C.B-17 scid Publications

C.B-17 scid Model Page

Filter publications by application: All Breast Cancer Colitis Colon Cancer Crohn's Disease Epstein-Barr Virus HIV Humanized Infectious Disease Inflammation Leukemia Lung Cancer Lymphoma Melanoma Microbiome Myeloma Oncology Pancreatic And Other Biliary Tract Cancers Prostate Cancer T And/Or B Cell Function Vaccine Research
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Lindebo Holm T, et al.
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Lindebo Holm T, Poulsen SS, Markholst H, Reedtz-Runge S
(2012) Pharmacological Evaluation of the SCID T Cell Transfer Model of Colitis: As a Model of Crohn's Disease. Int J Inflam 2012:412178
Opata MM, et al.
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Opata MM, Hollifield ML, Lund FE, Randall TD, Dunn R, Garvy BA, Feola DJ
(2015) B Lymphocytes Are Required during the Early Priming of CD4+ T Cells for Clearance of Pneumocystis Infection in Mice. J. Immunol. 195(2):611-20
T And/Or B Cell Function, Infectious Disease
Castro-Mejía J, et al.
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Castro-Mejía J, Jakesevic M, Krych Ł, Nielsen DS, Hansen LH, Sondergaard BC, Kvist PH, Hansen AK, Holm TL
(2016) Treatment with a Monoclonal Anti-IL-12p40 Antibody Induces Substantial Gut Microbiota Changes in an Experimental Colitis Model. Gastroenterol Res Pract 2016:4953120
Colitis, Crohn's Disease, Microbiome
Jeremiah van Doren, et al.
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Jeremiah van Doren, Kun Zhang, Dai-Ying Zhou, Ning Ding, Xing-Chuan Wei, Zhi-Yun Du, Allan H. Conney, Xi Zheng
(2014) Effects of Curcumin Analogues for Inhibiting Human Prostate Cancer Cells and the Growth of Human PC-3 Prostate Xenografts in Immunodeficient Mice Biological and Pharmaceutical Bulletin Vol. 37 (2014) No. 6 p. 1029-1034
Prostate Cancer
Wang M, et al.
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Wang M, Hu Y, Stearns ME
(2009) RPS2: a novel therapeutic target in prostate cancer. J. Exp. Clin. Cancer Res. 28:6
Prostate Cancer
Tassone P, et al.
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Tassone P, Neri P, Carrasco DR, Burger R, Goldmacher VS, Fram R, Munshi V, Shammas MA, Catley L, Jacob GS, Venuta S, Anderson KC, Munshi NC
(2005) A clinically relevant SCID-hu in vivo model of human multiple myeloma. Blood 106(2):713-6
Myeloma
Stanciu-Herrera C, et al.
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Stanciu-Herrera C, Morgan C, Herrera L
(2008) Anti-CD19 and anti-CD22 monoclonal antibodies increase the effectiveness of chemotherapy in Pre-B acute lymphoblastic leukemia cell lines. Leuk. Res. 32(4):625-32
Leukemia
Oflazoglu E, et al.
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Oflazoglu E, Elliott M, Takita H, Ferrone S, Henderson RA, Repasky EA
(2007) Adoptively transferred human lung tumor specific cytotoxic T cells can control autologous tumor growth and shape tumor phenotype in a SCID mouse xenograft model. J Transl Med 5:29
Lung Cancer
Robin E. Norris, et al.
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Robin E. Norris, M.D., Vu T. Nguyen, B.S., and Peter C. Adamson
(2014) Evaluation of the Retinoids with Cisplatin and Vincristine in Xenograft Models of Neuroblastoma J Pediatr Hematol Oncol. 2014 Jan; 36(1): 10.1097/MPH.0b013e3182915d4a.
Lung Cancer
Chiou-Yan Lai, et al.
