka S
(2008) Overexpressed NF-kappaB-inducing kinase contributes to the tumorigenesis of adult T-cell leukemia and Hodgkin Reed-Sternberg cells. Blood 111(10):5118-29
Leukemia
Ninomiya M, et al.
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Ninomiya M, Abe A, Katsumi A, Xu J, Ito M, Arai F, Suda T, Ito M, Kiyoi H, Kinoshita T, Naoe T
(2007) Homing, proliferation and survival sites of human leukemia cells in vivo in immunodeficient mice. Leukemia 21(1):136-42
Leukemia
Ninomiya M, et al.
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Ninomiya M, Abe A, Yokozawa T, Ozeki K, Yamamoto K, Ito M, Ito M, Kiyoi H, Emi N, Naoe T
(2006) Establishment of a myeloid leukemia cell line, TRL-01, with MLL-ENL fusion gene. Cancer Genet. Cytogenet. 169(1):1-11
Leukemia
Dewan MZ, et al.
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Dewan MZ, Uchihara JN, Terashima K, Honda M, Sata T, Ito M, Fujii N, Uozumi K, Tsukasaki K, Tomonaga M, Kubuki Y, Okayama A, Toi M, Mori N, Yamamoto N
(2006) Efficient intervention of growth and infiltration of primary adult T-cell leukemia cells by an HIV protease inhibitor, ritonavir. Blood 107(2):716-24
Leukemia, Therapeutic Efficacy Evaluation
Nakamura Y, et al.
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Nakamura Y, Ito M, Yamamoto T, Yan XY, Yagasaki H, Kamachi Y, Kudo K, Kojima S
(2005) Engraftment of NOD/SCID/gammac(null) mice with multilineage neoplastic cells from patients with juvenile myelomonocytic leukaemia. Br. J. Haematol. 130(1):51-7
Leukemia
Pernodet N, et al.
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Pernodet N, Hermetet F, Adami P, Vejux A, Descotes F, Borg C, Adams M, Pallandre JR, Viennet G, Esnard F, Jouvenot M, Despouy G
(2012) High expression of QSOX1 reduces tumorogenesis, and is associated with a better outcome for breast cancer patients. Breast Cancer Res. 14(5):R136
Breast Cancer
Bertelsen LB, et al.
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Bertelsen LB, Bohn AB, Shen YY, Falborg L, Stødkilde-Jørgensen H, Horsman MR
(2014) Treatment with a vascular disrupting agent does not increase recruitment of indium labelled human endothelial outgrowth cells in an experimental tumour model. BMC Cancer 14:903
Breast Cancer
McAuliffe PF, et al.
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McAuliffe PF, Evans KW, Akcakanat A, Chen K, Zheng X, Zhao H, Eterovic AK, Sangai T, Holder AM, Sharma C, Chen H, Do KA, Tarco E, Gagea M, Naff KA, Sahin A, Multani AS, Black DM, Mittendorf EA, Bedrosian I, Mills GB, Gonzalez-Angulo AM, Meric-Bernstam F
(2015) Ability to Generate Patient-Derived Breast Cancer Xenografts Is Enhanced in Chemoresistant Disease and Predicts Poor Patient Outcomes. PLoS ONE 10(9):e0136851
Breast Cancer
Dewan MZ, et al.
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Dewan MZ, Ahmed S, Iwasaki Y, Ohba K, Toi M, Yamamoto N
(2006) Stromal cell-derived factor-1 and CXCR4 receptor interaction in tumor growth and metastasis of breast cancer. Biomed. Pharmacother. 60(6):273-6
Breast Cancer
Dewan MZ, et al.
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Dewan MZ, Terunuma H, Takada M, Tanaka Y, Abe H, Sata T, Toi M, Yamamoto N
(2007) Role of natural killer cells in hormone-independent rapid tumor formation and spontaneous metastasis of breast cancer cells in vivo. Breast Cancer Res. Treat. 104(3):267-75
Breast Cancer
Poillet L, et al.
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Poillet L, Pernodet N, Boyer-Guittaut M, Adami P, Borg C, Jouvenot M, Delage-Mourroux R, Despouy G
(2014) QSOX1 inhibits autophagic flux in breast cancer cells. PLoS ONE 9(1):e86641
Breast Cancer
Borriello L, et al.
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Borriello L, Montès M, Lepelletier Y, Leforban B, Liu WQ, Demange L, Delhomme B, Pavoni S, Jarray R, Boucher JL, Dufour S, Hermine O, Garbay C, Hadj-Slimane R, Raynaud F
(2014) Structure-based discovery of a small non-peptidic Neuropilins antagonist exerting in vitro and in vivo anti-tumor activity on breast cancer model. Cancer Lett. 349(2):120-7
Breast Cancer
Li X, et al.
