APOE3 Publications

APOE3 Model Page

Filter publications by application: All Alzheimer's Behavior Cardiovascular Diabetes (Type 2) Metabolism Neuroscience
Filter publications by model type: All Gene replacement Humanization Knock in



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Margeta MA, et al.
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Margeta MA, Yin Z, Madore C, Pitts KM, Letcher SM, Tang J, Jiang S, Gauthier CD, Silveira SR, Schroeder CM, Lad EM, Proia AD, Tanzi RE, Holtzman DM, Krasemann S, Chen DF, Butovsky O
(2022) Apolipoprotein E4 impairs the response of neurodegenerative retinal microglia and prevents neuronal loss in glaucoma. Immunity
Pontifex MG, et al.
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Pontifex MG, Martinsen A, Saleh RNM, Harden G, Fox C, Muller M, Vauzour D, Minihane AM
(2022) DHA-Enriched Fish Oil Ameliorates Deficits in Cognition Associated with Menopause and the APOE4 Genotype in Rodents. Nutrients 14(9)
Miranda AM, et al.
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Miranda AM, Ashok A, Chan RB, Zhou B, Xu Y, McIntire LB, Area-Gomez E, Di Paolo G, Duff KE, Oliveira TG, Nuriel T
(2022) Effects of APOE4 allelic dosage on lipidomic signatures in the entorhinal cortex of aged mice. Transl Psychiatry 12(1):129
Keeney JT, et al.
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Keeney JT, Ibrahimi S, Zhao L
(2015) Human ApoE Isoforms Differentially Modulate Glucose and Amyloid Metabolic Pathways in Female Brain: Evidence of the Mechanism of Neuroprotection by ApoE2 and Implications for Alzheimer's Disease Prevention and Early Intervention. J Alzheimers Dis 48(2):411-24
Gene replacement
Cardiovascular, Metabolism, Alzheimer's
Pohlkamp T, et al.
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Pohlkamp T, Xian X, Wong CH, Durakoglugil MS, Werthmann GC, Saido TC, Evers BM, White CL, Connor J, Hammer RE, Herz J
(2021) NHE6 depletion corrects ApoE4-mediated synaptic impairments and reduces amyloid plaque load. Elife 10
Fang W, et al.
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Fang W, Xiao N, Zeng G, Bi D, Dai X, Mi X, Ye Q, Chen X, Zhang J
(2021) APOE4 genotype exacerbates the depression-like behavior of mice during aging through ATP decline. Transl Psychiatry 11(1):507
Behavior, Metabolism
Toro CA, et al.
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Toro CA, Hansen J, Siddiq MM, Johnson K, Zhao W, Azulai D, Das DK, Bauman W, Sebra R, Cai D, Iyengar R, Cardozo CP
(2021) The Human ApoE4 Variant Reduces Functional Recovery and Neuronal Sprouting After Incomplete Spinal Cord Injury in Male Mice. Front Cell Neurosci 15:626192
Schmitt J, et al.
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Schmitt J, Paradis AL, Boucher M, Andrieu L, Barnéoud P, Rondi-Reig L
(2021) Flexibility as a marker of early cognitive decline in humanized apolipoprotein E ε4 (ApoE4) mice. Neurobiol Aging 102:129-138
Shang Y, et al.
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Shang Y, Mishra A, Wang T, Wang Y, Desai M, Chen S, Mao Z, Do L, Bernstein AS, Trouard TP, Brinton RD
(2020) Evidence in support of chromosomal sex influencing plasma based metabolome vs APOE genotype influencing brain metabolome profile in humanized APOE male and female mice. PLoS ONE 15(1):e0225392
Caberlotto L, et al.
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Caberlotto L, Nguyen TP, Lauria M, Priami C, Rimondini R, Maioli S, Cedazo-Minguez A, Sita G, Morroni F, Corsi M, Carboni L
(2019) Cross-disease analysis of Alzheimer's disease and type-2 Diabetes highlights the role of autophagy in the pathophysiology of two highly comorbid diseases. Sci Rep 9(1):3965
Alzheimer's, Diabetes (Type 2)
Wu L, et al.
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Wu L, Zhang X, Zhao L
(2018) Human ApoE Isoforms Differentially Modulate Brain Glucose and Ketone Body Metabolism: Implications for Alzheimer's Disease Risk Reduction and Early Intervention. J. Neurosci.
Salomon-Zimri S, et al.
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Salomon-Zimri S, Glat MJ, Barhum Y, Luz I, Boehm-Cagan A, Liraz O, Ben-Zur T, Offen D, Michaelson DM
(2016) Reversal of ApoE4-Driven Brain Pathology by Vascular Endothelial Growth Factor Treatment. J. Alzheimers Dis. 53(4):1443-58
Knock in, Humanization
Cardiovascular, Metabolism, Neuroscience, Alzheimer's
Segev Y, et al.
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Segev Y, Livne A, Mints M, Rosenblum K
(2016) Concurrence of High Fat Diet and APOE Gene Induces Allele Specific Metabolic and Mental Stress Changes in a Mouse Model of Alzheimer's Disease. Front Behav Neurosci 10:170
Knock in
Behavior, Metabolism, Neuroscience, Alzheimer's
Sullivan PM, et al.
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Sullivan PM, Mezdour H, Aratani Y, Knouff C, Najib J, Reddick RL, Quarfordt SH, Maeda N
(1997) Targeted replacement of the mouse apolipoprotein E gene with the common human APOE3 allele enhances diet-induced hypercholesterolemia and atherosclerosis. J. Biol. Chem. 272(29):17972-80
Malek G, et al.
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Malek G, Johnson LV, Mace BE, Saloupis P, Schmechel DE, Rickman DW, Toth CA, Sullivan PM, Bowes Rickman C
(2005) Apolipoprotein E allele-dependent pathogenesis: a model for age-related retinal degeneration. Proc. Natl. Acad. Sci. U.S.A. 102(33):11900-5
Knouff C, et al.
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Knouff C, Hinsdale ME, Mezdour H, Altenburg MK, Watanabe M, Quarfordt SH, Sullivan PM, Maeda N
(1999) Apo E structure determines VLDL clearance and atherosclerosis risk in mice. J. Clin. Invest. 103(11):1579-86
Sullivan PM, et al.
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Sullivan PM, Mezdour H, Quarfordt SH, Maeda N
(1998) Type III hyperlipoproteinemia and spontaneous atherosclerosis in mice resulting from gene replacement of mouse Apoe with human Apoe*2. J. Clin. Invest. 102(1):130-5
Burgos JS, et al.
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Burgos JS, Ramirez C, Sastre I, Valdivieso F
(2006) Effect of apolipoprotein E on the cerebral load of latent herpes simplex virus type 1 DNA. J. Virol. 80(11):5383-7

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