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Chiou-Yan Lai, Brian E. Schwartz, and Mei-Yu Hsu
(2012) CD133+ Melanoma Subpopulations Contribute to Perivascular Niche Morphogenesis and Tumorigenicity through Vasculogenic Mimicry Cancer Res. 2012 Oct 1; 72(19): 5111–5118.
Oncology
Joseph C. Klink, et al.
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Joseph C. Klink, Alok K. Tewari, Elizabeth M. Masko, Jodi Antonelli, Phillip G. Febbo, Pinchas Cohen, Mark W. Dewhirst, Salvatore V. Pizzo, and Stephen J. Freedland
(2013) Resveratrol Worsens Survival in SCID Mice With Prostate Cancer Xenografts in a Cell-Line Specific Manner, Through Paradoxical Effects on Oncogenic Pathways Prostate. 2013 May; 73(7): 754–762.
Melanoma, Prostate Cancer
Johnson EE, et al.
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Johnson EE, Buhtoiarov IN, Baldeshwiler MJ, Felder MA, Van Rooijen N, Sondel PM, Rakhmilevich AL
(2011) Enhanced T-cell-independent antitumor effect of cyclophosphamide combined with anti-CD40 mAb and CpG in mice. J. Immunother. 34(1):76-84
Melanoma
Jensen TJ, et al.
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Jensen TJ, Novak P, Wnek SM, Gandolfi AJ, Futscher BW
(2009) Arsenicals produce stable progressive changes in DNA methylation patterns that are linked to malignant transformation of immortalized urothelial cells. Toxicol. Appl. Pharmacol. 241(2):221-9
Oncology
Havens AM, et al.
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Havens AM, Pedersen EA, Shiozawa Y, Ying C, Jung Y, Sun Y, Neeley C, Wang J, Mehra R, Keller ET, McCauley LK, Loberg RD, Pienta KJ, Taichman RS
(2008) An in vivo mouse model for human prostate cancer metastasis. Neoplasia 10(4):371-80
Prostate Cancer
Joseph Hartwich, et al.
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Joseph Hartwich, W. Shannon Orr, Catherine Y. Ng, Yunyu Spence, Christopher Morton, Andrew M. Davidoff
(2013) HIF-1α activation mediates resistance to anti-angiogenic therapy in neuroblastoma xenografts Journal of Pediatric Surgery Volume 48, Issue 1, January 2013, Pages 39–46
Oncology
Govindan SV, et al.
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Govindan SV, Cardillo TM, Moon SJ, Hansen HJ, Goldenberg DM
(2009) CEACAM5-targeted therapy of human colonic and pancreatic cancer xenografts with potent labetuzumab-SN-38 immunoconjugates. Clin. Cancer Res. 15(19):6052-61
Colon Cancer
Goldenberg DM, et al.
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Goldenberg DM, Rossi EA, Stein R, Cardillo TM, Czuczman MS, Hernandez-Ilizaliturri FJ, Hansen HJ, Chang CH
(2009) Properties and structure-function relationships of veltuzumab (hA20), a humanized anti-CD20 monoclonal antibody. Blood 113(5):1062-70
Lymphoma
Fulciniti M, et al.
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Fulciniti M, Hideshima T, Vermot-Desroches C, Pozzi S, Nanjappa P, Shen Z, Patel N, Smith ES, Wang W, Prabhala R, Tai YT, Tassone P, Anderson KC, Munshi NC
(2009) A high-affinity fully human anti-IL-6 mAb, 1339, for the treatment of multiple myeloma. Clin. Cancer Res. 15(23):7144-52
Myeloma
Fulciniti M, et al.
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Fulciniti M, Tassone P, Hideshima T, Vallet S, Nanjappa P, Ettenberg SA, Shen Z, Patel N, Tai YT, Chauhan D, Mitsiades C, Prabhala R, Raje N, Anderson KC, Stover DR, Munshi NC
(2009) Anti-DKK1 mAb (BHQ880) as a potential therapeutic agent for multiple myeloma. Blood 114(2):371-9
Myeloma
Cabello CM, et al.