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Li X, Nadauld L, Ootani A, Corney DC, Pai RK, Gevaert O, Cantrell MA, Rack PG, Neal JT, Chan CW, Yeung T, Gong X, Yuan J, Wilhelmy J, Robine S, Attardi LD, Plevritis SK, Hung KE, Chen CZ, Ji HP, Kuo CJ
(2014) Oncogenic transformation of diverse gastrointestinal tissues in primary organoid culture. Nat. Med. 20(7):769-77
Colon Cancer, Gastric Cancer, Pancreatic And Other Biliary Tract Cancers
Nadauld LD, et al.
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Nadauld LD, Garcia S, Natsoulis G, Bell JM, Miotke L, Hopmans ES, Xu H, Pai RK, Palm C, Regan JF, Chen H, Flaherty P, Ootani A, Zhang NR, Ford JM, Kuo CJ, Ji HP
(2014) Metastatic tumor evolution and organoid modeling implicate TGFBR2 as a cancer driver in diffuse gastric cancer. Genome Biol. 15(8):428
Gastric Cancer
Wang ZA, et al.
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Wang ZA, Toivanen R, Bergren SK, Chambon P, Shen MM
(2014) Luminal cells are favored as the cell of origin for prostate cancer. Cell Rep 8(5):1339-46
Prostate Cancer
Ito M, et al.
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Ito M, Teshima K, Ikeda S, Kitadate A, Watanabe A, Nara M, Yamashita J, Ohshima K, Sawada K, Tagawa H
(2014) MicroRNA-150 inhibits tumor invasion and metastasis by targeting the chemokine receptor CCR6, in advanced cutaneous T-cell lymphoma. Blood 123(10):1499-511
Lymphoma, Pancreatic And Other Biliary Tract Cancers
Kato C, et al.
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Kato C, Fujii E, Chen YJ, Endaya BB, Matsubara K, Suzuki M, Ohnishi Y, Tamaoki N
(2009) Spontaneous thymic lymphomas in the non-obese diabetic/Shi-scid, IL-2R gamma (null) mouse. Lab. Anim. 43(4):402-4
Lymphoma
Watanabe M, et al.
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Watanabe M, Dewan MZ, Taira M, Shoda M, Honda M, Sata T, Higashihara M, Kadin ME, Watanabe T, Yamamoto N, Umezawa K, Horie R
(2007) IkappaBalpha independent induction of NF-kappaB and its inhibition by DHMEQ in Hodgkin/Reed-Sternberg cells. Lab. Invest. 87(4):372-82
Lymphoma
Dewan MZ, et al.
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Dewan MZ, Watanabe M, Ahmed S, Terashima K, Horiuchi S, Sata T, Honda M, Ito M, Watanabe T, Horie R, Yamamoto N
(2005) Hodgkin's lymphoma cells are efficiently engrafted and tumor marker CD30 is expressed with constitutive nuclear factor-kappaB activity in unconditioned NOD/SCID/gammac(null) mice. Cancer Sci. 96(8):466-73
Lymphoma
Ikoma N, et al.
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Ikoma N, Yamazaki H, Abe Y, Oida Y, Ohnishi Y, Suemizu H, Matsumoto H, Matsuyama T, Ohta Y, Ozawa A, Ueyama Y, Nakamura M
(2005) S100A4 expression with reduced E-cadherin expression predicts distant metastasis of human malignant melanoma cell lines in the NOD/SCID/gammaCnull (NOG) mouse model. Oncol. Rep. 14(3):633-7
Melanoma
Chijiwa T, et al.
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Chijiwa T, Abe Y, Ikoma N, Yamazaki H, Tsukamoto H, Suemizu H, Kawai K, Wakui M, Nishime C, Matsumoto H, Matsuyama M, Mukai M, Ueyama Y, Nakamura M
(2009) Thrombospondin 2 inhibits metastasis of human malignant melanoma through microenvironment-modification in NOD/SCID/gammaCnull (NOG) mice. Int. J. Oncol. 34(1):5-13
Melanoma
Einarsdottir BO, et al.
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Einarsdottir BO, Bagge RO, Bhadury J, Jespersen H, Mattsson J, Nilsson LM, Truvé K, López MD, Naredi P, Nilsson O, Stierner U, Ny L, Nilsson JA
(2014) Melanoma patient-derived xenografts accurately model the disease and develop fast enough to guide treatment decisions. Oncotarget 5(20):9609-18
Melanoma, Patient Derived Xenograft (PDX)
Dewan MZ, et al.
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Dewan MZ, Watanabe M, Terashima K, Aoki M, Sata T, Honda M, Ito M, Yamaoka S, Watanabe T, Horie R, Yamamoto N
(2004) Prompt tumor formation and maintenance of constitutive NF-kappaB activity of multiple myeloma cells in NOD/SCID/gammacnull mice. Cancer Sci. 95(7):564-8
Myeloma
Miyakawa Y, et al.
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Miyakawa Y, Ohnishi Y, Tomisawa M, Monnai M, Kohmura K, Ueyama Y, Ito M, Ikeda Y, Kizaki M, Nakamura M
(2004) Establishment of a new model of human multiple myeloma using NOD/SCID/gammac(null) (NOG) mice. Biochem. Biophys. Res. Commun. 313(2):258-62
Myeloma
Iriuchishima H, et al.
