NIH nude rat

NIH nude Spontaneous Mutant Rat Model
  • Live
  • Rat
  • Male & Female Available
  • Various
  • Available for direct purchase by CRO
Model No.NomenclatureGenotype
NIHRNU-FNTac:NIH-Foxn1rnusp/sp
NIHRNU-MNTac:NIH-Foxn1rnusp/sp
NIHRNU-FNTac:NIH-Foxn1rnusp/wt
NIHRNU-MNTac:NIH-Foxn1rnusp/wt
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Overview

Nomenclature: NTac:NIH-Foxn1rnu

  • Exhibits deficient T cell activity with lymph nodes and Peyers patches showing lymphocyte depletion in T-lymphocyte dependent regions
  • In this outbred immunodeficient model the vibrissae are present in the homozygous nude rat but bent with some short hairs on the head and occasionally on the rest of the body
  • At later ages some hair growth occurs but rats become hairless again within a few weeks
  • Skin of homozygous rat is generally pigmented, but occasionally an albino rat is seen
  • Consistent with ILAR nomenclature rules, Taconic has recently updated the nomenclature for the NIHRNU from NTac:NIH-Whn to NTac:NIH-Foxn1rnu.
  • Taconic has identified a defect in tooth enamel in the NIHRNU, which presents as white teeth in affected animals. This defect does/does not affect overall health of affected animals. Representative sampling of NIHRNU animals in our colonies revealed that on average 21% (frequency: 0.208 +/- 0.109 SD) of animals showed this phenotype.

Origin

The NIH nude Spontaneous mutant model was developed by NIH in 1979-1980 by intercrossing eight strains of rats. Taconic received stock from NIH Animal Genetic Resource in 1981. The rats were derived by hysterectomy in 1987 and again in 1998. Animals are randomly bred at Taconic without selection for coat color or pigmentation.

Genetics

Species:Rat
Strain Type:Outbred or Mixed
Allele Type:Spontaneous Mutant
Coat Color:Various
Genetic Background:NTac:NIH

Applications & Therapeutic Areas

  • Cell and Tissue Humanized
  • Immunology
  • Inflammation
  • Oncology & Immuno-Oncology

Transit, Housing & Welfare

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Packing Practices

Taconic standard practice is to recombine animals of different home cages and/or ages from a single model and sex during packing, except in specific cases where Taconic's animal welfare policy prohibits recombination due to aggression or other concerns.  When an order is fulfilled with animals from more than one week of birth, this standard practice results in animals from a range of birth weeks packed together in a single TTC. When an order is fulfilled with animals from genotyped models, this standard practice results in animals from different home cages packed together in a single TTC.

Customers who wish to keep animals from different weeks of birth separated should place orders with the special instruction "Divide and label by age."  Note that this special request can result in increased costs for additional Taconic Transit Cages, dividers and/or freight charges.

Data

Average litter size: 8

Pricing - USD

Opportunist Free (OF) Health Standard

NIHRNU Female

NIHRNU-F Genotype sp/sp

Age in WeeksQuantity 1 - 999
3 to 4$285.00
5 to 8$358.00
9 to 12$401.00

NIHRNU-F Genotype sp/wt

Age in WeeksQuantity 1 - 999
3 to 12$150.00

Specialized Inventory

NIHRNU-RF Genotype sp/wtQuantity 1 - 199
Retired Female Breeder$286.00

Specialized Inventory

NIHRNU-UPQuantity 1 - 199
Untimed Pregnant Female$2,144.00

*Untimed pregnant requests are filled with late gestation pregnant females. Pups may be delivered in transit.

Specialized Inventory

NIHRNU-FLQuantity 1 - 199
Female With Litter$2,476.00

NIHRNU Male

NIHRNU-M Genotype sp/sp

Age in WeeksQuantity 1 - 999
3 to 4$285.00
5 to 8$358.00
9 to 12$401.00

NIHRNU-M Genotype sp/wt

Age in WeeksQuantity 1 - 999
3 to 12$150.00

Specialized Inventory

NIHRNU-RM Genotype sp/spQuantity 1 - 199
Retired Male Breeder$286.00

Pricing - EUR

Opportunist Free (OF) Health Standard

NIHRNU Female

NIHRNU-F Genotype sp/sp

Age in WeeksQuantity 1 - 999
3 to 4€290,00
5 to 8€342,00
9 to 12€401,00

NIHRNU-F Genotype sp/wt

Age in WeeksQuantity 1 - 999
4 to 12€151,00

Specialized Inventory

NIHRNU-RF Genotype sp/wtQuantity 1 - 199
Retired Female Breeder€200,00

Specialized Inventory

NIHRNU-UPQuantity 1 - 199
Untimed Pregnant Female€1.541,00

*Untimed pregnant requests are filled with late gestation pregnant females. Pups may be delivered in transit.

Specialized Inventory

NIHRNU-FLQuantity 1 - 199
Female With Litter€2.524,00

NIHRNU Male

NIHRNU-M Genotype sp/sp

Age in WeeksQuantity 1 - 999
3 to 4€290,00
5 to 8€342,00
9 to 12€401,00

NIHRNU-M Genotype sp/wt

Age in WeeksQuantity 1 - 999
4 to 12€151,00

Specialized Inventory

NIHRNU-RM Genotype sp/spQuantity 1 - 199
Retired Male Breeder€401,00

Pricing - USD Nonprofit

Opportunist Free (OF) Health Standard

NIHRNU Female

NIHRNU-F Genotype sp/sp

Age in WeeksQuantity 1 - 999
3 to 4$256.00
5 to 8$322.00
9 to 12$361.00

NIHRNU-F Genotype sp/wt

Age in WeeksQuantity 1 - 999
3 to 12$135.00

Specialized Inventory

NIHRNU-RF Genotype sp/wtQuantity 1 - 199
Retired Female Breeder$286.00

Specialized Inventory

NIHRNU-UPQuantity 1 - 199
Untimed Pregnant Female$2,144.00

*Untimed pregnant requests are filled with late gestation pregnant females. Pups may be delivered in transit.

Specialized Inventory

NIHRNU-FLQuantity 1 - 199
Female With Litter$2,476.00

NIHRNU Male

NIHRNU-M Genotype sp/sp

Age in WeeksQuantity 1 - 999
3 to 4$256.00
5 to 8$322.00
9 to 12$361.00

NIHRNU-M Genotype sp/wt

Age in WeeksQuantity 1 - 999
3 to 12$135.00

Pricing - EUR Nonprofit

Opportunist Free (OF) Health Standard

NIHRNU Female

NIHRNU-F Genotype sp/sp

Age in WeeksQuantity 1 - 999
3 to 4€261,00
5 to 8€308,00
9 to 12€361,00

NIHRNU-F Genotype sp/wt

Age in WeeksQuantity 1 - 999
4 to 12€136,00

Specialized Inventory

NIHRNU-RF Genotype sp/wtQuantity 1 - 199
Retired Female Breeder€200,00

Specialized Inventory

NIHRNU-UPQuantity 1 - 199
Untimed Pregnant Female€1.541,00

*Untimed pregnant requests are filled with late gestation pregnant females. Pups may be delivered in transit.

Specialized Inventory

NIHRNU-FLQuantity 1 - 199
Female With Litter€2.524,00

NIHRNU Male

NIHRNU-M Genotype sp/sp

Age in WeeksQuantity 1 - 999
3 to 4€261,00
5 to 8€308,00
9 to 12€361,00

NIHRNU-M Genotype sp/wt

Age in WeeksQuantity 1 - 999
4 to 12€136,00

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