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Cabello CM, Bair WB, Lamore SD, Ley S, Bause AS, Azimian S, Wondrak GT
(2009) The cinnamon-derived Michael acceptor cinnamic aldehyde impairs melanoma cell proliferation, invasiveness, and tumor growth. Free Radic. Biol. Med. 46(2):220-31
Melanoma
Cabello CM, et al.
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Cabello CM, Bair WB, Bause AS, Wondrak GT
(2009) Antimelanoma activity of the redox dye DCPIP (2,6-dichlorophenolindophenol) is antagonized by NQO1. Biochem. Pharmacol. 78(4):344-54
Melanoma
Bredfeldt TG, et al.
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Bredfeldt TG, Jagadish B, Eblin KE, Mash EA, Gandolfi AJ
(2006) Monomethylarsonous acid induces transformation of human bladder cells. Toxicol. Appl. Pharmacol. 216(1):69-79
Oncology
Ali S, et al.
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Ali S, Banerjee S, Schaffert JM, El-Rayes BF, Philip PA, Sarkar FH
(2010) Concurrent inhibition of NF-kappaB, cyclooxygenase-2, and epidermal growth factor receptor leads to greater anti-tumor activity in pancreatic cancer. J. Cell. Biochem. 110(1):171-81
Pancreatic And Other Biliary Tract Cancers
Ahmed N, et al.
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Ahmed N, Salsman VS, Yvon E, Louis CU, Perlaky L, Wels WS, Dishop MK, Kleinerman EE, Pule M, Rooney CM, Heslop HE, Gottschalk S
(2009) Immunotherapy for osteosarcoma: genetic modification of T cells overcomes low levels of tumor antigen expression. Mol. Ther. 17(10):1779-87
Breast Cancer
Wang L, et al.
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Wang L, Li L, Kamath A, Das H, Bukowski JF
(2001) Antibacterial effect of human V gamma 2V delta 2 T cells in vivo. J Clin Invest. 108(9):1349-1357.
Stoddart CA, et al.
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Stoddart CA, Keir ME, McCune JM
(2010) IFN-alpha-induced upregulation of CCR5 leads to expanded HIV tropism in vivo. PLoS Pathog. 6(2):e1000766
HIV
Stoddart CA, et al.
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Stoddart CA, Joshi P, Sloan B, Bare JC, Smith PC, Allaway GP, Wild CT, Martin DE
(2007) Potent activity of the HIV-1 maturation inhibitor bevirimat in SCID-hu Thy/Liv mice. PLoS ONE 2(11):e1251
HIV
Stoddart CA, et al.
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Stoddart CA, Galkina SA, Joshi P, Kosikova G, Long BR, Maidji E, Moreno ME, Rivera JM, Sanford UR, Sloan B, Cieplak W, Wrin T, Chan-Hui PY
(2014) Efficacy of broadly neutralizing monoclonal antibody PG16 in HIV-infected humanized mice. Virology 462-463:115-25
HIV
Stoddart CA, et al.
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Stoddart CA, Galkina SA, Joshi P, Kosikova G, Moreno ME, Rivera JM, Sloan B, Reeve AB, Sarafianos SG, Murphey-Corb M, Parniak MA
(2015) Oral administration of the nucleoside EFdA (4'-ethynyl-2-fluoro-2'-deoxyadenosine) provides rapid suppression of HIV viremia in humanized mice and favorable pharmacokinetic properties in mice and the rhesus macaque. Antimicrob. Agents Chemother. 59(7):4190-8
HIV
Stoddart CA, et al.
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Stoddart CA, Bales CA, Bare JC, Chkhenkeli G, Galkina SA, Kinkade AN, Moreno ME, Rivera JM, Ronquillo RE, Sloan B, Black PL
(2007) Validation of the SCID-hu Thy/Liv mouse model with four classes of licensed antiretrovirals. PLoS ONE 2(7):e655
Reinders ME, et al.