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Iriuchishima H, Takubo K, Miyakawa Y, Nakamura-Ishizu A, Miyauchi Y, Fujita N, Miyamoto K, Miyamoto T, Ikeda E, Kizaki M, Nojima Y, Suda T
(2012) Neovascular niche for human myeloma cells in immunodeficient mouse bone. PLoS ONE 7(2):e30557
Myeloma, Therapeutic Efficacy Evaluation
Hosen N, et al.
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Hosen N, Matsuoka Y, Kishida S, Nakata J, Mizutani Y, Hasegawa K, Mugitani A, Ichihara H, Aoyama Y, Nishida S, Tsuboi A, Fujiki F, Tatsumi N, Nakajima H, Hino M, Kimura T, Yata K, Abe M, Oka Y, Oji Y, Kumanogoh A, Sugiyama H
(2012) CD138-negative clonogenic cells are plasma cells but not B cells in some multiple myeloma patients. Leukemia 26(9):2135-41
Myeloma
Machida K, et al.
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Machida K, Suemizu H, Kawai K, Ishikawa T, Sawada R, Ohnishi Y, Tsuchiya T
(2009) Higher susceptibility of NOG mice to xenotransplanted tumors. J Toxicol Sci 34(1):123-7
Therapeutic Efficacy Evaluation
Yokoyama Y, et al.
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Yokoyama Y, Miyagi T, Hikita H, Yoshioka T, Mukai K, Nawa T, Sakamori R, Ohkawa K, Hiramatsu N, Takahashi T, Suemizu H, Ryo A, Tatsumi T, Takehara T
(2015) The Hepatitis B Virus Genotype Affects the Persistence of Viral Replication in Immunodeficient NOG Mice. PLoS ONE 10(12):e0144775
Infectious Disease, Safety Assessment
Kondo Y, et al.
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Kondo Y, Kimura O, Tanaka Y, Ninomiya M, Iwata T, Kogure T, Inoue J, Sugiyama M, Morosawa T, Fujisaka Y, Shimosegawa T
(2015) Differential Expression of CX3CL1 in Hepatitis B Virus-Replicating Hepatoma Cells Can Affect the Migration Activity of CX3CR1+ Immune Cells. J. Virol. 89(14):7016-27
Infectious Disease, Hepatocellular Carcinoma (HCC)
Yamauchi Y, et al.
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Yamauchi Y, Izumi Y, Asakura K, Kawai K, Wakui M, Ohmura M, Suematsu M, Nomori H
(2013) Lewis lung carcinoma progression is facilitated by TIG-3 fibroblast cells. Anticancer Res. 33(9):3791-8
Infectious Disease
Andreassen J, et al.
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Andreassen J, Ito A, Ito M, Nakao M, Nakaya K
(2004) Hymenolepis microstoma: direct life cycle in immunodeficient mice. J. Helminthol. 78(1):1-5
Infectious Disease
Choi YY, et al.
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Choi YY, Lee JE, Kim H, Sim MH, Kim KK, Lee G, Kim HI, An JY, Hyung WJ, Kim CB, Noh SH, Kim S, Cheong JH
(2016) Establishment and characterisation of patient-derived xenografts as paraclinical models for gastric cancer. Sci Rep 6:22172
Epstein-Barr Virus, Gastric Cancer, Patient Derived Xenograft (PDX)
Radaelli E, et al.
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Radaelli E, Hermans E, Omodho L, Francis A, Vander Borght S, Marine JC, van den Oord J, Amant F
(2015) Spontaneous Post-Transplant Disorders in NOD.Cg- Prkdcscid Il2rgtm1Sug/JicTac (NOG) Mice Engrafted with Patient-Derived Metastatic Melanomas. PLoS ONE 10(5):e0124974
Epstein-Barr Virus
Imadome K
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Imadome K
(2013) A novel mouse xenotransplantation model of EBV-T/NK-LPD and the application of the mouse model. Nihon Rinsho Meneki Gakkai Kaishi 36(6):433-41
Epstein-Barr Virus
Sato K, et al.
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Sato K, Misawa N, Nie C, Satou Y, Iwakiri D, Matsuoka M, Takahashi R, Kuzushima K, Ito M, Takada K, Koyanagi Y
(2011) A novel animal model of Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis in humanized mice. Blood 117(21):5663-73
Epstein-Barr Virus
Yajima M, et al.
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Yajima M, Imadome K, Nakagawa A, Watanabe S, Terashima K, Nakamura H, Ito M, Shimizu N, Yamamoto N, Fujiwara S
(2009) T cell-mediated control of Epstein-Barr virus infection in humanized mice. J. Infect. Dis. 200(10):1611-5
Epstein-Barr Virus
Dewan MZ, et al.
