CIEA BRG mouse Publications

CIEA BRG mouse Model Page

Filter publications by application: All Autoimmune Breast Cancer HIV Hematopoietic Stem Cell Engraftment Immunology Infectious Disease Leukemia NK Oncology T And/Or B Cell Function Transplantation Research And Graft Versus Host Disease (GVHD)
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Xu H, et al.
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Xu H, Cheng M, Guo H, Chen Y, Huse M, Cheung NK
(2015) Retargeting T cells to GD2 pentasaccharide on human tumors using Bispecific humanized antibody. Cancer Immunol Res 3(3):266-77
T And/Or B Cell Function, Oncology
Zhao Q, et al.
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Zhao Q, Ahmed M, Guo HF, Cheung IY, Cheung NK
(2015) Alteration of Electrostatic Surface Potential Enhances Affinity and Tumor Killing Properties of Anti-ganglioside GD2 Monoclonal Antibody hu3F8. J. Biol. Chem. 290(21):13017-27
Oncology
Zhao Q, et al.
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Zhao Q, Ahmed M, Tassev DV, Hasan A, Kuo TY, Guo HF, O'Reilly RJ, Cheung NK
(2015) Affinity maturation of T-cell receptor-like antibodies for Wilms tumor 1 peptide greatly enhances therapeutic potential. Leukemia 29(11):2238-47
T And/Or B Cell Function, Leukemia
Cheng M, et al.
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Cheng M, Ahmed M, Xu H, Cheung NK
(2015) Structural design of disialoganglioside GD2 and CD3-bispecific antibodies to redirect T cells for tumor therapy. Int. J. Cancer 136(2):476-86
Oncology
Ahmed M, et al.
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Ahmed M, Cheng M, Cheung IY, Cheung NK
(2015) Human derived dimerization tag enhances tumor killing potency of a T-cell engaging bispecific antibody. Oncoimmunology 4(4):e989776
T And/Or B Cell Function, Oncology
Scielzo C, et al.
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Scielzo C, Bertilaccio MT, Simonetti G, Dagklis A, ten Hacken E, Fazi C, Muzio M, Caiolfa V, Kitamura D, Restuccia U, Bachi A, Rocchi M, Ponzoni M, Ghia P, Caligaris-Cappio F
(2010) HS1 has a central role in the trafficking and homing of leukemic B cells. Blood 116(18):3537-46
Leukemia
Nanni P, et al.
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Nanni P, Nicoletti G, Landuzzi L, Croci S, Murgo A, Palladini A, Antognoli A, Ianzano ML, Stivani V, Grosso V, Maira SM, García-Echeverría C, Scotlandi K, De Giovanni C, Lollini PL
(2010) High metastatic efficiency of human sarcoma cells in Rag2/gammac double knockout mice provides a powerful test system for antimetastatic targeted therapy. Eur. J. Cancer 46(3):659-68
Oncology
Nanni P, et al.
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Nanni P, Nicoletti G, Palladini A, Croci S, Murgo A, Ianzano ML, Grosso V, Stivani V, Antognoli A, Lamolinara A, Landuzzi L, di Tomaso E, Iezzi M, De Giovanni C, Lollini PL
(2012) Multiorgan metastasis of human HER-2+ breast cancer in Rag2-/-;Il2rg-/- mice and treatment with PI3K inhibitor. PLoS ONE 7(6):e39626
Breast Cancer
Lollini PL, et al.
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Lollini PL, De Giovanni C, Nanni P
(2013) Preclinical HER-2 Vaccines: From Rodent to Human HER-2. Front Oncol 3:151
Oncology
Klar R, et al.
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Klar R, Schober S, Rami M, Mall S, Merl J, Hauck SM, Ueffing M, Admon A, Slotta-Huspenina J, Schwaiger M, Stevanović S, Oostendorp RA, Busch DH, Peschel C, Krackhardt AM
(2014) Therapeutic targeting of naturally presented myeloperoxidase-derived HLA peptide ligands on myeloid leukemia cells by TCR-transgenic T cells. Leukemia 28(12):2355-66
T And/Or B Cell Function, Leukemia
De Giovanni C, et al.
