Author(s) |
(Date) |
Paper Title |
Citation |
Model Type |
Applications |
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| McGovern J, et al. Mouse over for full list |
(2022) | Forced Fox-P3 expression can improve the safety and antigen-specific function of engineered regulatory T cells. | J Autoimmun 132:102888 | Immuno-Oncology | ||
| Nelson SA, et al. Mouse over for full list |
(2022) | CD4 T cell epitope abundance in ferritin core potentiates responses to hemagglutinin nanoparticle vaccines. | NPJ Vaccines 7(1):124 | Vaccine Research | ||
| Cook K, et al. Mouse over for full list |
(2022) | Vaccine Can Induce CD4-Mediated Responses to Homocitrullinated Peptides Multiple HLA-Types and Confer Anti-Tumor Immunity. | Front Immunol 13:873947 | Vaccine Research, Immuno-Oncology | ||
| Poole JA, et al. Mouse over for full list |
(2022) | Increased susceptibility to organic dust exposure-induced inflammatory lung disease with enhanced rheumatoid arthritis-associated autoantigen expression in HLA-DR4 transgenic mice. | Respir Res 23(1):160 | Inflammation | ||
| Kilian M, et al. Mouse over for full list |
(2022) | T-cell Receptor Therapy Targeting Mutant Capicua Transcriptional Repressor in Experimental Gliomas. | Clin Cancer Res 28(2):378-389 | Oncology, Immuno-Oncology | ||
| Pishesha N, et al. Mouse over for full list |
(2021) | A class II MHC-targeted vaccine elicits immunity against SARS-CoV-2 and its variants. | Proc Natl Acad Sci U S A 118(44) | Infectious Disease, Vaccine Research | ||
| Brentville VA, et al. Mouse over for full list |
(2020) | Combination vaccine based on citrullinated vimentin and enolase peptides induces potent CD4-mediated anti-tumor responses. | J Immunother Cancer 8(1) | Oncology, Vaccine Research, Immuno-Oncology | ||
| Choudhury RH, et al. Mouse over for full list |
(2022) | PAD-2-mediated citrullination of nucleophosmin provides an effective target for tumor immunotherapy. | J Immunother Cancer 10(2) | Oncology, Vaccine Research, Immuno-Oncology | ||
| Lim JJ, et al. Mouse over for full list |
(2021) | The shared susceptibility epitope of HLA-DR4 binds citrullinated self-antigens and the TCR. | Sci Immunol 6(58) | Rheumatoid Arthritis | ||
| Yang J, et al. Mouse over for full list |
(2009) | Searching immunodominant epitopes prior to epidemic: HLA class II-restricted SARS-CoV spike protein epitopes in unexposed individuals. | Int. Immunol. 21(1):63-71 | Infectious Disease | ||
| Das K, et al. Mouse over for full list |
(2019) | A transplantable tumor model allowing investigation of NY-BR-1-specific T cell responses in HLA-DRB1*0401 transgenic mice. | BMC Cancer 19(1):914 | T And/Or B Cell Function, Breast Cancer | ||
| Verhagen J, et al. Mouse over for full list |
(2018) | Proinsulin-mediated induction of type 1 diabetes in HLA-DR4-transgenic mice. | Sci Rep 8(1):14106 | Diabetes (Type 1) | ||
| Xue W, et al. Mouse over for full list |
(2016) | SCIB1, a huIgG1 antibody DNA vaccination, combined with PD-1 blockade induced efficient therapy of poorly immunogenic tumors. | Oncotarget 7(50):83088-83100 | Oncology, Immunotherapy, Vaccine Research, Immuno-Oncology | ||
| Hurtgen BJ, et al. Mouse over for full list |
(2016) | Preclinical identification of vaccine induced protective correlates in human leukocyte antigen expressing transgenic mice infected with Coccidioides posadasii. | Vaccine 34(44):5336-5343 | Infectious Disease, Vaccine Research | ||
| Szabo PA, et al. Mouse over for full list |
(2016) | Swift Intrahepatic Accumulation of Granulocytic Myeloid-Derived Suppressor Cells in a Humanized Mouse Model of Toxic Shock Syndrome. | J. Infect. Dis. 213(12):1990-5 | Immunology | ||
| DiPiazza A, et al. Mouse over for full list |
(2017) | Avian and Human Seasonal Influenza Hemagglutinin Proteins Elicit CD4 T Cell Responses That Are Comparable in Epitope Abundance and Diversity. | Clin. Vaccine Immunol. 24(3) | Vaccine Research | ||
| Pal S, et al. Mouse over for full list |
(2018) | Transcervical Inoculation with Chlamydia trachomatis Induces Infertility in HLA-DR4 Transgenic and Wild-Type Mice. | Infect. Immun. 86(1) | Vaccine Research | ||