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Dewan MZ, Tomita M, Katano H, Yamamoto N, Ahmed S, Yamamoto M, Sata T, Mori N, Yamamoto N
(2009) An HIV protease inhibitor, ritonavir targets the nuclear factor-kappaB and inhibits the tumor growth and infiltration of EBV-positive lymphoblastoid B cells. Int. J. Cancer 124(3):622-9
Epstein-Barr Virus
Miyake A, et al.
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Miyake A, Dewan MZ, Ishida T, Watanabe M, Honda M, Sata T, Yamamoto N, Umezawa K, Watanabe T, Horie R
(2008) Induction of apoptosis in Epstein-Barr virus-infected B-lymphocytes by the NF-kappaB inhibitor DHMEQ. Microbes Infect. 10(7):748-56
Epstein-Barr Virus
Yajima M, et al.
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Yajima M, Imadome K, Nakagawa A, Watanabe S, Terashima K, Nakamura H, Ito M, Shimizu N, Honda M, Yamamoto N, Fujiwara S
(2008) A new humanized mouse model of Epstein-Barr virus infection that reproduces persistent infection, lymphoproliferative disorder, and cell-mediated and humoral immune responses. J. Infect. Dis. 198(5):673-82
Epstein-Barr Virus
Shigemura T, et al.
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Shigemura T, Shiohara M, Kato M, Furuta S, Kaneda K, Morishita K, Hasegawa H, Fujii M, Gorlach A, Koike K, Kamata T
(2015) Superoxide-Generating Nox5α Is Functionally Required for the Human T-Cell Leukemia Virus Type 1-Induced Cell Transformation Phenotype. J. Virol. 89(17):9080-9
HTLV-1
Tezuka K, et al.
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Tezuka K, Xun R, Tei M, Ueno T, Tanaka M, Takenouchi N, Fujisawa J
(2014) An animal model of adult T-cell leukemia: humanized mice with HTLV-1-specific immunity. Blood 123(3):346-55
HTLV-1, Leukemia
Yamamoto I, et al.
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Yamamoto I, Takajo I, Umeki K, Morishita K, Hatakeyama K, Kataoka H, Nomura H, Okayama A
(2010) Multiple integrations of human T-lymphotropic virus type 1 proviruses in the engrafted cells from the asymptomatic carriers in NOD/SCID/gammacnull mice. Intervirology 53(4):229-39
HTLV-1
Takajo I, et al.
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Takajo I, Umeki K, Morishita K, Yamamoto I, Kubuki Y, Hatakeyama K, Kataoka H, Okayama A
(2007) Engraftment of peripheral blood mononuclear cells from human T-lymphotropic virus type 1 carriers in NOD/SCID/gammac(null) (NOG) mice. Int. J. Cancer 121(10):2205-11
HTLV-1
Amet T, et al.
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Amet T, Nonaka M, Dewan MZ, Saitoh Y, Qi X, Ichinose S, Yamamoto N, Yamaoka S
(2008) Statin-induced inhibition of HIV-1 release from latently infected U1 cells reveals a critical role for protein prenylation in HIV-1 replication. Microbes Infect. 10(5):471-80
HIV
Okuma K, et al.
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Okuma K, Tanaka R, Ogura T, Ito M, Kumakura S, Yanaka M, Nishizawa M, Sugiura W, Yamamoto N, Tanaka Y
(2008) Interleukin-4-transgenic hu-PBL-SCID mice: a model for the screening of antiviral drugs and immunotherapeutic agents against X4 HIV-1 viruses. J. Infect. Dis. 197(1):134-41
HIV, Therapeutic Efficacy Evaluation
Sato K, et al.
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Sato K, Izumi T, Misawa N, Kobayashi T, Yamashita Y, Ohmichi M, Ito M, Takaori-Kondo A, Koyanagi Y
(2010) Remarkable lethal G-to-A mutations in vif-proficient HIV-1 provirus by individual APOBEC3 proteins in humanized mice. J. Virol. 84(18):9546-56
HIV, Humanized
Dewan MZ, et al.
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Dewan MZ, Terashima K, Ahmed S, Ohba K, Taruishi M, Yamamoto N
(2005) Mouse serum factor(s) down-modulate the CD4 and CXCR4 molecules on human T cells conferring resistance to HIV infection in NOG mice. Med. Microbiol. Immunol. 194(4):175-80
HIV
Nakauchi Y, et al.
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Nakauchi Y, Yamazaki S, Napier SC, Usui J, Ota Y, Takahashi S, Watanabe N, Nakauchi H
(2015) Effective treatment against severe graft-versus-host disease with allele-specific anti-HLA monoclonal antibody in a humanized mouse model. Exp. Hematol. 43(2):79-88.e1-4
Transplantation Research And Graft Versus Host Disease (GVHD)
Mizukami Y, et al.
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Mizukami Y, Abe T, Shibata H, Makimura Y, Fujishiro SH, Yanase K, Hishikawa S, Kobayashi E, Hanazono Y
(2014) MHC-matched induced pluripotent stem cells can attenuate cellular and humoral immune responses but are still susceptible to innate immunity in pigs. PLoS ONE 9(6):e98319
Transplantation Research And Graft Versus Host Disease (GVHD), Induced Pluripotent Stem Cells (iPSCs)
Tomita H, et al.