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De Giovanni C, Nicoletti G, Landuzzi L, Romani F, Croci S, Palladini A, Murgo A, Antognoli A, Ianzano ML, Stivani V, Grosso V, Iezzi M, Stramucci L, Barbieri E, Lemoli RM, Nanni P, Lollini PL
(2012) Human responses against HER-2-positive cancer cells in human immune system-engrafted mice. Br. J. Cancer 107(8):1302-9
Oncology
Bertilaccio MT, et al.
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Bertilaccio MT, Scielzo C, Simonetti G, Ponzoni M, Apollonio B, Fazi C, Scarfò L, Rocchi M, Muzio M, Caligaris-Cappio F, Ghia P
(2010) A novel Rag2-/-gammac-/--xenograft model of human CLL. Blood 115(8):1605-9
Oncology, Leukemia
Noguchi D, et al.
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Noguchi D, Wakita D, Ohkuri T, Tajima M, Chamoto K, Kitamura H, Nishimura T
(2011) Blockade of IL-6-signaling inhibits the pathogenesis of CD4+ T cell-mediated lethal graft-versus-host reaction against minor histocompatibility antigen. Immunol. Lett. 136(2):146-55
Andrade D, et al.
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Andrade D, Redecha PB, Vukelic M, Qing X, Perino G, Salmon JE, Koo GC
(2011) Engraftment of peripheral blood mononuclear cells from systemic lupus erythematosus and antiphospholipid syndrome patient donors into BALB-RAG-2-/- IL-2Rγ-/- mice: a promising model for studying human disease. Arthritis Rheum. 63(9):2764-73
Autoimmune
Barra NG, et al.
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Barra NG, Chew MV, Reid S, Ashkar AA
(2012) Interleukin-15 treatment induces weight loss independent of lymphocytes. PLoS ONE 7(6):e39553
Immunology
Traggiai E, et al.
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Traggiai E, Chicha L, Mazzucchelli L, Bronz L, Piffaretti JC, Lanzavecchia A, Manz MG
(2004) Development of a human adaptive immune system in cord blood cell-transplanted mice. Science 304(5667):104-7
Hematopoietic Stem Cell Engraftment
Pek EA, et al.
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Pek EA, Chan T, Reid S, Ashkar AA
(2011) Characterization and IL-15 dependence of NK cells in humanized mice. Immunobiology 216(1-2):218-24
Hematopoietic Stem Cell Engraftment, NK
Lang J, et al.
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Lang J, Weiss N, Freed BM, Torres RM, Pelanda R
(2011) Generation of hematopoietic humanized mice in the newborn BALB/c-Rag2null Il2rγnull mouse model: a multivariable optimization approach. Clin. Immunol. 140(1):102-16
Hematopoietic Stem Cell Engraftment
Kwant-Mitchell A, et al.
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Kwant-Mitchell A, Pek EA, Rosenthal KL, Ashkar AA
(2009) Development of functional human NK cells in an immunodeficient mouse model with the ability to provide protection against tumor challenge. PLoS ONE 4(12):e8379
Hematopoietic Stem Cell Engraftment, NK, Oncology
Kwant-Mitchell A, et al.
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Kwant-Mitchell A, Ashkar AA, Rosenthal KL
(2009) Mucosal innate and adaptive immune responses against herpes simplex virus type 2 in a humanized mouse model. J. Virol. 83(20):10664-76
Hematopoietic Stem Cell Engraftment, Infectious Disease
Hofer U, et al.
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Hofer U, Baenziger S, Heikenwalder M, Schlaepfer E, Gehre N, Regenass S, Brunner T, Speck RF
(2008) RAG2-/- gamma(c)-/- mice transplanted with CD34+ cells from human cord blood show low levels of intestinal engraftment and are resistant to rectal transmission of human immunodeficiency virus. J. Virol. 82(24):12145-53
Hematopoietic Stem Cell Engraftment, Infectious Disease
Gorantla S, et al.