| Gebe JA, et al. Mouse over for full list |
(2006) | Age-dependent loss of tolerance to an immunodominant epitope of glutamic acid decarboxylase in diabetic-prone RIP-B7/DR4 mice. | Clin. Immunol. 121(3):294-304 | |||
| Gibson VB, et al. Mouse over for full list |
(2015) | Proinsulin multi-peptide immunotherapy induces antigen-specific regulatory T cells and limits autoimmunity in a humanized model. | Clin. Exp. Immunol. 182(3):251-60 | |||
| Wei Xue, et al. Mouse over for full list |
(2015) | SCIB1 DNA vaccination synergises with PD-1 blockade to induce efficient tumor therapy of poorly immunogenic tumours | Poster | Vaccine Research | ||
| V.Brentville, et al. Mouse over for full list |
(2015) | Adjuvant choice modulates self antigen specific CD4 responses generated by peptide vaccination | Poster | |||
| Zang Y, et al. Mouse over for full list |
(2014) | Conservation of pathogenic TCR homology across class II restrictions in anti-ribonucleoprotein autoimmunity: extended efficacy of T cell vaccine therapy. | J. Immunol. 192(9):4093-102 | T And/Or B Cell Function, Vaccine Research | ||
| Yu JJ, et al. Mouse over for full list |
(2010) | Francisella tularensis T-cell antigen identification using humanized HLA-DR4 transgenic mice. | Clin. Vaccine Immunol. 17(2):215-22 | T And/Or B Cell Function, Vaccine Research | ||
| Xu SX, et al. Mouse over for full list |
(2014) | Superantigens subvert the neutrophil response to promote abscess formation and enhance Staphylococcus aureus survival in vivo. | Infect. Immun. 82(9):3588-98 | |||
| Xu SX, et al. Mouse over for full list |
(2015) | Superantigens Modulate Bacterial Density during Staphylococcus aureus Nasal Colonization. | Toxins (Basel) 7(5):1821-36 | |||
| Willett TA, et al. Mouse over for full list |
(2004) | An effective second-generation outer surface protein A-derived Lyme vaccine that eliminates a potentially autoreactive T cell epitope. | Proc. Natl. Acad. Sci. U.S.A. 101(5):1303-8 | T And/Or B Cell Function, Vaccine Research | ||
| Wijayalath W, et al. Mouse over for full list |
(2014) | HLA class II (DR0401) molecules induce Foxp3+ regulatory T cell suppression of B cells in Plasmodium yoelii strain 17XNL malaria. | Infect. Immun. 82(1):286-97 | T And/Or B Cell Function, Malaria | ||
| Wijayalath W, et al. Mouse over for full list |
(2014) | Humanized HLA-DR4 mice fed with the protozoan pathogen of oysters Perkinsus marinus (Dermo) do not develop noticeable pathology but elicit systemic immunity. | PLoS ONE 9(1):e87435 | |||
| Walker KM, et al. Mouse over for full list |
(2012) | Preventing and curing citrulline-induced autoimmune arthritis in a humanized mouse model using a Th2-polarizing iNKT cell agonist. | Immunol. Cell Biol. 90(6):630-9 | |||
| Touloukian CE, et al. Mouse over for full list |
(2000) | Identification of a MHC class II-restricted human gp100 epitope using DR4-IE transgenic mice. | J. Immunol. 164(7):3535-42 | T And/Or B Cell Function, Vaccine Research | ||
| Schumacher T, et al. Mouse over for full list |
(2014) | A vaccine targeting mutant IDH1 induces antitumour immunity. | Nature 512(7514):324-7 | Vaccine Research | ||
| Sloan JM, et al. Mouse over for full list |
(2002) | MHC class I and class II presentation of tumor antigen in retrovirally and adenovirally transduced dendritic cells. | Cancer Gene Ther. 9(11):946-50 | |||
| Scally SW, et al. Mouse over for full list |
(2013) | A molecular basis for the association of the HLA-DRB1 locus, citrullination, and rheumatoid arthritis. | J. Exp. Med. 210(12):2569-82 | Rheumatoid Arthritis | ||
| Rojas JM, et al. Mouse over for full list |
(2005) | Peptide immunisation of HLA-DR-transgenic mice permits the identification of a novel HLA-DRbeta1*0101- and HLA-DRbeta1*0401-restricted epitope from p53. | Cancer Immunol. Immunother. 54(3):243-53 | Immunology, T And/Or B Cell Function | ||
| Musson JA, et al. Mouse over for full list |
(2014) | CD4+ T cell epitopes of FliC conserved between strains of Burkholderia: implications for vaccines against melioidosis and cepacia complex in cystic fibrosis. | J. Immunol. 193(12):6041-9 | T And/Or B Cell Function, Vaccine Research | ||