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Tomita H, Fuchimoto Y, Mori T, Kato J, Uemura T, Handa M, Tazawa H, Ohdan H, Okamoto S, Kuroda T
(2013) Production of anti-ABO blood group antibodies after minor ABO-incompatible bone marrow transplantation in NOD/SCID/gamma(c)(null) mice. Clin Transplant 27(6):E702-8
Transplantation Research And Graft Versus Host Disease (GVHD)
Ito R, et al.
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Ito R, Katano I, Kawai K, Hirata H, Ogura T, Kamisako T, Eto T, Ito M
(2009) Highly sensitive model for xenogenic GVHD using severe immunodeficient NOG mice. Transplantation 87(11):1654-8
Transplantation Research And Graft Versus Host Disease (GVHD)
Cox JH, et al.
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Cox JH, Hussell S, Søndergaard H, Roepstorff K, Bui JV, Deer JR, Zhang J, Li ZG, Lamberth K, Kvist PH, Padkjær S, Haase C, Zahn S, Odegard VH
(2013) Antibody-mediated targeting of the Orai1 calcium channel inhibits T cell function. PLoS ONE 8(12):e82944
T And/Or B Cell Function, Transplantation Research And Graft Versus Host Disease (GVHD)
Søndergaard H, et al.
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Søndergaard H, Kvist PH, Haase C
(2013) Human T cells depend on functional calcineurin, tumour necrosis factor-α and CD80/CD86 for expansion and activation in mice. Clin. Exp. Immunol. 172(2):300-10
T And/Or B Cell Function, Transplantation Research And Graft Versus Host Disease (GVHD)
Katano I, et al.
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Katano I, Ito R, Eto T, Aiso S, Ito M
(2011) Immunodeficient NOD-scid IL-2Rγ(null) mice do not display T and B cell leakiness. Exp. Anim. 60(2):181-6
T And/Or B Cell Function
Inoue M, et al.
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Inoue M, Senju S, Hirata S, Irie A, Baba H, Nishimura Y
(2009) An in vivo model of priming of antigen-specific human CTL by Mo-DC in NOD/Shi-scid IL2rgamma(null) (NOG) mice. Immunol. Lett. 126(1-2):67-72
T And/Or B Cell Function, Immunotherapy, Therapeutic Efficacy Evaluation
Oh JY, et al.
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Oh JY, Kim MK, Ko JH, Lee HJ, Kim Y, Park CS, Park CG, Kim SJ, Wee WR, Lee JH
(2009) Acute cell-mediated rejection in orthotopic pig-to-mouse corneal xenotransplantation. Xenotransplantation 16(2):74-82
Transplantation Research And Graft Versus Host Disease (GVHD), Regeneration Of Human Tissue
Ito A, et al.
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Ito A, Ishida T, Utsunomiya A, Sato F, Mori F, Yano H, Inagaki A, Suzuki S, Takino H, Ri M, Kusumoto S, Komatsu H, Iida S, Inagaki H, Ueda R
(2009) Defucosylated anti-CCR4 monoclonal antibody exerts potent ADCC against primary ATLL cells mediated by autologous human immune cells in NOD/Shi-scid, IL-2R gamma(null) mice in vivo. J. Immunol. 183(7):4782-91
Antibody-Dependent-Cellular Cytotoxicity (ADCC), Immunotherapy, Lymphoma, Therapeutic Efficacy Evaluation
Ito A, et al.
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Ito A, Ishida T, Yano H, Inagaki A, Suzuki S, Sato F, Takino H, Mori F, Ri M, Kusumoto S, Komatsu H, Iida S, Inagaki H, Ueda R
(2009) Defucosylated anti-CCR4 monoclonal antibody exercises potent ADCC-mediated antitumor effect in the novel tumor-bearing humanized NOD/Shi-scid, IL-2Rgamma(null) mouse model. Cancer Immunol. Immunother. 58(8):1195-206
Antibody-Dependent-Cellular Cytotoxicity (ADCC), Immunotherapy, Lymphoma, Therapeutic Efficacy Evaluation
Mori F, et al.
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Mori F, Ishida T, Ito A, Sato F, Masaki A, Narita T, Suzuki S, Yamada T, Takino H, Ri M, Kusumoto S, Komatsu H, Hishizawa M, Imada K, Takaori-Kondo A, Niimi A, Ueda R, Inagaki H, Iida S
(2014) Antitumor effects of bevacizumab in a microenvironment-dependent human adult T-cell leukemia/lymphoma mouse model. Eur. J. Haematol. 92(3):219-28
NK, Leukemia
Shiokawa M, et al.
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Shiokawa M, Takahashi T, Murakami A, Kita S, Ito M, Sugamura K, Ishii N
(2010) In vivo assay of human NK-dependent ADCC using NOD/SCID/gammac(null) (NOG) mice. Biochem. Biophys. Res. Commun. 399(4):733-7
NK, Antibody-Dependent-Cellular Cytotoxicity (ADCC), Lymphoma
Terunuma H, et al.
