APPSWE - Model 1349 Publications

APPSWE - Model 1349 Model Page

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Sooy K, et al.
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Sooy K, Noble J, McBride A, Binnie M, Yau JL, Seckl JR, Walker BR, Webster SP
(2015) Cognitive and Disease-Modifying Effects of 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibition in Male Tg2576 Mice, a Model of Alzheimer's Disease. Endocrinology 156(12):4592-603
Levenson JM, et al.
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Levenson JM, Schroeter S, Carroll JC, Cullen V, Asp E, Proschitsky M, Chung CH, Gilead S, Nadeem M, Dodiya HB, Shoaga S, Mufson EJ, Tsubery H, Krishnan R, Wright J, Solomon B, Fisher R, Gannon KS
(2016) NPT088 reduces both amyloid-β and tau pathologies in transgenic mice. Alzheimers Dement (N Y) 2(3):141-155
Ishida K, et al.
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Ishida K, Misawa K, Nishimura H, Hirata T, Yamamoto M, Ota N
(2020) 5-Caffeoylquinic Acid Ameliorates Cognitive Decline and Reduces Aβ Deposition by Modulating Aβ Clearance Pathways in APP/PS2 Transgenic Mice. Nutrients 12(2)
Tackenberg C, et al.
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Tackenberg C, Kulic L, Nitsch RM
(2020) Familial Alzheimer's disease mutations at position 22 of the amyloid β-peptide sequence differentially affect synaptic loss, tau phosphorylation and neuronal cell death in an ex vivo system. PLoS One 15(9):e0239584
Salazar JG, et al.
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Salazar JG, Marsillach J, Reverte I, Mackness B, Mackness M, Joven J, Camps J, Colomina MT
(2021) Paraoxonase-1 and -3 Protein Expression in the Brain of the Tg2576 Mouse Model of Alzheimer's Disease. Antioxidants (Basel) 10(3)
Alzheimer's
Guo HH, et al.
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Guo HH, Xiong L, Pan JX, Lee D, Liu K, Ren X, Wang B, Yang X, Cui S, Mei L, Xiong WC
(2021) Hepcidin contributes to Swedish mutant APP-induced osteoclastogenesis and trabecular bone loss. Bone Res 9(1):31
Wiȩckowska-Gacek A, et al.
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Wiȩckowska-Gacek A, Mietelska-Porowska A, Chutorański D, Wydrych M, Długosz J, Wojda U
(2021) Western Diet Induces Impairment of Liver-Brain Axis Accelerating Neuroinflammation and Amyloid Pathology in Alzheimer's Disease. Front Aging Neurosci 13:654509
Alzheimer's
Wei Z, et al.
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Wei Z, Xu J, Chen L, Hirschler L, Barbier EL, Li T, Wong PC, Lu H
(2021) Brain metabolism in tau and amyloid mouse models of Alzheimer's disease: An MRI study. NMR Biomed :e4568
Alzheimer's
Calvo-Rodriguez M, et al.
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Calvo-Rodriguez M, Hou SS, Snyder AC, Kharitonova EK, Russ AN, Das S, Fan Z, Muzikansky A, Garcia-Alloza M, Serrano-Pozo A, Hudry E, Bacskai BJ
(2020) Increased mitochondrial calcium levels associated with neuronal death in a mouse model of Alzheimer's disease. Nat Commun 11(1):2146
Alzheimer's
Lee WJ, et al.
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Lee WJ, Moon J, Jeon D, Shin YW, Yoo JS, Park DK, Lee ST, Jung KH, Park KI, Jung KY, Kim M, Lee SK, Chu K
(2019) Possible epigenetic regulatory effect of dysregulated circular RNAs in Alzheimer's disease model. Sci Rep 9(1):11956
Alzheimer's
Snellman A, et al.
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Snellman A, Takkinen JS, López-Picón FR, Eskola O, Solin O, Rinne JO, Haaparanta-Solin M
(2019) Effect of genotype and age on cerebral [18F]FDG uptake varies between transgenic APPSWE-PS1dE9 and Tg2576 mouse models of Alzheimer's disease. Sci Rep 9(1):5700
Alzheimer's
Zhang C, et al.
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Zhang C, Griciuc A, Hudry E, Wan Y, Quinti L, Ward J, Forte AM, Shen X, Ran C, Elmaleh DR, Tanzi RE
(2018) Cromolyn Reduces Levels of the Alzheimer's Disease-Associated Amyloid β-Protein by Promoting Microglial Phagocytosis. Sci Rep 8(1):1144
Alzheimer's
Fryer JD, et al.