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Gorantla S, Sneller H, Walters L, Sharp JG, Pirruccello SJ, West JT, Wood C, Dewhurst S, Gendelman HE, Poluektova L
(2007) Human immunodeficiency virus type 1 pathobiology studied in humanized BALB/c-Rag2-/-gammac-/- mice. J. Virol. 81(6):2700-12
Hematopoietic Stem Cell Engraftment, Infectious Disease
Frecha C, et al.
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Frecha C, Toscano MG, Costa C, Saez-Lara MJ, Cosset FL, Verhoeyen E, Martin F
(2008) Improved lentiviral vectors for Wiskott-Aldrich syndrome gene therapy mimic endogenous expression profiles throughout haematopoiesis. Gene Ther. 15(12):930-41
Hematopoietic Stem Cell Engraftment
Frecha C, et al.
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Frecha C, Costa C, Nègre D, Amirache F, Trono D, Rio P, Bueren J, Cosset FL, Verhoeyen E
(2012) A novel lentiviral vector targets gene transfer into human hematopoietic stem cells in marrow from patients with bone marrow failure syndrome and in vivo in humanized mice. Blood 119(5):1139-50
Hematopoietic Stem Cell Engraftment
Choudhary SK, et al.
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Choudhary SK, Rezk NL, Ince WL, Cheema M, Zhang L, Su L, Swanstrom R, Kashuba AD, Margolis DM
(2009) Suppression of human immunodeficiency virus type 1 (HIV-1) viremia with reverse transcriptase and integrase inhibitors, CD4+ T-cell recovery, and viral rebound upon interruption of therapy in a new model for HIV treatment in the humanized Rag2-/-{gamma}c-/- mouse. J. Virol. 83(16):8254-8
Hematopoietic Stem Cell Engraftment, Infectious Disease
Chicha L, et al.
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Chicha L, Tussiwand R, Traggiai E, Mazzucchelli L, Bronz L, Piffaretti JC, Lanzavecchia A, Manz MG
(2005) Human adaptive immune system Rag2-/-gamma(c)-/- mice. Ann. N. Y. Acad. Sci. 1044:236-43
Hematopoietic Stem Cell Engraftment
Berges BK, et al.
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Berges BK, Akkina SR, Folkvord JM, Connick E, Akkina R
(2008) Mucosal transmission of R5 and X4 tropic HIV-1 via vaginal and rectal routes in humanized Rag2-/- gammac -/- (RAG-hu) mice. Virology 373(2):342-51
Hematopoietic Stem Cell Engraftment, Infectious Disease
Berges BK, et al.
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Berges BK, Wheat WH, Palmer BE, Connick E, Akkina R
(2006) HIV-1 infection and CD4 T cell depletion in the humanized Rag2-/-gamma c-/- (RAG-hu) mouse model. Retrovirology 3:76
Hematopoietic Stem Cell Engraftment, T And/Or B Cell Function, Infectious Disease, HIV
Baenziger S, et al.
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Baenziger S, Tussiwand R, Schlaepfer E, Mazzucchelli L, Heikenwalder M, Kurrer MO, Behnke S, Frey J, Oxenius A, Joller H, Aguzzi A, Manz MG, Speck RF
(2006) Disseminated and sustained HIV infection in CD34+ cord blood cell-transplanted Rag2-/-gamma c-/- mice. Proc. Natl. Acad. Sci. U.S.A. 103(43):15951-6
Hematopoietic Stem Cell Engraftment, Infectious Disease
Ito R, et al.
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Ito R, Katano I, Kawai K, Hirata H, Ogura T, Kamisako T, Eto T, Ito M
(2009) Highly sensitive model for xenogenic GVHD using severe immunodeficient NOG mice. Transplantation 87(11):1654-8
Transplantation Research And Graft Versus Host Disease (GVHD)