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Terunuma H, Deng X, Dewan Z, Fujimoto S, Yamamoto N
(2008) Potential role of NK cells in the induction of immune responses: implications for NK cell-based immunotherapy for cancers and viral infections. Int. Rev. Immunol. 27(3):93-110
NK
Dewan MZ, et al.
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Dewan MZ, Terunuma H, Toi M, Tanaka Y, Katano H, Deng X, Abe H, Nakasone T, Mori N, Sata T, Yamamoto N
(2006) Potential role of natural killer cells in controlling growth and infiltration of AIDS-associated primary effusion lymphoma cells. Cancer Sci. 97(12):1381-7
NK, Lymphoma
Dewan MZ, et al.
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Dewan MZ, Terunuma H, Ahmed S, Ohba K, Takada M, Tanaka Y, Toi M, Yamamoto N
(2005) Natural killer cells in breast cancer cell growth and metastasis in SCID mice. Biomed. Pharmacother. 59 Suppl 2:S375-9
NK, Breast Cancer
Dewan MZ, et al.
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Dewan MZ, Terashima K, Taruishi M, Hasegawa H, Ito M, Tanaka Y, Mori N, Sata T, Koyanagi Y, Maeda M, Kubuki Y, Okayama A, Fujii M, Yamamoto N
(2003) Rapid tumor formation of human T-cell leukemia virus type 1-infected cell lines in novel NOD-SCID/gammac(null) mice: suppression by an inhibitor against NF-kappaB. J. Virol. 77(9):5286-94
NK, Leukemia, Therapeutic Efficacy Evaluation
Féraud O, et al.
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Féraud O, Valogne Y, Melkus MW, Zhang Y, Oudrhiri N, Haddad R, Daury A, Rocher C, Larbi A, Duquesnoy P, Divers D, Gobbo E, Brunet de la Grange P, Louache F, Bennaceur-Griscelli A, Mitjavila-Garcia MT
(2016) Donor Dependent Variations in Hematopoietic Differentiation among Embryonic and Induced Pluripotent Stem Cell Lines. PLoS ONE 11(3):e0149291
Hematopoietic Stem Cell Engraftment
Ohshima S, et al.
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Ohshima S, Mori S, Shigenari A, Miyamoto A, Takasu M, Imaeda N, Nunomura S, Okayama Y, Tanaka M, Kitagawa H, Kulski JK, Inoko H, Ando A, Kametani Y
(2014) Differentiation ability of multipotent hematopoietic stem/progenitor cells detected by a porcine specific anti-CD117 monoclonal antibody. Biosci Trends 8(6):308-15
Hematopoietic Stem Cell Engraftment
Nakatsuka R, et al.
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Nakatsuka R, Matsuoka Y, Uemura Y, Sumide K, Iwaki R, Takahashi M, Fujioka T, Sasaki Y, Sonoda Y
(2015) Mouse dental pulp stem cells support human umbilical cord blood-derived hematopoietic stem/progenitor cells in vitro. Cell Transplant 24(1):97-113
Hematopoietic Stem Cell Engraftment
Hirosawa T, et al.
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Hirosawa T, Torikai H, Yanagisawa M, Kamei M, Imahashi N, Demachi-Okamura A, Tanimoto M, Shiraishi K, Ito M, Miyamura K, Shibata K, Kikkawa F, Morishima Y, Takahashi T, Emi N, Kuzushima K, Akatsuka Y
(2011) Mismatched human leukocyte antigen class II-restricted CD8⁺ cytotoxic T cells may mediate selective graft-versus-leukemia effects following allogeneic hematopoietic cell transplantation. Cancer Sci. 102(7):1281-6
Hematopoietic Stem Cell Engraftment, Transplantation Research And Graft Versus Host Disease (GVHD), Leukemia
Wakui M, et al.
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Wakui M, Suemizu H
(2010) [Development of humanized models using NOG mice]. Seikagaku 82(4):314-8
Hematopoietic Stem Cell Engraftment
Zhang L, et al.
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Zhang L, Meissner E, Chen J, Su L
(2010) Current humanized mouse models for studying human immunology and HIV-1 immuno-pathogenesis. Sci China Life Sci 53(2):195-203
Humanization
Hematopoietic Stem Cell Engraftment, HIV
Sato K, et al.
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Sato K, Nie C, Misawa N, Tanaka Y, Ito M, Koyanagi Y
(2010) Dynamics of memory and naïve CD8+ T lymphocytes in humanized NOD/SCID/IL-2Rgammanull mice infected with CCR5-tropic HIV-1. Vaccine 28 Suppl 2:B32-7
Hematopoietic Stem Cell Engraftment, T And/Or B Cell Function, HIV
Watanabe Y, et al.