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Reinders ME, Sho M, Izawa A, Wang P, Mukhopadhyay D, Koss KE, Geehan CS, Luster AD, Sayegh MH, Briscoe DM
(2003) Proinflammatory functions of vascular endothelial growth factor in alloimmunity. J. Clin. Invest. 112(11):1655-65
Humanized
Maruyama K, et al.
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Maruyama K, Ii M, Cursiefen C, Jackson DG, Keino H, Tomita M, Van Rooijen N, Takenaka H, D'Amore PA, Stein-Streilein J, Losordo DW, Streilein JW
(2005) Inflammation-induced lymphangiogenesis in the cornea arises from CD11b-positive macrophages. J. Clin. Invest. 115(9):2363-72
Inflammation
Majewski M, et al.
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Majewski M, Korecka M, Kossev P, Li S, Goldman J, Moore J, Silberstein LE, Nowell PC, Schuler W, Shaw LM, Wasik MA
(2000) The immunosuppressive macrolide RAD inhibits growth of human Epstein-Barr virus-transformed B lymphocytes in vitro and in vivo: A potential approach to prevention and treatment of posttransplant lymphoproliferative disorders. Proc. Natl. Acad. Sci. U.S.A. 97(8):4285-90
Epstein-Barr Virus
Maidji E, et al.
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Maidji E, Kosikova G, Joshi P, Stoddart CA
(2012) Impaired surfactant production by alveolar epithelial cells in a SCID-hu lung mouse model of congenital human cytomegalovirus infection. J. Virol. 86(23):12795-805
Li Y, et al.
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Li Y, Che M, Bhagat S, Ellis KL, Kucuk O, Doerge DR, Abrams J, Cher ML, Sarkar FH
(2004) Regulation of gene expression and inhibition of experimental prostate cancer bone metastasis by dietary genistein. Neoplasia 6(4):354-63
Prostate Cancer
Kurtz A, et al.
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Kurtz A, Aigner A, Cabal-Manzano RH, Butler RE, Hood DR, Sessions RB, Czubayko F, Wellstein A
(2004) Differential regulation of a fibroblast growth factor-binding protein during skin carcinogenesis and wound healing. Neoplasia 6(5):595-602
Gigliotti F, et al.
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Gigliotti F, Crow EL, Bhagwat SP, Wright TW
(2006) Sensitized CD8+ T cells fail to control organism burden but accelerate the onset of lung injury during Pneumocystis carinii pneumonia. Infect. Immun. 74(11):6310-6
T And/Or B Cell Function
Cheever AW, et al.
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Cheever AW, Poindexter RW, Wynn TA
(1999) Egg laying is delayed but worm fecundity is normal in SCID mice infected with Schistosoma japonicum and S. mansoni with or without recombinant tumor necrosis factor alpha treatment. Infect. Immun. 67(5):2201-8
Chambers TJ, et al.
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Chambers TJ, Nickells M
(2001) Neuroadapted yellow fever virus 17D: genetic and biological characterization of a highly mouse-neurovirulent virus and its infectious molecular clone. J. Virol. 75(22):10912-22
Bardeesy N, et al.
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Bardeesy N, Kim M, Xu J, Kim RS, Shen Q, Bosenberg MW, Wong WH, Chin L
(2005) Role of epidermal growth factor receptor signaling in RAS-driven melanoma. Mol. Cell. Biol. 25(10):4176-88
Melanoma
Wyatt LS, et al.
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Wyatt LS, Earl PL, Eller LA, Moss B
(2004) Highly attenuated smallpox vaccine protects mice with and without immune deficiencies against pathogenic vaccinia virus challenge. Proc. Natl. Acad. Sci. U.S.A. 101(13):4590-5
Vaccine Research