| Murthy AK, et al. Mouse over for full list |
(2006) | Chlamydial protease-like activity factor induces protective immunity against genital chlamydial infection in transgenic mice that express the human HLA-DR4 allele. | Infect. Immun. 74(12):6722-9 | |||
| Meyer AL, et al. Mouse over for full list |
(2000) | Direct enumeration of Borrelia-reactive CD4 T cells ex vivo by using MHC class II tetramers. | Proc. Natl. Acad. Sci. U.S.A. 97(21):11433-8 | |||
| Klucar P, et al. Mouse over for full list |
(2009) | Vaccination strategies to enhance local immunity and protection against Mycobacteriun tuberculosis. | Vaccine 27(12):1816-24 | Tuberculosis, Vaccine Research | ||
| Kim H, et al. Mouse over for full list |
(2014) | Mesenchymal stromal (stem) cells suppress pro-inflammatory cytokine production but fail to improve survival in experimental staphylococcal toxic shock syndrome. | BMC Immunol. 15:1 | |||
| Khan AM, et al. Mouse over for full list |
(2008) | Conservation and variability of dengue virus proteins: implications for vaccine design. | PLoS Negl Trop Dis 2(8):e272 | |||
| Kawamura K, et al. Mouse over for full list |
(2008) | Myelin-reactive type B T cells and T cells specific for low-affinity MHC-binding myelin peptides escape tolerance in HLA-DR transgenic mice. | J. Immunol. 181(5):3202-11 | Multiple Sclerosis | ||
| James EA, et al. Mouse over for full list |
(2014) | Citrulline-specific Th1 cells are increased in rheumatoid arthritis and their frequency is influenced by disease duration and therapy. | 66(7):1712-22 | Rheumatoid Arthritis, T And/Or B Cell Function | ||
| Ito K, et al. Mouse over for full list |
(1996) | HLA-DR4-IE chimeric class II transgenic, murine class II-deficient mice are susceptible to experimental allergic encephalomyelitis. | J. Exp. Med. 183(6):2635-44 | Autoimmune | ||
| Iliopoulou BP, et al. Mouse over for full list |
(2008) | Persistent arthritis in Borrelia burgdorferi-infected HLA-DR4-positive CD28-negative mice post-antibiotic treatment. | Arthritis Rheum. 58(12):3892-901 | Rheumatoid Arthritis | ||
| Hill JA, et al. Mouse over for full list |
(2003) | The relationship between predicted peptide-MHC class II affinity and T-cell activation in a HLA-DRbeta1*0401 transgenic mouse model. | Arthritis Res. Ther. 5(1):R40-8 | Rheumatoid Arthritis, T And/Or B Cell Function | ||
| Hill JA, et al. Mouse over for full list |
(2008) | Arthritis induced by posttranslationally modified (citrullinated) fibrinogen in DR4-IE transgenic mice. | J. Exp. Med. 205(4):967-79 | Rheumatoid Arthritis | ||
| Hayworth JL, et al. Mouse over for full list |
(2009) | Attenuation of massive cytokine response to the staphylococcal enterotoxin B superantigen by the innate immunomodulatory protein lactoferrin. | Clin. Exp. Immunol. 157(1):60-70 | Immunology | ||
| Grusby MJ, et al. Mouse over for full list |
(1991) | Depletion of CD4+ T cells in major histocompatibility complex class II-deficient mice. | Science. 1991 Sep 20;253(5026):1417-20. | T And/Or B Cell Function | ||
| Greidinger EL, et al. Mouse over for full list |
(2008) | CD4+ T cells target epitopes residing within the RNA-binding domain of the U1-70-kDa small nuclear ribonucleoprotein autoantigen and have restricted TCR diversity in an HLA-DR4-transgenic murine model of mixed connective tissue disease. | J. Immunol. 180(12):8444-54 | Immunology, T And/Or B Cell Function | ||
| Call MJ, et al. Mouse over for full list |
(2009) | In vivo enhancement of peptide display by MHC class II molecules with small molecule catalysts of peptide exchange. | J. Immunol. 182(10):6342-52 | Immunology | ||
| Brentville VA, et al. Mouse over for full list |
(2016) | Citrullinated Vimentin Presented on MHC-II in Tumor Cells Is a Target for CD4+ T-Cell-Mediated Antitumor Immunity. | Cancer Res | T And/Or B Cell Function, Oncology | ||
| Blazanovic K, et al. Mouse over for full list |
(2015) | Structure-based redesign of lysostaphin yields potent antistaphylococcal enzymes that evade immune cell surveillance. | Mol Ther Methods Clin Dev 2:15021 | Infectious Disease |
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