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Watanabe Y, Takahashi T, Okajima A, Shiokawa M, Ishii N, Katano I, Ito R, Ito M, Minegishi M, Minegishi N, Tsuchiya S, Sugamura K
(2009) The analysis of the functions of human B and T cells in humanized NOD/shi-scid/gammac(null) (NOG) mice (hu-HSC NOG mice). Int. Immunol. 21(7):843-58
Humanization
Hematopoietic Stem Cell Engraftment, T And/Or B Cell Function, Humanized
Kawaguchi AT, et al.
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Kawaguchi AT, Kametani Y, Kato S, Furuya H, Tamaoki K, Habu S
(2009) Effects of liposome-encapsulated hemoglobin on human immune system: evaluation in immunodeficient mice reconstituted with human cord blood stem cells. Artif Organs 33(2):169-76
Hematopoietic Stem Cell Engraftment, Therapeutic Efficacy Evaluation
Shima H, et al.
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Shima H, Takubo K, Iwasaki H, Yoshihara H, Gomei Y, Hosokawa K, Arai F, Takahashi T, Suda T
(2009) Reconstitution activity of hypoxic cultured human cord blood CD34-positive cells in NOG mice. Biochem. Biophys. Res. Commun. 378(3):467-72
Hematopoietic Stem Cell Engraftment
Nogami W, et al.
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Nogami W, Yoshida H, Koizumi K, Yamada H, Abe K, Arimura A, Yamane N, Takahashi K, Yamane A, Oda A, Tanaka Y, Takemoto H, Ohnishi Y, Ikeda Y, Miyakawa Y
(2008) The effect of a novel, small non-peptidyl molecule butyzamide on human thrombopoietin receptor and megakaryopoiesis. Haematologica 93(10):1495-504
Hematopoietic Stem Cell Engraftment
Yamane A, et al.
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Yamane A, Nakamura T, Suzuki H, Ito M, Ohnishi Y, Ikeda Y, Miyakawa Y
(2008) Interferon-alpha 2b-induced thrombocytopenia is caused by inhibition of platelet production but not proliferation and endomitosis in human megakaryocytes. Blood 112(3):542-50
Hematopoietic Stem Cell Engraftment
Koyanagi Y, et al.
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Koyanagi Y, Tanaka Y, Ito M, Yamamoto N
(2008) Humanized mice for human retrovirus infection. Curr. Top. Microbiol. Immunol. 324:133-48
Hematopoietic Stem Cell Engraftment, HIV
Ito R, et al.
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Ito R, Shiina M, Saito Y, Tokuda Y, Kametani Y, Habu S
(2008) Antigen-specific antibody production of human B cells in NOG mice reconstituted with the human immune system. Curr. Top. Microbiol. Immunol. 324:95-107
Hematopoietic Stem Cell Engraftment
Ito M, et al.
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Ito M, Kobayashi K, Nakahata T
(2008) NOD/Shi-scid IL2rgamma(null) (NOG) mice more appropriate for humanized mouse models. Curr. Top. Microbiol. Immunol. 324:53-76
Hematopoietic Stem Cell Engraftment
Nomura T, et al.
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Nomura T, Tamaoki N, Takakura A, Suemizu H
(2008) Basic concept of development and practical application of animal models for human diseases. Curr. Top. Microbiol. Immunol. 324:1-24
Hematopoietic Stem Cell Engraftment
Fujino H, et al.
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Fujino H, Hiramatsu H, Tsuchiya A, Niwa A, Noma H, Shiota M, Umeda K, Yoshimoto M, Ito M, Heike T, Nakahata T
(2007) Human cord blood CD34+ cells develop into hepatocytes in the livers of NOD/SCID/gamma(c)null mice through cell fusion. FASEB J. 21(13):3499-510
Hematopoietic Stem Cell Engraftment, Differentiation Of HSC Into Hepatocytes
Watanabe S, et al.
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Watanabe S, Ohta S, Yajima M, Terashima K, Ito M, Mugishima H, Fujiwara S, Shimizu K, Honda M, Shimizu N, Yamamoto N
(2007) Humanized NOD/SCID/IL2Rgamma(null) mice transplanted with hematopoietic stem cells under nonmyeloablative conditions show prolonged life spans and allow detailed analysis of human immunodeficiency virus type 1 pathogenesis. J. Virol. 81(23):13259-64
Hematopoietic Stem Cell Engraftment, HIV
Watanabe S, et al.
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Watanabe S, Terashima K, Ohta S, Horibata S, Yajima M, Shiozawa Y, Dewan MZ, Yu Z, Ito M, Morio T, Shimizu N, Honda M, Yamamoto N
(2007) Hematopoietic stem cell-engrafted NOD/SCID/IL2Rgamma null mice develop human lymphoid systems and induce long-lasting HIV-1 infection with specific humoral immune responses. Blood 109(1):212-8
Hematopoietic Stem Cell Engraftment, HIV
Muguruma Y, et al.