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Fryer JD, Simmons K, Parsadanian M, Bales KR, Paul SM, Sullivan PM, Holtzman DM
(2005) Human apolipoprotein E4 alters the amyloid-beta 40:42 ratio and promotes the formation of cerebral amyloid angiopathy in an amyloid precursor protein transgenic model. J. Neurosci. 25(11):2803-10
Alzheimer's
Arbel-Ornath M, et al.
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Arbel-Ornath M, Hudry E, Boivin JR, Hashimoto T, Takeda S, Kuchibhotla KV, Hou S, Lattarulo CR, Belcher AM, Shakerdge N, Trujillo PB, Muzikansky A, Betensky RA, Hyman BT, Bacskai BJ
(2017) Soluble oligomeric amyloid-β induces calcium dyshomeostasis that precedes synapse loss in the living mouse brain. Mol Neurodegener 12(1):27
Rustay NR, et al.
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Rustay NR, Cronin EA, Curzon P, Markosyan S, Bitner RS, Ellis TA, Waring JF, Decker MW, Rueter LE, Browman KE
(2010) Mice expressing the Swedish APP mutation on a 129 genetic background demonstrate consistent behavioral deficits and pathological markers of Alzheimer's disease. Brain Res. 1311:136-47
Wolf A, et al.
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Wolf A, Bauer B, Abner EL, Ashkenazy-Frolinger T, Hartz AM
(2016) A Comprehensive Behavioral Test Battery to Assess Learning and Memory in 129S6/Tg2576 Mice. PLoS ONE 11(1):e0147733
Neuroscience
Hsiao K, et al.
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Hsiao K, Chapman P, Nilsen S, Eckman C, Harigaya Y, Younkin S, Yang F, Cole G
(1996) Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice. Science 274(5284):99-102
Sevigny J, et al.
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Sevigny J, Chiao P, Bussière T, Weinreb PH, Williams L, Maier M, Dunstan R, Salloway S, Chen T, Ling Y, O'Gorman J, Qian F, Arastu M, Li M, Chollate S, Brennan MS, Quintero-Monzon O, Scannevin RH, Arnold HM, Engber T, Rhodes K, Ferrero J, Hang Y, Mikulskis A, Grimm J, Hock C, Nitsch RM, Sandrock A
(2016) The antibody aducanumab reduces Aβ plaques in Alzheimer's disease. Nature 537(7618):50-6
Alzheimer's
Yao Y, et al.
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Yao Y, Chinnici C, Tang H, Trojanowski JQ, Lee VM, Praticò D
(2004) Brain inflammation and oxidative stress in a transgenic mouse model of Alzheimer-like brain amyloidosis. J Neuroinflammation 1(1):21
Alzheimer's
Urbanc B, et al.
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Urbanc B, Cruz L, Le R, Sanders J, Ashe KH, Duff K, Stanley HE, Irizarry MC, Hyman BT
(2002) Neurotoxic effects of thioflavin S-positive amyloid deposits in transgenic mice and Alzheimer's disease. Proc. Natl. Acad. Sci. U.S.A. 99(22):13990-5
Alzheimer's
Stobart MJ, et al.
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Stobart MJ, Parchaliuk D, Simon SL, Lemaistre J, Lazar J, Rubenstein R, Knox JD
(2007) Differential expression of interferon responsive genes in rodent models of transmissible spongiform encephalopathy disease. Mol Neurodegener 2:5
Spires TL, et al.
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Spires TL, Hyman BT
(2005) Transgenic models of Alzheimer's disease: learning from animals. NeuroRx 2(3):423-37
Alzheimer's
Skovronsky DM, et al.
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Skovronsky DM, Zhang B, Kung MP, Kung HF, Trojanowski JQ, Lee VM
(2000) In vivo detection of amyloid plaques in a mouse model of Alzheimer's disease. Proc. Natl. Acad. Sci. U.S.A. 97(13):7609-14
Alzheimer's
Puglielli L, et al.
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Puglielli L, Friedlich AL, Setchell KD, Nagano S, Opazo C, Cherny RA, Barnham KJ, Wade JD, Melov S, Kovacs DM, Bush AI
(2005) Alzheimer disease beta-amyloid activity mimics cholesterol oxidase. J. Clin. Invest. 115(9):2556-63
Alzheimer's
Poduslo JF, et al.