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Muguruma Y, Yahata T, Miyatake H, Sato T, Uno T, Itoh J, Kato S, Ito M, Hotta T, Ando K
(2006) Reconstitution of the functional human hematopoietic microenvironment derived from human mesenchymal stem cells in the murine bone marrow compartment. Blood 107(5):1878-87
Hematopoietic Stem Cell Engraftment
Yahata T, et al.
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Yahata T, Yumino S, Seng Y, Miyatake H, Uno T, Muguruma Y, Ito M, Miyoshi H, Kato S, Hotta T, Ando K
(2006) Clonal analysis of thymus-repopulating cells presents direct evidence for self-renewal division of human hematopoietic stem cells. Blood 108(7):2446-54
Hematopoietic Stem Cell Engraftment
Kametani Y, et al.
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Kametani Y, Shiina M, Katano I, Ito R, Ando K, Toyama K, Tsukamoto H, Matsumura T, Saito Y, Ishikawa D, Taki T, Ito M, Imai K, Tokuda Y, Kato S, Tamaoki N, Habu S
(2006) Development of human-human hybridoma from anti-Her-2 peptide-producing B cells in immunized NOG mouse. Exp. Hematol. 34(9):1240-8
Hematopoietic Stem Cell Engraftment
Kai M, et al.
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Kai M, Hagiwara T, Emuta C, Chisaka Y, Tsuruhata K, Endo C, Inagaki Y, Miyazaki H, Kataoka S
(2009) In vivo efficacy of anti-MPL agonist antibody in promoting primary human hematopoietic cells. Blood 113(10):2213-6
Hematopoietic Stem Cell Engraftment, Therapeutic Efficacy Evaluation
Nakata H, et al.
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Nakata H, Maeda K, Miyakawa T, Shibayama S, Matsuo M, Takaoka Y, Ito M, Koyanagi Y, Mitsuya H
(2005) Potent anti-R5 human immunodeficiency virus type 1 effects of a CCR5 antagonist, AK602/ONO4128/GW873140, in a novel human peripheral blood mononuclear cell nonobese diabetic-SCID, interleukin-2 receptor gamma-chain-knocked-out AIDS mouse model. J. Virol. 79(4):2087-96
Humanization
HIV
Kambe N, et al.
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Kambe N, Hiramatsu H, Shimonaka M, Fujino H, Nishikomori R, Heike T, Ito M, Kobayashi K, Ueyama Y, Matsuyoshi N, Miyachi Y, Nakahata T
(2004) Development of both human connective tissue-type and mucosal-type mast cells in mice from hematopoietic stem cells with identical distribution pattern to human body. Blood 103(3):860-7
Hematopoietic Stem Cell Engraftment
Yahata T, et al.
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Yahata T, Ando K, Miyatake H, Uno T, Sato T, Ito M, Kato S, Hotta T
(2004) Competitive repopulation assay of two gene-marked cord blood units in NOD/SCID/gammac(null) mice. Mol. Ther. 10(5):882-91
Hematopoietic Stem Cell Engraftment
Matsumura T, et al.
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Matsumura T, Kametani Y, Ando K, Hirano Y, Katano I, Ito R, Shiina M, Tsukamoto H, Saito Y, Tokuda Y, Kato S, Ito M, Motoyoshi K, Habu S
(2003) Functional CD5+ B cells develop predominantly in the spleen of NOD/SCID/gammac(null) (NOG) mice transplanted either with human umbilical cord blood, bone marrow, or mobilized peripheral blood CD34+ cells. Exp. Hematol. 31(9):789-97
Hematopoietic Stem Cell Engraftment
Yahata T, et al.
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Yahata T, Ando K, Nakamura Y, Ueyama Y, Shimamura K, Tamaoki N, Kato S, Hotta T
(2002) Functional human T lymphocyte development from cord blood CD34+ cells in nonobese diabetic/Shi-scid, IL-2 receptor gamma null mice. J. Immunol. 169(1):204-9
Hematopoietic Stem Cell Engraftment
Hiramatsu H, et al.
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Hiramatsu H, Nishikomori R, Heike T, Ito M, Kobayashi K, Katamura K, Nakahata T
(2003) Complete reconstitution of human lymphocytes from cord blood CD34+ cells using the NOD/SCID/gammacnull mice model. Blood 102(3):873-80
Hematopoietic Stem Cell Engraftment
Saito Y, et al.
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Saito Y, Kametani Y, Hozumi K, Mochida N, Ando K, Ito M, Nomura T, Tokuda Y, Makuuchi H, Tajima T, Habu S
(2002) The in vivo development of human T cells from CD34(+) cells in the murine thymic environment. Int. Immunol. 14(10):1113-24
Hematopoietic Stem Cell Engraftment
Ito M, et al.
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Ito M, Hiramatsu H, Kobayashi K, Suzue K, Kawahata M, Hioki K, Ueyama Y, Koyanagi Y, Sugamura K, Tsuji K, Heike T, Nakahata T
(2002) NOD/SCID/gamma(c)(null) mouse: an excellent recipient mouse model for engraftment of human cells. Blood 100(9):3175-82
Humanization
Hematopoietic Stem Cell Engraftment