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Poduslo JF, Curran GL, Wengenack TM, Malester B, Duff K
(2001) Permeability of proteins at the blood-brain barrier in the normal adult mouse and double transgenic mouse model of Alzheimer's disease. Neurobiol. Dis. 8(4):555-67
Alzheimer's
Norris CM, et al.
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Norris CM, Kadish I, Blalock EM, Chen KC, Thibault V, Porter NM, Landfield PW, Kraner SD
(2005) Calcineurin triggers reactive/inflammatory processes in astrocytes and is upregulated in aging and Alzheimer's models. J. Neurosci. 25(18):4649-58
Alzheimer's
Niwa K, et al.
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Niwa K, Younkin L, Ebeling C, Turner SK, Westaway D, Younkin S, Ashe KH, Carlson GA, Iadecola C
(2000) Abeta 1-40-related reduction in functional hyperemia in mouse neocortex during somatosensory activation. Proc. Natl. Acad. Sci. U.S.A. 97(17):9735-40
Alzheimer's
McGowan E, et al.
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McGowan E, Pickford F, Kim J, Onstead L, Eriksen J, Yu C, Skipper L, Murphy MP, Beard J, Das P, Jansen K, Delucia M, Lin WL, Dolios G, Wang R, Eckman CB, Dickson DW, Hutton M, Hardy J, Golde T
(2005) Abeta42 is essential for parenchymal and vascular amyloid deposition in mice. Neuron 47(2):191-9
Alzheimer's
Loeffler DA
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Loeffler DA
(2004) Using animal models to determine the significance of complement activation in Alzheimer's disease. J Neuroinflammation 1(1):18
Alzheimer's
Li Q, et al.
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Li Q, Cao C, Chackerian B, Schiller J, Gordon M, Ugen KE, Morgan D
(2004) Overcoming antigen masking of anti-amyloidbeta antibodies reveals breaking of B cell tolerance by virus-like particles in amyloidbeta immunized amyloid precursor protein transgenic mice. BMC Neurosci 5:21
T And/Or B Cell Function
Lee JY, et al.
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Lee JY, Cole TB, Palmiter RD, Suh SW, Koh JY
(2002) Contribution by synaptic zinc to the gender-disparate plaque formation in human Swedish mutant APP transgenic mice. Proc. Natl. Acad. Sci. U.S.A. 99(11):7705-10
Alzheimer's
Kelly BL, et al.
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Kelly BL, Vassar R, Ferreira A
(2005) Beta-amyloid-induced dynamin 1 depletion in hippocampal neurons. A potential mechanism for early cognitive decline in Alzheimer disease. J. Biol. Chem. 280(36):31746-53
Alzheimer's
Frautschy SA, et al.
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Frautschy SA, Yang F, Irrizarry M, Hyman B, Saido TC, Hsiao K, Cole GM
(1998) Microglial response to amyloid plaques in APPsw transgenic mice. Am. J. Pathol. 152(1):307-17
Alzheimer's
Eriksen JL, et al.
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Eriksen JL, Sagi SA, Smith TE, Weggen S, Das P, McLendon DC, Ozols VV, Jessing KW, Zavitz KH, Koo EH, Golde TE
(2003) NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower Abeta 42 in vivo. J. Clin. Invest. 112(3):440-9
Alzheimer's
Dong H, et al.
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Dong H, Csernansky CA, Martin MV, Bertchume A, Vallera D, Csernansky JG
(2005) Acetylcholinesterase inhibitors ameliorate behavioral deficits in the Tg2576 mouse model of Alzheimer's disease. Psychopharmacology (Berl.) 181(1):145-52
Alzheimer's
Chapman PF, et al.
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Chapman PF, White GL, Jones MW, Cooper-Blacketer D, Marshall VJ, Irizarry M, Younkin L, Good MA, Bliss TV, Hyman BT, Younkin SG, Hsiao KK
(1999) Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice. Nat. Neurosci. 2(3):271-6
Alzheimer's
Chang KA, et al.
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Chang KA, Kim HS, Ha TY, Ha JW, Shin KY, Jeong YH, Lee JP, Park CH, Kim S, Baik TK, Suh YH
(2006) Phosphorylation of amyloid precursor protein (APP) at Thr668 regulates the nuclear translocation of the APP intracellular domain and induces neurodegeneration. Mol. Cell. Biol. 26(11):4327-38
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